Adaptive evolution of animal toxin multigene families

Gene

Volumn 261, Issue 1, 2000, Pages 43-52

  Kordiš, Dušan ^a   Gubenšek, Franc ^a,b  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Adaptive evolution; Molecular evolution; Multigene family; Positive Darwinian selection; Rapid divergence; Toxin

Indexed keywords

CONOTOXIN; SCORPION VENOM; SNAKE VENOM;

ADAPTATION; ARTICLE; BIODIVERSITY; CONTROLLED STUDY; GENE DUPLICATION; GENETIC CODE; IMMOBILIZATION; INTRON; MOLECULAR EVOLUTION; MULTIGENE FAMILY; NATURAL SELECTION; NONHUMAN; PREDATOR; PRIORITY JOURNAL; SPECIES DIFFERENTIATION; TOXIN ANALYSIS;

ADAPTATION, BIOLOGICAL; ANIMALS; EVOLUTION, MOLECULAR; MULTIGENE FAMILY; TOXINS, BIOLOGICAL; VENOMS;

ANIMALIA; DARWINIA;

EID: 0034736505     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(00)00490-X     Document Type: Article

References (54)

1. Elapid venom toxins: Multiple recruitments of ancient scaffolds
2. Toxins and genes isolated from scorpions of the genus Tityus
3. Foci of amino acid residue conservation in the 3D structures of the Kunitz BPTI proteinase inhibitors: How do variants from snake venom differ?
4. Locus-specific conservation of the HLA class I introns by intra-locus homogenization
5. The multiplicity of cardiotoxins from Naja naja atra (Taiwan cobra) venom
6. 2 isoenzymes of Trimeresurus flavoviridis snakes in the southwestern islands of Japan
7. Diet and snake venom evolution
8. Accelerated evolution of Crotalinae snake venom gland serine proteinases
9. Molecular genetics of ecological diversification: Duplication and rapid evolution of toxin genes of the venomous gastropod Conus
10. 2 genes: An application of FORS-D analysis
11. Dynamic diversification from a putative common ancestor of scorpion toxins affecting sodium, potassium, and chloride channels
12. Molecular cloning, characterization and evolution of the gene encoding a new group of short-chain α-neurotoxins in an Australian elapid, Pseudonaja textilis
13. 2 genes and their molecular evolution
14. Crystal structure of an acethylcholinesterase-fasciculin complex: Interaction of a three-finger toxin from snake venom with its target
15. Twenty years of dendrotoxins
16. Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection
17. The evolution of functionally novel proteins after gene duplication
18. Genomic sequences encoding the acidic and basic subunits of mojave toxin: Unusually high sequence identity of non-coding regions
19. 2s, but having different exons
20. Snake toxins and venom: An evolutionary perspective
21. 2 - A complex multifunctional protein puzzle
22. Proline brackets and identification of potential functional sites in proteins: Toxins to therapeutics
23. 2 enzymes
24. The origin of snakes and the evolution of venomous apparatus
25. 2 genes
26. 2 genes and in genomes of Viperidae snakes
27. 2 genes is unexpectedly limited to the third exon
28. Structure and organization of the cardiotoxin genes in Naja naja sputatrix
29. 2
30. Proteinase inhibitor homologues as potassium channel blockers
31. + channels
32. Functional architectures of animal toxins: A clue to drug design?
33. Evolution of disintegrin cysteine- rich and mammalian matrix-degrading metalloproteinases: Gene duplication and divergence of a common ancestor rather than convergent evolution
34. Accelerated evolution of Trimeresurus flavoviridis venom gland phospholipase A2 isozymes
35. 2 isozyme genes
36. 2 isozyme-encoding genes
37. 2 inhibitors from the serum of Trimeresurus flavoviridis snake
38. The cystine knot structure of ion channel toxins and related polypeptides
39. 2
40. Molecular evolution of snake toxins: Is the functional diversity of snake toxins associated with a mechanism of accelerated evolution?
41. Conus venom peptides, receptor and ion channel targets, and drug design: 50 Million years of neuropharmacology
42. Diversity of Conus neuropeptides
43. Speciation of cone snails and interspecific hyperdivergence of their venom peptides. Potential evolutionary significance of introns
44. Cloning of metalloprotease genes in the carpet viper (Echis pyramydatum leakeyi). Further members of the metalloprotease/disintegrin gene family
45. +-channels
46. Evolutionary trace analysis of the Kunitz/BPTI family of proteins: Functional divergence may have been based on conformational adjustment
47. Protein structures sustain evolutionary drift
48. Scorpion toxins as natural scaffolds for protein engineering
49. How often do duplicate genes genes evolve new functions?
50. Constant and hypervariable regions in conotoxin propeptides
51. Positive Darwinian selection after gene duplication in primate ribonuclease genes