Role of transcription factor Kar4 in regulating downstream events in the Saccharomyces cerevisiae pheromone response pathway

Molecular and Cellular Biology

Volumn 27, Issue 3, 2007, Pages 818-829

  Lahav, Ron ^a,b   Gammie, Alison ^a   Tavazoie, Saeed ^a   Rose, Mark D ^a  

^a PRINCETON UNIVERSITY   (United States)

^b GENZYME CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; PHEROMONE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR KAR4; TRANSCRIPTION FACTOR STE12; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL FUSION; CHROMATIN IMMUNOPRECIPITATION; CIK1 GENE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA HYBRIDIZATION; DNA SEQUENCE; DNA STRUCTURE; FUNGAL GENE; FUNGAL REPRODUCTION; GEL MOBILITY SHIFT ASSAY; GENE CLUSTER; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE INDUCTION; GENE MUTATION; HAPLOIDY; KAR3 GENE; KARYOGAMY; MATING; MICROARRAY ANALYSIS; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PRM2 GENE; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN FUNCTION; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION INITIATION;

AMINO ACID SEQUENCE; BASE SEQUENCE; CLUSTER ANALYSIS; CONSENSUS SEQUENCE; DNA, FUNGAL; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; PHEROMONES; PROMOTER REGIONS (GENETICS); SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TIME FACTORS; TRANSCRIPTION FACTORS;

SACCHAROMYCES CEREVISIAE;

EID: 33846636439     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00439-06     Document Type: Article

References (50)

1. Ausubel, F. M. 1987. Current protocols in molecular biology. Greene Publishing Associates, Media, PA.
2. Baur, M., R. K. Esch, and B. Errede. 1997. Cooperative binding interactions required for function of the Ty1 sterile responsive element. Mol. Cell. Biol. 17:4330-4337.
3. Beh, C. T., V. Brizzio, and M. D. Rose. 1997. KAR5 encodes a novel pheromone-inducible protein required for homotypic nuclear fusion. J. Cell Biol. 139:1063-1076.
4. Bohm, S., D. Frishman, and H. W. Mewes. 1997. Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. Nucleic Acids Res. 25:2464-2469.
5. 6A methyltransferase. J. Mol. Evol. 55:431-444.
6. Burke, D., D. Dawson, T. Stearns, et al. 2000. Methods in yeast genetics. Cold Spring Harbor Laboratory Press, Plainview, NY.
7. Claney, M. J., M. E. Shambaugh, C. S. Timpte, and J. A. Bokar. 2002. Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene. Nucleic Acids Res. 30:4509-4518.
8. Desjarlais, J. R., and J. M. Berg. 1992. Toward rules relating zinc finger protein sequences and DNA binding site preferences. Proc. Natl. Acad. Sci. USA 89:7345-7349.
9. Dohlman, H. G., and J. W. Thorner. 2001. Regulation of G protein-initiated signal transduction in yeast: paradigms and principles. Annu. Rev. Biochem. 70:703-754.
10. Dolan, J. W., C. Kirkman, and S. Fields. 1989. The yeast STE12 protein binds to the DNA sequence mediating pheromone induction. Proc. Natl. Acad. Sci. USA 86:5703-5707.
11. Elion, E. A., M. Qi, and W. Chen. 2005. Signal transduction: signaling specificity in yeast. Science 307:687-688.
12. Errede, B., and G. Ammerer. 1989. STE12, a protein involved in cell-type-specific transcription and signal transduction in yeast, is part of protein-DNA complexes. Genes Dev. 3:1349-1361.
13. Fitch, P. G., A. E. Gammie, D. J. Lee, V. B. de Candal, and M. D. Rose. 2004. Lrg1p Is a Rho1 GTPase-activating protein required for efficient cell fusion in yeast. Genetics 168:733-746.
14. Gammie, A. E., B. G. Stewart, C. F. Scott, and M. D. Rose. 1999. The two forms of karyogamy transcription factor Kar4p are regulated by differential initiation of transcription, translation, and protein turnover. Mol. Cell. Biol. 19:817-825.
15. Guarente, L., and M. Ptashne. 1981. Fusion of Escherichia coli lacZ to the cytochrome c gene of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 78:2199-2203.
16. Hagen, D. C., G. McCaffrey, and G. F. Sprague, Jr. 1991. Pheromone response elements are necessary and sufficient for basal and pheromone-induced transcription of the FUS1 gene of Saccharomyces cerevisiae. Mol. Cell. Biol. 11:2952-2961.
17. Heiman, M. G., and P. Walter. 2000. Prm1p, a pheromone-regulated multispanning membrane protein, facilitates plasma membrane fusion during yeast mating. J. Cell Biol. 151:719-730.
18. Hughes, J. D., P. W. Estep, S. Tavazoie, and G. M. Church. 2000. Computational identification of cis-regulatory elements associated with groups of functionally related genes in Saccharomyces cerevisiae. J. Mol. Biol. 296:1205-1214.
19. James, P., J. Halladay, and E. A. Craig. 1996. Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144:1425-1436.
20. Kim, T. S-, H. Y. Kim, J. H. Yoon, and H. S. Kang. 2004. Recruitment of the Swi/Snf complex by Ste12-Tec1 promotes Flo8-Mss11-mediated activation of STA1 expression. Mol. Cell. Biol. 24:9542-9556.
21. Kurdistani, S. K., D. Robyr, S. Tavazoie, and M. Grunstein. 2002. Genome-wide binding map of the histone deacetylase Rpd3 in yeast. Nat. Genet. 31:248-254.
22. Kurihara, L. J., C. T. Beh, M. Latterich, R. Schekman, and M. D. Rose. 1994. Nuclear congression and membrane fusion: two distinct events in the yeast karyogamy pathway. J. Cell Biol. 126:911-923.
23. Kurihara, L. J., B. G. Stewart, A. E. Gammie, and M. D. Rose. 1996. Kar4p, a karyogamy-specific component of the yeast pheromone response pathway. Mol. Cell. Biol. 16:3990-4002.
24. Lockhart, S. R., R. Zhao, K. J. Daniels, and D. R. Soil. 2003. Alpha-pheromone-induced "shmooing" and gene regulation require white-opaque switching during Candida albicans mating. Eukaryot. Cell 2:847-855.
25. Mackey, A. T., L. R. Sproul, C. A. Sontag, L. L. Satterwhite, J. J. Correia, and S. P. Gilbert. 2004. Mechanistic analysis of the Saccharomyces cerevisiae kinesin Kar3. J. Biol. Chem. 279:51354-51361.
26. Maddox, P., E. Chin, A. Mallavarapu, E. Yeh, E. D. Salmon, and K. Bloom. 1999. Microtubule dynamics from mating through the first zygotic division in the budding yeast Saccharomyces cerevisiae. J. Cell Biol. 144:977-987.
27. Madhani, H. D., and G. R. Fink. 1997. Combinatorial control required for the specificity of yeast MAPK signaling. Science 275:1314-1317.
28. Madhani, H. D., T. Galitski, E. S. Lander, and G. R. Fink. 1999. Effectors of a developmental mitogen-activated protein kinase cascade revealed by expression signatures of signaling mutants. Proc. Natl. Acad. Sci. USA 96:12530-12535.
29. Mangan, S., and U. Alon. 2003. Structure and function of the feed-forward loop network motif. Proc. Natl. Acad. Sci. USA 100:11980- 11985.
30. Mangan, S., A. Zaslaver, and U. Alon. 2003. The coherent feed-forward loop serves as a sign-sensitive delay element in transcription networks. J. Mol. Biol. 334:197-204.
31. 31. Marsh, L., and M. D. Rose. 1997. The pathway of cell and nuclear fusion during mating in Saccharomyces cerevisiae, p. 827-888. In J. Pringle, J. R. Broach, and E. W. Jones (ed.), The molecular and cellular biology of the yeast Saccharomyces, vol. 3. Cell cycle and cell biology. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
32. McCaffrey, G., F. J. Clay, K. Kelsay, and G. F. Sprague, Jr. 1987. Identification and regulation of a gene required for cell fusion during mating of the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 7:2680-2690.
33. Meluh, P. B., and M. D. Rose. 1990. KAR3, a kinesin-related gene required for yeast nuclear fusion. Cell 60:1029-1041.
34. Miller, R. K., and M. D. Rose. 1998. Kar9p is a novel cortical protein required for cytoplasmic microtubule orientation in yeast. J. Cell Biol. 140:377-390.
35. Oehlen, L. J., J. D. McKinney, and F. R. Cross. 1996. Ste12 and Mcm1 regulate cell cycle-dependent transcription of FAR1. Mol. Cell. Biol. 16:2830-2837.
36. 1 is processed in two steps, one of them heme-dependent. J. Biol. Chem. 257:13042-13047.
37. Oldenburg, K. R., K. T. Vo, S. Michaelis, and C. Paddon. 1997. Recombination-mediated PCR-directed plasmid construction in vivo in yeast. Nucleic Acids Res. 25:451-452.
38. Page, B. D., L. L. Satterwhite, M. D. Rose, and M. Snyder. 1994. Localization of the Kar3 kinesin heavy chain-related protein requires the Cik1 interacting protein. J. Cell Biol. 124:507-519.
39. Roberts, C. J., B. Nelson, M. J. Marton, R. Stoughton, M. R. Meyer, H. A. Bennett, Y. D. He, H. Dai, W. L. Walker, T. R. Hughes, M. Tyers, C. Boone, and S. H. Friend. 2000. Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. Science 287:873-880.
40. Robinson, M. D., J. Grigull, N. Mohammad, and T. R. Hughes. 2002. FunSpec: a web-based cluster interpreter for yeast. BMC Bioinformatics 3:35-39.
41. Rose, M. D. 1996. Nuclear fusion in the yeast Saccharomyces cerevisiae. Annu. Rev. Cell Dev. Biol. 12:663-695.
42. Rose, M. D., F. M. Winston, P. Hieter, et al. 1990. Methods in yeast genetics: a laboratory course manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
43. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
44. Schmitt, M. E., T. A. Brown, and B. L. Trumpower. 1990. A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae. Nucleic Acids Res. 18:3091-3092.
45. Sikorski, R. S., and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19-27.
46. Spellman, P. T., G. Sherlock, M. Q. Zhang, V. R. Iyer, K. Anders, M. B. Eisen, P. O. Brown, D. Botstein, and B. Futcher. 1998. Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Mol. Biol. Cell 9:3273-3297.
47. Sprague, G. F., and J. W. Thorner. 1992. Pheromone response and signal transduction during the mating process of Saccharomyces cerevisiae, p. 657-744. In J. R. Broach, J. Pringle, and E. W. Jones (ed.), The molecular and cellular biology of the yeast Saccharomyces, vol. 2. Gene expression. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
48. Tavazoie, S., J. D. Hughes, M. J. Campbell, R. J. Cho, and G. M. Church. 1999. Systematic determination of genetic network architecture. Nat. Genet. 22:281-285.
49. Winzeler, E. A., D. D. Shoemaker, A. Astromoff, H. Liang, K. Anderson, B. Andre, R. Bangham, R. Benito, J. D. Boeke, H. Bussey, A. M. Chu, C. Connelly, K. Davis, F. Dietrich, S. W. Dow, M. El Bakkoury, F. Foury, S. H. Friend, E. Gentalen, G. Giaever, J. H. Hegemann, T. Jones, M. Laub, H. Liao, N. Liebundguth, D. J. Lockhart, A. Lucau-Danila, M. Lussier, N. M'Rabet, P. Menard, M. Mittmann, C. Pai, C. Rebischung, J. L. Revuelta, L. Riles, C. J. Roberts, P. Ross-MacDonald, B. Scherens, M. Snyder, S. Sookhai-Mahadeo, R. K. Storms, S. Veronneau, M. Voet, G. Volckaert, T. R. Ward, R. Wysocki, G. S. Yen, K. Yu, K. Zimmermann, P. Philippsen, M. Johnston, and R. W. Davis. 1999. Functional characterization of the Saccharomyces cerevisiae genome by gene deletion and parallel analysis. Science 285:901-906.
50. Zeitlinger, J., I. Simon, C. T. Harbison, N. M. Hannett, T. L. Volkert, G. R. Fink, and R. A. Young. 2003. Program-specific distribution of a transcription factor dependent on partner transcription factor and MAPK signaling. Cell 113:395-404.