The two forms of karyogamy transcription factor Kar4p are regulated by differential initiation of transcription, translation, and protein turnover

Molecular and Cellular Biology

Volumn 19, Issue 1, 1999, Pages 817-825

  Gammie, Alison E ^a   Stewart, Bruce G ^a,b   Scott, Charles F ^a,c   Rose, Mark D ^a  

^a PRINCETON UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ARTICLE; FUNGAL GENETICS; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TRANSLATION INITIATION; TRANSLATION REGULATION;

SACCHAROMYCES CEREVISIAE;

EID: 0032909654     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.1.817     Document Type: Article

References (47)

1. Apanovitch, D. M., K. C. Slep, P. B. Sigler, and H. G. Dohlman. 1998. Sst2 is a GTPase-activating protein for Gpa1: purification and characterization of a cognate RGS-Gα protein pair in yeast. Biochemistry 37:4815-4822.
2. Ausubel, F. M. 1987. Current protocols in molecular biology. Greene Publishing Associates, Brooklyn, N.Y.
3. Bachmair, A., D. Finley, and A. Varshavsky. 1986. In vivo half-life of a protein is a function of its amino-terminal residue. Science 234:179-186.
4. Beh, C. T., V. Brizzio, and M. D. Rose. 1997. KAR5 encodes a novel pheromone-inducible protein required for homotypic nuclear fusion. J. Cell Biol. 139:1063-1076.
5. Beltzer, J. P., S. R. Morris, and G. B. Kohlhaw. 1988 Yeast LEU4 encodes mitochondrial and nonmitochondrial forms of alpha-isopropylmalate synthase. J. Biol. Chem. 263:368-374.
6. Boguta, M., L. A. Hunter, W.-C. Shen, E. C. Gillman, N. C. Martin, and A. K. Hopper. 1994. Subcellular locations of MOD5 proteins: mapping of sequences sufficient for targeting to mitochondria and demonstration that mitochondrial and nuclear isoforms commingle in the cytosol. Mol. Cell. Biol. 14:2298-2306.
7. Byers, B., and L. Goetsch. 1975. Behavior of spindles and spindle plaques in the cell cycle and conjugation of Saccharomyces cerevisiae. J. Bacteriol. 124: 511-523.
8. Chatton, B., P. Walter, J. P. Ebel, F. Lacroute, and F. Fasiolo. 1988 The yeast VAS1 gene encodes both mitochondrial and cytoplasmic valyl-tRNA synthetases. J. Biol. Chem. 263:52-57.
9. Cigan, A. M., E. K. Pabich, and T. F. Donahue. 1988. Mutational analysis of the HIS4 translational initiator region in Saccharomyces cerevisiae. Mol. Cell. Biol. 8:2964-2975.
10. Donahue, T. F., and A. M. Cigan. 1988. Genetic selection for mutations that reduce or abolish ribosomal recognition of the HIS4 translational initiator region. Mol. Cell. Biol. 8:2955-2963.
11. Errede, B., R. M. Cade, B. M. Yashar, Y. Kamada, D. E. Levin, K. Irie, and K. Matsumoto. 1995. Dynamics and organization of MAP kinase signal pathways. Mol. Reprod. Dev. 42:477-485.
12. Gammie, A. E., and J. H. Crosa. 1991. Co-operative autoregulation of a replication protein gene. Mol. Microbiol. 5:3015-3023.
13. Gammie, A. E., L. J. Kurihara, R. B. Vallee, and M. D. Rose. 1995. DNM1, a dynamin-related gene, participates in endosomal trafficking in yeast. J. Cell Biol. 130:553-566.
14. Gill, G., and M. Ptashne. 1988. Negative effect of the transcriptional activator GAL4. Nature 334:721-724.
15. Hershko, A. 1997. Roles of ubiquitin-mediated proteolysis in cell cycle control. Curr. Opin. Cell Biol. 9:788-799.
16. Herskowitz, I. 1995. MAP kinase pathways in yeast: for mating and more. Cell 80:187-197.
17. Hicke, L., and H. Riezman. 1996. Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis. Cell 84:277-287.
18. Hicke, L., B. Zanolari, and H. Riezman. 1998. Cytoplasmic tail phosphorylation of the α-factor receptor is required for its ubiquitination and internalization. J. Cell Biol. 141:349-358.
19. Hinnebusch, A. G., and S. W. Liebman. 1991. Protein synthesis and translational control in Saccharomyces cerevisiae, p. 627-735. In J. R. Broach, J. R. Pringle, and E. W. Jones (ed.), The molecular and cellular biology of the yeast Saccharomyces: genome dynamics, protein synthesis, and energetics, vol. 1. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
20. Hochstrasser, M. 1992. Ubiquitin and intracellular protein degradation. Curr. Opin. Cell Biol. 4:1024-1031.
21. Hochstrasser, M. 1996. Ubiquitin-dependent protein degradation. Annu. Rev. Genet. 30:405-439.
22. Hochstrasser, M., M. J. Ellison, V. Chau, and A. Varshavsky. 1991. The short-lived MATα2 transcriptional regulator is ubiquitinated in vivo. Proc. Natl. Acad. Sci. USA 88:4606-4610.
23. Kassir, Y., and G. Simchen. 1991. Monitoring meiosis and sporulation in Saccharomyces cerevisiae. Methods Enzymol. 194:94-110.
24. Kurihara, L. J., C. T. Beh, M. Latterich, R. Schekman, and M. D. Rose. 1994. Nuclear congression and membrane fusion: two distinct events in the yeast karyogamy pathway. J. Cell Biol. 126:911-923.
25. Kurihara, L. J., B. G. Stewart, A. E. Gammie, and M. D. Rose. 1996. Kar4p, a karyogamy-specific component of the yeast pheromone response pathway. Mol. Cell. Biol. 16:3990-4002.
26. Leberer, E., D. Y. Thomas, and M. Whiteway. 1997. Pheromone signalling and polarized morphogenesis in yeast. Curr. Opin. Genet. Dev. 7:59-66.
27. Levin, D. E., and B. Errede. 1995. The proliferation of MAP kinase signaling pathways in yeast. Curr. Opin. Cell Biol. 7:197-202.
28. Madura, K., and A. Varshavsky. 1994. Degradation of G α by the N-end rule pathway. Science 265:1454-1458.
29. Marsh, L., and M. D. Rose. 1997. The pathway of cell and nuclear fusion during mating in S. cerevisiae, p. 827-888. In J. R. Pringle, J. R. Broach, and E. W. Jones (ed.), The molecular and cellular biology of the yeast Saccharomyces: cell cycle and cell biology, vol. 3. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
30. Meluh, P. B., and M. D. Rose. 1990. KAR3, a kinesin-related gene required for yeast nuclear fusion. Cell 60:1029-1041.
31. Miller, R. K., and M. D. Rose. 1998. Kar9p is a novel cortical protein required for cytoplasmic microtubule orientation in yeast. J. Cell Biol. 140: 377-390.
32. Natsoulis, G., F. Hilger, and G. R. Fink. 1986. The HTS1 gene encodes both the cytoplasmic and mitochondrial histidine tRNA synthetases of S. cerevisiae. Cell 46:235-243.
33. Ohashi, A., J. Gibson, I. Gregor, and G. Schatz. 1982. Import of proteins into mitochondria. The precursor of cytochrome c1 is processed in two steps, one of them heme-dependent. J. Biol. Chem. 257:13042-13047.
34. Page, B. D., L. L. Satterwhite, M. D. Rose, and M. Snyder. 1994. Localization of the Kar3 kinesin heavy chain-related protein requires the Cik1 interactine protein. J. Cell Biol. 124:507-519.
35. Rose, A. M., P. B. Joyce, A. K. Hopper, and N. C. Martin. 1992. Separate information required for nuclear and subnuclear localization: additional complexity in localizing an enzyme shared by mitochondria and nuclei. Mol. Cell. Biol. 12:5652-5658.
36. Rose, M. D., F. Winston, and P. Hieter. 1990. Methods in yeast genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
37. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
38. Schneider, B. L., W. Seufert, B. Steiner, Q. H. Yang, and A. B. Futcher. 1995. Use of polymerase chain reaction epitope tagging for protein tagging in Saccharomyces cerevisiae. Yeast 11:1265-1274.
39. Schwob, E., T. Bohm, M. D. Mendenhall, and K. Nasmyth. 1994. The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79:233-244.
40. Sikorski, R. S., and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19-27.
41. Smith, S. E., M. Koegl, and S. Jentsch. 1996. Role of the ubiquitin/proteasome system in regulated protein degradation in Saccharomyces cerivisiae. Biol. Chem. 377:437-446.
42. Sprague, G. F., and J. W. Thorner. 1992. Pheromone response and signal transduction during the mating process of Saccharomyces cerevisiae, p. 657-744. In J. R. Broach, J. R. Pringle, and E. W. Jones (ed.), The molecular and cellular biology of the yeast Saccharomyces: gene expression, vol. 2. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
43. Taussig, R., and M. Carlson. 1983. Nucleotide sequence of the yeast SUC2 gene for invertase. Nucleic Acids Res. 11:1943-1954.
44. Varshavsky, A. 1995. The N-end rule. Cold Spring Harbor Symp. Quant. Biol. 60:461-478.
45. Varshavsky, A. 1992. The N-end rule. Cell 69:725-735.
46. Wolfe, C. L., Y. C. Lou, A. K. Hopper, and N. C. Martin. 1994. Interplay of heterogeneous transcriptional start sites and translational selection of AUGs dictate the production of mitochondrial and cytosolic/nuclcar tRNA nucleotidyltransferase from the same gene in yeast. J. Biol. Chem. 269:13361-13366.
47. Zitomer, R. S., D. A. Walthall, B. C. Rymond, and C. P. Hollenberg. 1984. Saccharomyces cerevisiae ribosomes recognize non-AUG initiation codons. Mol. Cell. Biol. 4:1191-1197.