Genomic screening in vivo reveals the role played by vacuolar H+ ATPase and cytosolic acidification in sensitivity to DNA-damaging agents such as cisplatin

Molecular Pharmacology

Volumn 71, Issue 2, 2007, Pages 416-425

  Liao, Chunyan ^a   Hu, Bin ^a   Arno, Matthew J ^a   Panaretou, Barry ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHECKPOINT KINASE 2; CISPLATIN; HYDROXYUREA; MESYLIC ACID METHYL ESTER; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ACIDIFICATION; ARTICLE; CELL DEATH; CELL PH; CELL VACUOLE; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DRUG SENSITIVITY; ENZYME ACTIVITY; GENE DELETION; GENETIC SCREENING; GENOMICS; IN VIVO STUDY; NONHUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE; ULTRAVIOLET IRRADIATION;

ANTINEOPLASTIC AGENTS, ALKYLATING; CISPLATIN; CYTOSOL; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DRUG RESISTANCE; GENE LIBRARY; GENOME, FUNGAL; HYDROGEN-ION CONCENTRATION; SACCHAROMYCES CEREVISIAE; SEQUENCE DELETION; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 33846443975     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.030494     Document Type: Article

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