Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via Pkcδ activation

Biochemical and Biophysical Research Communications

Volumn 354, Issue 1, 2007, Pages 184-189

  Hwang, Mi Na ^a   Ha, Tae Hun ^a   Park, Jongsun ^b   Shim, Jaegal ^a   Lee, Ho ^a   Kim, Young Nyun ^a   Lee, Eun Sook ^a   Yoon, Sungpil ^a  

^a National Cancer Center   (South Korea)

^b Chungnam National University College of Medicine   (South Korea)

Author keywords

Erk; HEK293T; N terminal region; PKC; Pkc ; PMA; SOCS box; SOCS6; Stability

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; PHORBOL 13 ACETATE 12 MYRISTATE; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE C; PROTEIN PROTEIN KINASE C GAMMA; PROTEIN SOCS6; SUPPRESSOR OF CYTOKINE SIGNALING; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL STRAIN HEK293; CELL STRAIN MCF 7; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEOMICS; SIGNAL TRANSDUCTION;

CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; KIDNEY; MAP KINASE SIGNALING SYSTEM; PROTEIN KINASE C-DELTA; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TETRADECANOYLPHORBOL ACETATE;

EID: 33846539778     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.12.175     Document Type: Article

References (19)

1. Krebs D.L., and Hilton D.J. SOCS: physiological suppressors of cytokine signaling. J. Cell Sci. 113 (2000) 2813-2819
2. Endo T.A., Masuhara M., Yokouchi M., Suzuki R., Sakamoto H., Mitsui K., Matsumoto A., Tanimura S., Ohtsubo M., Misawa H., Miyazaki T., Leonor N., Taniguchi T., Fujita T., Kanakura Y., Komiya S., and Yoshimura A. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387 (1997) 921-924
3. Hansen J.A., Lindberg K., Hilton D.J., Nielsen J.H., and Billestrup N. Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins. Mol. Endocrinol. 13 (1999) 1832-1843
4. Nicholson S.E., Metcalf D., Sprigg N.S., Columbus R., Walker F., Silva A., Cary D., Willson T.A., Zhang J.G., Hilton D.J., Alexander W.S., and Nicola N.A. Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling. Proc. Natl. Acad. Sci. USA 102 (2005) 2328-2333
5. Hilton D.J., Richardson R.T., Alexander W.S., Viney E.M., Willson T.A., Sprigg N.S., Starr R., Nicholson S.E., Metcalf D., and Nicola N.A. Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc. Natl. Acad. Sci. USA 95 (1998) 114-119
6. Wormald S., and Hilton D.J. Inhibitors of cytokine signal transduction. J. Biol. Chem. 279 (2004) 821-824
7. Masuhara M., Sakamoto H., Matsumoto A., Suzuki R., Yasukawa H., Mitsui K., Wakioka T., Tanimura S., Sasaki A., Misawa H., Yokouchi M., Ohtsubo M., and Yoshimura A. Cloning and characterization of novel CIS family genes. Biochem. Biophys. Res. Commun. 239 (1997) 439-446
8. Nicholson S.E., Willson T.A., Farley A., Starr R., Zhang J.G., Baca M., Alexander W.S., Metcalf D., Hilton D.J., and Nicola N.A. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J. 18 (1999) 375-385
9. Bayle J., Lopez S., Iwai K., Dubreuil P., and De Sepulveda P. The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins. FEBS Lett. 580 (2006) 2609-2614
10. Inoue R., and Shiraishi T. PKCalpha is involved in phorbol ester TPA-mediated stabilization of p14ARF. Biochem. Biophys. Res. Commun. 330 (2005) 1314-1318
11. Choi B.H., Chae H.D., Park T.J., Oh J., Lim J., Kang S.S., Ha H., and Kim K.T. Protein kinase C regulates the activity and stability of serotonin N-acetyltransferase. J. Neurochem. 90 (2004) 442-454
12. Cohen S., Dovrat S., Sarid R., Huberman E., and Salzberg S. JAK-STAT signaling involved in phorbol 12-myristate 13-acetate- and dimethyl sulfoxide-induced 2′-5′ oligoadenylate synthetase expression in human HL-60 Leukemia cells. Leuk. Res. 29 (2005) 923-931
13. Percherancier Y., Planchenault T., Valenzuela-Fernandez A., Virelizier J.L., Arenzana-Seisdedos F., and Bachelerie F. Palmitoylation-dependent control of degradation, life span, and membrane expression of the CCR5 receptor. J. Biol. Chem. 276 (2001) 31936-31944
14. Reid G.A., and Schatz G. Import of proteins into mitochondria. Extramitochondrial pools and post-translational import of mitochondrial protein precursors in vivo. J. Biol. Chem. 257 (1982) 13062-13067
15. Li L., Gronning L.M., Anderson P.O., Li S., Edvardsen K., Johnston J., Kioussis D., Shepherd P.R., and Wang P. Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism. J. Biol. Chem. 279 (2004) 34107-34114
16. Tanaka Y., Gavrielides M.V., Mitsuuchi Y., Fujii T., and Kazanietz M.G. Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway. J. Biol. Chem. 278 (2003) 33753-33762
17. Li L., Sampat K., Hu N., Zakari J., and Yuspa S.H. Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes. J. Biol. Chem. 281 (2006) 3237-3243
18. Kim Y.S., Ko J., Kim I.S., Jang S.W., Sung H.J., Lee H.J., Lee S.Y., Kim Y., and Na D.S. PKCdelta-dependent cleavage and nuclear translocation of annexin A1 by phorbol 12-myristate 13-acetate. Eur. J. Biochem. 270 (2003) 4089-4094
19. Iturroiz X., Durgan J., Calleja V., Larijani B., Okuda H., Whelan R., and Parker P.J. The von Hippel-Lindau tumor-suppressor protein interaction with protein kinase Cdelta. Biochem. J. 397 (2006) 109-120