Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocin

Neuropharmacology

Volumn 52, Issue 3, 2007, Pages 1034-1043

  Succu, Salvatora ^a,b   Sanna, Fabrizio ^a,b   Melis, Tiziana ^a,b   Boi, Antonio ^a,b   Argiolas, Antonio ^a,b   Melis, Maria Rosaria ^a,b  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b CNR   (Italy)

Author keywords

Dopamine; Microdialysis; Nucleus accumbens; Oxytocin; Paraventricular nucleus of the hypothalamus; Penile erection; Rat; Sexual motivation

Indexed keywords

3 [[4 (4 CHLOROPHENYL) 1 PIPERAZINYL]METHYL] 1H PYRROLO[2,3 B]PYRIDINE; 3,4 DIHYDROXYPHENYLACETIC ACID; APOMORPHINE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT; N [4 (2 CYANOPHENYL)PIPERAZIN 1 YLMETHYL] 3 METHYLBENZAMIDE MALEATE; OXYTOCIN; OXYTOCIN RECEPTOR; PD 168077; RACLOPRIDE; UNCLASSIFIED DRUG; VASOTOCIN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTERIOR HYPOTHALAMUS; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIALYSATE; DOPAMINERGIC NERVE CELL; HYPOTHALAMUS; LATERAL BRAIN VENTRICLE; LIMBIC CORTEX; MALE; MEASUREMENT; MICRODIALYSIS; NONHUMAN; NUCLEUS ACCUMBENS; PENIS ERECTION; PRIORITY JOURNAL; RAT; REINFORCEMENT; SEXUAL BEHAVIOR; STIMULATION; THALAMUS MIDLINE NUCLEUS;

3,4-DIHYDROXYPHENYLACETIC ACID; ANIMALS; BENZAMIDES; DOPAMINE; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; DRUG INTERACTIONS; ELECTROCHEMISTRY; MALE; MICROINJECTIONS; NUCLEUS ACCUMBENS; OXYTOCIN; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PENILE ERECTION; PIPERAZINES; PYRIDINES; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE;

EID: 33846879393     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2006.10.019     Document Type: Article

References (66)

1. Andersson K.E. Pharmacology of penile erection. Pharmacological Reviews 53 (2001) 417-450
2. Argiolas A. The chemical pharmacology of male erectile dysfunction. Drugs Discovery Today: Therapeutic Strategies 2 (2005) 31-36
3. Argiolas A., and Melis M.R. Neuromodulation of penile erection: an overview of the role of neurotransmitters and neuropeptides. Progress in Neurobiology 47 (1995) 235-255
4. Argiolas A., and Melis M.R. The role of oxytocin and the paraventricular nucleus in the sexual behaviour of male mammals. Physiology and Behavior 83 (2004) 309-317
5. Argiolas A., and Melis M.R. Central control of penile erection: role of the paraventricular nucleus of the hypothalamus. Progress in Neurobiology 76 (2005) 1-21
6. Bankowski K., Manning M., Seto J., Haldar J., and Sawyer W.H. Design and synthesis of potent in vivo antagonists of oxytocin. International Journal of Peptide and Protein Research 16 (1980) 382-391
7. Bitner R.S., Nikkel A.L., Otte S., Martino B., Barlow E.H., Bhatia P., Stewart A.O., Brioni J.D., Decker M.W., and Moreland R.B. Dopamine D4 receptor signalling in the rat paraventricular hypothalamic nucleus: evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation. Neuropharmacology 50 (2006) 521-531
8. Blaha C.D., Yang C.R., Floresco S.B., Barr A.M., and Phillips A.G. Stimulation of the ventral subiculum of the hippocampus evokes glutamate receptor-mediated changes in dopamine efflux in the rat nucleus accumbens. European Journal of Neuroscience 9 (1997) 902-911
9. 4 receptors by ABT-724 induces penile erection in rats. Proceedings of the National Academy of Sciences of the United States of America 101 (2004) 6758-6763
10. Buijs R.M., Geffard M., Pool C.W., and Hoorneman E.M.D. The dopaminergic innervation of the supraoptic and paraventricular nucleus. A light and electron microscopy study. Brain Research 323 (1984) 65-72
11. Buijs R.M. Intra- and extra-hypothalamic vasopressin and oxytocin pathways in the rat. Cell and Tissue Research 192 (1978) 423-435
12. Dahlstrom A., and Fuxe K. Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brainstem neurons. Acta Physiologica Scandinavica 62 Suppl. 232 (1964) 1-54
13. Eaton R.C., Markowski V.P., Lumley L.A., Thompson J.T., Moses J., and Hull E.M. D2 receptors in the paraventricular nucleus regulate genital responses and copulation in male rats. Pharmacology, Biochemistry and Behavior 39 (1991) 177-181
14. Everitt B.J. Sexual motivation: a neural and behavioural analysis of the mechanisms underlying appetitive and copulatory responses male rats. Neuroscience and Biobehavioral Reviews 14 (1990) 217-232
15. Fibiger H.C., and Phillips A.G. Mesocortico-limbic dopamine system and reward. Annals of the New York Academy of Sciences 5 (1988) 206-215
16. Floresco S.B., Blaha C.D., Yang C.R., and Phillips A.G. Modulation of hippocampal and amygdalar-evoked activity of nucleus accumbens neurons by dopamine: cellular mechanisms of input selection. Journal of Neuroscience 21 (2001) 2851-2860
17. Floresco S.B., Todd C.L., and Grace A.A. Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons. Journal of Neuroscience 21 (2001) 4915-4922
18. 3H oxytocin binding sites in the Wistar rat brain studied by autoradiography. Neuroscience 20 (1987) 599-614
19. Gazi L., Schoeffter P., Nunn C., Croskery K., Hoyer D., and Feuerbach D. Cloning, expression, functional coupling and pharmacological characterization of the rat dopamine D4 receptor. Naunyn-Schmiedeberg's Archives of Pharmacology 361 (2000) 555-564
20. Giuliano F., and Rampin O. Central neural control of penile erection. Neuroscience and Biobehavioral Reviews 24 (2000) 517-533
21. Giuliano F., Allard J., Rampin O., Droupy S., Benoit G., Alexandre L., and Bernabe J. Pro-erectile effect of systemic apomorphine: existence of a spinal site of action. Journal of Urology 167 (2002) 402-406
22. Glase S.A., Akunne H.C., Georgic L.M., Heffner T.G., MacKenzie R.G., Manley P.J., Pugsley T.A., and Wise L.D. Substituted [(4-phenylpiperazinyl)-methyl] benzamides: selective dopamine D4 agonists. Journal of Medicinal Chemistry 40 (1997) 1771-1772
23. Goto Y., and Grace A.A. Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior. Nature Neuroscience 8 (2005) 805-812
24. Heier R.F., Dolak L.A., Duncan J.N., Hyslop D.K., Lipton M.F., Martin L.J., Mauragis M.A., Piercey M.F., Nichols N.F., Schreur P.J., Smith M.W., and Moon M.W. Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites. Journal of Medicinal Chemistry 40 (1997) 639-646
25. Hsieh G.C., Hollingsworth P.R., Martino B., Chang R., Terranova M.A., O'Neill A.B., Lynch J.J., Moreland R.B., Donnelly-Roberts D.L., Kolasa T., Mikusa J.P., McVey J.M., Marsh K.C., Sullivan J.P., and Brioni J.D. Central mechanisms regulating penile erection in conscious rats: the dopaminergic systems related to the proerectile effect of apomorphine. Journal of Pharmacology and Experimental Therapeutics 308 (2004) 330-338
26. Hull E.M., Du J., Lorrain D.S., and Matuszewich L. Extra-cellular dopamine in the medial preoptic area: implications for sexual motivation and hormonal control of copulation. Journal of Neuroscience 15 (1995) 7465-7471
27. Hull E.M., Meisel R.L., and Sachs B.D. Male sexual behavior. In: Pfaff D.W., Arnold A.P., Etgen A.M., Fahrbach S.E., and Rubin R.T. (Eds). Hormones, Brain and Behavior (2002), Academic Press, New York 3-137
28. Ignarro L.J. Biosynthesis and metabolism of endothelium-derived nitric oxide. Annual Review of Pharmacology and Toxicology 30 (1990) 535-560
29. Imperato A., Tanda G., Frau R., and Di Chiara G. Pharmacological profile of dopamine receptor agonists as studied by brain dialysis in behaving rats. Journal of Pharmacology and Experimental Therapeutics 245 (1988) 257-264
30. Lindvall O., Bjorklund A., and Skagerberg G. Selective istochemical demonstration of dopamine terminal systems in rat di- and telencephalon: new evidence for dopaminergic innervation of hypothalamic neurosecretory nuclei. Brain Research 306 (1984) 19-30
31. Liu Y.-C., Sachs B.D., and Salomone J.D. Sexual behavior in male rats after radiofrequency or dopamine-depleting lesions in nucleus accumbens. Pharmacology, Biochemistry and Behavior 60 (1998) 585-592
32. Liu Y.-C., Salamone J.D., and Sachs B.D. Lesions in medial preoptic area and bed nucleus of the stria terminalis: differential effects on copulatory behaviour and noncontact erections in male rats. Journal of Neuroscience 17 (1997) 5245-5253
33. McKenna K.E. Some proposals regarding the organization of the central nervous system control of penile erection. Neuroscience and Biobehavioral Reviews 24 (2000) 535-540
34. Martino B., Hsieh G.C., Hollingsworth P.R., Mikusa J.P., Moreland R.B., and Bitner R.S. Central oxytocinergic and dopaminergic mechanisms regulating penile erection in conscious rats. Pharmacology, Biochemistry and Behavior 81 (2005) 797-804
35. Melis M.R., and Argiolas A. Dopamine and sexual behaviour. Neuroscience and Biobehavioral Reviews 19 (1995) 19-38
36. Melis M.R., and Argiolas A. Central oxytocinergic neurotransmission: a drug target for the therapy of psycogenic erectile dysfunction. Current Drug Targets 4 (2003) 55-66
37. Melis M.R., Argiolas A., and Gessa G.L. Apomorphine-induced penile erection and yawning: site of action in the brain. Brain Research 415 (1987) 98-104
38. Melis M.R., Argiolas A., Stancampiano R., and Gessa G.L. Effect of apomorphine on oxytocin concentrations in different brain areas and plasma of male rats. European Journal of Pharmacology 182 (1990) 101-107
39. 8-vasotocin reduces non-contact penile erections in male rats. Neuroscience Letters 265 (1999) 171-174
40. Melis M.R., Stancampiano R., and Argiolas A. Hippocampal oxytocin mediates apomorphine-induced penile erection and yawning. Pharmacology, Biochemistry and Behavior 42 (1992) 61-66
41. Melis M.R., Succu S., and Argiolas A. Dopamine agonists increase nitric oxide production in the paraventricular nucleus of the hypothalamus: correlation with penile erection and yawning. European Journal of Neuroscience 8 (1996) 2056-2063
42. Melis M.R., Succu S., Mauri A., and Argiolas A. Nitric oxide production is increased in the paraventricular nucleus of the hypothalamus of male rats during non-contact penile erections and copulation. European Journal of Neuroscience 10 (1998) 1968-1974
43. Melis M.R., Succu S., Mascia M.S., Cortis L., and Argiolas A. Extra-cellular dopamine increases in the paraventricular nucleus of male rats during sexual activity. European Journal of Neuroscience 17 (2003) 1266-1272
44. 4 receptor agonist, induces penile erection when injected into the paraventricular nucleus of male rats. Neuroscience Letters 379 (2005) 59-62
45. Melis M.R., Succu S., Sanna F., Melis T., Mascia M.S., Enguehard-Gueiffier C., Hubner H., Gmeiner P., Gueiffier A., and Argiolas A. PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain. European Journal of Neuroscience 24 (2006) 2021-2030
46. Millan M.J., Newman-Tancredi A., Brocco M., Gobert A., Lejeune F., Audinot V., Rivet J.M., Schreiber R., Dekeyne A., Spedding M., Nicolas J.P., and Peglion J.L. S 18126 ({2-[4-(2,3-dihydrobenzo[1,4]dioxin-6-yl)piperazin-1-yl methyl]indan-2-yl}), a potent selective and competitive antagonist at dopamine D4 receptors: an in vitro and in vivo comparison with L-745,870 (3-(4-[4-chlorophenyl]piperazin-1-yl)methyl-1H-pyrrolo[2,3b]pyridine) and raclopride. Journal of Pharmacology and Experimental Therapeutics 287 (1998) 167-186
47. Montorsi F., Perani D., Anchisi D., Salonia A., Scifo P., Rigiroli P., Deho F., De Vito M.L., Heaton J., Rigatti P., and Fazio F. Brain activation patterns during video sexual stimulation following the administration of apomorphine: results of a placebo-controlled study. European Urology 43 (2003) 405-411
48. Moreland R.B., Patel M., Hsieh G.C., Wetter J.M., Marsh K., and Brioni J.D. A-412997 is a selective dopamine D4 receptor agonist in rats. Pharmacology, Biochemistry and Behavior 82 (2005) 140-147
49. Patel S., Freedman S., Chapman K.L., Emms F., Fletcher A.E., Knowles M., Marwood R., Mccallister G., Myers J., Curtis J.J., Kulagowski J.J., Leeson P.D., Ridgill M., Graham M., Matheson S., Rathbone D., Watt A.P., Bristow L.J., Rupniak N.M., Baskin E., Lynch J.J., and Ragan C.I. Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor. Journal of Pharmacology and Experimental Therapeutics 283 (1997) 636-647
50. Pellegrino L.J., and Cushman A.J. A Stereotaxic Atlas of The Rat Brain (1971), Meredith, New York
51. Pfaus J.G., and Everitt B.J. The psychopharmacology of sexual behavior. In: Knobil F.E., and Kupfer D.J. (Eds). Psychopharmacology: The Fourth Generation of Progress (1995), Raven Press, New York 742-758
52. Raggenbass M., Waurin J.P., Gahwiler B.H., and Dreifruss J.J. Opposing effect of oxytocin and mu receptor agonistic opioid peptide on the same class of non-pyramidal neurons in rat hippocampus. Brain Research 344 (1985) 392-396
53. Roeling T.P.A., Veening J.G., Peters J.P.W., Vermelis M.E.J., and Nieuwenhuys R. Efferent connections of the hypothalamic grooming area in the rat. Neuroscience 56 (1993) 199-225
54. Sachs B.D. Contextual approaches to the physiology and classification of erectile function, erectile dysfunction, and sexual arousal. Neuroscience and Biobehavioral Reviews 24 (2000) 541-560
55. Sachs B.D., Akasofu K., Citro J.K., Daniels S.B., and Natoli J.H. Non-contact stimulation from estrus females evokes penile erection in rats. Physiology and Behaviour 55 (1994) 1073-1079
56. Sanchez F., Alonso J.R., Arevalo R., Blanco E., Aijon J., and Vazquez R. Coexistence of NADPH-diaphorase with vasopressin and oxytocin in the hypothalamic magnocellular neurosecretory nuclei of the rat. Cell and Tissue Research 276 (1994) 31-34
57. Sato-Suzuki I., Kita I., Oguri M., and Arita H. Stereotyped yawning responses induced by electrical and chemical stimulation of paraventricular nucleus of the rat. Journal of Neurophysiology 80 (1998) 2765-2775
58. Sofroniew M.V. Vasopressin and oxytocin in the mammalian brain and spinal cord. Trends in Neurosciences 6 (1983) 467-472
59. Swanson L.W., and Sawchensko P.E. Hypothalamic integration: organization of the paraventricular and supraoptic nuclei. Annual Review of Neuroscience 6 (1983) 269-324
60. Torres G., Lee S., and Rivier C. Ontogeny of the rat hypothalamic nitric oxide synthase and co-localization with neuropeptides. Molecular and Cellular Neuroscience 4 (1993) 155-163
61. Vaccari C., Lolait S.J., and Ostrowski N.L. Comparative distribution of vasopressin V1b and oxytocin receptor messenger ribonucleic acids in brain. Endocrinology 139 (1998) 5015-5033
62. Veronneau-Longueville F., Rampin O., Freund-Mercier M.J., Tang Y., Calas A., Marson L., McKenna K.E., Stoeckel M.E., Benoit G., and Giuliano F. Oxytocinergic innervation of autonomic nuclei controlling penile erection in the rat. Neuroscience 93 (1999) 1437-1447
63. Vincent S.R., and Kimura H. Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience 46 (1992) 755-784
64. Wagner C.K., and Clemens L.G. Neurophysin-containing pathway from the paraventricular nucleus of the hypothalamus to a sexually dimorphic motor nucleus in lumbar spinal cord. Journal of Comparative Neurology 336 (1993) 106-116
65. Wise R.A., and Rompre P.-P. Brain dopamine and reward. Annual Review of Psychology 40 (1989) 191-225
66. Witt D.M., and Insel T.R. Increased Fos expression in oxytocin neurons following masculine sexual behavior. Journal of Neuroendocrinology 6 (1994) 13-18