Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: Effect of replacing the inner polymethylene chain with cyclic moieties

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 6, 2007, Pages 2312-2321

  Tumiatti, Vincenzo ^a   Minarini, Anna ^a   Milelli, Andrea ^a   Rosini, Michela ^a   Buccioni, Michela ^b   Marucci, Gabriella ^b   Ghelardini, Carla ^c   Bellucci, Cristina ^c   Melchiorre, Carlo ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF CAMERINO   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Methoctramine; Muscarinic antagonists; Pain; Polyamines

Indexed keywords

6,6' [4,4' (ETHANE 1,2 DIYL)BIS(PIPERIDINE 4,1 DIYL)]BIS[N (2 METHOXYBENZYL)HEXAN 1 AMINE]; ACETYLCHOLINE; ANILINE; ATROPINE; CARBENE; METHOCTRAMINE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M1 RECEPTOR ANTAGONIST; MUSCARINIC M2 RECEPTOR; MUSCARINIC M2 RECEPTOR ANTAGONIST; MUSCARINIC M3 RECEPTOR; MUSCARINIC M3 RECEPTOR ANTAGONIST; NALOXONE; NITROGEN; PIPERIDINE; POLYAMINE; RECEPTOR SUBTYPE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ACETYLCHOLINE RELEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BINDING ASSAY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; FEMALE; FRONTAL CORTEX; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; MICRODIALYSIS; MOUSE; NONHUMAN; PAIN; PARIETAL LOBE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ANIMALS; BUTYRYLCHOLINESTERASE; CEREBRAL CORTEX; CHO CELLS; CHOLINESTERASE INHIBITORS; CRICETINAE; CRICETULUS; DIAMINES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; GUINEA PIGS; HEART ATRIA; HUMANS; ILEUM; MALE; MICE; MOLECULAR STRUCTURE; MUSCARINIC ANTAGONISTS; MUSCLE, SKELETAL; PARIETAL LOBE; PHOTOAFFINITY LABELS; POLYAMINES; RABBITS; RADIOLIGAND ASSAY; RATS; RECEPTORS, MUSCARINIC; STRUCTURE-ACTIVITY RELATIONSHIP; VAS DEFERENS;

RATTUS;

EID: 33846915747     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.01.022     Document Type: Article

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