Functional characterization of the placental fusogenic membrane protein syncytin

Biology of Reproduction

Volumn 71, Issue 6, 2004, Pages 1956-1962

  Chang, Chingwen ^a   Chen, Po Tsang ^b   Chang, Geen Dong ^b   Huang, Chang Jen ^a   Chen, Hungwen ^b  

^a INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Cell fusion; Placenta; Pregnancy; Syncytin; Syncytiotrophoblast; Trophoblast

Indexed keywords

AMINO ACID; ENVELOPE PROTEIN; GLUTAMIC ACID; MEMBRANE PROTEIN; POLYPEPTIDE; SERINE; SYNCYTIN; UNCLASSIFIED DRUG; VALINE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL FUSION; CONTROLLED STUDY; CYTOPLASMIC DOMAIN; DELETION MUTANT; HELA CELL; HEPTAD REPEAT REGION A; HEPTAD REPEAT REGION B; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NUCLEOTIDE REPEAT; PLACENTA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN STRUCTURE; REGULATORY MECHANISM; RETROVIRUS; STRUCTURE ACTIVITY RELATION; SYNCYTIOTROPHOBLAST; TROPHOBLAST;

BASE SEQUENCE; CELL FUSION; CELL LINE; CYTOPLASM; GENE PRODUCTS, ENV; HELA CELLS; HUMANS; MUTATION; PEPTIDES; PLACENTA; PREGNANCY PROTEINS; PROTEIN STRUCTURE, TERTIARY; REPETITIVE SEQUENCES, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; TROPHOBLASTS;

MAMMALIA; UNIDENTIFIED RETROVIRUS;

EID: 9744241673     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.104.033340     Document Type: Article

References (24)

1. Benirschke K, Kaufmann P. Pathology of the human placenta. New York: Springer-Verlag; 2001:49-56.
2. Mi S, Lee X, Li X, Veldman GM, Finnerty H, Racie L, LaVallie E, Tang XY, Edouard P, Howes S, Keith JC Jr, McCoy JM. Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis. Nature 2000; 403:785-789.
3. Blond JL, Lavillette D, Cheynet V, Bouton O, Oriol G, Chapel-Fernandes S, Mandrand B, Mallet F, Cosset FL. An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor. J Virol 2000; 74:3321-3329.
4. Lavillette D, Marin M, Ruggieri A, Mallet F, Cosset FL, Kabat D. The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors. J Virol 2002; 76:6442-6452.
5. Colman PM, Lawrence MC. The structural biology of type I viral membrane fusion. Nat Rev Mol Cell Biol 2003; 4:309-319.
6. Wyatt LS, Moss B, Rozenblatt S. Replication-deficient vaccinia virus encoding bacteriophage T7 RNA polymerase for transient gene expression in mammalian cells. Virology 1995; 210:202-205.
7. Andersen KB. A domain of murine retrovirus surface protein gp70 mediates cell fusion, as shown in a novel SC-1 cell fusion system. J Virol 1994; 68:3175-3182.
8. Chang CD, Felix AM, Jimenez MH, Meienhofer J. Solid-phase peptide synthesis of somatostatin using mild base cleavage of N alpha-9- fluorenylmethyloxycarbonylamino acids. Int J Pept Protein Res 1980; 15:485-494.
9. Chambers P, Pringle CR, Easton AJ. Heptad repeat sequences are located adjacent to hydrophobic regions in several types of virus fusion glycoproteins. J Gen Virol 1990; 71:3075-3080.
10. Delwart EL, Mosialos G, Gilmore T. Retroviral envelope glycoproteins contain a "leucine zipper"-like repeat. AIDS Res Hum Retroviruses 1990; 6:703-706,
11. Wild C, Oas T, McDanal C, Bolognesi D, Matthews T. A synthetic peptide inhibitor of human immunodeficiency virus replication: correlation between solution structure and viral inhibition. Proc Natl Acad Sci U S A 1992; 89:10537-10541.
12. Wild CT, Shugars DC, Greenwell TK, McDanal CB, Matthews TJ. Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection. Proc Natl Acad Sci U S A 1994; 91:9770-9774.
13. Combet C, Blanchet C, Geourjon C, Deleage G. NPS@: network protein sequence analysis. Trends Biochem Sci 2000; 25:147-150.
14. Lupas A, Van Dyke M, Stock J. Predicting coiled coils from protein sequences. Science 1991; 252:1162-1164.
15. Frendo JL, Olivier D, Cheynet V, Blond JL, Bouton O, Vidaud M, Rabreau M, Evain-Brion D, Mallet F. Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation. Mol Cell Biol 2003; 23:3566-3574.
16. Knerr I, Beinder E, Rascher W Syncytin, a novel human endogenous retroviral gene in human placenta: evidence for its dysregulation in preeclampsia and HELLP syndrome. Am J Obstet Gynecol 2002; 186: 210-213.
17. Yang C, Compans RW. Analysis of the cell fusion activities of chimeric simian immunodeficiency virus-murine leukemia virus envelope proteins: inhibitory effects of the R peptide. J Virol 1996; 70:248-254.
18. Yang C, Compans RW. Analysis of the murine leukemia virus R peptide: delineation of the molecular determinants which are important for its fusion inhibition activity. J Virol 1997; 71:8490-8496.
19. Green N, Shinnick TM, Witte O, Ponticelli A, Sutcliffe JG, Lerner RA. Sequence-specific antibodies show that maturation of Moloney leukemia virus envelope polyprotein involves removal of a COOH-terminal peptide. Proc Natl Acad Sci U S A 2004; 78:6023-6027.
20. Brody BA, Rhee SS, Sommerfell MA, Hunter E. A viral protease-mediated cleavage of the transmembrane glycoprotein of Mason-Pfizer monkey virus can be suppressed by mutations within the matrix protein. Proc Natl Acad Sci U S A 1992; 89:3443-3447.
21. Bobkova M, Stitz J, Engelstadter M, Cichutek K, Buchholz CJ. Identification of R-peptides in envelope proteins of C-type retroviruses. J Gen Virol 2002; 83:2241-2246.
22. Bateman AR, Harrington KJ, Kottke T, Ahmed A, Melcher AA, Gough MJ, Linardakis E, Riddle D, Dietz A, Lohse CM, Strome S, Peterson T, Simari R, Vile RG. Viral fusogenic membrane glycoproteins kill solid tumor cells by nonapoptotic mechanisms that promote cross presentation of tumor antigens by dendritic cells. Cancer Res 2002; 62:6566-6578.
23. Higuchi H, Bronk SF, Bateman A, Harrington K, Vile RG, Gores GJ. Viral fusogenic membrane glycoprotein expression causes syncytia formation with bioenergetic cell death: implications for gene therapy. Cancer Res 2000; 60:6396-6402.
24. Gullick WJ. Type I growth factor receptors: current status and future work. Biochem Soc Symp 1998; 63:193-198.