Functional significance of erythropoietin receptor expression in breast cancer

Laboratory Investigation

Volumn 82, Issue 7, 2002, Pages 911-918

  Arcasoy, Murat O ^a   Amin, Khalid ^c   Karaysal, Aysen F ^a   Chou, Shu Chun ^b   Raleigh, James A ^b   Varia, Mahesh A ^b   Haroon, Zishan A ^c  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c SRI INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOKINE; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; ERYTHROPOIETIN RECEPTOR ANTIBODY; FIBRIN; JANUS KINASE; JANUS KINASE 2; MESSENGER RNA; NEUTRALIZING ANTIBODY; PIMONIDAZOLE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RECEPTOR ANTIBODY; TUMOR MARKER; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ANIMAL CELL; ANIMAL TISSUE; ANTIBODY DETECTION; ARTICLE; BREAST CANCER; CELL HYPOXIA; CELLULAR DISTRIBUTION; CYTOKINE PRODUCTION; DOSE RESPONSE; ERYTHROPOIESIS; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; RECEPTOR BINDING; SIGNAL TRANSDUCTION; TUMOR BIOPSY; TUMOR BLOOD FLOW; TUMOR GROWTH;

ANIMALS; BREAST NEOPLASMS; CELL HYPOXIA; DNA PRIMERS; FEMALE; HUMANS; MODELS, ANIMAL; POLYMERASE CHAIN REACTION; RATS; RATS, INBRED F344; RECEPTORS, ERYTHROPOIETIN; TUMOR CELLS, CULTURED;

EID: 0036318603     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.LAB.0000020415.72863.40     Document Type: Article

References (47)

1. Erythropoietin and erythropoietin receptor expression in human cancer
2. Erythropoietin receptor mRNA expression in human endothelial cells
3. Familial erythrocytosis associated with a short deletion in the erythropoietin receptor gene
4. Erythropoietin mediates terminal granulocytic differentiation of committed myeloid cells with ectopic erythropoietin receptor expression
5. Structural design and molecular evolution of a cytokine receptor superfamily
6. Tyrphostin B42 inhibits IL-12-induced tyrosine phosphorylation and activation of Janus kinase-2 and prevents experimental allergic encephalomyelitis
7. Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury
8. Oxygen sensing and molecular adaptation to hypoxia
9. A new hematopoietic growth factor receptor superfamily: Structural features and implications for signal transduction
10. Expression cloning of the murine erythropoietin receptor
11. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades
12. Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing
13. Expression of the erythropoietin receptor by trophoblast cells in the human placenta
14. SU5416 delays wound healing through inhibition of TGF-beta 1 activation
15. Early wound healing exhibits cytokine surge without evidence of hypoxia
16. Tissue distribution of erythropoietin and erythropoietin receptor in the developing human fetus
17. Origin and fate of erythropoietin in human milk
18. The role of tyrosine phosphorylation in proliferation and maturation of erythroid progenitor cells - Signals emanating from the erythropoietin receptor
19. Erythropoietin
20. Biology of erythropoietin
21. Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis
22. Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation
23. The erythropoietin receptor: Biogenesis, dimerization, and intracellular signal transduction
24. The oviduct produces erythropoietin in an estrogen and oxygen-dependent manner
25. Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells
26. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor
27. Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death
28. Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: Tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines
29. Erythropoietin stimulates proliferation and interferes with differentiation of myoblasts
30. Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker
31. Erythropoietin receptor activation by a ligand-induced conformation change
32. Quantitative image analysis of angiogenesis in rats implanted with a fibrin gel chamber
33. In vivo evidence that erythropoietin protects neurons from ischemic damage
34. Erythroid progenitors differentiate and mature in response to endogenous erythropoietin
35. Human hematopoietic progenitors express erythropoietin
36. Erythropoietin stimulates proliferation of human renal carcinoma cells
37. Human, rat, and mouse kidney cells express functional erythropoietin receptors
38. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
39. Signal transduction in the erythropoietin receptor system
40. Inactivation of erythropoietin leads to defects in cardiac morphogenesis
41. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
42. Constitutive tyrosine phosphorylation of ErbB-2 via Jak2 by autocrine secretion of prolactin in human breast cancer
43. Estrogen-dependent production of erythropoietin in uterus and its implication in uterine angiogenesis
44. Inhibition of erythropoietin signalling destroys xenografts of ovarian and uterine cancers in nude mice
45. Structure, function, and activation of the erythropoietin receptor
46. Erythropoietin-dependent inhibition of apoptosis is supported by carboxyl-truncated receptor forms and blocked by dominant-negative forms of Jak2
47. Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2