Functional characterization of syncytin-A, a newly murine endogenous virus envelope protein: Implication for its fusion mechanism

Journal of Biological Chemistry

Volumn 282, Issue 1, 2007, Pages 381-389

  Peng, Xiaoxue ^a   Pan, Ji'An ^a   Gong, Rui ^a   Liu, Yang ^a   Kang, Shuli ^a   Feng, Huixing ^a   Qiu, Gang ^a   Guo, Deyin ^a   Tien, Po ^a   Xiao, Gengfu ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CELL CULTURE; FUNCTIONAL GROUPS; FUSION REACTIONS; VIRUSES;

CELL FUSION; FUSION CORE STRUCTURES; TROPHOBLASTS; VIRAL ENVELOPE FUSION PROTEINS;

PROTEINS;

SYNCYTIN A; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; DISULFIDE; PLACENTA PROTEIN; SYNCYTIN;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL FUSION; CYTOTROPHOBLAST; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; THERMOSTABILITY; TROPHOBLAST; VIRUS ENVELOPE; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; IC 50; METABOLISM; MOLECULAR GENETICS; MOUSE; PLASMID; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY;

MURIDAE; MURINAE;

AMINO ACID SEQUENCE; ANIMALS; CIRCULAR DICHROISM; DISULFIDES; GENE PRODUCTS, ENV; INHIBITORY CONCENTRATION 50; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PLASMIDS; PREGNANCY PROTEINS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; VIRAL ENVELOPE PROTEINS;

EID: 33846957705     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M606353200     Document Type: Article

References (51)

1. Bannert, N., and Kurth, R. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, Suppl. 2, 14572-14579
2. Boeke, J. D., and Stoye, J. P. (1997) in Retroviruses (Coffin, J. M., Hughes, S. H., and Varmus, H. E., eds) pp. 343-435, Cold Spring Harbor Laboratory Press, Plainview, NY
3. Turner, G., Barbulescu, M., Su, M., Jensen-Seaman, M. I., Kidd, K. K., and Lenz, J. (2001) Curr. Biol. 11, 1531-1535
4. Benit, L., Dessen, P., and Heidmann, T. (2001) J. Virol. 75, 11709-11719
5. Tristem, M. (2000) J. Virol. 74, 3715-3730
6. Lower, R., Lower, J., and Kurth, R. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 5177-5184
7. Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., Doyle, M., FitzHugh, W., Funke, R., Gage, D., Harris, K., Heaford, A., Howland, J., Kann, L., Lehoczky, J., LeVine, R., McEwan, P., McKernan, K., Meldrim, J., Mesirov, J. P., Miranda, C., Morris, W., Naylor, J., Raymond, C., Rosetti, M., Santos, R., Sheridan, A., Sougnez, C., Stange-Thomann, N., Stojanovic, N., Subramanian, A., Wyman, D., Rogers, J., Sulston, J., Ainscough, R., Beck, S., Bentley, D., Burton, J., Clee, C., Carter, N., Coulson, A., Deadman, R., Deloukas, P., Dunham, A., Dunham, I., Durbin, R., French, L., Grafham, D., Gregory, S., Hubbard, T., Humphray, S., Hunt, A., Jones, M., Lloyd, C., McMurray, A., Matthews, L., Mercer, S., Milne, S., Mullikin, J. C., Mungall, A., Plumb, R., Ross, M., Shownkeen, R., Sims, S., Waterston, R. H., Wilson, R. K., Hillier, L. W., McPherson, J. D., Marra, M. A., Mardis, E. R., Fulton, L. A., Chinwalla, A. T., Pepin, K. H., Gish, W. R., Chissoe, S. L., Wendl, M. C., Delehaunty, K. D., Miner, T. L., Delehaunty, A., Kramer, J. B., Cook, L. L., Fulton, R. S., Johnson, D. L., Minx, P. J., Clifton, S. W., Hawkins, T., Branscomb, E., Predki, P., Richardson, P., Wenning, S., Slezak, T., Doggett, N., Cheng, J. F., Olsen, A., Lucas, S., Elkin, C., Uberbacher, E., Frazier, M., Gibbs, R. A., Muzny, D. M., Scherer, S. E., Bouck, J. B., Sodergren, E. J., Worley, K. C., Rives, C. M., Gorrell, J. H., Metzker, M. L., Naylor, S. L., Kucherlapati, R. S., Nelson, D. L., Weinstock, G. M., Sakaki, Y., Fujiyama, A., Hattori, M., Yada, T., Toyoda, A., Itoh, T., Kawagoe, C., Watanabe, H., Totoki, Y., Taylor, T., Weissenbach, J., Heilig, R., Saurin, W., Artiguenave, F., Brottier, P., Bruls, T., Pelletier, E., Robert, C., Wincker, P., Smith, D. R., Doucette-Stamm, L., Rubenfield, M., Weinstock, K., Lee, H. M., Dubois, J., Rosenthal, A., Platzer, M., Nyakatura, G., Taudien, S., Rump, A., Yang, H., Yu, J., Wang, J., Huang, G., Gu, J., Hood, L., Rowen, L., Madan, A., Qin, S., Davis, R. W., Federspiel, N. A., Abola, A. P., Proctor, M. J., Myers, R. M., Schmutz, J., Dickson, M., Grimwood, J., Cox, D. R., Olson, M. V., Kaul, R., Raymond, C., Shimizu, N., Kawasaki, K., Minoshima, S., Evans, G. A., Athanasiou, M., Schultz, R., Roe, B. A., Chen, F., Pan, H., Ramser, J., Lehrach, H., Reinhardt, R., McCombie, W. R., de la Bastide, M., Dedhia, N., Blocker, H., Hornischer, K., Nordsiek, G., Agarwala, R., Aravind, L., Bailey, J. A., Bateman, A., Batzoglou, S., Birney, E., Bork, P., Brown, D. G., Burge, C. B., Cerutti, L., Chen, H. C., Church, D., Clamp, M., Copley, R. R., Doerks, T., Eddy, S. R., Eichler, E. E., Furey, T. S., Galagan, J., Gilbert, J. G., Harmon, C., Hayashizaki, Y., Haussler, D., Hermjakob, H., Hokamp, K., Jang, W., Johnson, L. S., Jones, T. A., Kasif, S., Kaspryzk, A., Kennedy, S., Kent, W. J., Kitts, P., Koonin, E. V., Korf, I., Kulp, D., Lancet, D., Lowe, T. M., McLysaght, A., Mikkelsen, T., Moran, J. V., Mulder, N., Pollara, V. J., Ponting, C. P., Schuler, G., Schultz, J., Slater, G., Smit, A. F., Stupka, E., Szustakowski, J., Thierry-Mieg, D., Thierry-Mieg, J., Wagner, L., Wallis, J., Wheeler, R., Williams, A., Wolf, Y. I., Wolfe, K. H., Yang, S. P., Yeh, R. F., Collins, F., Guyer, M. S., Peterson, J., Felsenfeld, A., Wetterstrand, K. A., Patrinos, A., Morgan, M. J., de Jong, P., Catanese, J. J., Osoegawa, K., Shizuya, H., Choi, S., and Chen, Y. J. (2001) Nature 409, 860-921
8. Waterston, R. H., Lindblad-Toh, K., Birney, E., Rogers, J., Abril, J. F., Agarwal, P., Agarwala, R., Ainscough, R., Alexandersson, M., An, P., Antonarakis, S. E., Attwood, J., Baertsch, R., Bailey, J., Barlow, K., Beck, S., Berry, E., Birren, B., Bloom, T., Bork, P., Botcherby, M., Bray, N., Brent, M. R., Brown, D. G., Brown, S. D., Bult, C., Burton, J., Butler, J., Campbell, R. D., Carninci, P., Cawley, S., Chiaromonte, F., Chinwalla, A. T., Church, D. M., Clamp, M., Clee, C., Collins, F. S., Cook, L. L., Copley, R. R., Coulson, A., Couronne, O., Cuff, J., Curwen, V., Cutts, T., Daly, M., David, R., Davies, J., Delehaunty, K. D., Deri, J., Dermitzakis, E. T., Dewey, C., Dickens, N. J., Diekhans, M., Dodge, S., Dubchak, I., Dunn, D. M., Eddy, S. R., Elnitski, L., Emes, R. D., Eswara, P., Eyras, E., Felsenfeld, A., Fewell, G. A., Flicek, P., Foley, K., Frankel, W. N., Fulton, L. A., Fulton, R. S., Furey, T. S., Gage, D., Gibbs, R. A., Glusman, G., Gnerre, S., Goldman, N., Goodstadt, L., Grafham, D., Graves, T. A., Green, E. D., Gregory, S., Guigo, R., Guyer, M., Hardison, R. C., Haussler, D., Hayashizaki, Y., Hillier, L. W., Hinrichs, A., Hlavina, W., Holzer, T., Hsu, F., Hua, A., Hubbard, T., Hunt, A., Jackson, I., Jaffe, D. B., Johnson, L. S., Jones, M., Jones, T. A., Joy, A., Kamal, M., Karlsson, E. K., Karolchik, D., Kasprzyk, A., Kawai, J., Keibler, E., Kells, C., Kent, W. J., Kirby, A., Kolbe, D. L., Korf, I., Kucherlapati, R. S., Kulbokas, E. J., Kulp, D., Landers, T., Leger, J. P., Leonard, S., Letunic, I., Levine, R., Li, J., Li, M., Lloyd, C., Lucas, S., Ma, B., Maglott, D. R., Mardis, E. R., Matthews, L., Mauceli, E., Mayer, J. H., McCarthy, M., McCombie, W. R., McLaren, S., McLay, K., McPherson, J. D., Meldrim, J., Meredith, B., Mesirov, J. P., Miller, W., Miner, T. L., Mongin, E., Montgomery, K. T., Morgan, M., Mott, R., Mullikin, J. C., Muzny, D. M., Nash, W. E., Nelson, J. O., Nhan, M. N., Nicol, R., Ning, Z., Nusbaum, C., O'Connor, M. J., Okazaki, Y., Oliver, K., Overton-Larty, E., Pachter, L., Parra, G., Pepin, K. H., Peterson, J., Pevzner, P., Plumb, R., Pohl, C. S., Poliakov, A., Ponce, T. C., Ponting, C. P., Potter, S., Quail, M., Reymond, A., Roe, B. A., Roskin, K. M., Rubin, E. M., Rust, A. G., Santos, R., Sapojnikov, V., Schultz, B., Schultz, J., Schwartz, M. S., Schwartz, S., Scott, C., Seaman, S., Searle, S., Sharpe, T., Sheridan, A., Shownkeen, R., Sims, S., Singer, J. B., Slater, G., Smit, A., Smith, D. R., Spencer, B., Stabenau, A., Stange-Thomann, N., Sugnet, C., Suyama, M., Tesler, G., Thompson, J., Torrents, D., Trevaskis, E., Tromp, J., Ucla, C., Ureta-Vidal, A., Vinson, J. P., Von Niederhausern, A. C., Wade, C. M., Wall, M., Weber, R. J., Weiss, R. B., Wendl, M. C., West, A. P., Wetterstrand, K., Wheeler, R., Whelan, S., Wierzbowski, J., Willey, D., Williams, S., Wilson, R. K., Winter, E., Worley, K. C., Wyman, D., Yang, S., Yang, S. P., Zdobnov, E. M., Zody, M. C., and Lander, E. S. (2002) Nature 420, 520-562
9. Lavillette, D., Marin, M., Ruggieri, A., Mallet, F., Cosset, F. L., and Kabat, D. (2002) J. Virol. 76, 6442-6452
10. Blond, J. L., Lavillette, D., Cheynet, V., Bouton, O., Oriol, G., Chapel-Fernandes, S., Mandrand, B., Mallet, F., and Cosset, F. L. (2000) J. Virol. 74, 3321-3329
11. Frendo, J. L., Olivier, D., Cheynet, V., Blond, J. L., Bouton, O., Vidaud, M., Rabreau, M., Evain-Brion, D., and Mallet, F. (2003) Mol. Cell. Biol. 23, 3566-3574
12. Mi, S., Lee, X., Li, X., Veldman, G. M., Finnerty, H., Racie, L., LaVallie, E., Tang, X. Y., Edouard, P., Howes, S., Keith, J. C., Jr., and McCoy, J. M. (2000) Nature 403, 785-789
13. Blond, J. L., Beseme, F., Duret, L., Bouton, O., Bedin, F., Perron, H., Mandrand, B., and Mallet, F. (1999) J. Virol. 73, 1175-1185
14. Renard, M., Varela, P. F., Letzelter, C., Duquerroy, S., Rey, F. A., and Heidmann, T. (2005) J. Mol. Biol. 352, 1029-1034
15. Blaise, S., Ruggieri, A., Dewannieux, M., Cosset, F. L., and Heidmann, T. (2004) J. Virol. 78, 1050-1054
16. Blaise, S., de Parseval, N., Benit, L., and Heidmann, T. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 13013-13018
17. Dupressoir, A., Marceau, G., Vernochet, C., Benit, L., Kanellopoulos, C., Sapin, V., and Heidmann, T. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 725-730
18. Chang, C., Chen, P. T., Chang, G. D., Huang, C. J., and Chen, H. (2004) Biol. Reprod. 71, 1956-1962
19. Potgens, A. J., Drewlo, S., Kokozidou, M., and Kaufmann, P. (2004) Hum. Reprod. Update 10, 487-496
20. Mallet, F., Bouton, O., Prudhomme, S., Cheynet, V., Oriol, G., Bonnaud, B., Lucotte, G., Duret, L., and Mandrand, B. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 1731-1736
21. Eaton, B., and Contractor, S. (1993) in The Human Placenta (Redman, C. W., Sargent, I. L., and Starkey, P. M., eds) pp. 471-503, Blackwell Scientific Publications, London
22. Harris, J. R. (1998) BioEssays 20, 307-316
23. Bullough, P. A., Hughson, F. M., Treharne, A. C., Ruigrok, R. W., Skehel, J. J., and Wiley, D. C. (1994) J. Mol. Biol. 236, 1262-1265
24. Bullough, P. A., Hughson, F. M., Skehel, J. J., and Wiley, D. C. (1994) Nature 371, 37-43
25. Fass, D., Harrison, S. C., and Kim, P. S. (1996) Nat. Struct. Biol. 3, 465-469
26. Kobe, B., Center, R. J., Kemp, B. E., and Poumbourios, P. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 4319-4324
27. Malashkevich, V. N., Schneider, B. J., McNally, M. L., Milhollen, M. A., Pang, J. X., and Kim, P. S. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 2662-2667
28. Weissenhorn, W., Carfi, A., Lee, K. H., Skehel, J. J., and Wiley, D. C. (1998) Mol. Cell 2, 605-616
29. Weissenhorn, W., Dessen, A., Harrison, S. C., Skehel, J. J., and Wiley, D. C. (1997) Nature 387, 426-430
30. Tan, K., Liu, J., Wang, J., Shen, S., and Lu, M. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 12303-12308
31. Chan, D. C., Fass, D., Berger, J. M., and Kim, P. S. (1997) Cell 89, 263-273
32. Malashkevich, V. N., Chan, D. C., Chutkowski, C. T., and Kim, P. S. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 9134-9139
33. Caffrey, M., Cai, M., Kaufman, J., Stahl, S. J., Wingfield, P. T., Covell, D. G., Gronenborn, A. M., and Clore, G. M. (1998) EMBO J. 17, 4572-4584
34. Zhao, X., Singh, M., Malashkevich, V. N., and Kim, P. S. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 14172-14177
35. Baker, K. A., Dutch, R. E., Lamb, R. A., and Jardetzky, T. S. (1999) Mol. Cell 3, 309-319
36. Wild, C. T., Shugars, D. C., Greenwell, T. K., McDanal, C. B., and Matthews, T. J. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 9770-9774
37. Wild, C., Oas, T., McDanal, C., Bolognesi, D., and Matthews, T. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 10537-10541
38. Lu, M., Blacklow, S. C., and Kim, P. S. (1995) Nat. Struct. Biol. 2, 1075-1082
39. Jiang, S., Lin, K., Strick, N., and Neurath, A. R. (1993) Nature 365, 113
40. Gong, R., Peng, X., Kang, S., Feng, H., Huang, J., Zhang, W., Lin, D., Tien, P., and Xiao, G. (2005) Biochem. Biophys. Res. Commun. 331, 1193-1200
41. Ji, H., Bracken, C., and Lu, M. (2000) Biochemistry 39, 676-685
42. Weissenhorn, W., Calder, L. J., Wharton, S. A., Skehel, J. J., and Wiley, D. C. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6032-6036
43. Delwart, E. L., Mosialos, G., and Gilmore, T. (1990) AIDS Res. Hum. Retroviruses 6, 703-706
44. Chambers, P., Pringle, C. R., and Easton, A. J. (1990) J. Gen. Virol. 71, 3075-3080
45. Jiang, S., Lin, K., Strick, N., and Neurath, A. R. (1993) Biochem. Biophys. Res. Commun. 195, 533-538
46. Joshi, S. B., Dutch, R. E., and Lamb, R. A. (1998) Virology 248, 20-34
47. Rapaport, D., Ovadia, M., and Shai, Y. (1995) EMBO J. 14, 5524-5531
48. Blacklow, S. C., Lu, M., and Kim, P. S. (1995) Biochemistry 34, 14955-14962
49. Wang, E., Sun, X., Qian, Y., Zhao, L., Tien, P., and Gao, G. F. (2003) Biochem. Biophys. Res. Commun. 302, 469-475
50. Watanabe, S., Takada, A., Watanabe, T., Ito, H., Kida, H., and Kawaoka, Y. (2000) J. Virol. 74, 10194-10201
51. Liu, S., Xiao, G., Chen, Y., He, Y., Niu, J., Escalante, C. R., Xiong, H., Farmar, J., Debnath, A. K., Tien, P., and Jiang, S. (2004) Lancet 363, 938-947