Diffuse optical imaging and spectroscopy for cancer

Expert Review of Medical Devices

Volumn 4, Issue 1, 2007, Pages 83-95

  Xu, Ronald X ^a   Povoski, Stephen P ^b  

^a Ohio State University   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Absorption; Cancer; Diffuse optical imaging and spectroscopy; Fluorescence; Hemoglobin concentration; Oxygen saturation; Scattering

Indexed keywords

ANTIBODY 9.2.27; CANCER ANTIBODY; CARBOCYANINE; CARCINOEMBRYONIC ANTIBODY; CYANINE DYE; CYANINE DYE 3; CYANINE DYE 5; CYANINE DYE 5.5; EPIDERMAL GROWTH FACTOR; FLUORESCEIN; FLUORESCENT DYE; HUMAN SERUM ALBUMIN; IC GREEN; INDOCYANINE GREEN; INDOTRICARBOCYANINE DERIVATIVE; MACROGOL DERIVATIVE; METHOXYPOLYETHYLENE GLYCOL; POLYLYSINE; PROTEIN ANTIBODY; STAGE SPECIFIC EMBRYO ANTIGEN 1; STAGE SPECIFIC EMBRYO ANTIGEN 1 ANTIBODY; TRANSFERRIN; UNCLASSIFIED DRUG;

CANCER; CANCER RESEARCH; CANCER TISSUE; COMPUTER ASSISTED TOMOGRAPHY; COST EFFECTIVENESS ANALYSIS; DIAGNOSTIC IMAGING; DRUG CONJUGATION; HUMAN; IMAGE RECONSTRUCTION; IMAGING SYSTEM; INFORMATION PROCESSING; INFRARED RADIATION; LIGHT; LIGHT ABSORPTION; LIGHT SCATTERING; NON INVASIVE MEASUREMENT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RADIATION; REPRODUCIBILITY; REVIEW; SIGNAL PROCESSING; SPECTROSCOPY; TECHNOLOGY; TISSUE INTERACTION;

BIOMEDICAL TECHNOLOGY; CONTRAST MEDIA; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; NEOPLASMS; SPECTROSCOPY, NEAR-INFRARED; TECHNOLOGY ASSESSMENT, BIOMEDICAL;

EID: 33846553566     PISSN: 17434440     EISSN: 17452422     Source Type: Journal    
DOI: 10.1586/17434440.4.1.83     Document Type: Review

References (127)

1. Sarasin A. An overview of the mechanisms of mutagenesis and carcinogenesis. Mutat. Res. 544, 99-106 (2003).
2. Kubota K. From tumor biology to clinical Pet: A review of positron emission tomography (PET) in oncology. Ann. Nucl. Med. 15, 471-486 (2001).
3. Podoloff DA, Kim EE, Haynie TP. SPECT in the evaluation of cancer patients: Not quo vadis; rather, ibi fere summus. Radiology 183, 305-317 (1992).
4. Krishna MC, Subramanian S, Kuppusamy P, Mitchell JB. Magnetic resonance imaging for in vivo assessment of tissue oxygen concentration. Semin. Radiat. Oncol. 11, 58-69 (2001).
5. Gallez B, Baudelet C, Jordan BF. Assessment of tumor oxygenation by electron paramagnetic resonance: Principles and applications. NMR Biomed. 17, 240-262 (2004).
6. Tromberg BJ, Shah N, Lanning R et al. Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy. Neoplasia 2, 26-40 (2000).
7. Vaupel P and Harrison L. Tumor hypoxia: Causative factors, compensatory mechanisms, and cellular response. Oncologist 9 Suppl 5, 4-9 (2004).
8. Garcia-Uribe A, Kehtarnavaz N, Marquez G, Prieto V, Duvic M, Wang LV. Skin cancer detection by spectroscopic oblique-incidence reflectometry: classification and physiological origins. Appl. Opt. 43, 2643-2650 (2004).
9. Mahmood U, Weissleder R. Near-infrared optical imaging of proteases in cancer. Mol. Cancer Ther. 2, 489-496 (2003).
10. Achilefu S. Lighting up tumors with receptor-specific optical molecular probes. Technol. Cancer Res. Treat. 3, 393-409 (2004).
11. Gurfinkel M, Ke S, Wen X, Li C, Sevick-Muraca EM. Near-infrared fluorescence optical imaging and tomography. Dis. Markers 19, 107-121 (2003).
12. Cope M. The development of a near-infrared spectroscopy system and its application for non-invasive monitoring of cerebral blood and tissue oxygenation in the newborn infant. University College London, Thesis (1991).
13. Specific extinction spectra of tissue chromophores. www.medphys.ucl.ac.uk/research/borl/research/NIR_topics/spectra/ spectra.htm (accessed on June 4, 2006)
14. Optical properties spectra, http://omlc.ogi.edu/spectra/index.html (accessed on June 4, 2006)
15. Durduran T, Choe R, Culver JP et al. Bulk optical properties of healthy female breast tissue. Phys. Med. Biol. 47, 2847-2861 (2002).
16. Schmidt FEW. Development of a time-resolved optical tomography system for neonatal brain imaging. University College London, Thesis (1999).
17. Gibson AP, Hebden JC, Arridge SR. Recent advances in diffuse optical imaging. Phys. Med. Biol. 50, R1-43 (2005).
18. Boas DA, Brooks DH, Miller EL et al. Imaging the body with diffuse optical tomography. IEEE Signal Processing Magazine 18, 57-75 (2001).
19. Hebden JC, Arridge SR, Delpy DT. Optical imaging in medicine: I. Experimental techniques. Phys. Med. Biol. 42, 825-840 (1997).
20. Chance B, Luo Q, Nioka S, Alsop DC. Detre JA. Optical investigations of p0hysiology: A study of intrinsic and extrinsic biomedical contrast. Philos. Trans. R. Soc. Lond. B Biol. Sci. 352, 707-716 (1997).
21. Chance B, Nioka S, Kent J et al. Time-resolved spectroscopy of hemoglobin and myoglobin in resting and ischemic muscle. Anal. Biochem. 174, 698-707 (1988).
22. Fantini S, Fanceschini MA, Maier JS, Walker SA, Barbieri B, Gratton E. Frequency-domain meultichannel optical detector for non-invasice tissue spectroscopy and oximetry. Optical Engineering 34, 32-42 (1995).
23. Arridge SR, Lionheart WRB. Nonuniqueness in diffusion-basedoptical tomography. Optics Letters 23, 882-884 (1998).
24. Hebden JC. Evaluating the spatial resolution performance of a time-resolved optical imaging system. Med. Phys. 19, 1081-1087 (1992).
25. Grosenick D, Moesta KT, Wabnitz H et al. Time-domain optical mammography: Initial clinical results on detection and characterization of breast tumors. Appl. Opt. 42, 3170-3186 (2003).
26. Rolfe P. In vivo near-infrared spectroscopy. Annu. Rev. Biomed. Eng. 2, 715-754 (2000).
27. Utzinger U, Richards-Kortum RR. Fiber optic probes for biomedical optical spectroscopy. J. Biomed. Opt. 8, 121-147 (2003).
28. Bigio IJ,Bown SG. Spectroscopic sensing of cancer and cancer therapy: current status of translational research. Cancer Biol. Ther. 3, 259-267 (2004).
29. Reynolds JS, Troy TL, Mayer RH et al. Imaging of spontaneous canine mammary tumors using fluorescent contrast agents. Photochem. Photobiol. 70, 87-94 (1999).
30. De Grand AM, Frangioni JV. An operational near-infrared fluorescence imaging system prototype for large animal surgery. Technol. Cancer Res. Treat. 2, 553-562 (2003).
31. Mahmood U, Tung CH, Bogdanov A Jr, Weissleder R. Near-infrared optical imaging of protease activity for tumor detection. Radiology 213, 866-870 (1999).
32. Hielscher AH, Bluestone AY, Abdoulaev GS et al. Near-infrared diffuse optical tomography. Dis. Markers 18, 313-337 (2002).
33. Gallant P, Belenkov A, Ma G et al. A quantitative time-domain optical imager for small animal in vivo fluorescence studies. Annual Conference of the Optical Society of America (2004).
34. Ntziachristos V, Tung CH, Bremer C, Weissleder R. Fluorescence molecular tomography resolves protease activity in vivo. Nat. Med. 8, 757-760 (2002).
35. Explore Optix Pre-clinical Optical Imaging System, www.pst.fraunhofer.de/ngfn/aktuell/kh/amersham/ eXplore_Optix_datasheet.pdf (accesse on October 30, 2006)
36. IVIS Imaging System 3D Series, http://www.xenogen.com/pdf/ Xenogen_IVIS%203d_update.pdf (accessed on October 30, 2006)
37. Piao D, Dehghani H, Jiang S, Srinivasan S and Pogue BW. Instrumentation for video-rate near-infrared diffuse optical tomography. Rev. Scientific Instruments 76, 124301 (2005).
38. Schmitz CH, Locker M, Lasker JM, Hielscher AH, Barbour RL. Instrumentation for fast functional optical tomography. Rev. Scientific Instruments 73, 429-439 (2002).
39. Boas DA, Dale AM, Franceschini MA. Diffuse optical imaging of brain activation: Approaches to optimizing image sensitivity, resolution, and accuracy Neuroimage 23 Suppl. 1. S275-288 (2004).
40. Sato H, Kiguchi M, Kawaguchi F, Maki A. Practicality of wavelength selection to improve signal-to-noise ratio in near-infrared spectroscopy. Neuroimage 21, 1554-1562 (2004).
41. Feng S, Zeng F-A, Chance B. Photon migration in the presence of a single defect: A perturbation analysis. Appl. Opt. 34, 3826 (1995).
42. Kumar G, Schmitt JM. Optimal probe geometry for near infrared spectroscopy of biological tissue. Appl. Opt. 36, 2286-2293 (1997).
43. Liu H. Unified Analysis of the Sensitivities of Reflectance and Path Length to Scattering Variations in a Diffusive Medium. Appl. Opt. 40, 1742-1746 (2001).
44. Mourant JR, Bigio IJ, Jack DA, Johnson TM, Miller HD. Measuring absorption coefficients in small volumes of highly scattering media: source-detector separations for which path lengths do not depend on scattering properties. Appl. Opt. 36, 5655-5661 (1997).
45. Xu R, Qiang B, Mao J. Near Infrared Imaging of Tissue Heterogeneity: Probe Design and Sensitivity Analysis. Proc. IEEE Eng. Med. Biol. Soc. 1385, 278-281 (2005).
46. Dehghani H, Pogue BW, Shudong J, Brooksby B and Paulsen KD. Three-dimensional optical tomography: Resolution in small-object imaging. Appl. Opt. 42, 3117-3128 (2003).
47. Bard MP, Amelink A, Skurichina M et al. Optical spectroscopy for the classification of malignant lesions of the bronchial tree. Chest 129, 995-1001 (2006).
48. Jakubowski DB, Cerussi AE, Bevilacqua F et al. Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: A case study. J. Biomed. Opt. 9, 230-238 (2004).
49. Cerussi A, Shah N, Hsiang D, Durkin A, Butler J, Tromberg BJ. In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors detamitned by broadband diffuse optical spectroscopy. J. Biomed. Opt. 11, 044005 (2006).
50. Shah N, Cerussi AE, Jakubowski D, Hsiang D, Butler J, Tromberg BJ. The role of diffuse optical spectroscopy in the clinical management of breast cancer. Dis. Markers 19, 95-105 (2003).
51. Hsu CP, Razavi MK, So SK, Parachikov IH, Benaron DA. Liver tumor gross margin identification and ablation monitoring during liver radiofrequency treatment. J. Vasc. Interv. Radiol. 16, 1473-1478 (2005).
52. Maxim PG, Carson JJ, Benaron DA et al. Optical detection of tumors in vivo by visible light tissue oximetry. Technol. Cancer Res. Treat. 4, 227-234 (2005).
53. Schomacker KT, Meese TM, Jiang C et al. Novel optical detection system for in vivo identification and localization of cervical intraepithelial Neoplasia. J. Biomed. Opt. 11, 34009 (2006).
54. Nordstrom RJ, Burke L, Niloff JM, Myrtle JF. Identification of cervical intraepithelial Neoplasia (CIN) using UV-excited fluorescence and diffuse-reflectance tissue spectroscopy. Lasers Surg. Med. 29, 118-127 (2001).
55. Lin WC, Toms SA, Johnson M, Jansen ED, Mahadevan-Jansen A. In vivo brain tumor demarcation using optical spectroscopy. Photochem. Photobiol. 73, 396-402 (2001).
56. Koenig F, Larne R, Enquist H et al. Spectroscopic measurement of diffuse reflectance for enhanced detection of bladder carcinoma. Urology 51, 342-345 (1998).
57. Ntziachristos V, Yodh AG, Schnall MD, Chance B. MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions. Neoplasia 4, 347-354 (2002).
58. Gu X, Zhang Q, Bartlett M, Schutz L, Fajardo LL and Jiang H. Differentiation of cysts from solid tumors in the breast with diffuse optical tomography. Acad. Radiol. 11, 53-60 (2004).
59. Nioka S, Miwa M, Orel S et al. Optical imaging of human breast cancer. Adv. Exp. Med. Biol. 361, 171-179 (1994).
60. Pogue BW, Poplack SP, McBride TO et al. Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: Pilot results in the breast. Radiology 218, 261-266 (2001).
61. Zhu Q, Huang M, Chen N et al. Ultrasound-guided optical tomographic imaging of malignant and benign breast lesions: Initial clinical results of 19 cases. Neoplasia 5, 379-388 (2003).
62. Fantini S, Heffer E, Siebold H, Schutz O. Using near-infrared light to detect breast cancer. Optics & Photonics News 24-29 (2003).
63. Cheng X, Mao J, Zhu W et al. Optical detection of breast cancer: A pilot clinical trial at the Massachusetts General Hospital. Proc. SPIE 4949, 420-424 (2003).
64. Intes, X. Time-domain optical mammography SoftScan: Initial results. Acad. Radiol. 12, 934-947 (2005).
65. Schmitz CH, Klemer DP, Hardin R et al. Design and implementation of dynamic near-infrared optical tomographic imaging instrumentation for simultaneous dual-breast measurements. Appl. Opt. 44, 2140-2153 (2005).
66. Floery D, Helbich TH. Riedl CC et al. Characterization of benign and malignant breast lesions with computed tomography laser mammography (CTLM): Initial experience. Invest. Radiol. 40, 328-335 (2005).
67. Grosenick D, Wabnitz H, Moesta KT et al. Concentration and oxygen saturation of haemoglobin of 50 breast tumours determined by time-domain optical mammography. Phys. Med. Biol. 49, 1165-1181 (2004).
68. Bloch S, Lesage F, McIntosh L, Gandjbakhche A, Liang K, Achilefu S. Whole-body fluorescence lifetime imaging of a tumor-targeted near-infrared molecular probe in mice. J. Biomed. Opt. 10, 054003 (2005).
69. Choy G, Choyke P, Libutti SK. Current advances in molecular imaging: noninvasive in vivo bioluminescent and fluorescent optical imaging in Cancer Research. Mol. Imaging 2, 303-312 (2003).
70. Ferrari M, Mottola L and Quaresima V. Principles, techniques, and limitations of near infrared spectroscopy. Can J Appl Physiol 29, 463-487 (2004).
71. Arridge SR. Optical tomography in medical imaging. Inverse Promblems 15, R41-R93 (1999).
72. Brooksby B, Jiang S, Dehghani H et al. Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: Implementation of a Laplacian-type regularization to incorporate magnetic resonance structure. J. Biomed. Opt. 10, 051504 (2005).
73. Gulsen G, Yu H, Wang J et al. Congruent MRI and near-infrared spectroscopy for functional and structural imaging of tumors. Technol. Cancer Res. Treat. 1. 497-505 (2002).
74. Xu RX, Qiang B, Olsen JO, Povoski SP, Yee LD, Mao J. Localization and Functional Parameter Reconstruction of Suspicious Breast Lesions by Near Infrared/Ultrasound Dual Modal Imaging. Proc. IEEE Eng. Med. Biol. Soc. 1385, 4473-4476 (2005).
75. Zhu Q, Chen N, Kurtzman SH. Imaging tumor angiogenesis by use of combined near-infrared diffusive light and ultrasound. Opt. Lett. 28, 337-339 (2003).
76. Li A, Miller EL, Kilmer ME et al. Tomographic optical breast imaging guided by three-dimensional mammography. Appl. Opt. 42, 5181-5190 (2003).
77. Cheng X and Xu X. Study of the pressure effect in near infrared spectroscopy. Proc. SPIE 4955, 397-406 (2003).
78. Jiang S, Pogue BW, Paulsen KD, Kogel C, Poplack S. In vivo near-infrared spectral detection of pressure-induced changes in breast tissue. Optics Letters 28, 1212-1214 (2003).
79. Dehghani H, Doyley MM, Pogue BW, Jiang S, Geng J, Paulsen KD. Breast deformation modelling for image reconstruction in near infrared optical tomography. Phys. Med. Biol. 49, 1131-1145 (2004).
80. Shah N, Cerussi AE, Jakubowski D, Hsiang D, Butler J, Tromberg BJ. Spatial variations in optical and physiological properties of healthy breast tissue. J. Biomed. Opt. 9, 534-540 (2004).
81. Cubeddu R, D'Andrea C, Pifferi A, Taroni P, Torricelli A, Valentini G. Effects of the menstrual cycle on the red and near-infrared optical properties of the human breast. Photochem. Photobiol. 72, 383-391 (2000).
82. Gu Y, Bourke VA, Kim JG, Constantinescu A, Mason RP, Liu H. Dynamic response of breast tumor oxygenation to hyperoxic respiratory challenge monitored with three oxygen-sensitive parameters. Appl. Opt. 42, 2960-2967 (2003).
83. Xu R, Rana A. Dynamic near infrared imaging with ultrasound guidance (dnirus): Analytical model and benchtop validation on multi-layer tissue simulating phantoms. Proc. SPIE 6086, 353-364 (2006).
84. Vaupel P. The role of hypoxia-induced factors in tumor progression. Oncologist 9(Suppl. 5), 10-17 (2004).
85. Vaupel P, Kelleher DK, Thews O. Modulation of tumor oxygenation. Int. J. Radiat. Oncol. Biol. Phys 42, 843-848 (1998).
86. McDonald DM, Baluk P. Significance of blood vessel leakiness in cancer. Cancer Res. 62, 5381-5385 (2002).
87. Boucher Y, Leunig M, Jain RK. Tumor angiogenesis and interstitial hypertension. Cancer Res. 56, 4264-4266 (1996).
88. Hockel M, Vaupel P. Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects. J. Natl Cancer Inst. 93, 266-276 (2001).
89. Vaupel P, Schlenger K, Knoop C, Hockel M. Oxygenation of human tumors: evaluation of tissue oxygen distribution in bresat cancers by computerized O2 tension measurements. Cancer Res. 51, 3316-3322 (1991).
90. Folkman J. What is the evidence that tumors are angiogenesis dependent. J. Natl Cancer Inst. 82, 4-6 (1990).
91. Cheng X, Xu X, Zhou S et al. A novel optical scanning system for breast cancer imaging. Proc. SPIE 4244, 468-473 (2001).
92. Holboke MJ, Tromberg BJ, Li X et al. Three-dimensional diffuse optical mammography with ultrasound localization in a human subject. J. Biomed. Opt. 5, 237-247 (2000).
93. Pogue BW, Jiang S, Dehghani H et al. Characterization of hemoglobin, water, and NIR scattering in breast time: Analysis of intersubject variability and menstrual cycle changes. J. Biomed. Opt. 9, 541-552 (2004).
94. McBride TO, Pogue BW, Poplack S et al. Multispectral near-infrared tomography: A case study in compensating for water and lipid content in hemoglobin imaging of the breast. J. Biomed. Opt. 7, 72-79 (2002).
95. Cheng X, Mao J-m, Bush R, Kopans DB, Moore RH and Chorlton M. Breast cancer detection by mapping hemoglobin concentration and oxygen saturation. Applied Optics 42, 6412-6421 (2003).
96. Fujimoto D. Isolation and characterization of a fluorescent material in bovine achilles tendon collagen. Biochem. Biophys. Res. Commun. 76, 1124-1129 (1977).
97. Tinker DH, Rucker RB, Tappel AL. Variation of elastin fluorescence with method of preparation: Determination of the major fluorophore of fibrillar elastin. Connect. Tissue Res. 11, 299-308 (1983).
98. Wagnieres GA, Star WM, Wilson BC. In vivo fluorescence spectroscopy and imaging for oncological applications. Photochem. Photobiol. 68, 603-632 (1998).
99. Sterenborg HJ, Thomsen S, Jacques SL, Motamedi M. In vivo autofluorescence of an unpigmented melanoma in mice. Correlation of spectroscopic properties to microscopic structure. Melanoma Res. 5, 211-216 (1995).
100. Diagaradjane P, Yaseen MA, Yu J, Wong MS, Anvari B. Autofluorescence characterization for the early diagnosis of neoplastic changes in DMBA/ TPA-induced mouse skin carcinogenesis. Lasers Surg. Med. 37, 382-395 (2005).
101. Richards-Kortum R, Mitchell MF, Ramanujam N, Mahadevan A, Thomsen S. In vivo fluorescence spectroscopy: Potential for non-invasive, automated diagnosis of cervical intraepithelial Neoplasia and use as a surrogate endpoint biomarker. J. Cell Biochem. Suppl. 19, 111-119 (1994).
102. Pavlova I, Sokolov K, Drezek R, Malpica A, Follen M, Richards-Kortum R. Microanatomical and biochemical origins of normal and precancerous cervical autofluorescence using laser-scanning fluorescence confocal microscopy. Photochem. Photobiol. 77, 550-555 (2003).
103. Romer TJ, Fitzmaurice M, Cothren RM et al. Laser-induced fluorescence microscopy of normal colon and dysplasia in colonic adenomas: implications for spectroscopic diagnosis. Am. J. Gastroenterol. 90, 81-87 (1995).
104. Li BH, Xie SS. Autofluorescence excitation-emission matrices for diagnosis of colonic cancer. World J Gastroenterol 11, 3931-3934 (2005).
105. Chwirot BW, Chwirot S, Jedrzejczyk W et al. Ultraviolet laser-induced fluorescence of human stomach tissues: Detection of cancer tissues by imaging techniques. Lasers Surg. Med. 21, 149-158 (1997).
106. de Veld DC, Skurichina M, Witjes MJ, Duin RP, Sterenborg HJ, Roodenburg JL. Autofluorescence and diffuse reflectance spectroscopy for oral oncology. Lasers Surg. Med. 36, 356-364 (2005).
107. Ingrams DR, Dhingra JK, Roy K et al. Autofluorescence characteristics of oral mucosa. Head Neck 19, 27-32 (1997).
108. Folkman J. Tumor angiogenesis and tissue factor. Nat. Med. 2, 167-168 (1996).
109. Darland D, D'Amore P. Endothelial cells and pericytes in tumor vasculature. In: Tumor angiogenesis and microcirculation. Voest E and D'Amore P (Ed.), Marcel Dekker, Inc., New York, NY, 1-8 (2001).
110. Ballou B, Ernst LA, Waggoner AS. Fluorescence imaging of tumors in vivo. Curr. Med. Chem. 12, 795-805 (2005).
111. Sevick-Muraca EM, Houston JP, Gurfinkel M. Fluorescence-enhanced, near infrared diagnostic imaging with contrast agents. Curr. Opin. Chem. Biol. 6, 642-650 (2002).
112. Frangioni JV. In vivo near-infrared fluorescence imaging. Curr. Opin. Chem. Biol. 7, 626-634 (2003).
113. Licha K, Riefke B, Ntziachristos V, Becker A, Chance B, Semmler W. Hydrophilic cyanine dyes as contrast agents for near-infrared tumor imaging: Synthesis, photophysical properties and spectroscopic in vivo characterization. Photochem. Photobiol. 72, 392-398 (2000).
114. Desmettre T, Devoisselle JM, Mordon S. Fluorescence properties and metabolic features of indocyanine green (ICG) as related to angiography. Surv. Ophthalm. 45, 15-27 (2000).
115. Kupriyanov VV, Nighswander-Rempel S, Xiang B. Mapping regional oxygenation and flow in pig hearts in vivo using near-infrared spectroscopic imaging. J. Mol. Cell. Cardiol. 37, 947-957 (2004).
116. Caesar J, Shaldon S, Chiandussi L, Guevara L, Sherlock S. The use of indocyanine green in the measurement of hepatic blood flow and as a test of hepatic function. Clin. Sci. 21, 43-57 (1961).
117. Zhou JF, Chin MP, Schafer SA. Aggregation and degradation of indocyanine green. SPIE Proceedings 2128, 495-505 (1994).
118. Rajagopalan R, Uetrecht P, Bugaj JE, Achilefu SA, Dorshow RB. Stabilization of the optical tracer agent indocyanine green using noncovalent interactions. Photochem. Photobiol. 71, 347-350 (2000).
119. Becker A, Hessenius C, Licha K et al. Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands. Nat. Biotechnol. 19, 327-331 (2001).
120. Folli S, Wagnieres G, Pelegrin A et al. Immunophotodiagnosis of colon carcinomas in patients injected with fluoresceinated chimeric antibodies against carcinoembryonic antigen. Proc. Natl Acad. Sci. USA 89, 7973-7977 (1992).
121. Goldsmith SJ. Receptor imaging: Competitive or complementary to antibody imaging? Semin. Nucl. Med. 27, 85-93 (1997).
122. Jain RK. Barriers to drug delivery in solid tumors. Sci. Am. 271, 58-65 (1994).
123. Ke S, Wen X, Gurfinkel M et al. Near-infrared optical imaging of epidermal growth factor receptor in breast cancer xenografts. Cancer Res. 63, 7870-7875 (2003).
124. Becker A, Riefke B, Ebert B. et al. Macromolecular contrast agents for optical imaging of tumors: Comparison of indotricarbocyanine-labeled human serum albumin and transferrin. Photochem. Photobiol. 72, 234-241 (2000).
125. Tyagi S, Kramer FR. Molecular beacons: Probes that fluoresce upon hybridization. Nat. Biotechnol. 14, 303-308 (1996).
126. Weissleder R, Tung CH, Mahmood U, Bogdanov A, Jr. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat. Biotechnol. 17, 375-378 (1999).
127. Bremer C, Tung CH, Weissleder R. In vivo molecular target assessment of matrix metalloproteinase inhibition. Nat. Med. 7, 743-748 (2001).