Activation and role of mitogen-activated protein kinases in deoxycholic acid-induced apoptosis

Carcinogenesis

Volumn 22, Issue 1, 2001, Pages 35-41

  Qiao, D ^a   Stratagouleas, E D ^a   Martinez, J D ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; DEOXYCHOLIC ACID; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR PROMOTER;

ADENOCARCINOMA; APOPTOSIS; ARTICLE; COLON CARCINOGENESIS; COLON TUMOR; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; GENETICS; HUMAN; HUMAN CELL; IN VITRO STUDY; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR PROMOTION;

EID: 0035135599     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/22.1.35     Document Type: Article

References (42)

1. Increased serum deoxycholic acid levels in men with colorectal adenomas
2. Large-bowel carcinogenesis: Fecal constituents of populations with diverse incidence rates of colon cancer
3. Metabolic epidemiology of colon cancer. Fecal bile acids and neutral sterols in colon cancer patients and patients with adenomatous polyps
4. Fecal profiles of anaerobic microflora of large bowel cancer patients and patients with nonhereditary large bowel polyps
5. Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats
6. The effect of chenodeoxycholic acid on the development of aberrant crypt foci in the rat colon
7. Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N'-nitro-N-nitrosoguanidine in rats
8. Effect of change of fecal bile acid excretion achieved by operative procedures on 1,2-dimethylhydrazine-induced colon cancer in rats
9. Dihydroxy bile acids activate the transcription of cyclooxygenase-2
10. Bile acid activation of the GADD153 promoter and of p53-independent apoptosis: Relevance to colon cancer
11. Bile acid-induced activation of activator protein-1 requires both extracellular signal-regulated kinase and protein kinase C signaling
12. The stress-response proteins poly(ADP-ribose) polymerase and NF-κB protect against bile salt-induced apoptosis
13. Effects of different bile salts on steady-state mRNA levels and transcriptional activity of cholesterol 7 alpha-hydroxylase
14. Suppression of sterol 27-hydroxylase mRNA and transcriptional activity by bile acids in cultured rat hepatocytes
15. Identification and characterization of a putative bile acid-responsive element in cholesterol 7 alpha-hydroxylase gene promoter
16. Repression of cholesterol 7 alpha-hydroxylase transcription by bile acids is mediated through protein kinase C in primary cultures of rat hepatocytes
17. Activation of protein kinase C alpha and delta by bile acids: Correlation with bile acid structure and diacylglycerol formation
18. The regulation of protein kinase C by chenodeoxycholate, deoxycholate and several structurally related bile acids
19. Bile salt-induced apoptosis of hepatocytes involves activation of protein kinase C
20. Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human
21. The MAPK signaling cascade
22. Regulation of bad phosphorylation and association with Bcl-x (L) by the MAPK/Erk kinase
23. Sustained mitogen-activated protein kinase (MAPK) and cytoplasmic phospholipase A2 activation by macrophage migration inhibitory factor (MIF). Regulatory role in cell proliferation and glucocorticoid action
24. Cdk5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain
25. Regulation of transcription by MAP kinase cascades
26. Different bile acids exhibit distinct biological effects: The tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation
27. Signal transduction within the nucleus by mitogen-activated protein kinase
28. Current protocols in molecular biology
29. Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells
30. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
31. Inhibition of p38 MAP kinase increases okadaic acid mediated AP-1 expression and DNA binding but has no effect on TRE dependent transcription
32. One-way cross-talk between p38(MAPK) and p42/44(MAPK). Inhibition of p38(MAPK) induces low density lipoprotein receptor expression through activation of the p42/44(MAPK) cascade
33. Protein kinase C and mitogen-activated protein kinase are required for 1,25-dihydroxyvitamin D3-stimulated Egr induction
34. MEK1 activation rescues Jurkat T cells from Fas-induced apoptosis
35. Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1/2-mediated induction of cyclooxygenase-2
36. Apoptosis induction by the satratoxins and other trichothecene mycotoxins: Relationship to ERK, p38 MAPK and SAPK/JNK activation
37. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia
38. Role of apoptosis in biology and pathology: Resistance to apoptosis in colon carcinogenesis
39. A genetic model for colorectal tumorigenesis
40. Altered protein kinase C activity in biopsies of human colonic adenomas and carcinomas
41. Ras target proteins in eukaryotic cells
42. Transgenic coexpression of v-Ha-ras and transforming growth factor alpha increases epidermal hyperproliferation and tumorigenesis and predisposes to malignant conversion via endogenous c-Ha-ras activation