Removal of the circumsporozoite protein (CSP) glycosylphosphatidylinositol signal sequence from a CSP DNA vaccine enhances induction of CSP-specific Th2 type immune responses and improves protection against malaria infection

European Journal of Immunology

Volumn 31, Issue 3, 2001, Pages 692-698

  Scheiblhofer, Sandra ^a   Chen, Defeng ^b   Weiss, Richard ^a   Khan, Farhat ^b   Mostböck, Sven ^a   Fegeding, Konstantin ^b   Leitner, Wolfgang W ^b   Thalhamer, Josef ^a,c   Lyon, Jeffrey A ^b  

^a UNIVERSITY OF SALZBURG   (Austria)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Circumsporozoite protein; DNA vaccine; Gene gun; Glycosylphosphatidylinositol anchor

Indexed keywords

CELL SURFACE PROTEIN; DNA VACCINE; GENE PRODUCT; GLYCOSYLPHOSPHATIDYLINOSITOL; IMMUNOGLOBULIN G; SPOROZOITE VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; CELL POLARITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GENE CONSTRUCT; GENE SEQUENCE; GENETIC ENGINEERING; IMMUNE RESPONSE; IMMUNIZATION; MALARIA; MOUSE; MOUSE STRAIN; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN SECRETION; SIGNAL TRANSDUCTION; SOLUBILITY; SPOROZOITE; TH2 CELL;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; BIOLISTICS; FEMALE; GLYCOSYLPHOSPHATIDYLINOSITOLS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN ISOTYPES; MALARIA; MICE; MICE, INBRED BALB C; PLASMODIUM BERGHEI; PROTEIN SORTING SIGNALS; PROTOZOAN PROTEINS; SEQUENCE DELETION; TH2 CELLS; TIME FACTORS; VACCINES, DNA;

EID: 0035085052     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200103)31:3<692::AID-IMMU692>3.0.CO;2-Y     Document Type: Article

References (21)

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3. An internally positioned signal can direct attachment of a glycophospholipid membrane anchor
4. The structure and biosynthesis of glycosyl phosphatidylinositol protein anchors
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