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Volumn 118, Issue 3, 2006, Pages 9-17

Genetic vaccination approaches against malaria based on the circumsporozoite protein

Author keywords

Circumsporozoite protein; DNA vaccine; Gene gun; Genetic immunization; Malaria

Indexed keywords

CIRCUMSPOROZOITE PROTEIN; DNA VACCINE; MALARIA VACCINE;

EID: 33846397189     PISSN: 03005178     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00508-006-0676-0     Document Type: Review
Times cited : (5)

References (58)
  • 1
    • 0035525357 scopus 로고    scopus 로고
    • Towards a blood-stage vaccine for malaria: Are e following all the leads?
    • Good MF (2001) Towards a blood-stage vaccine for malaria: are e following all the leads? Nat Rev Immunol 1: 117-125
    • (2001) Nat Rev Immunol , vol.1 , pp. 117-125
    • Good, M.F.1
  • 2
    • 0036704783 scopus 로고    scopus 로고
    • Development of malaria vaccines that block transmission of parasites by mosquito vectors
    • Hisaeda H, Yasutomo K (2002) Development of malaria vaccines that block transmission of parasites by mosquito vectors. J Med Invest 49: 118-123
    • (2002) J Med Invest , vol.49 , pp. 118-123
    • Hisaeda, H.1    Yasutomo, K.2
  • 3
    • 0024312642 scopus 로고
    • Rationale for the development of an engineered sporozoite malaria vaccine
    • Nussenzweig V, Nussenzweig RS (1989) Rationale for the development of an engineered sporozoite malaria vaccine. Adv Immunol 45: 283-334
    • (1989) Adv Immunol , vol.45 , pp. 283-334
    • Nussenzweig, V.1    Nussenzweig, R.S.2
  • 4
    • 0033693818 scopus 로고    scopus 로고
    • Malaria vaccines-targeting infected hepatocytes
    • Hoffman SL, Doolan DL (2000) Malaria vaccines-targeting infected hepatocytes. Nat Med 6: 1218-1219
    • (2000) Nat Med , vol.6 , pp. 1218-1219
    • Hoffman, S.L.1    Doolan, D.L.2
  • 5
    • 0033182171 scopus 로고    scopus 로고
    • Pre-erythrocytic malaria vaccine: Mechanisms of protective immunity and human vaccine trials
    • Nardin E, Zavala F, Nussenzweig V, Nussenzweig RS (1999) Pre-erythrocytic malaria vaccine: mechanisms of protective immunity and human vaccine trials. Parassitologia 41: 397-402
    • (1999) Parassitologia , vol.41 , pp. 397-402
    • Nardin, E.1    Zavala, F.2    Nussenzweig, V.3    Nussenzweig, R.S.4
  • 6
    • 0034990655 scopus 로고    scopus 로고
    • DNA-based vaccines against malaria: Status and promise of the Multi-Stage Malaria DNA Vaccine Operation
    • Doolan DL, Hoffman SL (2001) DNA-based vaccines against malaria: status and promise of the Multi-Stage Malaria DNA Vaccine Operation. Int J Parasitol 31: 753-762
    • (2001) Int J Parasitol , vol.31 , pp. 753-762
    • Doolan, D.L.1    Hoffman, S.L.2
  • 7
    • 20044362219 scopus 로고    scopus 로고
    • Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: Progress at the Walter Reed Army Institute of Research
    • Heppner DG Jr, Kester KE, Ockenhouse CF, Tornieporth N, Ofori O, Lyon JA, et al (2005) Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research. Vaccine 23: 2243-2250
    • (2005) Vaccine , vol.23 , pp. 2243-2250
    • Heppner Jr, D.G.1    Kester, K.E.2    Ockenhouse, C.F.3    Tornieporth, N.4    Ofori, O.5    Lyon, J.A.6
  • 9
    • 0034046182 scopus 로고    scopus 로고
    • DNA vaccines: Immunology, application, and optimization
    • Gurunathan S, Klinman DM, Seder RA (2000) DNA vaccines: immunology, application, and optimization. Annu Rev Immunol 18: 927-974
    • (2000) Annu Rev Immunol , vol.18 , pp. 927-974
    • Gurunathan, S.1    Klinman, D.M.2    Seder, R.A.3
  • 10
    • 0028077102 scopus 로고
    • Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein
    • Sedegah M, Hedstrom R, Hobart P, Hoffman SL (1994) Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. Proc Natl Acad Sci USA 91: 9866-9870
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9866-9870
    • Sedegah, M.1    Hedstrom, R.2    Hobart, P.3    Hoffman, S.L.4
  • 11
    • 0028080309 scopus 로고
    • Protection against malaria by immunization with a Plasmodium yoelii circumsporozoite protein nucleic acid vaccine
    • Hoffman SL, Sedegah M, Hedstrom RC (1994) Protection against malaria by immunization with a Plasmodium yoelii circumsporozoite protein nucleic acid vaccine. Vaccine 12: 1529-1533
    • (1994) Vaccine , vol.12 , pp. 1529-1533
    • Hoffman, S.L.1    Sedegah, M.2    Hedstrom, R.C.3
  • 12
    • 0029157095 scopus 로고
    • Complexity of the cytokine and antibody response elicited by immunizing mice with Plasmodium yoelii circumsporozoite protein plasmid DNA
    • Mor G, Klinman DM, Shapiro S, Hagiwara E, Sedegah M, Norman JA, et al (1995) Complexity of the cytokine and antibody response elicited by immunizing mice with Plasmodium yoelii circumsporozoite protein plasmid DNA. J Immunol 155: 2039-2046
    • (1995) J Immunol , vol.155 , pp. 2039-2046
    • Mor, G.1    Klinman, D.M.2    Shapiro, S.3    Hagiwara, E.4    Sedegah, M.5    Norman, J.A.6
  • 13
    • 0029989274 scopus 로고    scopus 로고
    • Circumventing genetic restriction of protection against malaria with multigene DNA immunization: CD8+ cell-, interferon gamma-, and nitric oxide-dependent immunity
    • Doolan DL, Sedegah M, Hedstrom RC, Hobart P, Charoenvit Y, Hoffman SL (1996) Circumventing genetic restriction of protection against malaria with multigene DNA immunization: CD8+ cell-, interferon gamma-, and nitric oxide-dependent immunity. J Exp Med 183: 1739-1746
    • (1996) J Exp Med , vol.183 , pp. 1739-1746
    • Doolan, D.L.1    Sedegah, M.2    Hedstrom, R.C.3    Hobart, P.4    Charoenvit, Y.5    Hoffman, S.L.6
  • 14
    • 0029954237 scopus 로고    scopus 로고
    • Identification and characterization of the protective hepatocyte erythrocyte protein 17 kDa gene of Plasmodium yoelii, homolog of Plasmodium falciparum exported protein 1
    • Doolan DL, Hedstrom RC, Rogers WO, Charoenvit Y, Rogers M, de la Vega P, et al (1996) Identification and characterization of the protective hepatocyte erythrocyte protein 17 kDa gene of Plasmodium yoelii, homolog of Plasmodium falciparum exported protein 1. J Biol Chem 271: 17861-17868
    • (1996) J Biol Chem , vol.271 , pp. 17861-17868
    • Doolan, D.L.1    Hedstrom, R.C.2    Rogers, W.O.3    Charoenvit, Y.4    Rogers, M.5    de la Vega, P.6
  • 15
    • 0032007497 scopus 로고    scopus 로고
    • DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: Immunogenicity in mice
    • Hanke T, Schneider J, Gilbert SC, Hill AV, McMichael A (1998) DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice. Vaccine 16: 426-435
    • (1998) Vaccine , vol.16 , pp. 426-435
    • Hanke, T.1    Schneider, J.2    Gilbert, S.C.3    Hill, A.V.4    McMichael, A.5
  • 17
    • 0034756981 scopus 로고    scopus 로고
    • Disruption of disulfide linkages of the Plasmodium falciparum circumsporozoite protein: Effects on cytotoxic and antibody responses in mice
    • Rathore D, Kumar S, Lanar DE, McCutchan TF (2001) Disruption of disulfide linkages of the Plasmodium falciparum circumsporozoite protein: effects on cytotoxic and antibody responses in mice. Mol Biochem Parasitol 118: 75-82
    • (2001) Mol Biochem Parasitol , vol.118 , pp. 75-82
    • Rathore, D.1    Kumar, S.2    Lanar, D.E.3    McCutchan, T.F.4
  • 18
    • 0032167401 scopus 로고    scopus 로고
    • A plasmid encoding murine granulocyte-macrophage colony-stimulating factor increases protection conferred by a malaria DNA vaccine
    • Weiss WR, Ishii KJ, Hedstrom RC, Sedegah M, Ichino M, Barnhart K, et al (1998) A plasmid encoding murine granulocyte-macrophage colony-stimulating factor increases protection conferred by a malaria DNA vaccine. J Immunol 161: 2325-2332
    • (1998) J Immunol , vol.161 , pp. 2325-2332
    • Weiss, W.R.1    Ishii, K.J.2    Hedstrom, R.C.3    Sedegah, M.4    Ichino, M.5    Barnhart, K.6
  • 20
    • 0032754052 scopus 로고    scopus 로고
    • Prevention of neonatal tolerance by a plasmid encoding granulocyte-macrophage colony stimulating factor
    • Ishii KJ, Weiss WR, Klinman DM (1999) Prevention of neonatal tolerance by a plasmid encoding granulocyte-macrophage colony stimulating factor. Vaccine 18: 703-710
    • (1999) Vaccine , vol.18 , pp. 703-710
    • Ishii, K.J.1    Weiss, W.R.2    Klinman, D.M.3
  • 21
    • 0042834290 scopus 로고    scopus 로고
    • Successful induction of CD8 T cell-dependent protection against malaria by sequential immunization with DNA and recombinant poxvirus of neonatal mice born to immune mothers
    • Sedegah M, Belmonte M, Epstein JE, Siegrist CA, Weiss WR, Jones TR, et al (2003) Successful induction of CD8 T cell-dependent protection against malaria by sequential immunization with DNA and recombinant poxvirus of neonatal mice born to immune mothers. J Immunol 171: 3148-3153
    • (2003) J Immunol , vol.171 , pp. 3148-3153
    • Sedegah, M.1    Belmonte, M.2    Epstein, J.E.3    Siegrist, C.A.4    Weiss, W.R.5    Jones, T.R.6
  • 22
    • 18844463657 scopus 로고    scopus 로고
    • Improving protective immunity induced by DNA-based immunization: Priming with antigen and GM-CSF-encoding plasmid DNA and boosting with antigen-expressing recombinant poxvirus
    • Sedegah M, Weiss W, Sacci JB Jr, Charoenvit Y, Hedstrom R, Gowda K, et al (2000) Improving protective immunity induced by DNA-based immunization: priming with antigen and GM-CSF-encoding plasmid DNA and boosting with antigen-expressing recombinant poxvirus. J Immunol 164: 5905-5912
    • (2000) J Immunol , vol.164 , pp. 5905-5912
    • Sedegah, M.1    Weiss, W.2    Sacci Jr, J.B.3    Charoenvit, Y.4    Hedstrom, R.5    Gowda, K.6
  • 23
    • 0036083954 scopus 로고    scopus 로고
    • Persistence of protective immunity to malaria induced by DNA priming and poxvirus boosting: Characterization of effector and memory CD8(+)-T-cell populations
    • Sedegah M, Brice GT, Rogers WO, Doolan DL, Charoenvit Y, Jones TR, et al (2002) Persistence of protective immunity to malaria induced by DNA priming and poxvirus boosting: characterization of effector and memory CD8(+)-T-cell populations. Infect Immun 70: 3493-3499
    • (2002) Infect Immun , vol.70 , pp. 3493-3499
    • Sedegah, M.1    Brice, G.T.2    Rogers, W.O.3    Doolan, D.L.4    Charoenvit, Y.5    Jones, T.R.6
  • 24
    • 8844245611 scopus 로고    scopus 로고
    • Effect on antibody and T-cell responses of mixing five GMP-produced DNA plasmids and administration with plasmid expressing GM-CSF
    • Sedegah M, Charoenvit Y, Aguiar J, Sacci J, Hedstrom R, Kumar S, et al (2004) Effect on antibody and T-cell responses of mixing five GMP-produced DNA plasmids and administration with plasmid expressing GM-CSF. Genes Immun 5: 553-561
    • (2004) Genes Immun , vol.5 , pp. 553-561
    • Sedegah, M.1    Charoenvit, Y.2    Aguiar, J.3    Sacci, J.4    Hedstrom, R.5    Kumar, S.6
  • 25
    • 0034728778 scopus 로고    scopus 로고
    • Direct immunization of malaria DNA vaccine into the liver by gene gun protects against lethal challenge of Plasmodium berghei sporozoite
    • Yoshida S, Kashiwamura SI, Hosoya Y, Luo E, Matsuoka H, Ishii A, et al (2000) Direct immunization of malaria DNA vaccine into the liver by gene gun protects against lethal challenge of Plasmodium berghei sporozoite. Biochem Biophys Res Commun 271: 107-115
    • (2000) Biochem Biophys Res Commun , vol.271 , pp. 107-115
    • Yoshida, S.1    Kashiwamura, S.I.2    Hosoya, Y.3    Luo, E.4    Matsuoka, H.5    Ishii, A.6
  • 26
    • 0035850961 scopus 로고    scopus 로고
    • Enhancement of the immune response in rabbits to a malaria DNA vaccine by immunization with a needle-free jet device
    • Aguiar JC, Hedstrom RC, Rogers WO, Charoenvit Y, Sacci JB Jr, Lanar DE, et al (2001) Enhancement of the immune response in rabbits to a malaria DNA vaccine by immunization with a needle-free jet device. Vaccine 20: 275-280
    • (2001) Vaccine , vol.20 , pp. 275-280
    • Aguiar, J.C.1    Hedstrom, R.C.2    Rogers, W.O.3    Charoenvit, Y.4    Sacci Jr, J.B.5    Lanar, D.E.6
  • 27
    • 0034860454 scopus 로고    scopus 로고
    • Multistage multiantigen heterologous prime boost vaccine for Plasmodium knowlesi malaria provides partial protection in rhesus macaques
    • Rogers WO, Baird JK, Kumar A, Tine JA, Weiss W, Aguiar JC, et al (2001) Multistage multiantigen heterologous prime boost vaccine for Plasmodium knowlesi malaria provides partial protection in rhesus macaques. Infect Immun 69: 5565-5572
    • (2001) Infect Immun , vol.69 , pp. 5565-5572
    • Rogers, W.O.1    Baird, J.K.2    Kumar, A.3    Tine, J.A.4    Weiss, W.5    Aguiar, J.C.6
  • 29
    • 0036377874 scopus 로고    scopus 로고
    • Safety, tolerability, and lack of antibody responses after administration of a PfCSP DNA malaria vaccine via needle or needle-free jet injection, and comparison of intramuscular and combination intramuscular/ intradermal routes
    • Epstein JE, Gorak EJ, Charoenvit Y, Wang R, Freydberg N, Osinowo O, et al (2002) Safety, tolerability, and lack of antibody responses after administration of a PfCSP DNA malaria vaccine via needle or needle-free jet injection, and comparison of intramuscular and combination intramuscular/ intradermal routes. Hum Gene Ther 13: 1551-1560
    • (2002) Hum Gene Ther , vol.13 , pp. 1551-1560
    • Epstein, J.E.1    Gorak, E.J.2    Charoenvit, Y.3    Wang, R.4    Freydberg, N.5    Osinowo, O.6
  • 30
    • 11144357988 scopus 로고    scopus 로고
    • Safety, tolerability, and antibody responses in humans after sequential immunization with a PfCSP DNA vaccine followed by the recombinant protein vaccine RTS,S/AS02A
    • Epstein JE, Charoenvit Y, Kester KE, Wang R, Newcomer R, Fitzpatrick S, et al (2004) Safety, tolerability, and antibody responses in humans after sequential immunization with a PfCSP DNA vaccine followed by the recombinant protein vaccine RTS,S/AS02A. Vaccine 22: 1592-1603
    • (2004) Vaccine , vol.22 , pp. 1592-1603
    • Epstein, J.E.1    Charoenvit, Y.2    Kester, K.E.3    Wang, R.4    Newcomer, R.5    Fitzpatrick, S.6
  • 31
    • 11144356341 scopus 로고    scopus 로고
    • Induction in humans of CD8+ and CD4+ T cell and antibody responses by sequential immunization with malaria DNA and recombinant protein
    • Wang R, Epstein J, Charoenvit Y, Baraceros FM, Rahardjo N, Gay T, et al (2004) Induction in humans of CD8+ and CD4+ T cell and antibody responses by sequential immunization with malaria DNA and recombinant protein. J Immunol 172: 5561-5569
    • (2004) J Immunol , vol.172 , pp. 5561-5569
    • Wang, R.1    Epstein, J.2    Charoenvit, Y.3    Baraceros, F.M.4    Rahardjo, N.5    Gay, T.6
  • 32
    • 0036597928 scopus 로고    scopus 로고
    • Targeting epidermal Langerhans cells by epidermal powder immunization
    • Chen D, Payne LG (2002) Targeting epidermal Langerhans cells by epidermal powder immunization. Cell Res 12: 97-104
    • (2002) Cell Res , vol.12 , pp. 97-104
    • Chen, D.1    Payne, L.G.2
  • 33
    • 0031573524 scopus 로고    scopus 로고
    • Immune responses induced by intramuscular or gene gun injection of protective deoxyribonucleic acid vaccines that express the circumsporozoite protein from Plasmodium berghei malaria parasites
    • Leitner WW, Seguin MC, Ballou WR, Seitz JP, Schultz AM, Sheehy MJ, et al (1997) Immune responses induced by intramuscular or gene gun injection of protective deoxyribonucleic acid vaccines that express the circumsporozoite protein from Plasmodium berghei malaria parasites. J Immunol 159: 6112-6119
    • (1997) J Immunol , vol.159 , pp. 6112-6119
    • Leitner, W.W.1    Seguin, M.C.2    Ballou, W.R.3    Seitz, J.P.4    Schultz, A.M.5    Sheehy, M.J.6
  • 34
    • 0033797173 scopus 로고    scopus 로고
    • Genetic vaccination against malaria infection by intradermal and epidermal injections of a plasmid containing the gene encoding the Plasmodium berghei circumsporozoite protein
    • Weiss R, Leitner WW, Scheiblhofer S, Chen D, Bernhaupt A, Mostbock S, et al (2000) Genetic vaccination against malaria infection by intradermal and epidermal injections of a plasmid containing the gene encoding the Plasmodium berghei circumsporozoite protein. Infect Immun 68: 5914-5919
    • (2000) Infect Immun , vol.68 , pp. 5914-5919
    • Weiss, R.1    Leitner, W.W.2    Scheiblhofer, S.3    Chen, D.4    Bernhaupt, A.5    Mostbock, S.6
  • 35
    • 0035085052 scopus 로고    scopus 로고
    • Removal of the circumsporozoite protein (CSP) glycosylphosphatidylinositol signal sequence from a CSP DNA vaccine enhances induction of CSP-specific Th2 type immune responses and improvesprotection against malaria infection
    • Scheiblhofer S, Chen D, Weiss R, Khan F, Mostbock S, Fegeding K, et al (2001) Removal of the circumsporozoite protein (CSP) glycosylphosphatidylinositol signal sequence from a CSP DNA vaccine enhances induction of CSP-specific Th2 type immune responses and improvesprotection against malaria infection. Eur J Immunol 31: 692-698
    • (2001) Eur J Immunol , vol.31 , pp. 692-698
    • Scheiblhofer, S.1    Chen, D.2    Weiss, R.3    Khan, F.4    Mostbock, S.5    Fegeding, K.6
  • 37
    • 0037408159 scopus 로고    scopus 로고
    • Predominant cell-mediated immunity in the oral mucosa: Gene gun-based vaccination against infectious diseases
    • Wang J, Murakami T, Yoshida S, Matsuoka H, Ishii A, Tanaka T, et al (2003) Predominant cell-mediated immunity in the oral mucosa: gene gun-based vaccination against infectious diseases. J Dermatol Sci 31: 203-210
    • (2003) J Dermatol Sci , vol.31 , pp. 203-210
    • Wang, J.1    Murakami, T.2    Yoshida, S.3    Matsuoka, H.4    Ishii, A.5    Tanaka, T.6
  • 38
    • 33747356806 scopus 로고    scopus 로고
    • Heterologous primeboost immunization in rhesus macaques by two, optimally spaced particle-mediated epidermal deliveries of Plasmodium falciparum circumsporozoite protein-encoding DNA, followed by intramuscular RTS,S/AS02A
    • Walsh DS, Gettayacamin M, Leitner WW, Lyon JA, Stewart VA, Marit G, et al (2006) Heterologous primeboost immunization in rhesus macaques by two, optimally spaced particle-mediated epidermal deliveries of Plasmodium falciparum circumsporozoite protein-encoding DNA, followed by intramuscular RTS,S/AS02A. Vaccine 24: 4167-4178
    • (2006) Vaccine , vol.24 , pp. 4167-4178
    • Walsh, D.S.1    Gettayacamin, M.2    Leitner, W.W.3    Lyon, J.A.4    Stewart, V.A.5    Marit, G.6
  • 39
    • 0034701959 scopus 로고    scopus 로고
    • Expression library immunization protects mice against a challenge with virulent rodent malaria
    • Smooker PM, Setiady YY, Rainczuk A, Spithill TW (2000) Expression library immunization protects mice against a challenge with virulent rodent malaria. Vaccine 18: 2533-2540
    • (2000) Vaccine , vol.18 , pp. 2533-2540
    • Smooker, P.M.1    Setiady, Y.Y.2    Rainczuk, A.3    Spithill, T.W.4
  • 40
    • 32544448799 scopus 로고    scopus 로고
    • Vaxfectin enhances immunogenicity and protective efficacy of P. yoelii circumsporozoite DNA vaccines
    • Sedegah M, Rogers WO, Belmonte A, Belmonte M, Banania G, Patterson N, et al (2006) Vaxfectin enhances immunogenicity and protective efficacy of P. yoelii circumsporozoite DNA vaccines. Vaccine 24: 1921-1927
    • (2006) Vaccine , vol.24 , pp. 1921-1927
    • Sedegah, M.1    Rogers, W.O.2    Belmonte, A.3    Belmonte, M.4    Banania, G.5    Patterson, N.6
  • 41
    • 0142199964 scopus 로고    scopus 로고
    • Hepatitis B DNA vaccine induces protective antibody responses in human non-responders to conventional vaccination
    • Rottinghaus ST, Poland GA, Jacobson RM, Barr LJ, Roy MJ (2003) Hepatitis B DNA vaccine induces protective antibody responses in human non-responders to conventional vaccination. Vaccine 21: 4604-4608
    • (2003) Vaccine , vol.21 , pp. 4604-4608
    • Rottinghaus, S.T.1    Poland, G.A.2    Jacobson, R.M.3    Barr, L.J.4    Roy, M.J.5
  • 42
    • 18344403351 scopus 로고    scopus 로고
    • In vitro expression and in vivo immunogenicity of Plasmodium falciparum pre-erythrocytic stage DNA vaccines
    • Hedstrom RC, Doolan DL, Wang R, Kumar A, Sacci JB Jr, Gardner MJ, et al (1998) In vitro expression and in vivo immunogenicity of Plasmodium falciparum pre-erythrocytic stage DNA vaccines. Int J Mol Med 2: 29-38
    • (1998) Int J Mol Med , vol.2 , pp. 29-38
    • Hedstrom, R.C.1    Doolan, D.L.2    Wang, R.3    Kumar, A.4    Sacci Jr, J.B.5    Gardner, M.J.6
  • 43
    • 0031691783 scopus 로고    scopus 로고
    • Simultaneous induction of multiple antigen-specific cytotoxic T lymphocytes in non-human primates by immunization with a mixture of four Plasmodium falciparum DNA plasmids
    • Wang R, Doolan DL, Charoenvit Y, Hedstrom RC, Gardner MJ, Hobart P, et al (1998) Simultaneous induction of multiple antigen-specific cytotoxic T lymphocytes in non-human primates by immunization with a mixture of four Plasmodium falciparum DNA plasmids. Infect Immun 66: 4193-4202
    • (1998) Infect Immun , vol.66 , pp. 4193-4202
    • Wang, R.1    Doolan, D.L.2    Charoenvit, Y.3    Hedstrom, R.C.4    Gardner, M.J.5    Hobart, P.6
  • 44
    • 0031960365 scopus 로고    scopus 로고
    • Multi-plasmid DNA vaccination avoids antigenic competition and enhances immunogenicity of a poorly immunogenic plasmid
    • Grifantini R, Finco O, Bartolini E, Draghi M, Del Giudice G, Kocken C, et al (1998) Multi-plasmid DNA vaccination avoids antigenic competition and enhances immunogenicity of a poorly immunogenic plasmid. Eur J Immunol 28: 1225-1232
    • (1998) Eur J Immunol , vol.28 , pp. 1225-1232
    • Grifantini, R.1    Finco, O.2    Bartolini, E.3    Draghi, M.4    Del Giudice, G.5    Kocken, C.6
  • 45
    • 0033529699 scopus 로고    scopus 로고
    • Construction and immunogenicity of DNA vaccine plasmids encoding four Plasmodium vivax candidate vaccine antigens
    • Rogers WO, Gowda K, Hoffman SL (1999) Construction and immunogenicity of DNA vaccine plasmids encoding four Plasmodium vivax candidate vaccine antigens. Vaccine 17: 3136-3144
    • (1999) Vaccine , vol.17 , pp. 3136-3144
    • Rogers, W.O.1    Gowda, K.2    Hoffman, S.L.3
  • 47
    • 0032560547 scopus 로고    scopus 로고
    • Boosting with recombinant vaccinia increases immunogenicity and protective efficacy of malaria DNA vaccine
    • Sedegah M, Jones TR, Kaur M, Hedstrom R, Hobart P, Tine JA, et al (1998) Boosting with recombinant vaccinia increases immunogenicity and protective efficacy of malaria DNA vaccine. Proc Natl Acad Sci USA 95: 7648-7653
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7648-7653
    • Sedegah, M.1    Jones, T.R.2    Kaur, M.3    Hedstrom, R.4    Hobart, P.5    Tine, J.A.6
  • 48
    • 0031924077 scopus 로고    scopus 로고
    • Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara
    • Schneider J, Gilbert SC, Blanchard TJ, Hanke T, Robson KJ, Hannan CM, et al (1998) Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara. Nat Med 4: 397-402
    • (1998) Nat Med , vol.4 , pp. 397-402
    • Schneider, J.1    Gilbert, S.C.2    Blanchard, T.J.3    Hanke, T.4    Robson, K.J.5    Hannan, C.M.6
  • 49
    • 0345447538 scopus 로고    scopus 로고
    • DNA prime-protein boost immunization in monkeys: Efficacy of a novel construct containing functional domains of Plasmodium cynomolgi CS and TRAP
    • Bhardwaj D, Kushwaha A, Puri SK, Herrera A, Singh N, Chauhan VS (2003) DNA prime-protein boost immunization in monkeys: efficacy of a novel construct containing functional domains of Plasmodium cynomolgi CS and TRAP. FEMS Immunol Med Microbiol 39: 241-250
    • (2003) FEMS Immunol Med Microbiol , vol.39 , pp. 241-250
    • Bhardwaj, D.1    Kushwaha, A.2    Puri, S.K.3    Herrera, A.4    Singh, N.5    Chauhan, V.S.6
  • 50
    • 33244471717 scopus 로고    scopus 로고
    • Pre-erythrocytic malaria vaccines: Towards greater efficacy
    • Hill AV (2006) Pre-erythrocytic malaria vaccines: towards greater efficacy. Nat Rev Immunol 6: 21-32
    • (2006) Nat Rev Immunol , vol.6 , pp. 21-32
    • Hill, A.V.1
  • 51
  • 52
    • 0033586277 scopus 로고    scopus 로고
    • Plasmid DNA malaria vaccine: The potential for genomic integration after intramuscular injection
    • Martin T, Parker SE, Hedstrom R, Le T, Hoffman SL, Norman J, et al (1999) Plasmid DNA malaria vaccine: the potential for genomic integration after intramuscular injection. Hum Gene Ther 10: 759-768
    • (1999) Hum Gene Ther , vol.10 , pp. 759-768
    • Martin, T.1    Parker, S.E.2    Hedstrom, R.3    Le, T.4    Hoffman, S.L.5    Norman, J.6
  • 54
    • 0034469447 scopus 로고    scopus 로고
    • Plasmid DNA vaccines: Tissue distribution and effects of DNA sequence, adjuvants and delivery method on integration into host DNA
    • Manam S, Ledwith BJ, Barnum AB, Troilo PJ, Pauley CJ, Harper LB, et al (2000) Plasmid DNA vaccines: tissue distribution and effects of DNA sequence, adjuvants and delivery method on integration into host DNA. Intervirology 43: 273-281
    • (2000) Intervirology , vol.43 , pp. 273-281
    • Manam, S.1    Ledwith, B.J.2    Barnum, A.B.3    Troilo, P.J.4    Pauley, C.J.5    Harper, L.B.6
  • 55
    • 0141958017 scopus 로고    scopus 로고
    • Safety evaluation of GX-12, a new HIV therapeutic vaccine: Investigation of integration into the host genome and expression in the reproductive organs
    • Kang KK, Choi SM, Choi JH, Lee DS, Kim CY, Ahn BO, et al (2003) Safety evaluation of GX-12, a new HIV therapeutic vaccine: investigation of integration into the host genome and expression in the reproductive organs. Intervirology 46: 270-276
    • (2003) Intervirology , vol.46 , pp. 270-276
    • Kang, K.K.1    Choi, S.M.2    Choi, J.H.3    Lee, D.S.4    Kim, C.Y.5    Ahn, B.O.6
  • 56
    • 0032538597 scopus 로고    scopus 로고
    • Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine
    • Wang R, Doolan DL, Le TP, Hedstrom RC, Coonan KM, Charoenvit Y, et al (1998) Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science 282: 476-480
    • (1998) Science , vol.282 , pp. 476-480
    • Wang, R.1    Doolan, D.L.2    Le, T.P.3    Hedstrom, R.C.4    Coonan, K.M.5    Charoenvit, Y.6
  • 57
    • 0034002258 scopus 로고    scopus 로고
    • Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers
    • Le TP, Coonan KM, Hedstrom RC, Charoenvit Y, Sedegah M, Epstein JE, et al (2000) Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers. Vaccine 18: 1893-1901
    • (2000) Vaccine , vol.18 , pp. 1893-1901
    • TP, L.1    Coonan, K.M.2    Hedstrom, R.C.3    Charoenvit, Y.4    Sedegah, M.5    Epstein, J.E.6
  • 58
    • 4143053709 scopus 로고    scopus 로고
    • Preliminary results of an anticircumsporozoite DNA vaccine trial for protection against avian malaria in captive African black-footed penguins (Spheniscus demersus)
    • Grim KC, McCutchan T, Li J, Sullivan M, Graczyk TK, McConkey G, et al (2004) Preliminary results of an anticircumsporozoite DNA vaccine trial for protection against avian malaria in captive African black-footed penguins (Spheniscus demersus). J Zoo Wildl Med 35: 154-161
    • (2004) J Zoo Wildl Med , vol.35 , pp. 154-161
    • Grim, K.C.1    McCutchan, T.2    Li, J.3    Sullivan, M.4    Graczyk, T.K.5    McConkey, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.