Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3- oxathiolan-5-yl)pyrrolidine derivatives

Biochemical Pharmacology

Volumn 69, Issue 11, 2005, Pages 1637-1645

  Dei, Silvia ^a   Angeli, Piero ^b   Bellucci, Cristina ^a   Buccioni, Michela ^b   Gualtieri, Fulvio ^a   Marucci, Gabriella ^b   Manetti, Dina ^a   Matucci, Rosanna ^a   Romanelli, Maria Novella ^a   Scapecchi, Serena ^a   Teodori, Elisabetta ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF CAMERINO   (Italy)

Author keywords

Binding studies; Dioxolane derivative; Functional studies; Muscarinic agonist; Oxathiolane derivative; Subtype selectivity

Indexed keywords

1 METHYL 2 (2 METHYL 1,3 DIOXOLAN 4 YL)PYRROLIDINE; 1 METHYL 2 (2 METHYL 1,3 OXATHIOLAN 5 YL)PYRROLIDINE; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC RECEPTOR; NITROGEN; PARTIAL AGONIST; PYRROLIDINE DERIVATIVE; TERTIARY AMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATOM; BINDING AFFINITY; BRAIN CORTEX; CENTRAL NERVOUS SYSTEM; CHO CELL; DRUG SELECTIVITY; GUINEA PIG; MALE; MOLECULE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; RECEPTOR AFFINITY; SYNTHESIS;

ANIMALS; CHO CELLS; CRICETINAE; GUINEA PIGS; HUMANS; MALE; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; PROTEIN BINDING; PROTEIN ISOFORMS; PYRROLIDINES; RABBITS; RECEPTORS, MUSCARINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 21144452382     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.03.009     Document Type: Article

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