Structure of tick anticoagulant peptide at 1.6 Å resolution complexed with bovine pancreatic trypsin inhibitor

Protein Science

Volumn 9, Issue 2, 2000, Pages 265-272

  St Charles, Robert ^a   Padmanabhan, K ^a,b   Arni, R V ^a,c   Padmanabhan, K P ^a   Tulinsky, A ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Michigan State University   (United States)

^c SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Bovine pancreatic trypsin inhibitor; Conformational changes; Factor Xa, tick anticoagulant peptide

Indexed keywords

ANTICOAGULANT AGENT; APROTININ; BLOOD CLOTTING FACTOR 10A; TETRAPEPTIDE;

ARTICLE; BLOOD CLOTTING; CRYSTAL STRUCTURE; HYDROGEN BOND; MOLECULAR INTERACTION; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; TICK; X RAY CRYSTALLOGRAPHY;

ACARI; BOVINAE;

EID: 0034005173     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.9.2.265     Document Type: Article

References (27)

1. Antuch W, Guntert P, Billeter M, Hawthorne T, Grossenbacher H, Wuthrich K. 1994. NMR solution structure of the recombinant tick anticoagulant protein (rTAP), a factor Xa inhibitor from the tick Ornithodoros moubata. FEBS Lett 352:251-257.
2. Bode W, Huber R. 1992. Natural protein proteinase inhibitors and their interaction with proteinases. Eur J Biochem 204:433-451.
3. Brandstetter H, Kuhns A, Bode W, Huber R, van der Saal W, Withersohn K, Engh RA. 1996. X-ray structure of active site-inhibited clotting factor Xa. J Biol Chem 271:29988-29992.
4. Brünger AT. 1998. Crystallography and NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D54:905-921.
5. Dougherty DA, Stauffer DA. 1990. Acetylcholine binding by a synthetic receptor: Implications for biological recognition. Science 250:1558-1560.
6. Dunwiddie CT, Neeper MP, Nutt EM, Waxman L, Smith DE, Hofmann KJ, Lumma PK, Garsky VM, Vlasuk GP. 1992. Site-directed analysis of the functional domains in the factor Xa inhibitor tick anticoagulant peptide. Biochemistry 31:12126-12131.
7. Higashi T. 1990. Auto-indexing of oscillation images. J Appl Crystallogr 23:252-257.
8. Jordan SP, Mao SS, Lewis SD, Shafer JA. 1992. Reaction pathways for inhibition of blood coagulation factor Xa by tick anticoagulant peptide. Biochemistry 31:5374-5380.
9. Laskowski RA, MacArthur MW, Moss DS, Thorton JM. 1993. PROCHECK: A program to check the stereochemical quality of protein structures. J Appl Crystallogr 26:283-291.
10. Lim-Wilby MSL, Hallenga K, de Maeyer M, Lasters I, Vlasuk GP, Brunck TK. 1995. NMR structure determination of tick anticoagulant peptide (TAP). Protein Sci 4:178-186.
11. Lin Z, Johnson ME. 1995. Proposed cation-π mediated binding by factor Xa. FEBS Lett 370:1-5.
12. Lubkowski J, Wlodawer A. 1999. Decamers observed in crystals of bovine pancreatic trypsin inhibitor. Acta Crystallogr D55:.335-337.
13. Marquart M, Walter J, Deisenhofer J, Bode W, Huber R. 1983. The geometry of the reactive site and the peplide groups in trypsin, trypsinogen and its complexes with inhibitors. Acta Crystallogr B39:480-490.
14. Mochalkin I, Tulinsky A. 1999. Structures of thrombin retro-inhibited with SEL2711 and SEL2770 as they relate to factor Xa binding. Acta Crystallogr D55:785-793.
15. Navaza J. 1994. AMoRe: An automated package for molecular replacement. Acta Crystallogr A50:157-163.
16. Nicholls A, Sharp KA, Honig B. 1991. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins 11:281-296.
17. Nienaber VL, Amparo EC. 1996. A noncleavable retro-binding peptide that spans the substrate binding cleft of serine proteases. J Am Chem Soc 118:6807-6810.
18. Rydel TJ, Tulinsky A, Bode W, Huber R. 1991. Refined structure of the hirudin-thrombin complex. J Mol Biol 221:583-601.
19. Schechter I, Berger A. 1967. On the size of the active site in proteases. Biochem Biophys Res Commun 27:157-162.
20. Schwabacher AW, Zhang S, Davy W. 1993. Directionality of the cation-π effect: A charge-mediated size selectivity in binding. J Am Chem Soc 115:6995-6996.
21. Tabernero L, Chang CY, Ohringer SL, Lau WF, Iwanowicz EJ, Han WC, Wang TC, Seiler SM, Roberts DGM, Sack JS. 1995. Structure of a retro-binding peptide inhibitor complexed with human α-thrombin. J Mol Biol 246:14-20.
22. van de Locht A, Stubbs MT, Bode W, Friedrich T, Bollschweiler C, Hoffken W, Huber R. 1996. The ornithodorin-thrombin crystal structure, a key to the TAP enigma? EMBO J 15:6011-6017.
23. Waxman L, Smith DE, Arcuri KE, Vlasuk GP. 1990. Tick anticoagulant peptide (TAP) is a novel inhibitor of blood coagulation factor Xa. Science 248:593-596.
24. Wei A, Alexander RS, Duke J, Ross H, Rosenfeld SA, Chang C. 1998. Unexpected binding mode of tick anticoagulant peptide complexed with bovine factor Xa. J Mol Biol 283:147-154.
25. Wlodawer A, Deisenhofer J, Huber R. 1987a. Comparison of two highly refined structures of bovine pancreatic trypsin inhibitor. J Mol Biol 193:145-156.
26. Wlodawer A, Nachman J, Gilliland GL, Gallagher W, Woodward C. 1987b. Structure of form III crystals of bovine pancreatic trypsin inhibitor. J Mol Biol 198:469-480.
27. 1 binding site of thrombin. Biophys Chem 63:185-200.