Neurophysiological and anatomical plasticity in the adult sensorimotor cortex

Reviews in the Neurosciences

Volumn 17, Issue 6, 2006, Pages 561-580

  Dancause, Numa ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Cortex; Learning; Neuroanatomy; Neurophysiology; Plasticity; Recovery; Stroke

Indexed keywords

BRAIN CORTEX LESION; BRAIN FUNCTION; BRAIN MAPPING; FORELIMB; LEARNING; NERVE CELL PLASTICITY; NEUROPHYSIOLOGY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SENSORIMOTOR CORTEX; SENSORIMOTOR FUNCTION; STROKE;

EID: 33846459392     PISSN: 03341763     EISSN: None     Source Type: Journal    
DOI: 10.1515/REVNEURO.2006.17.6.561     Document Type: Review

References (171)

1. Adkins-Muir DL, Jones TA. Cortical electrical stimulation combined with rehabilitative training: enhanced functional recovery and dendritic plasticity following focal cortical ischemia in rats. Neurol Res 2003; 25: 780-788.
2. Aizawa H, Inase M, Mushiake H, Shima K, Tanji J. Reorganization of activity in the supplementary motor area associated with motor learning and functional recovery. Exp Brain Res 1991; 84: 668-671.
3. Asanuma H, Pavlides C. Neurobiological basis of motor learning in mammals. NeuroReport 1997; 8: i-vi.
4. Asanuma H, Rosen I. Topographical organization of cortical efferent zones projecting to distal forelimb muscles in the monkey. Exp Brain Res 1972; 14: 243-256.
5. Barbay S, Peden EK, Falchook G, Nudo RJ. Sensitivity of neurons in somatosensory cortex (S1) to cutaneous stimulation of the hindlimb immediately following a sciatic nerve crush. Somatosens Mot Res 1999; 16: 103-114.
6. Barbay S, Peden EK, Falchook G, Nudo RJ. An index of topographic normality in rat somatosensory cortex: application to a sciatic nerve crush model. J Neurophysiol 2002; 88: 1339-1351.
7. Basmajian JV. Motor learning and control: a working hypothesis. Arch Phys Med Rehabil 1977; 58: 38-41.
8. Belhaj-Saif A, Cheney PD. Plasticity in the distribution of the red nucleus output to forearm muscles after unilateral lesions of the pyramidal tract. J Neurophysiol 2000; 83: 3147-3153.
9. Bogousslavsky J, Van Melle G, Regli F. The Lausanne Stroke Registry: analysis of 1,000 consecutive patients with first stroke. Stroke 1988; 19: 1083-1092.
10. Buchkremer-Ratzmann I, August M, Hagemann G, Witte OW. Electrophysiological transcortical diaschisis after cortical photothrombosis in rat brain. Stroke 1996; 27: 1105-1109; discussion 1109-1111.
11. Bucy PC. The Precentral Motor Cortex. Urbana, IL: P.C. Bucy, 1944; 353-394.
12. Canning CG, Ada L, O'Dwyer NJ. Abnormal muscle activation characteristics associated with loss of dexterity after stroke. J Neurol Sci 2000; 176: 45-56.
13. Carey LM, Abbott DF, Egan GF, Bernhardt J, Donnan GA. Motor impairment and recovery in the upper limb after stroke: behavioral and neuroanatomical correlates. Stroke 2005; 36: 625-629.
14. Carmichael ST, Archibeque I, Luke L, Nolan T, Momiy J, Li S. Growth-associated gene expression after stroke: evidence for a growth-promoting region in peri-infarct cortex. Exp Neurol 2005; 193: 291-311.
15. Carmichael ST, Chesselet MF. Synchronous neuronal activity is a signal for axonal sprouting after cortical lesions in the adult. J Neurosci 2002; 22: 6062-6070.
16. Carmichael ST, Wei L, Rovainen CM, Woolsey TA. New patterns of intracortical projections after focal cortical stroke. Neurobiol Dis 2001; 8: 910-922.
17. Carr JH, Shepherd RB. Stroke Rehabilitation: Guidelines for Exercise and Training to Optimize Motor Skill. Oxford: Butterworth-Heinemann Medial, 2003.
18. Castro-Alamancos MA, Borrel J. Functional recovery of forelimb response capacity after forelimb primary motor cortex damage in the rat is due to the reorganization of adjacent areas of cortex. Neuroscience 1995; 68: 793-805.
19. nd ed. San Diego, CA: Academic Press, 2002; 189-226.
20. Cheney PD, Fetz EE. Functional classes of primate corticomotoneuronal cells and their relation to active force. J Neurophysiol 1980; 44: 773-791.
21. Cheney PD, Fetz EE. Comparable patterns of muscle facilitation evoked by individual corticomotoneuronal (CM) cells and by single intracortical microstimuli in primates: evidence for functional groups of CM cells. J Neurophysiol 1985; 53: 786-804.
22. Cheney PD, Hill-Karrer J, Belhaj-Saif A, McKiernan BJ, Park MC, Marcario JK. Cortical motor areas and their properties: implications for neuroprosthetics. Prog Brain Res 2000; 128: 135-160.
23. Classen J, Liepert J, Hallett M, Cohen L. Plasticity of movement representation in the human motor cortex. Electroencephalogr Clin Neurophysiol Suppl 1999; 51: 162-173.
24. Classen J, Schnitzler A, Binkofski F, Werhahn KJ, Kim YS, Kessler KR, Benecke R. The motor syndrome associated with exaggerated inhibition within the primary motor cortex of patients with hemiparetic. Brain 1997; 120: 605-619.
25. Coq JO, Xerri C. Acute reorganization of the forepaw representation in the rat SI cortex after focal cortical injury: neuroprotective effects of piracetam treatment. Eur J Neurosci 1999; 11: 2597-2608.
26. Corcos DM, Jaric S, Agarwal GC, Gottlieb GL. Principles for learning single-joint movements. I. Enhanced performance by practice. Exp Brain Res 1993; 94: 499-513.
27. Cramer SC, Bastings EP. Mapping clinically relevant plasticity after stroke. Neuropharmacology 2000; 39: 842-851.
28. Cramer SC, Nelles G, Benson RR, Kaplan JD, Parker RA, Kwong KK, Kennedy DN, Finklestein SP, Rosen BR. A functional MRI study of subjects recovered from hemiparetic stroke. Stroke 1997; 28: 2518-2527.
29. Dancause N, Barbay S, Frost SB, Plautz EJ, Chen D, Zoubina EV, Stowe AM, Nudo RJ. Extensive cortical rewiring after brain injury. J Neurosci 2005; 25: 10167-10179.
30. Dancause N, Barbay S, Frost SB, Plautz EJ, Popescu M, Dixon PM, Stowe AM, Friel KM, Nudo RJ. Topographically divergent and convergent connectivity between premotor and primary motor cortex. Cereb Cortex 2006; 16: 1057-1068.
31. Dancause N, Barbay S, Frost SB, Plautz EJ, Stowe AM, Friel KM, Nudo RJ. Ipsilateral connections of the ventral premotor cortex in a New World primate. J Comp Neurol 2006; 495: 374-390.
32. Dancause N, Barbay S, Frost SB, Zoubina EV, Plautz EJ, Mahnken JD, Nudo RJ. Effects of small ischemic lesions in the primary motor cortex on neurophysiological organization in the ventral premotor cortex. J Neurophysiol 2006; 96: 3506-3511.
33. Darian-Smith C, Gilbert CD. Topographic reorganization in the striate cortex of the adult cat and monkey is cortically mediated. J Neurosci 1995; 15: 1631-1647.
34. Darian-Smith I, Galea MP, Darian-Smith C, Sugitani M, Tan A, Burman K. The anatomy of manual dexterity. The new connectivity of the primate sensorimotor thalamus and cerebral cortex. Adv Anat Embryol Cell Biol 1996; 133: 1-140.
35. Dennis MS, Burn JP, Sandercock PA, Bamford JM, Wade DT, Warlow CP. Long-term survival after first-ever stroke: the Oxfordshire Community Stroke Project. Stroke 1993; 24: 796-800.
36. Donoghue JP, Leibovic S, Sanes JN. Organization of the forelimb area in squirrel monkey motor cortex: representation of digit, wrist, and elbow muscles. Exp Brain Res 1992; 89: 1-19.
37. Donoghue JP, Suner S, Sanes JN. Dynamic organization of primary motor cortex output to target muscles in adult rats. II. Rapid reorganization following motor nerve lesions. Exp Brain Res 1990; 79: 492-503.
38. Duncan PW, Badke MB. Stroke Rehabilitation: The Recovery of Motor Control. Chicago, IL: Year Book Medical Publishers, 1987.
39. Duncan PW, Lai SM. Stroke recovery. Top Stroke Rehabil 1997; 4: 51-58.
40. Dykes RW. Mechanisms controlling neuronal plasticity in somatosensory cortex. Can J Physiol Pharmacol 1997; 75: 535-545.
41. Evarts EV. Pyramidal tract activity associated with a conditioned hand movement in the monkey. J Neurophysiol 1966; 29: 1011-1027.
42. Fang PC, Jain N, Kaas JH. Few intrinsic connections cross the hand-face border of area 3b of New World monkeys. J Comp Neurol 2002; 454: 310-319.
43. Florence SL, Taub HB, Kaas JH. Large-scale sprouting of cortical connections after peripheral injury in adult macaque monkeys. Science 1998; 282: 1117-1121.
44. Frackowiak RS, Weiller C, Chollet F. The functional anatomy of recovery from brain injury. CIBA Found Symp 1991; 163: 235-244.
45. Fridman EA, Hanakawa T, Chung M, Hummel F, Leiguarda RC, Cohen LG. Reorganization of the human ipsilesional premotor cortex after stroke. Brain 2004; 127: 747-758.
46. Friel KM, Barbay S, Frost SB, Plautz EJ, Hutchinson DM, Stowe AM, Dancause N, Zoubina EV, Quaney BM, Nudo RJ. Dissociation of sensorimotor deficits after rostral versus caudal lesions in the primary motor cortex hand representation. J Neurophystol 2005; 94: 1312-1324.
47. Frost SB, Barbay S, Friel KM, Plautz EJ, Nudo RJ. Reorganization of remote cortical regions after ischemic brain injury: a potential substrate for stroke recovery. J Neurophysiol 2003; 89: 3205-3214.
48. Garraghty PE, Pons TP, Sur M, Kaas JH. The arbors of axons terminating in middle cortical layers of somatosensory area 3b in owl monkeys. Somatosens Mot Res 1989; 6: 401-411.
49. Gass P, Spranger M, Herdegen T, Bravo R, Kock P, Hacke W, Kiessling M. Induction of Fos and Jun proteins after focal ischemia in the rat: differential effect of the N-methyl-D-aspartate receptor antagonist MK-801. Acta Neuropathol 1992; 84: 545-553.
50. Gates JR. Transcranial magnetic stimulation. Neuroimaging Clin N Am 1995; 5: 711-720.
51. Georgopoulos AP, Caminiti R, Kalaska JF, Massey JT. Spatial coding of movement: a hypothesis concerning the coding of movement direction by motor cortical populations. Exp Brain Res 1983; Suppl 7: 327-336.
52. Georgopoulos AP, Schwartz AB, Kettner RE. Neuronal population coding of movement direction. Science 1986; 233: 1416-1419.
53. Gillen G, Burkhard A. Stroke Rehabilitation: A Function-Based Approach. St Louis, MO: Mosby Year Book, Inc., 1998.
54. Glees P, Cole J. Recovery of skilled motor functions after small repeated lesions of motor cortex in macaque. J Neurophysiol 1950; 13: 137-148.
55. Goldberger ME, Murray M. Lack of sprouting and its presence after lesions of the cat spinal cord. Brain Res 1982; 241: 227-239.
56. rd, Cusick CG, Pons TP, Kaas JH. The relationship of corpus callosum connections to electrical stimulation maps of motor, supplementary motor, and the frontal eye fields in owl monkeys. J Comp Neurol 1986; 247: 297-325.
57. Grafton ST. PET: activation of cerebral blood flow and glucose metabolism. Adv Neurol 2000; 83: 87-103.
58. Gregersen R, Christensen T, Lehrmann E, Diemer NH, Finsen B. Focal cerebral ischemia induces increased myelin basic protein and growth-associated protein-43 gene transcription in peri-infarct areas in the rat brain. Exp Brain Res 2001; 138: 384-392.
59. He SQ, Dum RP, Strick PL. Topographic organization of corticospinal projections from the frontal lobe: motor areas on the lateral surface of the hemisphere. J Neurosci 1993; 13: 952-980.
60. He SQ, Dum RP, Strick PL. Topographic organization of corticospinal projections from the frontal lobe: motor areas on the medial surface of the hemisphere. J Neurosci 1995; 15: 3284-3306.
61. Hobart DJ, Kelley DL, Bradley LS. Modifications occurring during acquisition of a novel throwing task. Am J Phys Med 1975; 54: 1-24.
62. Hoffman DS, Strick PL. Effects of a primary motor cortex lesion on step-tracking movements of the wrist. J Neurophysiol 1995; 73: 891-895.
63. Huk WJ, Gademann G. Magnetic resonance imaging (MRI): method and early clinical experiences in diseases of the central nervous system. Neurosurg Rev 1984; 7: 259-280.
64. Huntley GW, Jones EG. Relationship of intrinsic connections to forelimb movement representations in monkey motor cortex: a correlative anatomic and physiological study. J Neurophysiol 1991; 66: 390-413.
65. Indovina I, Sanes JN. On somatotopic representation centers for finger movements in human primary motor cortex and supplementary motor area. Neuroimage 2001; 13: 1027-1034.
66. Jaillard A, Martin CD, Garambois K, Lebas JF, Hommel M. Vicarious function within the human primary motor cortex? A longitudinal fMRI stroke study. Brain 2005; 128: 1122-1138.
67. Jang SH, Han BS, Chang Y, Byun WM, Lee J, Ahn SH. Functional MRI evidence for motor cortex reorganization adjacent to a lesion in a primary motor cortex. Am J Phys Med Rehabil 2002; 81: 844-847.
68. Jankowska E, Padel Y, Tanaka R. Projections of pyramidal tract cells to alpha-motoneurones innervating hind-limb muscles in the monkey. J Physiol 1975; 249: 637-667.
69. Jenkins WM, Merzenich MM. Reorganization of neocortical representations after brain injury: a neurophysiological model of the bases of recovery from stroke. Prog Brain Res 1987; 71: 249-266.
70. Jenkins WM, Merzenich MM, Ochs MT, Allard T, Guic-Robles E. Functional reorganization of primary somatosensory cortex in adult owl monkeys after behaviorally controlled tactile stimulation. J Neurophysiol 1990; 63: 82-104.
71. Jensen KF, Killackey HP. Terminal arbors of axons projecting to the somatosensory cortex of the adult rat. I. The normal morphology of specific thalamocortical afferents. J Neurosci 1987; 7: 3529-3543.
72. Johansson BB. Functional outcome in rats transferred to an enriched environment 15 days after focal brain ischemia. Stroke 1996; 27: 324-326.
73. Jones EG, Pons TP. Thalamic and brainstem contributions to large-scale plasticity of primate somatosensory cortex. Science 1998; 282: 1121-1125.
74. Jones TA, Schallert T. Overgrowth and pruning of dendrites in adult rats recovering from neocortical damage. Brain Res 1992; 581: 156-160.
75. Jones TA, Schallert T. Use-dependent growth of pyramidal neurons after neocortical damage. J Neurosci 1994; 14: 2140-2152.
76. Kaas JH. The functional organization of somatosensory cortex in primates. Anat Anz 1993; 175: 509-518.
77. Kaas JH, Merzenich MM, Killackey HP. The reorganization of somatosensory cortex following peripheral nerve damage in adult and developing mammals. Annu Rev Neurosci 1983; 6: 325-356.
78. Kaas JH, Nelson RJ, Sur M, Lin CS, Merzenich MM. Multiple representations of the body within the primary somatosensory cortex of primates. Science 1979; 204: 521-523.
79. Kamada K, Saguer M, Moller M, Wicklow K, Katenhauser M, Kober H, Vieth J. Functional and metabolic analysis of cerebral ischemia using magnetoencephalography and proton magnetic resonance spectroscopy. Ann Neurol 1997; 42: 554-563.
80. Karni A, Meyer G, Jezzard P, Adams MM, Turner R, Ungerleider LG. Functional MRI evidence for adult motor cortex plasticity during motor skill learning. Nature 1995; 377: 155-158.
81. Karni A, Meyer G, Rey-Hipolito C, Jezzard P, Adams MM, Turner R, Ungerleider LG. The acquisition of skilled motor performance: fast and slow experience-driven changes in primary motor cortex. Proc Natl Acad Sci USA 1998; 95: 861-868.
82. Kautz SA, Brown DA. Relationships between timing of muscle excitation and impaired motor performance during cyclical lower extremity movement in post-stroke hemiplegia. Brain 1998; 121: 515-526.
83. Kawamata T, Dietrich WD, Schallert T, Gotts JE, Cocke RR, Benowitz LI, Finklestein SP. Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction. Proc Natl Acad Sci USA 1997; 94: 8179-8184.
84. Keller A, Arissian K, Asanuma H. Formation of new synapses in the cat motor cortex following lesions of the deep cerebellar nuclei. Exp Brain Res 1990; 80: 23-33.
85. Keller A, Arissian K, Asanuma H. Synaptic proliferation in the motor cortex of adult cats after long-term thalamic stimulation. J Neurophysiol 1992; 68: 295-308.
86. Kelley MS, Steward O. Injury-induced physiological events that may modulate gene expression in neurons and glia. Rev Neurosci 1997; 8: 147-177.
87. Kleim JA, Barbay S, Cooper NR, Hogg TM, Reidel CN, Remple MS, Nudo RJ. Motor learning-dependent synaptogenesis is localized to functionally reorganized motor cortex. Neurobiol Learn Mem 2002; 77: 63-77.
88. Kleim JA, Barbay S, Nudo RJ. Functional reorganization of the rat motor cortex following motor skill learning. J Neurophysiol 1998; 80: 3321-3325.
89. Kleim JA, Cooper NR, VandenBerg PM. Exercise induces angiogenesis but does not alter movement representations within rat motor cortex. Brain Res 2002; 934: 1-6.
90. Kolb B. Brain Plasticity and behavior. Mahwah, NJ: Erlbaum, 1995.
91. Kolb B, Cote S, Ribeiro-da-Silva A, Cuello AC. Nerve growth factor treatment prevents dendritic atrophy and promotes recovery of function after cortical injury. Neuroscience 1997; 76: 1139-1151.
92. Kolb B, Whishaw IQ. Plasticity in the neocortex: mechanisms underlying recovery from early brain damage. Prog Neurobiol 1989; 32: 235-276.
93. Kwan HC, Mackay WA, Murphy JT, Wong YC. An intracortical microstimulation study of output organization in precentral cortex of awake primates. J Physiol (Paris) 1978; 74: 231-233.
94. Lashley KS. Brain Mechanisms and Intelligence: A Quantitative Study of Injuries to the Brain. Chicago, IL: University of Chicago Press, 1929.
95. Lashley KS. Basic neural mechanisms in behavior. Psychol Rev 1930; 37: 1-24.
96. Lawrence DG, Kuypers HG. The functional organization of the motor system in the monkey. I. The effects of bilateral pyramidal lesions. Brain 1968; 91: 1-14.
97. Lee WH, Bondy CA. Ischemic injury induces brain glucose transporter gene expression. Endocrinology 1993; 133: 2540-2544.
98. Liepert J, Weiller C. Mapping plastic brain changes after acute lesions. Curr Opin Neurol 1999; 12: 709-713.
99. Liu Y, Rouiller EM. Mechanisms of recovery of dexterity following unilateral lesion of the sensorimotor cortex in adult monkeys. Exp Brain Res 1999; 128: 149-159.
100. Loubinoux I, Carel C, Pariente J, Dechaumon S t, Albucher JF, Marque P, Manelfe C, Chollet F. Correlation between cerebral reorganization and motor recovery after subcortical infarcts. Neuroimage 2003; 20: 2166-2180.
101. Lynch G, Stanfieid B, Cotman CW. Developmental differences in post-lesion axonal growth in the hippocampus. Brain Res 1973; 59: 155-168.
102. Mark VW, Taub E. Constraint-induced movement therapy for chronic stroke hemiparesis and other disabilities. Restor Neurol Neurosci 2004; 22: 317-336.
103. Menon V, Crottaz-Herbette S. Combined EEG and fMRI studies of human brain function. Int Rev Neurobiol 2005; 66: 291-321.
104. Merrill E, Wall P. Plasticity of connections in the adult nervous system. In: Cotman CW, ed. Neuronal Plasticity. New York: Raven Press, 1978; 97-111.
105. Merzenich MM, Kaas JH, Sur M, Lin CS. Double representation of the body surface within cytoarchitectonic areas 3b and 1 in "SI" in the owl monkey (Aotus trivirgatus). J Comp Neurol 1978; 181: 41-73.
106. Merzenich MM, Kaas JH, Wall J, Nelson RJ, Sur M, Felleman D. Topographic reorganization of somatosensory cortical areas 3b and 1 in adult monkeys following restricted deafferentation. Neuroscience 1983; 8: 33-55.
107. Merzenich MM, Nelson RJ, Kaas JH, Stryker MP, Jenkins WM, Zook JM, Cynader MS, Schoppmann A. Variability in hand surface representations in areas 3b and 1 in adult owl and squirrel monkeys. J Comp Neurol 1987; 258: 281-296.
108. Miyai I, Suzuki T, Kang J, Kubota K, Volpe BT. Middle cerebral artery stroke that includes the premotor cortex reduces mobility outcome. Stroke 1999; 30: 1380-1383.
109. Moore SP, Marteniuk RG. Kinematic and electromyoraphic changes that occur as a function of learning a time-constrained aiming task. J Mot Behav 1986; 8: 397-426.
110. Mountcastle VB, Powell TP. Neural mechanisms subserving cutaneous sensibility, with special reference to the role of afferent inhibition in sensory perception and discrimination. Bull Johns Hopkins Hosp 1959; 105: 201-232.
111. Nelles G, Spiekramann G, Jueptner M, Leonhardt G, Muller S, Gerhard H, Diener HC. Evolution of functional reorganization in hemiplegic stroke: a serial positron emission tomographic activation study. Ann Neurol 1999; 46: 901-909.
112. A-receptor alpha1- and alpha2-subunit mRNAs following ischemic cortical lesions in rats. Brain Res 1999; 816: 234-237.
113. Neumann-Haefelin T, Staiger JF, Redecker C, Zilles K, Fritschy JM, Mohler H, Witte OW. Immunohistochemical evidence for dysregulation of the GABAergic system ipsilateral to photochemically induced cortical infarcts in rats. Neuroscience 1998; 87: 871-879.
114. Nudo RJ, Friel KM, Delia SW. Role of sensory deficits in motor impairments after injury to primary motor cortex. Neuropharmacology 2000; 39: 733-742.
115. Nudo RJ, Jenkins WM, Merzenich MM, Prejean T, Grenda R. Neurophysiological correlates of hand preference in primary motor cortex of adult squirrel monkeys. J Neurosci 1992; 12: 2918-2947.
116. Nudo RJ, Milliken GW. Reorganization of movement representations in primary motor cortex following focal ischemic infarcts in adult squirrel monkeys. J Neurophysiol 1996; 75: 2144-2149.
117. Nudo RJ, Milliken GW, Jenkins WM, Merzenich MM, Use-dependent alterations of movement representations in primary motor cortex of adult squirrel monkeys. J Neurosci 1996; 16: 785-807.
118. Nudo RJ, Wise BM, SiFuentes F, Milliken GW. Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct. Science 1996; 272: 1791-1794.
119. Ogden R, Franz SI. On cerebral motor control: the recovery of function from experimentally produced hemiplegia. Psychbiology 1917; 1: 33-50.
120. Padberg J, Disbrow E, Krubitzer L. The organization and connections of anterior and posterior parietal cortex in titi monkeys: do New World monkeys have an area 2? Cereb Cortex 2005; 15: 1938-1963.
121. Park MC, Belhaj-Saif A, Gordon M, Cheney PD. Consistent features in the forelimb representation of primary motor cortex in rhesus macaques. J Neurosci 2001; 21: 2784-2792.
122. Pascual-Leone A. Reorganization of cortical motor outputs in the acquisition of new motor skills. In: Kinura J, Shibasaki H, eds. Recent Advances in Clinical Neurophysiology. Amsterdam: Elsevier, 1996.
123. Pascual-Leone A, Nguyet D, Cohen LG, Brasil-Neto JP, Cammarota A, Hallett M. Modulation of muscle responses evoked by transcranial magnetic stimulation during the acquisition of new fine motor skills. J Neurophysiol 1995; 74: 1037-1045.
124. Passingham RE, Perry VH, Wilkinson F. The long-term effects of removal of sensorimotor cortex in infant and adult rhesus monkeys. Brain 1983; 106: 675-705.
125. Pavlides C, Miyashita E, Asanuma H. Projection from the sensory to the motor cortex is important in learning motor skills in the monkey. J Neurophysiol 1993; 70: 733-741.
126. Payton OD, Kelley DL. Electromyographic evidence of the acquisition of a motor skill. A pilot study. Phys Ther 1972; 52: 261-266.
127. Penfield W, Boldrey E. Somatic motor and sensory representation in the cerebreal cortex of man as studied by electrical stimulation. Brain 1937; 60: 389-443.
128. Phillips CG, Porter R. Corticospinal neurones. Their role in movement. Monogr Physiol Soc 1977; 34: v-xii, 1-450.
129. Pineiro R, Pendlebury S, Johansen-Berg H, Matthews PM. Functional MRI detects posterior shifts in primary sensorimotor cortex activation after stroke: evidence of local adaptive reorganization? Stroke 2001; 32: 1134-1139.
130. Plautz EJ, Barbay S, Frost SB, Friel KM, Dancause N, Zoubina EV, Stowe AM, Quaney BM, Nudo RJ. Post-infarct cortical plasticity and behavioral recovery using concurrent cortical stimulation and rehabilitative training: a feasibility study in primates. Neurol Res 2003; 25: 801-810.
131. Plautz EJ, Milliken GW, Knox-DuBois C, Nudo RJ. Comparison of propofol and ketamine anesthesia for cortical mapping studies. Society for Neuroscience Meeting, New Orleans, LA, 2000.
132. Plautz EJ, Milliken GW, Nudo RJ. Effects of repetitive motor training on movement representations in adult squirrel monkeys: role of use versus learning. Neurobiol Learn Mem 2000; 74: 27-55.
133. Pons TP, Garraghty PE, Mishkin M. Lesion-induced plasticity in the second somatosensory cortex of adult macaques. Proc Natl Acad Sci USA 1988; 85: 5279-5281.
134. Pons TP, Garraghty PE, Ommaya AK, Kaas JH, Taub E, Mishkin M. Massive cortical reorganization after sensory deafferentation in adult macaques. Science 1991; 252: 1857-1860.
135. Pons TP, Kaas JH. Corticocortical connections of area 2 of somatosensory cortex in macaque monkeys: a correlative anatomical and electrophysiological study. J Comp Neurol 1986; 248: 313-335.
136. A receptor binding following focal cortical photothrombotic lesions in the rat brain. Brain Res 1998; 813: 374-380.
137. Recanzone GH, Jenkins WM, Hradek GT, Merzenich MM. Progressive improvement in discriminative abilities in adult owl monkeys performing a tactile frequency discrimination task. J Neurophysiol 1992; 67: 1015-1030.
138. Recanzone GH, Merzenich MM, Dinse HR. Expansion of the cortical representation of a specific skin field in primary somatosensory cortex by intracortical microstimulation. Cereb Cortex 1992; 2: 181-196.
139. Recanzone GH, Merzenich MM, Jenkins WM. Frequency discrimination training engaging a restricted skin surface results in an emergence of a cutaneous response zone in cortical area 3a. J Neurophysiol 1992; 67: 1057-1070.
140. Recanzone GH, Merzenich MM, Jenkins WM, Grajski KA, Dinse HR. Topographic reorganization of the hand representation in cortical area 3b owl monkeys trained in a frequency-discrimination task. J Neurophysiol 1992; 67: 1031-1056.
141. Remple MS, Bruneau RM, VandenBerg PM, Goertzen C, Kleim JA. Sensitivity of cortical movement representations to motor experience: evidence that skill learning but not strength training induces cortical reorganization. Behav Brain Res 2001; 123: 133-141.
142. Sasaki K, Gemba H. Compensatory motor function of the somatosensory cortex for the motor cortex temporarity impaired by cooling in the monkey. Exp Brain Res 1984; 55: 60-68.
143. Schauwecker PE, Cheng HW, Serquinia RM, Mori N, McNeill TH. Lesion-induced sprouting of commissural/associational axons and induction of GAP-43 mRNA in hilar and CA3 pyramidal neurons in the hippocampus are diminished in aged rats. J Neurosci 1995; 15: 2462-2470.
144. A-receptor expression in the surround of cerebral photothrombosis. J Cereb Blood Flow Metab 1996; 16: 906-914.
145. Schroeter M, Schiene K, Kraemer M, Hagemann G, Weigel H, Eysel UT, Witte OW, Stoll G. Astroglial responses in photochemically induced focal ischemia of the rat cortex. Exp Brain Res 1995; 106: 1-6.
146. Seitz RJ, Huang Y, Knorr U, Tellmann L, Herzog H, Freund HJ. Large-scale plasticity of the human motor cortex. NeuroReport 1995; 6: 742-744.
147. Seitz RJ, Kleiser R, Butefisch CM. Reorganization of cerebral circuits in human brain lesion. Acta Neurochir Suppl 2005; 93: 65-70.
148. Seitz RJ, Roland PE. Learning of sequential finger movements in man: a combined kinematic and positron emission tomography (PET) study. Eur J Neurosci 1992; 4: 154-165.
149. Sessle BJ, Wiesendanger M. Structural and functional definition of the motor cortex in the monkey (Macaca fascicularis). J Physiol 1982; 323: 245-265.
150. Snow PJ, Nudo RJ, Rivers W, Jenkins WM, Merzenich MM. Somatotopically inappropriate projections from thalamocortical neurons to the SI cortex of the cat demonstrated by the use of intracortical microstimulation. Somatosens Res 1988; 5: 349-372.
151. Stepniewska I, Preuss TM, Kaas JH. Architectonics, somatotopic organization, and ipsilateral cortical connections of the primary motor area (M1) of owl monkeys. J Comp Neurol 1993; 330: 238-271.
152. Stoney SD Jr, Thompson WD, Asanuma H. Excitation of pyramidal tract cells by intracortical microstimulation: effective extent of stimulating current. J Neurophysiol 1968; 31: 659-669.
153. Stroemer RP, Kent TA, Hulsebosch CE. Neocortical neural sprouting, synaptogenesis, and behavioral recovery after neocortical infarction in rats. Stroke 1995; 26: 2135-2144.
154. Stryker MP, Jenkins WM, Merzenich MM. Anesthetic state does not affect the map of the hand representation within area 3b somatosensory cortex in owl monkey. J Comp Neurol 1987; 258: 297-303.
155. Sur M. Receptive fields of neurons in areas 3b and 1 of somatosensory cortex in monkeys. Brain Res 1980; 198: 465-471.
156. Sur M, Merzenich MM, Kaas JH. Magnification, receptive-field area, and "hypercolumn" size in areas 3b and 1 of somatosensory cortex in owl monkeys. J Neurophysiol 1980; 44: 295-311.
157. Tanné-Gariepy J, Rouiller EM, Boussaoud D. Parietal inputs to dorsal versus ventral premotor areas in the macaque monkey: evidence for largely segregated visuomotor pathways. Exp Brain Res 2002; 145: 91-103.
158. Thallmair M, Metz GA, Z'Graggen WJ, Raineteau O, Kartje GL, Schwab ME. Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions. Nat Neurosci 1998; 1: 124-131.
159. Turner AM, Greenough WT. Differential rearing effects on rat visual cortex synapses. I. Synaptic and neuronal density and synapses per neuron. Brain Res 1985; 329: 195-203.
160. Wall P. The presence of ineffective synapses and the circumstances which unmask them. Philos Trans R Soc Lond [Biol] 1977; 278: 361-372.
161. Ward NS, Brown MM, Thompson AJ, Frackowiak RS. Neural correlates of motor recovery after stroke: a longitudinal fMRI study. Brain 2003; 126: 2476-2496.
162. Ward NS, Brown MM, Thompson AJ, Frackowiak RS. Neural correlates of outcome after stroke: a cross-sectional fMRI study. Brain 2003; 126: 1430-1448.
163. Wenk CA, Thallmair M, Kartje GL, Schwab ME. Increased corticofugal plasticity after unilateral cortical lesions combined with neutralization of the IN-1 antigen in adult rats. J Comp Neurol 1999; 410: 143-157.
164. Whishaw IQ. Loss of the innate cortical engram for action patterns used in skilled reaching and the development of behavioral compensation following motor cortex lesions in the rat. Neuropharmacology 2000; 39: 788-805.
165. Whishaw IQ, Pellis SM, Gorny BP, Pellis VC. The impairments in reaching and the movements of compensation in rats with motor cortex lesions: an endpoint, videorecording, and movement notation analysis. Behav Brain Res 1991; 42: 77-91.
166. Witte OW, Stoll G. Delayed and remote effects of focal cortical infarctions: secondary damage and reactive plasticity. Adv Neurol 1997; 73: 207-227.
167. Woolsey CN, Settlage PH, Meyer DR, Spencer W, Hamuy TP, Travis AM. Patterns of localization in precentral and "supplementary" motor areas and their relation to the concept of a premotor area. Res Publ Assoc Res Nerv Ment Dis 1952; 30: 238-264.
168. Wu CW, Kaas JH. Somatosensory cortex of prosimian galagos: physiological recording, cytoarchitecture, and corticocortical connections of anterior parietal cortex and cortex of the lateral sulcus. J Comp Neurol 2003; 457: 263-292.
169. Xerri C, Merzenich MM, Peterson BE, Jenkins W. Plasticity of primary somatosensory cortex paralleling sensorimotor skill recovery from stroke in adult monkeys. J Neurophysiol 1998; 79: 2119-2148.
170. Z'Graggen WJ, Metz GA, Kartje GL, Thallmair M, Schwab ME. Functional recovery and enhanced corticofugal plasticity after unilateral pyramidal tract lesion and blockade of myelin-associated neurite growth inhibitors in adult rats. J Neurosci 1998; 18: 4744-4757.
171. Zimmer J. Extended commissural and ipsilateral projections in postnatally deentorhinated hippocampus and fascia dentata demonstrated in rats by silver impregnation. Brain Res 1973; 64: 293-311.