Transcription factors and growth factors in ulcer healing

Alimentary Pharmacology and Therapeutics, Supplement

Volumn 14, Issue 1, 2000, Pages 33-43

  Szabo, S ^a   Khomenko, T ^b   Gombos, Z ^b   Deng, X M ^b   Jadus, M R ^b   Yoshida, M ^b  

^a VA LONG BEACH HEALTHCARE SYSTEM   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CIS ACTING ELEMENT; ENDOTHELIN 1; ETHANOLAMINE; MERCAPTAMINE; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR; PROTEIN P21; TRANSCRIPTION FACTOR; VASCULOTROPIN; ENDOTHELIAL CELL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; LYMPHOKINE; VASCULOTROPIN A;

CONFERENCE PAPER; DUODENUM ULCER; GASTRODUODENAL ULCER; GENETIC REGULATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; ULCER HEALING; ANIMAL; CELL CYCLE; GENETIC TRANSCRIPTION; HUMAN; METABOLISM; PATHOLOGY; REVIEW;

ANIMALS; CELL CYCLE; CYSTEAMINE; DUODENAL ULCER; ENDOTHELIAL GROWTH FACTORS; FIBROBLAST GROWTH FACTOR 2; HUMANS; LYMPHOKINES; PLATELET-DERIVED GROWTH FACTOR; RATS; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0034118086     PISSN: 09530673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (88)

1. Szabo S, Sandor Z. Basic fibroblast growth factor and PDGF in GI diseases. Bailliere's Clin Gastroenterol 1996; 10: 97-112.
2. Szabo S, Vincze A, Sandor Z. et al. Vascular approach to gastroduodenal ulceration: new studies with endothelins and VEGF. Dig Dis Sci 1998; 43: 40S-5S.
3. Domschke W, Konturek SJ, eds. The Stomach: Physiology, Pathophysiology and Treatment. Berlin: Springer-Verlag, 1993.
4. Swabb EA, Szabo S, eds. Ulcer Disease: Investigation and Basis for Therapy. New York: Marcel Dekker, 1991.
5. Gaginella TS, ed. Experimental Models of Mucosal Inflammation. Boca Raton: CRC Press, 1996.
6. Szabo S, Kusstatscher S, Sakoulas G, et al. Growth factors: new 'endogenous drugs' for ulcer healing. Scand J Gastroenterol 1995; 210: 15S-8S.
7. Deng X, Szabo S, Khomenko T, Yoshida M, Sandor Z, Florsheim W. Changes in endogenous vascular endothelial growth factor (VEGF) in duodenal ulceration. Gastroenterology 1999; 116: A601.
8. Konturek SJ, Brzozowski T, Dembinski A, et al. Gastric protective and ulcer-healing action of epidermal growth factor. In: Garner A, Whittle BJR, eds. Advances in Drug Therapy of Gastrointestinal Ulceration. New York: Wiley-Interscience, 1989: 261-73.
9. Poulsen SS, Olsen KS, Kierkegaard P. Healing of cysteamine-induced duodenal ulcers in rats. Dig Dis Sci 1985; 30: 161-7.
10. Semenza GL, ed. Transcription Factors and Human Disease. New York: Oxford University Press, 1998.
11. Tjian R. Molecular machines that control genes. Sci Am 1995; 272: 54-61.
12. Tjian R, Maniatis T. Transcriptional activation: a complex puzzle with few easy pieces. Cell 1994; 77; 5-8.
13. Smith J. Regulation of gene expression. In: Goodman RS, ed. Medical Cell Biology. Philadelphia: JB Lippincott, 1994: 143-68.
14. Coonor JM, Ferguson MA. Essential Medical Genetics. Oxford: Blackwell Scientific, 1994.
15. Morgan JI, Curran T. Stimulus transcription coupling in neurons: role of cellular immediate-early genes. Trends Neurol Sci 1989; 12: 459-62.
16. Morgan JI, Curran T. Stimulus transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. Ann Rev Neurosci 1991; 14: 421-51.
17. Lemaire P, Relevant O, Bravo R, Charnay P. Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells. Proc Natl Acad Sci USA 1988; 85: 4691-5.
18. Schlingensiepen KH, Luno K, Brysch W. High basal expression of the zif/268 immediate-early gene in cortical layers IV and VI, in CA1 and in the corpus striatum - an in situ hybridization study. Neurosci Lett 1991; 122: 67-70.
19. Cao X, Koski RA, Gashler A, et al. Identification and characterization of the egr-1 gene product, a DNA binding zinc finger protein induced by differentiation and growth signals. Mol Cell Biol 1990; 10: 1931-9.
20. Turner R, Tjian R. Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers. Science 1989; 243: 1689-94.
21. Gentz R, Rauscher FJ III, Abate C, Curran T. Parallel association of fos and jun leucine zippers juxtaposes DNA binding domains. Science 1989; 245: 1695-9.
22. Hughes P, Dragunov M. Activation of pirenzepine-sensitive muscarinic receptors induces a specific pattern of immediate-early gene expression in rat brain neurons. Mol Brain Res 1994; 24: 166-78.
23. Shubeita HE, McDonough PM, Harris AN, et al. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly and cardiac gene expression in ventricular myocytes. J Biol Chem 1990; 265: 20555-62.
24. Simonson MS, Jones JM, Dunn MJ. Differential regulation of fos and jun gene expression and AP-I cis element activity by endothelin isopeptides. Possible implication for mitogenic signaling by endothelin. J Biol Chem 1992; 267: 8643-9.
25. Christy BA, Lau LF, Nathans DA. Gene activated in mouse 3T3 cells by serum growth factors encodes a protein with 'zinc finger' sequences. Proc Natl Acad Sci USA 1988; 85: 7857-61.
26. Hall SH, Berthelon MC, Avallet O, Saez JM. Regulation of c-fos, c-jun, jun-B, and c-myc messenger ribonucleic acids by gonadotrophin and growth factors in cultured pig Leydig cells. Endocrinology 1991; 129: 1243-9.
27. Rupprecht HD, Sukhatme VP, Lacy J, Sterzel RB, Coleman DL. PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements. Am J Physiol 1993; 265: F351-60.
28. Herdegen T, Brecht S, Mayer B, et al. Long-lasting expression of JUN and KROX transcription factors and nitric oxide synthase in intrinsic neurons of the rat brain following axotomy. J Neurosci 1993; 13: 4130-45.
29. Miano JM, Vlasic N, Tota RR, Stemermann M. Smooth muscle cell immediate-early gene and growth factor activation follows vascular injury. A putative in vivo mechanism for autocrine growth. Arterioscl Thromb 1993; 13: 211-9.
30. Cohen DM, Gullans SR. Urea induces Egr-1 and c-fos expression. Am J Physiol 1993; 264: F593-600.
31. Rupprecht HD, Dann P, Sukhatme VP, Sterzel RB, Coleman DL. Effect of vasoactive agents on induction of Egr-1 in rat mesangial cells: correlation with mitogenicity. Am J Physiol 1992; 263: F623-36.
32. Ford MG, Valle JD, Soroka CJ, Merchant JL. EGF receptor activation stimulates endogenous gastrin gene expressionin canine G cells and human gastric cell cultures. J Clin Invest 1997; 99: 2762-71.
33. Merchant JL, Iyer GR, Taylor BR, et al. ZBP-89. a Kruppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter. Mol Cell Biol 1996; 16: 6644-53.
34. Jiang JG, Chen Q, Bell A, Zarnegar R. Transcriptional regulation of the hepatocyte growth factor (HGF) gene by the Sp family of transcription factors. Oncogene 1997; 12: 3039-49.
35. Merchant JL, Shiotani A, Mortensen ER, Shumaker DK, Abraczinskas DR. Epidermal growth factor stimulation of the human gastrin promoter requires Sp1. J Biol Chem 1995; 270: 6314-9.
36. Taniuchi T, Mortensen ER, Ferguson A, Greenson J, Merchant JL. Overexpression of ZBP-89, a zinc finger DNA binding protein, in gastric cancer. Biochem Biophys Res Comm 1997; 233: 154-60.
37. Gospodarowitz D, Bialecki U, Greenburg GJ. Purification of the fibroblast growth factor activity factor from bovine brain. J Biol Chem 1978; 253: 3736-43.
38. Shing Y, Folkman J, Sullivan R, et al. Heparin affinity: purification of a tumor-derived capillary endothelial call growth factor. Science 1984; 223: 1296-9.
39. Florkiewicz RZ, Sommer A. The human bFGF gene encodes four polypeptide: three initiate translation from non ATG codons. Proc Nat Acad Sci USA 1989; 86: 3978-81.
40. Klagsbrun M. The fibroblast growth factor family: structural and biological properties. Prog Growth Factor Res 1989; 1: 207-35.
41. Prats H, Kaghad M, Prats AC, et al. High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons. Proc Nat Acad Sci USA 1989; 86: 1836-40.
42. Summer A, Moscatelli D, Rifkin DB. An amino terminally extended and post translationally modified form of a 25 kDa basic fibroblast growth factor. Biochem Biophys Res Commun 1989; 160: 1267-74.
43. Renko M, Quarto N, Morimoto T, et al. Nuclear and cytoplasmic localization of different basic fibroblast growth species. J Cell Physiol 1990; 144: 108-14.
44. Givol D, Yayon A. Complexity of FGF receptors: genetic basis for structural diversity and functional specificity. FASEB J 1992; 6: 3362-9.
45. Yayon A, Klagsbrun M, Esko JD, et al. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell 1991; 64: 841-8.
46. Partaken J, Macula YP, Earola E, et al. FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern. EMBO J 1991; 10: 1347-54.
47. Szabo S, Folkman J, Vattay P, et al. Duodenal ulcerogens: Effect of FGF on cysteamine-induced duodenal ulcer. In: Halter F. Garner A, Tytgat GNJ, eds. Mechanisms of Peptic Ulcer Healing. London: Kluwer Academic Publications. 1991: 139-50.
48. Folkman J, Szabo S, Stovroff M, et al. Duodenal ulcer: discovery of a new mechanism and development of angiogenic therapy which accelerates healing. Ann Surg 1991; 214: 414-26.
49. Szabo S, Folkman J, Vattay P, Morales RE, Pinkus GS, Kato K. Accelerated healing of duodenal ulcers by oral administration of a mutein of basic fibroblast growth factor in rats. Gastroenterology 1994; 106: 1106-11.
50. Kusstatscher S, Nagy L, Morales RE, Szabo S. Additive effect of basic fibroblast growth factor (bFGF) and cimetidine on chronic duodenal ulcer healing in rats. Gastroenterology 1993; 102: A104 (Abstract).
51. Kusstatseher S, Sandor Z, Szabo S, et al. Different molecular forms of basic fibroblast growth factor (bFGF) accelerate duodenal ulcer healing in rats. J Pharmacol Exp Ther 1995; 275: 456-61.
52. Satoh H, Shino A, Inatomi N, et al. Effect of rhbFGF mutein CS23 (TGP-580) on the healing of gastric ulcers induced by acetic acid in rats. Gastroenlerology 1991; 100: A155 (Abstract).
53. Kusstatscher S, Bishop J, Brown L, et al. Basic fibroblast growth factor (bFGF) immunolocalization in duodenum of normal rats after duodenal ulcer induction. Gastroenterology 1993; 104: A125 (Abstract).
54. Nakamura M, Ishii H. Increased effector site of platelet-derived growth factor-BB and basic fibroblast growth factor during acetic acid-induced gastric ulcer healing. GI Forum-Molecular Biological Approach to Peptic Ulcer Disease; 13-6, 1995.
55. Sakoulas G, Kusstatscher S, Ku PT, et al. Role of endogenous basic fibroblast growth factor in duodenal ulceration. Dig Dis Sci 1993; 38: A11 (Abstract).
56. Szabo S, Sakoulas G, Kusstatscher S, et al. Effects of endogenous and exogenous basic fibroblast growth factor in ulcer healing. Europ J Gastroenterol 1993; 5: S53-7.
57. Vincze A, Nagata M, Sandor Z, et al. ELISA and Western blot studies with basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) in experimental duodenal ulceration and healing. Inflammopharmacology 1996; 4: 261-5.
58. Kusstatscher S, Sandor Z, Satoli H, Szabo S. Inhibition of endogenous basic fibroblast growth factor (bFGF) delays duodenal ulcer healing in rats: implications for a physiologic role of bFGF. Gastroenterology 1994; 106: A113 (Abstract).
59. Antoniades HN, Hunkapiller MW. Human platelet-derived growth factor (PDGF): amino terminal amino acid sequence. Science 1983; 220: 963-5.
60. Johnson A, Heldin CH, Wasteson A, et al. The c-sis gene encodes a precursor of beta chain of platelet derived growth factor. EMBO J 1984; 3: 921-8.
61. Heldin CH, Westermark B. Platelet-derived growth factor: mechanism of action and possible in vivo function. Cell Reg 1990; 1: 555-66.
62. Westermark B, Heldin CH. Platelet-derived growth factor in autocrine transformation. Cancer Res 1991; 51: 5087-92.
63. Khachigan LM, Owemsby DA, Chesterman CN. A tyrosinated peptide representing the alternatively spliced exon of platelet-derived growth factor A-chain binds specifically to cultured cells and interferes with binding to several growth factors. J Biol Chem 1992; 267: 1660-6.
64. Raines EW, Ross R. Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences. J Cell Biol 1992; 116: 533-43.
65. Owen A, Gayer R, Antoniades HN. Human platelet-derived growth factor stimulates amino acid transport and protein synthesis by human diploid fibroblast in plasma-free media. Proc Nat Acad Sci USA 1982; 79: 3203-7.
66. Chait A, Ross R, Albers JJ, Bierman EL. Platelet-derived growth factor stimulates activity of low density lipoprotein receptors. Proc Nat Acad Sci USA 1980; 77: 4084-8.
67. Deuel TF, Kawahara RS. Platelet-derived growth factor. In: Aggarwal BB, Gutterman RS, eds. Human Cytokines: Handbook for Basic and Clinical Research. Boston: Blackwell, 1992: 301-27.
68. Vattay P, Gambier E, Morales RE, et al. Effect of orally administered platelet-derived growth factor (PDGF) on healing of chronic duodenal ulcers and gastric secretion in rats. Gastroenterology 1991; 100: A180 (Abstract).
69. Neufeld G, Cohen T, Gitay Groen H, et al. Similarities and differences between the vascular endothelial growth factor (VEGF) splice variants. Cancer Mets Rev 1996; 15: 153-8.
70. Keck PJ, Hauser SA, Krivi G, et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 1989; 246: 1309.
71. Pimentel E. Growth factors - Vol. II: Peptide Growth Factors. Boca Raton: CRC Press, 1994: 254-7.
72. Houck KA, Leung DW, Rowland AM, et al. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanism. J Biol Chem 1992; 267: 26031-7.
73. Dvorak HF, Brown LF, Detmar M, Dvorak M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 1995; 146: 1029-39.
74. Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocrinol Rev 1997; 18: 4-25.
75. Breier G, Clauss M, Risau W. Coordinate expression of vascular endothelial growth factor receptor-1 (fit-1) and its ligand suggests a paracrine regulation of murine vascular development. Dev Dyn 1995; 204: 228-39.
76. Nor JE, Christensen J, Mooney DJ, Polverini PJ. Vascular endothelial growth factor (VEGF) mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. Am J Pathol 1999; 154: 375-84.
77. Hayashi T, Abe K, Itoyama Y. Reduction of ischemic damage by application of vascular endothelial growth factor in rat brain after transient ischemia. J Cereb Blood Flow Metab 1998; 18: 887-95.
78. Dor Y, Keshet E. Ischemia-driven angiogenesis. Trends Cardiovasc Med 1997; 7: 289-94.
79. de Vries C, Escobedo JA, Ueno H, et al. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 1992; 255: 989-91.
80. Terman BI, Carrion ME, Kovacs E, et al. Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene 1991; 6: 519-24.
81. Szabo S, Folkman J, Vincze A, et al. Modulation of vascular factors by VEGF/VPF (vascular endothelial growth factor/ vascular permeability factor) is sufficient for chronic ulcer healing and acute gastroprotection. Gastroenterology 1997; 112: A303 (Abstract).
82. Yoshida M, Khomenko T, Deng X, et al. Endothelin-related increased vascular permeability is a common pathogenetic element in duodenal ulceration. Gastroenterology 1999; 116: A364.
83. Mundschau LJ, Forman LW, Weng H, Fallers V. Platelet-derived growth factor (PDGF) induction of egr-1 is independent of PDGF receptor autophosphorylation on tyrosine. J Biol Chem 1994; 269: 16137-42.
84. Hall SH, Berthelon MC, Avallet O, Sacz JM. Regulation of c-fos, c-jun, jun-B and c-myc messenger ribonucleic acids by gonadotrophin and growth factors in cultured pig Leydig cell. Endocrinology 1991; 129: 1243-9.
85. Hu RM, Levin ER. Astrocyte growth is regulated by neuropeptides through Tis 8 and basic fibroblast growth factor. J Clin Invest 1994; 93: 1820-7.
86. Szabo S, Levin ER, Vincze A, et al. Endothelin release and expression of immediate early genes in the early stage of duodenal ulceration. Gastroenterology 1996; 110: A267 (Abstract).
87. Al-Bassam J, Szabo S, Sandor Zs, Singh G. Changes in transcription factors Egr-1 and Sp-1 expression in the early stages of cysteamine-induced duodenal ulceration. Gastroenterology 1998; 114: A54 (Abstract).
88. Khomenko T, Szabo S, Masashi Y, Deng X, Florsheim W. The cell cycle inhibitor protein p21 is induced by the duodenal ulcerogen cysteamine. Gastroenterology 1999; 116: A212 (Abstract).