Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder

American Journal of Psychiatry

Volumn 155, Issue 6, 1998, Pages 835-837

  Lachman, Herbert M ^a   Nolan, Karen A ^b   Mohr, Pavel ^b   Saito, Takuya ^b   Volavka, Jan ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE; CATECHOLAMINE;

AGGRESSION; ALLELE; ARTICLE; ENZYME ACTIVITY; FEMALE; GENE FREQUENCY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCHIZOIDISM; SCHIZOPHRENIA; VIOLENCE;

ADULT; AGGRESSION; CATECHOL O-METHYLTRANSFERASE; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; VIOLENCE;

EID: 0031800071     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Pucilowski O, Kozak W, Valzelli L: Effect of 6-OHDA injected into the locus ceruleus on apomorphine-induced aggression. Pharmacol Biochem Behav 1986; 24:773-775
2. Coccaro EF, Lawrence T, Trestman R, Gabriel S, Klar HM, Siever LJ: Growth hormone responses to intravenous clonidine challenge correlate with behavioral irritability in psychiatric patients and healthy volunteers. Psychiatry Res 1991; 39:129-139
3. Ratey JJ, Gordon A: The psychopharmacology of aggression: toward a new day. Psychopharmacol Bull 1993; 29:65-73
4. Axelrod J, Tomchick R: Enzymatic O-methylation of epinephrine and other catechols. J Biol Chem 1958; 233:702-705
5. Weinshilboum RM, Raymond FA: Inheritance of low erythro-cyte catechol-O-methyltransferase activity in man. Am J Hum Genet 1977; 29:125-135
6. Boudikova B, Szumlanski C, Maidak B, Weinshilboum R: Human liver catechol-O-methyltransferase pharmacogenetics. Clin Pharmacol Ther 1990; 48:381-389
7. Spielman RS, Weinshilboum RM: Genetics of red cell COMT activity: analysis of thermal stability and family data. Am J Med Genet 1981; 10:279-290
8. Lotta T, Vidgren J, Tilgmann C, Ulmanen I, Melen K, Julkunen I, Taskinen J: Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 1995; 34:4202-4210
9. Lachman H, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM: Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatrie disorders. Pharmacogenetics 1996; 6:243-250
10. Karayiorgou M, Altemus M, Galke BL, Goldman D, Murphy DL, Ott J, Gogos JA: Genotype determining low catechol-Omethyltransferase activity as a risk factor for obsessive-compulsive disorder. Proc Natl Acad Sci USA 1997; 94:4572-575
11. Lachman HM, Morrow B, Shprintzen R, Veit S, Parsia SS, Faedda G, Goldberg R, Kucherlapati R, Papolos DF: Association of codon 108/158 catechol O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome. Am I Med Genet Neuropsychiatr Genet 1996; 67: 468-472
12. Strous RD, Bark N, Woerner M, Lachman HM: Lack of association of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia. Biol Psychiatry 1997; 41:493-495
13. Strous RD, Bark N, Parsia SS, Volavka J, Lachman HM: Analysis of a functional catechol O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior. Psychiatry Res 1997; 69:71-77
14. Sorgi PJ, Ratey JJ, Polakoff S: β-Adrenergic biockers for the control of aggressive behaviors in patients with chronic schizophrenia. Am J Psychiatry 1986; 143:775-776
15. Volavka J: Can aggressive behavior in humans be modified by bera blockers? Postgraduate Med Special Issue, Feb 29,1988, pp 163-168
16. Brunner HG, Nelen M, Breakfield XO, Ropers HH, van Oost BA: Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 1995; 262: 578-580
17. Syvanen AC, Tilgmann C, Rinne J, Ulmanen I: Genetic polymorphism of carecholamine O-methyltransferase (COMT); correlation of genotype with individual variation of S-COMT activity and comparison of the allele frequencies in the normal population and parkinsonian patients in Finland. Pharmacogenetics 1997; 7:65-71
18. McLeod HL, Fang L, Luo X, Scott EP, Evans WE: Ethnic differences in erythrocyte catechol O-methyltransferase activity in black and white Americans. J Pharmacol Exp Ther 1994; 270: 26-29