Microanatomical and Biochemical Origins of Normal and Precancerous Cervical Autofluorescence Using Laser-scanning Fluorescence Confocal Microscopy

Photochemistry and Photobiology

Volumn 77, Issue 5, 2003, Pages 550-555

  Pavlova, Ina ^a   Sokolov, Konstantin ^a   Drezek, Rebekah ^b   Malpica, Anais ^c   Follen, Michele ^c   Richards Kortum, Rebecca ^a  

^a The University of Texas at Austin   (United States)

^b Rice University   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DYE; NICOTINAMIDE ADENINE DINUCLEOTIDE; FLAVINE ADENINE NUCLEOTIDE; PHOTOPROTEIN;

ANATOMY; ARTICLE; AUTOFLUORESCENCE; CONTROLLED STUDY; FEMALE; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN TISSUE; LASER MICROSCOPY; LASER SCANNING FLUORESCENCE CONFOCAL MICROSCOPY; MITOCHONDRION; UTERINE CERVIX CARCINOMA IN SITU; CHEMISTRY; CONFOCAL MICROSCOPY; CYTOLOGY; EPITHELIUM CELL; FLUORESCENCE; PATHOLOGY; UTERINE CERVIX; UTERINE CERVIX TUMOR;

CERVIX UTERI; EPITHELIAL CELLS; FEMALE; FLAVIN-ADENINE DINUCLEOTIDE; FLUORESCENCE; HUMANS; LUMINESCENT PROTEINS; MICROSCOPY, CONFOCAL; NAD; UTERINE CERVICAL NEOPLASMS;

EID: 0038265551     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1562/0031-8655(2003)077<0550:MABOON>2.0.CO;2     Document Type: Article

References (34)

1. National Institutes of Health Consensus Development Statement Online (1996). http://consensus.nih.gov/cons/102/102_statement.htm.
2. Mitchell Follen, M., D. Schottenfeld, G. Tortolero-Luna, S. B. Cantor and R. Richards-Kortum (1998) Colposcopy for the diagnosis of squamous intraepithelial lesions. Obstet. Gynecol. 91, 626-631.
3. Kurman, R. J., D. E. Henson, A. L. Herbst, K. L. Noller and M. H. Schiffman (1994) Interim guidelines for management of abnormal cervical cytology. J. Am. Med. Assoc. 271, 1866-1869.
4. Richards-Kortum, R. and E. Sevick-Muraca (1996) Quantitative optical spectroscopy for tissue diagnosis. Annu. Rev. Phys. Chem. 47, 555-606.
5. Wagnieres, G. A., W. M. Star and B. C. Wilson (1998) In vivo fluorescence spectroscopy and imaging for oncological applications. Photochem. Photobiol. 68, 603-632.
6. Ramanujam, N. (2000) Fluorescent spectroscopy of neoplastic and non-neoplastic tissues. Neoplasia 2, 89-117.
7. Georgakoudi, I., E. E. Sheets, M. G. Muller, V. Backman, C. P. Crum, K. Badizdegan, R. R. Dasari and M. S. Feld (2002) Trimodal spectroscopy for the detection and characterization of cervical precancers in vivo. Am. J. Obstet. Gynecol. 186, 374-382.
8. Pogue, B. W., M. Mycek and D. Harper (2000) Image analysis for discrimination of cervical neoplasia. J. Biomed. Opt. 5, 72-82.
9. Balas, C. (2001) A novel optical imaging method for the early detection, quantitative grading, and mapping of cancerous and precancerous lesions of cervix. IEEE T. Biomed. Eng. 48, 96-104.
10. Ramanujam, N., M. M. Follen, A. Mahadevan, S. Thomsen, A. Malpica, T. Wright, N. Atkinson and R. Richards-Kortum (1996) Development of a multivariate statistical algorithm to analyze human cervical tissue fluorescence spectra acquired in vivo. Lasers Surg. Med. 19, 46-62.
11. Ramanujam, N., M. M. Follen, A. Mahadevan, S. Thomsen, A. Malpica, T. Wright, N. Atkinson and R. Richards-Kortum (1996) Spectroscopic diagnosis of cervical intraepithelial neoplasia (CIN) in vivo using laser induced fluorescence spectra at multiple excitation wavelengths. Lasers Surg. Med. 19, 63-74.
12. Ramanujam, N., M. M. Follen, A. Mahadevan-Jansen, S. L. Thomsen, G. Staerkel, A. Malpica, T. Wright, N. Atkinson and R. Richards-Kortum (1996) Cervical pre-cancer detection using a multivariate statistical algorithm based on laser induced fluorescence spectra at multiple excitation wavelengths. Photochem. Photobiol. 6, 720-735.
13. Nordstrom, R. J., L. Burke, J. M. Niloff and J. F. Myrtle (2001) Identification of cervical intraepithelial neoplasia (CIN) using UV-excited fluorescence and diffuse-reflectance tissue spectroscopy. Lasers Surg. Med. 29, 118-127.
14. Dattamajumdar, A. K., D. Wells, J. Parnell, J. T. Lewis, D. Ganguly and T. C. Wright Jr. (2001) Preliminary experimental results from multicenter clinical trials for detection of cervical precancerous lesions using the Cerviscan system: a novel full-field evoked tissue fluorescence based imaging instruments. 23rd Annual Meeting of IEEE Engineering in Medicine and Biology, Istanbul, Turkey.
15. Ferris, D. G., R. A. Lawhead, E. D. Dickman, N. Holtzapple, J. A. Miller, S. Grogan, S. Bambot, A. Agrawal and M. L. Faupel (2001) Multimodal hyperspectral imaging for the noninvasive diagnosis of cervical neoplasia. J. Lower Genital Tract Dis. 5, 65-72.
16. Weingandt, H., H. Stepp, R. Baumgartner, J. Diebold, W. Xiang and P. Hillemanns (2002) Autofluorescence spectroscopy for the diagnosis of cervical intraepithelial neoplasia. Ann. Int. J. Obstet. Gynecol. 109, 947-951.
17. Brookner, C., M. Follen, I. Boiko, J. Galvan, S. Thomsen, A. Malpica, S. Suzuki, R. Lotan and R. Richards-Kortum (2000) Tissue slices autofluorescence patterns in fresh cervical tissue. Photochem. Photobiol. 71, 730-736.
18. Sokolov, K., J. Galvan, A. Myakov, A. Lacy, R. Lotan and R. Richards-Kortum (2002) Realistic three-dimensional epithelial tissue phantoms for biomedical optics. J. Biomed. Opt. 7, 148-156.
19. Pitts, J. D., R. D. Sloboda, K. H. Dragnev, E. Dmitrovsky and M. Mycek (2001) Autofluorescence characteristics of immortalized and carcinogen-transformed human bronchial epithelial cells. J. Biomed. Opt. 6, 31-40.
20. Bailey, A. J., R. G. Paul and L. Knott (1998) Mechanisms of maturation and ageing of collagen. Mech. Ageing Dev. 106, 1-56.
21. Lohmann, W., J. Mussman, C. Lohmann and W. Kunzel (1989) Native fluorescence of unstained cryo-sections of the cervix uteri compared with histological observation. Naturwissenschaften. 96, 125-127.
22. Drezek, R., C. Brookner, I. Pavlova, I. Boiko, A. Malpica, R. Lotan, M. Follen and R. Richards-Kortum (2001) Autofluorescence microscopy of fresh cervical tissue sections reveals alterations in tissue biochemistry with dysplasia. Photochem. Photobiol. 73, 636-641.
23. Krumdieck, C. L., J. Ernesto Dos Santos and K. Ho (1980) A new instrument for the rapid preparation of tissue slices. Anal. Biochem. 104, 118-123.
24. Kucharz, E. J. (1992) The Collagens: Biochemistry and Pathophysiology. Springer-Verlag, Berlin, Germany.
25. Parks, W. C. (1998) Matrix Metalloproteinases. Academic Press, San Diego.
26. Heppner, K. J., L. M. Matrisian, R. A. Jensen and W. H. Rodgers (1996) Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response. Am. J. Pathol. 149, 666-672.
27. Ki Hong, W. and M. Sporn (1997) Recent advances in chemoprevention of cancer. Science 278, 1073-1077.
28. Smedts, F., F. Ramaekers, R. E. Leube, K. Keijser, M. Link and P. Vooijs (1993) Expression of keratins 1,6,15,16, and 20 in normal cervical epithelium, squamous metaplasia, cervical intraepithelial neoplasia, and cervical carcinoma. Am. J. Pathol. 142, 403-412.
29. Smith, G. J. and W. H. Melhuish (1985) Fluorescence and phosphorescence of wool keratin excited by UV-A radiation. Text. Res. J. 55, 304-307.
30. Georgakoudi, I., B. C. Jacobson, M. G. Muller, E. E. Sheets, D. Badizadegan, D. L. Carr-Locke, C. P. Crum, C. W. Boone, R. R. Dasari, J. Van Dam and M. S. Feld (2002) NADH and collagen as in vivo quantitative fluorescent biomarkers of epithelial precancerous changes. Cancer Res. 62, 682-687.
31. Drezek, R., K. Sokolov, U. Utzinger, I. Boiko, A. Malpica, M. Follen and R. Richards-Kortum (2001) Understanding the contributions of NADH and collagen to cervical tissue fluorescence spectra: modeling, measurements, and implications. J. Biomed. Opt. 6, 385-396.
32. Pouge, B. W. and G. Burke (1998) Fiber optic bundle design for quantitative fluorescence measurement from human tissue. Appl. Opt. 37, 7429-7436.
33. Pfefer, J. T., K. T. Schomacker, M. N. Ediger and N. S. Nishioka (2002) Multiple-fiber probe design for fluorescence spectroscopy in tissue. Appl. Opt. 41, 4712-4721.
34. Ramanujam, N. and L. Quan (2002) Relationship between depth of a target in a turbid medium and fluorescence measured by a variable-aperture method. Opt. Lett. 27, 104-106.