Measurement of process-dependent material properties of pharmaceutical solids by nanoindentation

Journal of Pharmaceutical Sciences

Volumn 94, Issue 1, 2005, Pages 79-92

  Liao, Xiangmin ^a   Wiedmann, Timothy Scott ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Acetaminophen; Creep; Elastic modulus; Hardness; Nanoindentation; Potassium chloride; Scanning probe microscopy

Indexed keywords

NANOPARTICLE; PARACETAMOL; POTASSIUM CHLORIDE;

ARTICLE; ATOMIC FORCE MICROSCOPY; CHEMICAL ANALYSIS; CRYSTAL STRUCTURE; CRYSTALLIZATION; ELASTICITY; HARDNESS; MATERIAL STATE; MELTING POINT; NANOINDENTATION; NONPHOTOCHEMICAL QUENCHING; SCANNING PROBE MICROSCOPY; SENSITIVITY AND SPECIFICITY; X RAY DIFFRACTION; YOUNG MODULUS;

EID: 12244311893     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20227     Document Type: Article

References (29)

1. Pedersen S, Kristensen HG. 1995. Compaction behavior of 4-hydroxybenzoic acid and two esters compared to their mechanical properties. Eur J Pharm Biopharm 41:323-328.
2. Doelker E. 1993. Comparative compaction properties of various microcrystalline cellulose types and generic products. Drug Dev Ind Pharm 19:2399-2471.
3. Michrafy A, Ringenbacher D, Tchoreloff P. 2002. Modeling the compaction behavior of powders: Application to pharmaceutical powders. Powder Technol 127:257-266.
4. Roberts RJ, Rowe RC. 1999. Relationships between the modulus of elasticity and tensile strength for pharmaceutical drugs and excipients. J Pharm Pharmacol 51:975-977.
5. Payne RS, Roberts RJ, Rowe RC, McPartlin M, Bashal A. 1996. The mechanical properties of two forms of primidone predicted from their crystal structures. Int J Pharm 145:165-173.
6. Roberts RJ, Rowe RC, York P. 1995. The relationship between the fracture properties, tensile strength and critical stress intensity factor of organic solids and their molecular structure. Int J Pharm 125:157-162.
7. Roberts RJ, Payne RS, Rowe RC. 2000. Mechanical property predictions for polymorphe of sulfathiazole and carbamazepine. Eur J Pharm Sci 9:277-283.
8. Ridgway K, Shotton E, Glasby J. 1969. The hardness and elastic modulus of some crystalline pharmaceutical materials. J Pharm Pharmacol 21:19S-23S.
9. Alderborn G, Nystroem C, editors. 1996. Pharmaceutical powder compaction technology. New York: Marcel Dekker.
10. Oliver WC, Pharr GM. 1992. An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments. J Mater Res 7:1564-1583.
11. Nix WD. 1997. Elastic and plastic properties of thin films on substrates: Nanoindentation techniques. Mater Sci Eng A A234-236:37-44.
12. Soifer YM, Verdyan A, Rapoport L. 2002. Nanoindentation size effect in alkali-halide single crystals. Mater Lett 56:127-130.
13. Fraxedas J, Garcia-Manyes S, Gorostiza P, Sanz F. 2002. Nanoindentation: Toward the sensing of atomic interactions. Proc Natl Acad Sci USA 99:5228-5232.
14. Balooch M, Wu-Magidi IC, Balazs A, Lundkvist AS, Marshall SJ, Marshall GW, Siekhaus WJ, Kinney JH. 1998. Viscoelastic properties of demineralized human dentin measured in water with atomic force microscope (AFM)-based indentation. J Biomed Mater Res 40:539-544.
15. Li X, Gao H, Murphy CJ, Caswell KK. 2003. Nanoindentation of silver nanowires. Nano Lett 3:1495-1498.
16. Page TF, Hainsworth SV. 1993. Using nanoindentation techniques for the characterization of coated systems: A critique. Surface Coat Technol 61:201-208.
17. Nagy P, Csanady A, Vero B, Palinkas G, Kalman E. 2003. The combined application of nanoindentation and scanning probe microscopy to materials sciences. Mater Sci Forum 414-415:297-303.
18. Khanna SK, Winter RM, Ranganathan P, Yedla SB, Kalukanimuttam M, Paruchuri K. 2003. Sample preparation techniques for nano-mechanical characterization of glass fiber reinforced polyester matrix composites. Composites Part A Appl Sci Manuf 34A:53-65.
19. Sangwal K, Gorostiza P, Servat J, Sanz F. 1999. Atomic force microscopy study of nanoindentation deformation and indentation size effect in MgO crystals. J Mater Res 14:3973-3982.
20. Doerner MF, Nix WD. 1986. A method for interpreting the data from depth-sensing indentation instruments. J Mater Res 1:601-609.
21. Malzbender J, De With G. 2002. Indentation load-displacement curve, plastic deformation, and energy. J Mater Res 17:502-511.
22. Liao X, Wiedmann TS. 2004. Characterization of pharmaceutical solids by scanning probe microscopy. J Pharm Sci 93:2250-2258.
23. Duncan-Hewitt WC, Weatherly GC. 1989. Evaluating the hardness, Young's modulus, and fracture toughness of some pharmaceutical crystals using microindentation techniques. J Mater Sci Lett 8:1350-1352.
24. Duncan-Hewitt WC, Weatherly GC. 1990. Modeling the uniaxial compaction of pharmaceutical powders using the mechanical properties of single crystals. II: Brittle materials. J Pharm Sci 79:273-278.
25. Lin M-C, Duncan-Hewitt WC. 1994. Deformation kinetics of acetaminophen crystals. Int J Pharm 106:187-200.
26. Soifer YM, Verdyan A. 2003. Investigation of the local mechanical properties of potassium chloride single crystals by atomic force microscopy. Phys Solid State 45:1701-1705.
27. Duncan-Hewitt WC, Mount DL, Yu A. 1994. Hardness anisotropy of acetaminophen crystals. Pharm Res 11:616-623.
28. Nabarro FRN. 1967. Theory of crystal dislocations. Minneola, NY: Dover.
29. Gaillard Y, Tromas C, Woirgard J. 2003. Study of the dislocation structure involved in a nanoindentation test by atomic force microscopy and controlled chemical etching. Acta Mater 51:1059-1065.