Dexamethasone inhibits epidermal growth factor-stimulated gastric epithelial cell proliferation

Journal of Pharmacology and Experimental Therapeutics

Volumn 320, Issue 2, 2007, Pages 687-694

  Luo, Jiing Chyuan ^a,b   Chi, Chin Wen ^b   Lin, Hsiao Yi ^a,b   Chang, Full Young ^a,b   Lu, Ching Liang ^a,b   Chen, Chih Yen ^a,b   Lee, Shou Dong ^a,b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYCLIN D1; CYCLOOXYGENASE 2; DEXAMETHASONE; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROSTAGLANDIN E2;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; EPITHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; STOMACH EPITHELIUM; WESTERN BLOTTING;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; CYCLOOXYGENASE 2; DEXAMETHASONE; EPIDERMAL GROWTH FACTOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; GASTRIC MUCOSA; NITROBENZENES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; SIGNAL TRANSDUCTION; SULFONAMIDES;

EID: 33846426812     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.113035     Document Type: Article

References (38)

1. Almawi WY, Melemedjian OK, and Rieder MJ (1999) An alternate mechanism of glucocorticoid anti-proliferative effect: promotion of a Th2 cytokine-secreting profile. Clin Transplant 13:365-374.
2. Blenis J (1993) Signal transduction via the MAP kinases: proceed at your own RSK. Proc Natl Acad Sci USA 90:5889-5892.
3. Brzozowski T, Konturek PC, Konturek SJ, Schuppan D, Drozdowicz D, Kwiecien S, Majka J, Nakamura T, and Hahn EG (2001) Effect of local application of growth factors on gastric ulcer healing and mucosal expression of cyclooxygenase-1 and -2. Digestion 64:15-29.
4. Carpani de Kaski M, Rentsch R, Levi S, and Hodgson HJ (1995) Corticosteroids reduce regenerative repair of epithelium in experimental gastric ulcers. Gut 537:613-616.
5. Filaretova LP, Bagaeva T, and Makara GB (2002) Aggravation of nonsteroidal anti-inflammatory drug gastropathy by glucocorticoid deficiency or blockade of glucocorticoid receptors in rats. Life Sci 71:2457-2468.
6. Filaretova LP, Filaretov AA, and Makara GB (1998) Corticosteroid increases inhibits stress-induced gastric erosions in rats. Am J Physiol 274:G1024-G1030.
7. Heldin CH (1995) Dimerization of cell surface receptors in signal transduction. Cell 80:213-223.
8. Hill CS and Treisman R (1995) Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell 80:199-211.
9. Huang CD, Chen HH, Wang CH, Chou CL, Lin SM, Lin HC, and Kuo HP (2004) Human neutrophil-derived elastase induces airway smooth muscle cell proliferation. Life Sci 74:2479-2492.
10. Huh YH, Kim SH, Kim SJ, and Chun JS (2003) Differentiation status-dependent regulation of cyclooxygenase-2 expression and prostaglandin E2 production by epidermal growth factor via mitogen-activated protein kinase in articular chondrocytes. J Biol Chem 278:9691-9697.
11. Jiang W, Kahn SM, Zhou P, Zhang YJ, Cacace AM, Infante AS, Doi S, Santella RM, and Weinstein IB (1993) Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression. Oncogene 8:3447-3457.
12. Konturek PC, Konturek SJ, Brzozowski T, and Ernst H (1995) Epidermal growth factor and transforming growth factor-α: role in protection and healing of gastric mucosal lesions. Eur J Gastroenterol Hepatol 7:933-938.
13. Lasa M, Mahtani KR, Finch A, Brewer G, Saklatvala J, and Clark AR (2000) Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade. Mol Cell Biol 20:4265-4274.
14. Lavoie JN, L'Allemain G, Brunet A, Muller R, and Pouysseger J (1996) Cyclin D1 expression is regulated positively by the p42/p44 MAPK and negatively by p38/HOGMAPK pathway. J Biol Chem 271:20608-20616.
15. Lee B, Vouthounis C, Stojadinovic O, Brem H, Im M, and Tomic-Canic M (2005) From an enhanceosome to a repressosome: molecular antagonism between glucocorticoids and EGF leads to inhibition of wound healing. J Mol Biol 345:1083-1097.
16. Lemmon MA and Schlessinger J (1994) Regulation of signal transduction and signal diversity by receptor oligomerization. Trends Biochem Sci 19:459-463.
17. Luo JC, Shin VY, Liu ESL, So WHL, Ye YN, Chang FY, and Cho CH (2003) Non-ulcerogenic dose of dexamethasone delays gastric ulcer healing in rats. J Pharmacol Exp Ther 307:692-698.
18. Luo JC, Shin VY, Liu ESL, Ye YN, Wu WKK, So WHL, Chang FY, and Cho CH (2004) Dexamethasone delays ulcer healing by inhibition of angiogenesis in rat stomachs. Eur J Pharmacol 485:275-281.
19. Matsuura H, Sakaue M, Subbaramaiah K, Kamitani H, Eling TE, Dannenberg AJ, Tanabe T, Inoue H, Arata J, and Jetten AM (1999) Regulation of cyclooxygenase-2 by interferon γ and transforming growth factor α in normal human epidermal keratinocytes and squamous carcinoma cells. Role of mitogen-activated protein kinases. J Biol Chem 274:29138-29148.
20. Pai R, Ohta M, Itani RM, Sarfeh IJ, and Tarnawski A (1998) Induction of mitogen-activated protein kinase signal transduction pathway during gastric ulcer healing in rats. Gastroenterology 114:706-713.
21. Peskar BM, Maricic N, Gretzer B, Schuligoi R, and Schmassmann A (2001) Role of cyclooxygenase-2 in gastric mucosal defense. Life Sci 69:2993-3003.
22. Resnitzky D, Gossen M, Bujard H, and Reed SI (1994) Acceleration of the G1/S phase transition by expression of cyclin D1 and E with an inducible system. Mol Cell Biol 14:1669-1679.
23. Roviezzo F, Getting SJ, Paul-Clark MJ, Yona S, Gavins FNE, Perretti M, Hannon R, Croxtall JD, Buckingham JC, and Flower RJ (2002) The annexin-1 knockout mouse: what it tell us about the inflammatory response. J Physiol Pharmacol 53:541-553.
24. Sasaki E, Tominaga K, Watanabe T, Fujiwara Y, Oshitani N, Matsumoto T, Higuchi K, Tarnawski AS, and Arakawa T (2003) COX-2 is essential for EGF induction of cell proliferation in gastric RGM1 cells. Dig Dis Sci 48:2257-2262.
25. Sheng H, Williams CS, Shao J, Liang P, DuBois RN, and Beauchamp RD (1998) Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathway. J Biol Chem 273:22120-22127.
26. SilenWand Ito S (1985) Mechanisms for rapid re-epithelialization of gastric mucosal surface. Annu Rev Physiol 47:217-229.
27. Szabo S, Khomenko T, Gombos Z, Deng XM, Jadus MR, and Yoshida M (2000) Review article: transcription factors and growth factors in ulcer healing. Aliment Pharmacol Ther 14 (Suppl 1):33-43.
28. Talarmin H, Rescan C, Carious S, Glaise D, Zanninelli G, Bilodeau M, Loyer P, Guguen-Guillouzo C, and Baffet G (1999) The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signaling pathway involved in the regulation of G1 phase progression in proliferating hepatocytes. Mol Cell Biol 19:6003-6011.
29. Tarnawski A and Jones MK (1998) The role of epidermal growth factor and its receptor in mucosal protection, adaptation to injury, and ulcer healing: involvement of EGF-R signal transduction pathways. J Clin Gastroenterol 27 (Suppl 1):S12-S20.
30. Tarnawski A, Stachura J, Durbin T, Sarfeh IJ, and Gergely H (1992) Increased expression of epidermal growth factor during gastric ulcer healing in rats. Gastroenterology 102:695-698.
31. Tarnawski A, Szabo IL, Husain SS, and Soreghan B (2001) Regeneration of gastric mucosa during ulcer healing is triggered by growth factors and signal transduction pathways. J Physiol (Paris) 95:337-344.
32. Tarnawski AS (2005) Cellular and molecular mechanisms of gastrointestinal ulcer healing. Dig Dis Sci 50 (Suppl):S24-S33.
33. Terada Y, Isoshita S, Nakashima O, Kuwahara M, Sasaki S, and Marumo F (1999) Regulation of cyclin D1 expression and cell cycle progression by mitogen-activated protein kinase cascade. Kidney Int 56:1258-1261.
34. Uribe JM and Barrett KE (1997) Nonmitogenic actions of growth factors: an integrated view of their role in intestinal physiology and pathophysiology. Gastroenterology 112:255-268.
35. Vietor I, Schwenger P, Li W, Schlessinger J, and Vilcek J (1993) Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein (MAP) kinase in human fibroblasts. J Biol Chem 268:18994-18999.
36. Xu D, Makkinje A, and Kyriakis JM (2005) Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function. J Biol Chem 280:2924-2933.
37. Yang YX and Lichtenstein GR (2002) Corticosteroids in Crohn's disease. Am J Gastroenterol 97:803-830.
38. Yoo J, Lotz MM, and Matthews JB (2002) Cytokines in restitution, in Gastrointestinal Mucosal Repairing and Experimental Therapeutics (Cho CH and Wang JY eds) pp 14-28, Karger, Basel, Switzerland.