A non-haem iron centre in the transcription factor NorR senses nitric oxide

Nature

Volumn 437, Issue 7059, 2005, Pages 769-772

  D'Autréaux, Benôt ^a   Tucker, Nicholas P ^a   Dixon, Ray ^a   Spiro, Stephen ^b  

^a JOHN INNES CENTRE   (United Kingdom)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; ENZYMES; ESCHERICHIA COLI; IRON; RNA;

GENES ENCODING; NITRIC OXIDE (NO); PATHOGENS;

GENETIC ENGINEERING;

ADENOSINE TRIPHOSPHATASE; BINDING PROTEIN; FLAVOPROTEIN; HEME; IRON; NITRIC OXIDE; REGULATOR PROTEIN; RNA POLYMERASE; RUBREDOXIN; TRANSCRIPTION FACTOR; DNA DIRECTED RNA POLYMERASE; ESCHERICHIA COLI PROTEIN; NORR PROTEIN, E COLI; TRANSACTIVATOR PROTEIN;

BIOLOGY;

ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ESCHERICHIA COLI; EUKARYOTE; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION INITIATION; BIOLOGICAL MODEL; CHEMISTRY; CYTOLOGY; ELECTRON SPIN RESONANCE; GENE EXPRESSION REGULATION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; PROMOTER REGION; TRANSACTIVATION;

ENTERIC BACTERIA; ESCHERICHIA COLI; EUKARYOTA;

ADENOSINE TRIPHOSPHATASES; DNA-DIRECTED RNA POLYMERASES; ELECTRON SPIN RESONANCE SPECTROSCOPY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; HEME; IRON; MODELS, GENETIC; NITRIC OXIDE; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS;

EID: 26944499456     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature03953     Document Type: Article

References (30)

1. Griffith, O. W. & Stuehr, D. J. Nitric oxide synthases: properties and catalytic mechanism. Annu. Rev. Physiol. 57, 707-736 (1995).
2. MacMicking, J., Xie, Q. W. & Nathan, C. Nitric oxide and macrophage function. Annu. Rev. Immunol. 15, 323-350 (1997).
3. Pohlmann, A., Cramm, R., Schmelz, K. & Friedrich, B. A novel NO-responding regulator controls the reduction of nitric oxide in Ralstonia eutropha. Mol. Microbiol. 38, 626-638 (2000).
4. Fang, F. C. Antimicrobial reactive oxygen and nitrogen species: Concepts and controversies. Nature Rev. Microbiol. 2, 820-832 (2004).
5. D'Autréaux, B., Touati, D., Bersch, B., Latour, J. M. & Michaud-Soret, I. Direct inhibition by nitric oxide of the transcriptional ferric uptake regulation protein via nitrosylation of the iron. Proc. Natl Acad. Sci. USA 99, 16619-16624 (2002).
6. Ding, H. G. & Demple, B. Direct nitric oxide signal transduction via nitrosylation of iron-sulfur centers in the SoxR transcription activator. Proc. Natl Acad. Sci. USA 97, 5146-5150 (2000).
7. Hausladen, A., Privalle, C. T., Keng, T., DeAngelo, J. & Stamler, J. S. Nitrosative stress: activation of the transcription factor OxyR. Cell 86, 719-729 (1996).
8. Cruz-Ramos, H. et al. NO sensing by FNR: regulation of the Escherichia coli NO-detoxifying flavohaemoglobin, Hmp. EMBO J. 21, 3235-3244 (2002).
9. Mukhopadhyay, P., Zheng, M., Bedzyk, L. A., LaRossa, R. A. & Storz, G. Prominent roles of the NorR and Fur regulators in the Escherichia coli transcriptional response to reactive nitrogen species. Proc. Natl Acad. Sci. USA 101, 745-750 (2004).
10. 54 in the nitric oxide stress response. J. Biol. Chem. 278, 10081-10086 (2003).
11. 54-dependent transcriptional activators. J. Bacteriol. 185, 1757-1767 (2003).
12. Tucker, N. P., D'Autreaux, B., Studholme, D. J., Spiro, S. & Dixon, R. DNA binding activity of the Escherichia coli nitric oxide sensor NorR suggests a conserved target sequence in diverse Proteobacteria. J. Bacteriol. 186, 6656-6660 (2004).
13. Gomes, C. M. et al. A novel type of nitric-oxide reductase. Escherichia coli flavorubredoxin. J. Biol. Chem. 277, 25273-25276 (2002).
14. Hutchings, M. I., Mandhana, N. & Spiro, S. The NorR protein of Escherichia coli activates expression of the flavorubredoxin gene norV in response to reactive nitrogen species. J. Bacteriol. 184, 4640-4643 (2002).
15. 2+ environment. J. Biol. Chem. 258, 14981-14991 (1983).
16. Clay, M. D., Cosper, C. A., Jenney, F. E. Jr, Adams, M. W. & Johnson, M. K. Nitric oxide binding at the mononuclear active site of reduced Pyrococcus furiosus superoxide reductase. Proc. Natl Acad. Sci. USA 100, 3796-3801 (2003).
17. Ray, M. et al. Structure and magnetic properties of trigonal bipyramidal iron nitrosyl complexes. Inorg. Chem. 38, 3110-3115 (1999).
18. 2 activation by non-heme iron enzyme active-sites. J. Am. Chem. Soc. 117, 715-732 (1995).
19. 6,7,8 elucidated by Mössbauer spectroscopy. J. Am. Chem. Soc. 122, 4352-4365 (2000).
20. Enemark, J. H. & Feltham, R. D. Principles of structure, bonding, and reactivity for metal nitrosyl complexes. Coord Chem. Rev. 13, 339-406 (1974).
21. Cannon, W. V., Gallegos, M. T. & Buck, M. Isomerization of a binary sigma-promoter DNA complex by transcription activators. Nature Struct. Biol. 7, 594-601 (2000).
22. Zhang, X. et al. Mechanochemical ATPases and transcriptional activation. Mol. Microbiol. 45, 895-903 (2002).
23. Austin, S. & Dixon, R. The prokaryotic enhancer binding protein NTRC has an ATPase activity which is phosphorylation and DNA dependent. EMBO J. 11, 2219-2228 (1992).
24. Roy, S., Sharma, S., Sharma, M., Aggarwal, R. & Bose, M. Induction of nitric oxide release from the human alveolar epithelial cell line A549: an in vitro correlate of innate immune response to Mycobacterium tuberculosis. Immunology 112, 471-480 (2004).
25. Aravind, L. & Ponting, C. P. The GAF domain: an evolutionary link between diverse phototransducing proteins. Trends Biochem. Sci. 22, 458-459 (1997).
26. D'Autreaux, B. et al. Spectroscopic description of the two nitrosyl-iron complexes responsible for Fur inhibition by nitric oxide. J. Am. Chem. Soc. 126, 6005-6016 (2004).
27. Zhao, Y., Brandish, P. E., Ballou, D. P. & Marietta, M. A. A molecular basis for nitric oxide sensing by soluble guanylate cyclase. Proc. Natl Acad. Sci. USA 96, 14753-14758 (1999).
28. Pr(NO)]. Inorg. Chem. 41, 3444-3456 (2002).
29. 2+/+/0. J. Am. Chem. Soc. 126, 5138-5153 (2004).
30. Little, R., Reyes-Ramirez, F., Zhang, Y., van Heeswijk, W. C. & Dixon, R. Signal transduction to the Azotobacter vinelandii NIFL-NIFA regulatory system is influenced directly by interaction with 2-oxoglutarate and the PII regulatory protein. EMBO J. 19, 6041-6050 (2000).