Synthesis of novel 5,6-substituted furo[2,3-d]pyrimidines via Pd-catalyzed cyclization of alkynylpyrimidinols with aryl iodides

Tetrahedron

Volumn 63, Issue 9, 2007, Pages 1931-1936

  Liu, Zhende ^a   Li, Dewen ^a   Li, Shukun ^a   Bai, Donglu ^a   He, Xuchang ^a   Hu, Youhong ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Furo 2,3 d pyrimidines; Palladium catalyzed cyclization; Sonogashira coupling reaction

Indexed keywords

2,4 DIMETHYL 5 (THIOPHEN 2 YL) 6 4 TOLYLFURO[2,3 D]PYRIMIDINE; 2,4 DIMETHYL 5 PHENYL 6 4 TOLYLFURO[2,3 D]PYRIMIDINE; 4 [5 (4 METHOXYPHENYL) 4 METHYL 2 PHENYLFURO[2,3 D]PYRIMIDIN 6 YL]BUTANONITRILE; 5 (4 METHOXYPHENYL) 2,4 DIMETHYL 6 4 TOLYLFURO[2,3 D]PYRIMIDINE; 5,6 BIS(4 METHOXYPHENYL) 2,4 DIMETHYLFURO[2,3 D]PYRIMIDINE; 5,6 BIS(4 METHOXYPHENYL) 4 METHYL 2 PHENYLFURO[2,3 D]PYRIMIDINE; 6 (2 FLUOROPHENYL) 5 (4 METHOXYPHENYL) 2,4 DIMETHYLFURO[2,3 D]PYRIMIDINE; 6 (2 FLUOROPHENYL) 5 (4 METHOXYPHENYL) 4 METHYL 2 PHENYLFURO[2,3 D]PYRIMIDINE; 6 [4 (TRIFLUOROMETHYL)PHENYL] 5 (4 METHOXYPHENYL) 2,4 DIMETHYLFURO[2,3 D]PYRIMIDINE; 6 [4 (TRIFLUOROMETHYL)PHENYL] 5 (4 METHOXYPHENYL) 4 METHYL 2 PHENYLFURO[2,3 D]PYRIMIDINE; ALKYNYL GROUP; FURO[2,3 D]PYRIMIDINE DERIVATIVE; IODINE DERIVATIVE; METHYL 4 (2,4 DIMETHYL 6 4 TOLYLFURO[2,3 D]PYRIMIDIN 5 YL)BENZOATE; PALLADIUM; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CYCLIZATION; DRUG SYNTHESIS; METHODOLOGY; PRIORITY JOURNAL;

EID: 33846394998     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2006.12.077     Document Type: Article

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