Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men

Journal of Endocrinology

Volumn 191, Issue 3, 2006, Pages 637-649

  Blouin, Karine ^b   Richard, Christian ^b   Brochu, Gaétan ^a   Hould, Frédéric Simon ^a   Lebel, Stéfane ^a   Marceau, Simon ^a   Biron, Simon ^a   Luu The, Van ^b   Tchernof, André ^b  

^a UNIVERSITÉ LAVAL   (Canada)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA DIOL GLUCURONIDE; 3BETA ANDROSTANEDIOL; ALDOKETOREDUCTASE 1C; ALDOKETOREDUCTASE 1C1; ALDOKETOREDUCTASE 1C2; ALDOKETOREDUCTASE 1C3; ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; ANDROSTENEDIONE; ANDROSTERONE GLUCURONIDE; ANTIOBESITY AGENT; DIPEPTIDYL CARBOXYPEPTIDASE; MESSENGER RNA; UNCLASSIFIED DRUG;

ABDOMINAL FAT; ABDOMINAL SURGERY; ADULT; ANDROGEN METABOLISM; ARTICLE; BILIOPANCREATIC BYPASS; BODY FAT DISTRIBUTION; BODY MASS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; HUMAN; HUMAN TISSUE; LEAN BODY WEIGHT; LIPID METABOLISM; MALE; OBESITY; OMENTUM; PRIORITY JOURNAL; PROADIPOCYTE; SUBCUTANEOUS FAT;

17-HYDROXYSTEROID DEHYDROGENASES; 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (B-SPECIFIC); 3-HYDROXYSTEROID DEHYDROGENASES; ABDOMINAL FAT; ADULT; ANALYSIS OF VARIANCE; ANDROGENS; ANDROSTANE-3,17-DIOL; CELLS, CULTURED; DIHYDROTESTOSTERONE; GENE EXPRESSION; HUMANS; HYDROXYPROSTAGLANDIN DEHYDROGENASES; HYDROXYSTEROID DEHYDROGENASES; MALE; MIDDLE AGED; OBESITY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUBCUTANEOUS FAT, ABDOMINAL; TESTOSTERONE;

EID: 33846798180     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.1.06365     Document Type: Article

References (50)

1. Bakker AH, Van Dielen FM, Greve JW, Adam JA & Buurman WA 2004 Preadipocyte number in omental and subcutaneous adipose tissue of obese individuals. Obesity Research 12 488-498.
2. Bélanger C, Luu-The V, Dupont P & Tchernof A 2002 Adipose tissue intracrinology: potential importance of local androgen/estrogen metabolism in the regulation of adiposity. Hormone and Metabolic Research 34 737-745.
3. Bélanger C, Hould FS, Lebel S, Biron S, Brochu G & Tchernof A 2006 Omental and subcutaneous adipose tissue steroid levels in obese men. Steroids 71 674-682.
4. Blanchette S, Blouin K, Richard C, Dupont P, Luu-The V & Tchernof A 2005 Expression and activity of 20alpha-hydroxysteroid dehydrogenase (AKR1C1) in abdominal subcutaneous and omental adipose tissue in women. Journal of Clinical Endocrinology and Metabolism 90 264-270.
5. Blouin K, Richard C, Bélanger C, Dupont P, Daris M, Laberge P, Luu-The V & Tchernof A 2003 Local androgen inactivation in abdominal visceral adipose tissue. Journal of Clinical Endocrinology and Metabolism 88 5944-5950.
6. Blouin K, Blanchette S, Richard C, Dupont P, Luu-The V & Tchernof A 2005 Expression and activity of steroid aldoketoreductases 1C in omental adipose tissue are positive correlates of adiposity in women. American Journal of Physiology. Endocrinology and Metabolism 288 E398-E404.
7. Boyanov MA, Boneva Z & Christov VG 2003 Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency. Aging Male 6 1-7.
8. Corbould AM, Bawden MJ, Lavranos TC, Rodgers RJ & Judd SJ 2002 The effect of obesity on the ratio of type 3 17beta-hydroxysteroid dehydrogenase mRNA to cytochrome P450 aromatase mRNA in subcutaneous abdominal and intra-abdominal adipose tissue of women. International Journal of Obesity and Related Metabolic Disorders 26 165-175.
9. Cormont M Tanti JF, Zahraoui A, Van Obberghen E, Tavitian A & Le Marchand-Brustel Y 1993 Insulin and okadaic acid induce Rab4 redistribution in adipocytes. Journal of Biological Chemistry 268 19491-19497.
10. Deslypere JP, Verdonck L & Vermeulen A 1985 Fat tissue: a steroid reservoir and site of steroid metabolism. Journal of Clinical Endocrinology and Metabolism 61 564-570.
11. Després JP, Mooijani S, Lupien PJ, Tremblay A, Nadeau A & Bouchard C 1990 Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease. Arteriosclerosis 10 497-511.
12. Dieudonné MN, Sammari A, Dos Santos E, Leneveu MC, Giudicelli Y & Pecquery R 2006 Sex steroids and leptin regulate 11beta-hydroxysteroid dehydrogenase I and P450 aromatase expressions in human preadipocytes: sex specificities. Journal of Steroid Biochemistry and Molectilar Biology 99 189-196.
13. Dufort I, Rheault P Huang XF, Soucy P & Luu-The V 1999 Characteristics of a highly labile human type 5 17beta-hydroxysteroid debydrogenase. Endocrinology 140 568-574.
14. Dufort I, Labrie F & Luu-The V 2001 Human types 1 and 3, 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution. Journal of Clinical Endocrinology and Metabolism 86 841-846.
15. Elbers JM, Asscheman H, Seidell JC & Gooren LJ 1999 Effects of sex steroid hormones on regional fat depots as assessed by magnetic resonance imaging in transsexuals. American Journal of Physiology 276 E317-E325.
16. Elbers JM, Giltay EJ, Teerlink T, Scheffer PG, Asscheman H, Seidell JC & Gooren LJ 2003 Effects of sex steroids on components of the insulin resistance syndrome in transsexual subjects. Clinical Endocrinology 58 562-571.
17. Feher T & Bodrogi L 1982 A comparative study of steroid concentrations in human adipose tissue and the peripheral circulation. Clinica Chimica Acta 126 135-141.
18. Gapstur SM, Gann PH, Kopp P, Colangelo L, Longcope C & Liu K 2002 Serum androgen concentrations in young men: a longitudinal analysis of associations with age, obesity, and race. The CARDIA male hormone study. Cancer Epidermiology, Biomarkers and Prevention 11 1041-1047.
19. van Harmelen V, Skurk T, Rohrig K, Lee YM Halbleib M, Apirath-Husmann I & Hauner H 2003 Effect of BMI and age on adipose tissue cellularity and differentiation capacity in women. International Journal of Obesity and Related Metabolic Disorders 27 889-895.
20. Hauner H 1990 Differentiation of human adipocyte precursor cells under chemically defined culture conditions. In Progress in Obesity Research, pp 213-218. Eds Y Oomura, S Tarui, S Inoue & T Shimazu. London, UK: John Libbey and Company Ltd.
21. Hauner H, Skurk T & Wabitsch M 2001 Cultures of human adipose precursor cells. Methods in Molecular Biology 155 239-247.
22. Juhan-Vague I, Morange PE & Alessi MC 2002 The insulin resistance syndrome: implications for thrombosis and cardiovascular disease. Pathophysiology of Haemostasis and Thrombosis 32 269-273.
23. Kather H, Schroder F & Simon B 1982 Microdetermination of glycerol using bacterial NADH-linked luciferase. Clinica Chimica Acta 120 295-300.
24. Kershaw EE & Flier JS 2004 Adipose tissue as an endocrine organ. Journal of Clinical Endocrinology and Metabolism 89 2548-2556.
25. Khaw KT & Barrett-Connor E 1992 Lower endogenous androgens predict central adiposity in men. Annals of Epidemiology 2 675-682.
26. Killinger DW, Perel E, Danilescu D, Kharlip L & Lindsay WR 1990 Influence of adipose tissue distribution on the biological activity of androgens. Annals of the New York Academy of Sciences 595 199-211.
27. Labrie F, Bélanger A, Cusan L, Gomez JL & Candas B 1997 Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. Journal of Clinical Endocrinology and Metabolism 82 2396-2402.
28. Lemieux I, Pascot A, Prud'homme D, Almeras N, Bogary P, Nadeau A, Bergeron J & Després JP 2001 Elevated C-reactive protein: another component of the atherothrombotic profile of abdominal obesity. Arteriosclerosis, Thrombosis, and Vascular Biology 21 961-967.
29. Lewis GF, Carpentier A, Adeli K & Giacca A 2002 Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocrine Reviews 23 201-229.
30. Lohman T, Roche A & Martorel R 1988 Standardization of anthropometric measurements. In: The Airlie (VA) consensus conference standardization of anthropometric measurements. Champaign, IL, Human Kinetics 39-80.
31. Luu-The V, Paquet N, Calvo E & Cumps J 2005 Improved real-time RT-PCR method for high-throughput measurements using second derivative calculation and double correction. Biotechniques 38 287-293.
32. Mårin P, Holmang S,Jonsson L, Sjostrom. L, Kvist H, Holm G, Lindstedt G & Björntorp P 1992 The elects of testosterone treatment on body composition and metabolism in middle-aged obese men. International Journal of Obesity and Related Metabolic Disorders 16 991-997.
33. Mårin P, Oden B & Björntorp P 1995 Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men effects of androgens. Journal of Clinical Endocrinology and Metabolism 80 239-243.
34. Mohamed-Ali V, Pinkney JH & Coppack SW 1998 Adipose tissue as an endocrine and paracrine organ. International Journal of Obesity and Related Metabolic Disorders 22 1145-1158.
35. Must A, Spadano J, Coakley EH, Field AE, Colditz G & Diem VIH 1999 The disease burden associated with overweight and obesity. Journal of the American Medical Association 282 1523-1529.
36. Pak TR, Chung WC, Lund TD, Hinds LR, Clay CM & Handa RJ 2005 The androgen metabolite, 5alpha-androstane-3beta, 17beta-diol, is a potent modulator of estrogen receptor-beta1-mediated gene transcription in neuronal cells. Endocrinology 146 147-155.
37. Pedersen SB, Bruun JM, Hube E Kristensen E, Hauner H & Richelsen B 2001 Demonstration of estrogen receptor subtypes alpha and beta in human adipose time: influences of adipose cell differentiation and fat depot localization. Molecular and Cellular Endocrinology 182 27-37.
38. Quinkler M, Sinha B, Tomlinson JW, Bujalska U, Stewart PM & Arlt W 2004 Androgen generation in adipose tissue in women with simple obesity - a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5. Journal of Endocrinology 183 331-342.
39. Rask E, Walker BR, Soderberg S, Livingstone DE, Eliasson M, Johnson O, Andrew R & Olsson T 2002 Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity. Journal of Clinical Endocrinology and Metabolism 87 3330-3336.
40. Ravussin E & Smith SR 2002 Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic, fat storage, insulin resistance, and type 2 diabetes mellitus. Annals of the New York Academy of Sciences 967 363-378.
41. Rodbell M 1964 Metabolism of isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis. Journal of Biological Chemistry 239 375-380.
42. Sato T. Matsumoto T, Yamada T, Watanabe T, Kawano H & Kato S 2003 Late onset of obesity in male androgen receptor-deficient (AR KO) mice. Biochemical and Biophysical Research Communications 300 167-171.
43. Singh R, Artaza JN, Taylor WE, Gonzalez-Cadavid NF & Bhasin S 2003 Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway. Endocrinology 144 5081-5088.
44. Singh R, Artaza JN, Taylor WE, Braga M Yuan X, Gonzalez-Cadavid NF & Bhasin S 2006 Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. Endocrinology 147 141-154.
45. Steckelbroeck S, Jin Y, Gopishetty S, Oyesanmi B & Penning TM 2004 Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action. Journal of Biological Chemistry 279 10784-10795.
46. Szymczak J, Milewicz A, Thijssen JH, Blankenstein MA & Daroszewski J 1998 Concentration of sex steroids in adipose tissue after menopause. Steroids 63 319-321.
47. Taskinen MR, Nikkila EA, Huttunen JK & Hilden H 1980 A micromethod for assay of lipoprotein lipase activity in needle biopsy samples of human adipose tissue and skeletal muscle. Clinica Chimica Acta 104 107-117.
48. Tchernof A, Després JP, Bélanger A, Dupont A, Prud'homme, D, Moorjani S, Lupien PJ & Labrie F 1995 Reduced testosterone and adrenal C19 steroid levels in obese men. Metabolism 44 513-519.
49. Tchernof A, Labrie F, Bélanger A, Prud'homme D, Bouchard C, Tremblay A, Nadeau A & Després JP 1997 Androstane-3alpha, 17beta-diol glucuronide as a steroid correlate of visceral obesity in men. Journal of Clinical Endocrinology and Metabolism 82 1528-1534.
50. Zhang Y, Dufort I, Rheault P & Luu-The V 2000 Characterization of a human 20alpha-hydroxysteroid dehydrogenase. Journal of Molecular Endocrinology 25 221-228.