Antimicrobial activity of omwaprin, a new member of the waprin family of snake venom proteins

Biochemical Journal

Volumn 402, Issue 1, 2007, Pages 93-104

  Nair, Dileep G ^a   Fry, Bryan G ^a,b,d   Alewood, Paul ^b   Kumar, Prakash P ^a   Kini, R Manjunatha ^a,c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Antibacterial protein; Antimicrobial protein; Inland taipan (Oxyuranus microlepidotus); Omwaprin; Snake venom; WAP domain (whey acidic protein domain)

Indexed keywords

AMINO ACIDS; ANTIBIOTICS; CELLS; ENZYME INHIBITION; ESCHERICHIA COLI;

ANTIBACTERIAL PROTEIN; ANTIMICROBIAL PROTEIN; INLAND TAIPAN; OMWAPRIN; SNAKE VENOM; WHEY ACIDIC PROTEIN DOMAIN;

PROTEINS;

ELAFIN; EPIDIDYMAL PROTEINASE INHIBITOR; NAWAPRIN; OMWAPRIN; PROTEINASE INHIBITOR; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; SINGLE WHEY ACIDIC PROTEIN MOTIF 1; SINGLE WHEY ACIDIC PROTEIN MOTIF 2; SNAKE VENOM; UNCLASSIFIED DRUG;

ALKYLATION; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DISULFIDE BOND; DRUG SYNTHESIS; ERYTHROCYTE; ESCHERICHIA COLI; HEMOLYSIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; SCANNING ELECTRON MICROSCOPY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MUS; OXYURANUS MICROLEPIDOTUS; POSIBACTERIA;

EID: 33846991985     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060318     Document Type: Article

References (55)

1. Ferreira, S. H., Bartelt, D. C. and Greene, L. J. (1970) Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom. Biochemistry 9, 2583-2593
2. Marsh, N. A. (1998) Use of snake venom fractions in the coagulation laboratory. Blood Coagulation Fibrinolysis 9, 395-404
3. Marsh, N. A. (2001) Diagnostic uses of snake venom. Haemostasis 31, 211-217
4. de Lima, D. C., Alvarez, A. P., de Freitas, C. C., Santos, D. O., Borges, R. O., Dos Santos, T. C., Mendes, C. L., Rodrigues, C. R. and Castro, H. C. (2005) Snake venom: any clue for antibiotics and CAM? Evidence-Based Complement Altern. Med. 2, 39-47
5. Sher, E., Giovannini, F., Boot, J. and Lang, B. (2000) Peptide neurotoxins, small-cell lung carcinoma and neurological paraneoplastic syndromes. Biochimie 82, 927-936
6. Kordis, D. and Gubensek, F. (2000) Adaptive evolution of animal toxin multigene families. Gene 261, 43-52
7. Bailey, G. S. (1998) Enzymes from Snake Venom, Alaken, Fort Collins
8. 2 Enzymes: Structure, Function and Mechanism, John Wiley and Sons, Chichester
9. Harvey, A. L. (1991) Snake Toxins, Pergamon Press, New York
10. 2 from the venom of Australian king brown snake (Pseudechis australis). Toxicon 28, 319-327
11. Braganca, B. M. and Sambray, Y. M. (1967) Multiple forms of cobra venom Phospholipase A. Nature 216, 1210-1211
12. Torres, A. M., Wong, H. Y., Desai, M., Moochhala, S., Kuchel, P. W. and Kini, R. M. (2003) Identification of a novel family of proteins in snake venoms: purification and structural characterization of nawaprin from Naja nigricollis snake venom. J. Biol. Chem. 278, 40097-40104
13. Pung, Y. F., Kumar, S. V., Rajagopalan, N., Fry, B. G., Kumar, P. P. and Kini, R. M. (2006) Ohanin, a novel protein from king cobra venom: its cDNA and genomic organization. Gene 371, 246-256
14. +-ATPase from porcine intestine. Biochem. Biophys. Res. Commun. 164, 496-502
15. Thompson, R. C. and Ohlsson, K. (1986) Isolation, properties, and complete amino acid sequence of human secretory leukocyte proteinase inhibitor, a potent inhibitor of leukocyte elastase. Proc. Natl. Acad. Sci. U.S.A. 83, 6692-6696
16. Wiedow, O., Schroder, J. M., Gregory, H., Young, J. A. and Christophers, E. (1990) Elafin: an elastase-specific inhibitor of human skin: purification, characterization, and complete amino acid sequence. J. Biol. Chem. 265, 14791-14795
17. Larsen, M., Ressler, S. J., Lu, B, Gerdes, M. J., McBride, L., Dang, T. D. and Rowley, D. R. (1998) Molecular cloning and expression of ps20 growth inhibitor: a novel WAP-type "four-disulfide core" domain protein expressed in smooth muscle. J. Biol. Chem. 273, 4574-4584
18. Hagiwara, K., Kikuchi, T., Endo, Y., Huqun, Usui K., Takahashi, M., Shibata, N., Kusakabe, T., Xin, H., Hoshi, S. et al. (2003) Mouse SWAM1 and SWAM2 are antibacterial proteins composed of a single whey acidic protein motif. J. Immunol. 170, 1973-1979
19. Pung, Y. F., Wong, P. T., Kumar, P. P., Hodgson, W. C. and Kini, R. M. (2005) Ohanin, a novel protein from king cobra venom, induces hypolocomotion and hyperalgesia in mice. J. Biol. Chem. 280, 13137-13147
20. Vila-Perello, M. and Andreu, D. (2005) Characterization and structural role of disulfide bonds in a highly knotted thionin from Pyrularia pubera. Biopolymers 80, 697-707
21. Takemura, H., Kaku, M., Kohno, S., Hirakata, Y., Tanaka, H., Yoshida, R., Tomono, K., Koga, H., Wada, A., Hirayama, T. and Kamihira, S. (1996) Evaluation of susceptibility of Gram-positive and -negative bacteria to human defensins by using radial diffusion assay. Antimicrob. Agents Chemother. 40, 2280-2284
22. Yenugu, S., Hamil, K. G., French, F. S. and Hall, S. H. (2004) The androgen-regulated epididymal sperm-binding protein, human β-defensin 118 (DEFB118) (formerly ESC42), is an antimicrobial β-defensin. Reprod. Biol. Endocrinol. 2, 61
23. Ryadnov, M. G., Degtyareva, O. V., Kashparov, I. A. and Mitin, Y. V. (2002) A new synthetic all-D-peptide with high bacterial and low mammalian cytotoxicity. Peptides 23, 1869-1871
24. + binding in SQD1, a protein essential for sulfolipid biosynthesis in Arabidopsis. Arch. Biochem. Biophys. 369, 30-41
25. Wu, J. and Watson, J. T. (1998) Optimization of the cleavage reaction for cyanylated cysteinyl proteins for efficient and simplified mass mapping. Anal. Biochem. 258, 268-276
26. 13 salt bridge conserved in mammalian α-defensins? J. Biol. Chem. 280, 43039-43047
27. Yenugu, S., Hamil, K. G., Birse, C. E., Ruben, S. M., French, F. S. and Hall, S. H. (2003) Antibacterial properties of the sperm-binding proteins and peptides human epididymis 2 (HE2) family: salt sensitivity, structural dependence and their interaction with outer and cytoplasmic membranes of Escherichia coli. Biochem. J. 372, 473-483
28. Fry, B. G. (2005) From genome to "venome": molecular origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences and related body proteins. Genome Res. 15, 403-420
29. Qi, J., Wu, J., Somkuti, G. A. and Watson, J. T. (2001) Determination of the disulfide structure of sillucin, a highly knotted, cysteine-rich peptide, by cyanylation/cleavage mass mapping. Biochemistry 40, 4531-4538
30. Yenugu, S., Richardson, R. T., Sivashanmugam, P., Wang, Z., O'rand, M. G., French, F. S. and Hall, S. H. (2004) Antimicrobial activity of human EPPIN, an androgen-regulated, sperm-bound protein with a whey acidic protein motif. Biol. Reprod. 71, 1484-1490
31. Couto, M. A., Harwig, S. S., Cullor, J. S., Hughes, J. P. and Lehrer, R. I. (1992) eNAP-2, a novel cysteine-rich bactericidal peptide from equine leukocytes. Infect. Immun. 60, 5042-5047
32. Nagaoka, I., Hirota, S., Yomogida, S., Ohwada, A. and Hirata, M. (2000) Synergistic actions of antibacterial neutrophil defensins and cathelicidins. Inflamm. Res. 49, 73-79
33. Yenugu, S., Hamil, K. G., Radhakrishnan, Y., French, F. S. and Hall, S. H. (2004) Antimicrobial actions of the human epididymis 2 (HE2) protein isoforms, HE2α, HE2β1 and HE2β2. Endocrinology 145, 3165-3173
34. Nakajima, Y., Ishibashi, J., Yukuhiro, F., Asaoka, A., Taylor, D. and Yamakawa, M. (2003) Antibacterial activity and mechanism of action of tick defensin against Gram-positive bacteria. Biochim. Biophys. Acta 1624, 125-130
35. Cociancich, S., Ghazi, A., Hetru, C., Hoffmann, J. A. and Letellier, L. (1993) Insect defensin, an inducible antibacterial peptide, forms voltage-dependent channels in Micrococcus luteus. J. Biol. Chem. 268, 19239-19245
36. Gao, Y., van Belkum, M. J. and Stiles, M. E. (1999) The outer membrane of Gram-negative bacteria inhibits antibacterial activity of brochocin-C. Appl. Environ. Microbiol. 65, 4329-4333
37. Devine, D. A. and Hancock, R. E. (2002) Cationic peptides: distribution and mechanisms of resistance. Curr. Pharm. Des. 8, 703-714
38. Skerlavaj, B., Gennaro, R., Bagella, L., Merluzzi, L., Risso, A. and Zanetti, M. (1996) Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities. J. Biol. Chem. 271, 28375-28381
39. Dempsey, C. E. (1990) The actions of melittin on membranes. Biochim. Biophys. Acta 1031, 143-161
40. Johansson, J., Gudmundsson, G. H., Rottenberg, M. E., Berndt, K. D. and Agerberth, B. (1998) Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37. J. Biol. Chem. 273, 3718-3724
41. Skerlavaj, B., Benincasa, M., Risso, A., Zanetti, M. and Gennaro, R. (1999) SMAP-29: a potent antibacterial and antifungal peptide from sheep leukocytes. FEBS Lett. 463, 58-62
42. Glukhov, E., Stark, M., Burrows, L. L. and Deber, C. M. (2005) Basis for selectivity of cationic antimicrobial peptides for bacterial versus mammalian membranes. J. Biol. Chem. 280, 33960-33967
43. Friedrich, C., Scott, M. G., Karunaratne, N., Yan, H. and Hancock, R. E. (1999) Salt-resistant α-helical cationic antimicrobial peptides. Antimicrob. Agents Chemother. 43, 1542-1548
44. Kini, R. M. and Evans, H. J. (1989) A common cytolytic region in myotoxins, hemolysins, cardiotoxins and antibacterial peptides. Int. J. Pept. Protein Res. 34, 277-286
45. Kini, R. M. and Evans, H. J. (1989) Role of cationic residues in cytolytic activity: modification of lysine residues in the cardiotoxin from Naja nigricollis venom and correlation between cytolytic and antiplatelet activity. Biochemistry 28, 9209-9215
46. Matsuzaki, K., Nakayama, M., Fukui, M., Otaka, A., Funakoshi, S., Fujii, N., Bessho, K. and Miyajima, K. (1993) Role of disulfide linkages in tachyplesin-lipid interactions. Biochemistry 32, 11704-11710
47. Mangoni, M. E., Aumelas, A., Charnet, P., Roumestand, C., Chiche, L., Despaux, E., Grassy, G., Calas, B. and Chavanieu, A. (1996) Change in membrane permeability induced by protegrin 1: implication of disulphide bridges for pore formation. FEBS Lett. 383, 93-98
48. Aloof-Hirsch, S., de Vries, A. and Berger, A. (1968) The direct lytic factor of cobra venom: purification and chemical characterization. Biochim. Biophys. Acta 154, 53-60
49. 49 myotoxin II-(115-129)-peptide identifies its bactericidal region. Eur. J. Biochem. 253, 452-461
50. Xie, J. P., Yue, J., Xiong, Y. L., Wang, W. Y., Yu, S. Q. and Wang, H. H. (2003) In vitro activities of small peptides from snake venom against clinical isolates of drug-resistant Mycobacterium tuberculosis. Int. J. Antimicrob. Agents 22, 172-174
51. Stiles, B. G., Sexton, F. W. and Weinstein, S. A. (1991) Antibacterial effects of different snake venoms: purification and characterization of antibacterial proteins from Pseudechis australis (Australian king brown or mulga snake) venom. Toxicon 29, 1129-1141
52. Barbosa, P. S., Martins, A. M., Havt, A., Toyama, D. O., Evangelista, J. S., Ferreira, D. P., Joazeiro, P. P., Beriam, L. O., Toyama, M. H., Fonteles, M. C. and Monteiro, H. S. (2005) Renal and antibacterial effects induced by myotoxin I and II isolated from Bothrops jararacussu venom. Toxicon 46, 375-386
53. Thomas, R. G. and Pough, F. H. (1979) The effect of rattlesnake venom on digestion of prey. Toxicon 17, 221-228
54. De Smet, K. and Contreras, R. (2005) Human antimicrobial peptides: defensins, cathelicidins and histatins. Biotechnol. Lett. 27, 1337-1347
55. Bals, R. (2000) Epithelial antimicrobial peptides in host defense against infection. Respir. Res. 1, 141-150