Genetic variations of the NR3A subunit of the NMDA receptor modulate prefrontal cerebral activity in humans

Journal of Cognitive Neuroscience

Volumn 19, Issue 1, 2007, Pages 59-68

  Gallinat, Jürgen ^a,d   Götz, Thomas ^a   Kalus, Peter ^a   Bajbouj, Malek ^a   Sander, Thomas ^b   Winterer, Georg ^c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^d MARTIN LUTHER KRANKENHAUS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT;

ADULT; ARTICLE; BRAIN DISEASE; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; FRONTAL LOBE; GENE EXPRESSION; GENE FREQUENCY; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; PREFRONTAL CORTEX; PRIORITY JOURNAL;

ADULT; ANALYSIS OF VARIANCE; ATTENTION; BRAIN MAPPING; ELECTROENCEPHALOGRAPHY; EVENT-RELATED POTENTIALS, P300; FEMALE; FUNCTIONAL LATERALITY; GENOTYPE; HUMANS; MALE; METHIONINE; MIDDLE AGED; PREFRONTAL CORTEX; RECEPTORS, N-METHYL-D-ASPARTATE; VALINE; VARIATION (GENETICS);

EID: 33846191870     PISSN: 0898929X     EISSN: 15308898     Source Type: Journal    
DOI: 10.1162/jocn.2007.19.1.59     Document Type: Article

References (80)

1. Andersson, O., Stenqvist, A., Attersand, A., & vonEuler, G. (2001). Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B. Genomics, 78, 178-184.
2. Baudena, P., Halgren, E., Heit, G., & Clarke, J. M. (1995). Intracerebral potentials to rare target and distractor auditory and visual stimuli: III. Frontal cortex. Electroencephalography and Clinical Neurophysiology, 94, 251-264.
3. Breier, A., Malhotra, A. K., Pinals, D. A., Weisenfeld, N. I., & Pickar, D. (1997). Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers. American Journal of Psychiatry, 154, 805-811.
4. Brody, S. A., Nakanishi, N., Tu, S., Lipton, S. A., & Geyer, M. A. (2005). A developmental influence of the N-methyl-D-aspartate receptor NR3A subunit on prepulse inhibition of startle. Biological Psychiatry, 57, 1147-1152.
5. Carlsson, A., Hansson, L. O., Waters, N., & Carlsson, M. L. (1999). A glutamatergic deficiency model of schizophrenia. British Journal of Psychiatry, Supplement, 2-6.
6. Chatterton, J. E., Awobuluyi, M., Premkumar, L. S., Takahashi, H., Talantova, M., Shin, Y., et al. (2002). Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Nature, 415, 793-798.
7. Chen, A. C., McDonald, B., Moss, S. J., & Gurling, H. M. (1998). Gene expression studies of mRNAs encoding the NMDA receptor subunits NMDAR1, NMDAR2A, NMDAR2B, NMDAR2C, and NMDAR2D following long-term treatment with cis- and trans-flupenthixol as a model for understanding the mode of action of schizophrenia drug treatment. Brain Research, Molecular Brain Research, 54, 92-100.
8. Ciabarra, A. M., Sullivan, J. M., Gahn, L. G., Pecht, G., Heinemann, S., & Sevarino, K. A. (1995). Cloning and characterization of chi-1: A developmentally regulated member of a novel class of the ionotropic glutamate receptor family. Journal of Neuroscience, 15, 6498-6508.
9. Cooper, D. C. (2002). The significance of action potential bursting in the brain reward circuit. Neurochemistry International, 41, 333-340.
10. Das, S., Sasaki, Y. F., Rothe, T., Premkumar, L. S., Takasu, M., Crandall, J. E., et al. (1998). Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature, 393, 377-381.
11. de Peralta Menendez, R. G., & Andino, S. L. (2000). Discussing the capabilities of Laplacian minimization. Brain Topography, 13, 97-104.
12. Ehlers, C. L., & Somes, C. (2002). Long latency event-related potentials in mice: Effects of stimulus characteristics and strain. Brain Research, 957, 117-128.
13. Gallinat, J., Bajbouj, M., Sander, T., Schlattmann, P., Xu, K., Ferro, E. F., et al. (2003). Association of the G1947A COMT (Val(108/158)Met) gene polymorphism with prefrontal P300 during information processing. Biological Psychiatry, 54, 40-48.
14. Gallinat, J., Kunz, D., Lang, U. E., Neu, P., Kassim, N., Kienast, T., et al. (In press). Association between cerebral glutamate and human behaviour: The sensation seeking personality trait. Neuroimage.
15. Gallinat, J., Kunz, D., Senkowski, D., Kienast, T., Seifert, F., Schubert, F., et al. (2006). Hippocampal glutamate concentration predicts cerebral theta oscillations during cognitive processing. Psychopharmacology, 187, 103-111.
16. Gallinat, J., Mulert, C., Bajbouj, M., Herrmann, W. M., Schunter, J., Senkowski, D., et al. (2002). Frontal and temporal dysfunction of auditory stimulus processing in schizophrenia. Neuroimage, 17, 110-127.
17. Gallinat, J., Riedel, M., Juckel, G., Sokullu, S., Frodl, T., Moukhtieva, R., et al. (2001). P300 and symptom improvement in schizophrenia. Psychopharmacology (Berlin), 158, 55-65.
18. Gallinat, J., Winterer, G., Herrmann, C. S., & Senkowski, D. (2004). Reduced oscillatory gamma-band responses in unmedicated schizophrenic patients indicate impaired frontal network processing. Clinical Neurophysiology, 115, 1863-1874.
19. Ghoneim, M. M., Hinrichs, J. V., Mewaldt, S. P., & Petersen, R. C. (1985). Ketamine: Behavioral effects of subanesthetic doses. Journal of Clinical Psychopharmacology, 5, 70-77.
20. Gratton, A., Hoffer, B. J., & Freedman, R. (1987). Electrophysiological effects of phencyclidine in the medial prefrontal cortex of the rat. Neuropharmacology, 26, 1275-1283.
21. Halgren, E., Baudena, P., Clarke, J. M., Heit, G., Liegeois, C., Chauvel, P., et al. (1995). Intracerebral potentials to rare target and distractor auditory and visual stimuli: I. Superior temporal plane and parietal lobe. Electroencephalography and Clinical Neurophysiology, 94, 191-220.
22. Halgren, E., Baudena, P., Clarke, J. M., Heit, G., Marinkovic, K., Devaux, B., et al. (1995). Intracerebral potentials to rare target and distractor auditory and visual stimuli: II. Medial, lateral and posterior temporal lobe. Electroencephalography and Clinical Neurophysiology, 94, 229-250.
23. Halgren, E., Marinkovic, K., & Chauvel, P. (1998). Generators of the late cognitive potentials in auditory and visual oddball tasks. Electroencephalography and Clinical Neurophysiology, 106, 156-164.
24. Harrison, P. J., & Weinberger, D. R. (2005). Schizophrenia genes, gene expression, and neuropathology: On the matter of their convergence. Molecular Psychiatry, 10, 40-68.
25. Hollmann, M., & Heinemann, S. (1994). Cloned glutamate receptors. Annual Review of Neuroscience, 17, 31-108.
26. Holmes, A. P., Blair, R. C., Watson, J. D., & Ford, I. (1996). Nonparametric analysis of statistic images from functional mapping experiments. Journal of Cerebral Blood Flow and Metabolism, 16, 7-22.
27. Jackson, M. E., Homayoun, H., & Moghaddam, B. (2004). NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex. Proceedings of the National Academy of Sciences, U.S.A., 101, 8467-8472.
28. Javitt, D. C., (2004). Glutamate as a therapeutic target in psychiatric disorders. Molecular Psychiatry, 9, 979, 984-997.
29. Kandel, E. R., & Siegelbaum, S. A. (2000). Synaptic integration. In E. R. Kandel, J. H. Schwartz, & T. M. Jessel (Eds.), Principles of neural science (pp. 207-228). New York: McGraw-Hill.
30. Kawakami, R., Shinohara, Y., Kato, Y., Sugiyama, H., Shigemoto, R., & Ito, I. (2003). Asymmetrical allocation of NMDA receptor epsilon2 subunits in hippocampal circuitry. Science, 300, 990-994.
31. Knight, R. T. (1984). Decreased response to novel stimuli after prefrontal lesions in man. Electroencephalography and Clinical Neurophysiology, 59, 9-20.
32. Kornhuber, J., Mack-Burkhardt, F., Riederer, P., Hebenstreit, G. F., Reynolds, G. P., Andrews, H. B., et al. (1989). [3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients. Journal of Neural Transmission, 77, 231-236.
33. Krystal, J. H., Karper, L. P., Seibyl, J. P., Freeman, G. K., Delaney, R., Bremner, J. D., et al. (1994). Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Archives of General Psychiatry, 51, 199-214.
34. Kutsuwada, T., Kashiwabuchi, N., Mori, H., Sakimura, K., Kushiya, E., Araki, K., et al. (1992). Molecular diversity of the NMDA receptor channel. Nature, 358, 36-41.
35. Linden, D. E., Prvulovic, D., Formisano, E., Vollinger, M., Zanella, F. E., Goebel, R., et al. (1999). The functional neuroanatomy of target detection: An fMRI study of visual and auditory oddball tasks. Cerebral Cortex, 9, 815-823.
36. Livak, K. J., (1999). Allelic discrimination using fluorogenic probes and the 50 nuclease assay. Genetic Analysis, 14, 143-149.
37. Ludvig, N., Mishra, P. K., Yan, Q. S., Lasley, S. M., Burger, R. L., & Jobe, P. C. (1992). The paradoxical effect of NMDA receptor stimulation on electrical activity of the sensorimotor cortex in freely behaving rats: Analysis by combined EEG-intracerebral microdialysis. Synapse, 12, 87-98.
38. Maragos, W. F., Penney, J. B., & Young, A. B. (1988). Anatomic correlation of NMDA and 3H-TCP-labeled receptors in rat brain. Journal of Neuroscience, 8, 493-501.
39. McBain, C. J., & Mayer, M. L. (1994). N-methyl-D-aspartic acid receptor structure and function. Physiological Reviews, 74, 723-760.
40. Mesulam, M. M. (1981). A cortical network for directed attention and unilateral neglect. Annals of Neurology, 10, 309-325.
41. Mesulam, M. M. (1990). Large-scale neurocognitive networks and distributed processing for attention, language, and memory. Annals of Neurology, 28, 597-613.
42. Michel, C. M., Murray, M. M., Lantz, G., Gonzalez, S., Spinelli, L., & Grave de, P. R. (2004). EEG source imaging. Clinical Neurophysiology, 115, 2195-2222.
43. Mitzdorf, U. (1991). Physiological sources of evoked potentials. Electroencephalography and Clinical Neurophysiology Supplement, 42, 47-57.
44. Monaghan, D. T., & Cotman, C. W. (1985). Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain. Journal of Neuroscience, 5, 2909-2919.
45. Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H. (1994). Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron, 12, 529-540.
46. Mueller, H. T., & Meador-Woodruff, J. H. (2003). Expression of the NR3A subunit of the NMDA receptor in human fetal brain. Annals of the New York Academy of Sciences, 1003, 448-451.
47. Mueller, H. T., & Meador-Woodruff, J. H. (2004). NR3A NMDA receptor subunit mRNA expression in schizophrenia, depression and bipolar disorder. Schizophrenia Research, 71, 361-370.
48. Mulert, C., Jager, L., Schmitt, R., Bussfeld, P., Pogarell, O., Moller, H. J., et al. (2004). Integration of fMRI and simultaneous EEG: Towards a comprehensive understanding of localization and time-course of brain activity in target detection. Neuroimage, 22, 83-94.
49. Neuhaus, A., Bajbouj, M., Kienast, T., Kalus, P., vonHaebler, D., Winterer, G., et al. (2006). Persistent dysfunctional frontal lobe activation in former smokers. Psychopharmacology, 186, 191-200.
50. O'Donnell, P., & Grace, A. A. (1995). Synaptic interactions among excitatory afferents to nucleus accumbens neurons: Hippocampal gating of prefrontal cortical input. Journal of Neuroscience, 15, 3622-3639.
51. Ohyama, M., Senda, M., Kitamura, S., & Terashi, A. (1993). Changes in regional cerebral blood flow during auditory cognitive tasks - a PET activation study with odd-ball paradigm. Rinsho Shinkeigaku, 33, 134-140.
52. Olney, J. W., & Farber, N. B. (1995). Glutamate receptor dysfunction and schizophrenia [see comments]. Archives of General Psychiatry, 52, 998-1007.
53. Oranje, B., van Berckel, B. N., Kemner, C., van Ree, J. M., Kahn, R. S., & Verbaten, M. N. (2000). The effects of a sub-anaesthetic dose of ketamine on human selective attention. Neuropsychopharmacology, 22, 293-302.
54. Pascual-Marqui, R. (1999). Review of methods for solving the EEG inverse problem. International Journal of Bioelectromagnetism, 1, 75-86.
55. Pascual-Marqui, R. D., Lehmann, D., Koenig, T., Kochi, K., Merlo, M. C., Hell, D., et al. (1999). Low resolution brain electromagnetic tomography (LORETA) functional imaging in acute, neuroleptic-naive, first-episode, productive schizophrenia. Psychiatry Research, 90, 169-179.
56. Pascual-Marqui, R. D., Michel, C. M., & Lehmann, D. (1994). Low resolution electromagnetic tomography: A new method for localizing electrical activity in the brain. International Journal of Psychophysiology, 18, 49-65.
57. Perez-Otano, I., Schulteis, C. T., Contractor, A., Lipton, S. A., Trimmer, J. S., Sucher, N. J., et al. (2001). Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors. Journal of Neuroscience, 21, 1228-1237.
58. Prabhu, V. R., Porjesz, B., Chorlian, D. B., Wang, K., Stimus, A., & Begleiter, H. (2001). Visual p3 in female alcoholics. Alcoholism: Clinical and Experimental Research, 25, 531-539.
59. Reischies, F. M., Neuhaus, A. H., Hansen, M. L., Mientus, S., Mulert, C., & Gallinat, J. (2005). Electrophysiological and neuropsychological analysis of a delirious state: The role of the anterior cingulate gyrus. Psychiatry Research, 138, 171-181.
60. Sasaki, Y. F., Rothe, T., Premkumar, L. S., Das, S., Cui, J., Talantova, M. V., et al. (2002). Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons. Journal of Neurophysiology, 87, 2052-2063.
61. Scherg, M. (1994). From EEG source localization to source imaging. Acta Neurologica Scandinavica. Supplementum, 152, 29-30.
62. Segalowitz, S. J., & Barnes, K. L. (1993). The reliability of ERP components in the auditory oddball paradigm. Psychophysiology, 30, 451-459.
63. Sheehan, D. V., Lecrubier, Y., Sheehan, K. H., Amorim, P., Janavs, J., Weiller, E., et al. (1998). The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry, (Suppl 20), 22-33.
64. Sherwin, A., Robitaille, Y., Quesney, F., Olivier, A., Villemure, J., Leblanc, R., et al. (1988). Excitatory amino acids are elevated in human epileptic cerebral cortex. Neurology, 38, 920-923.
65. Simpson, M. D., Slater, P., Royston, M. C., & Deakin, J. F. (1992). Regionally selective deficits in uptake sites for glutamate and gamma-aminobutyric acid in the basal ganglia in schizophrenia. Psychiatry Research, 42, 273-282.
66. Sucher, N. J., Akbarian, S., Chi, C. L., Leclerc, C. L., Awobuluyi, M., Deitcher, D. L., et al. (1995). Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain. Journal of Neuroscience, 15, 6509-6520.
67. Talairach, J., & Tournoux, P. (1988). Co-planar stereotaxic atlas of the human brain. Stuttgart: Thieme.
68. Tamminga, C. A. (1998). Schizophrenia and glutamatergic transmission. Critical Reviews in Neurobiology, 12, 21-36.
69. Towle, V. L., Bolanos, J., Suarez, D., Tan, K., Grzeszczuk, R., Levin, D. N., et al. (1993). The spatial location of EEG electrodes: Locating the best-fitting sphere relative to cortical anatomy. Electroencephalography and Clinical Neurophysiology, 86, 1-6.
70. Tsai, G., Passani, L. A., Slusher, B. S., Carter, R., Baer, L., Kleinman, J. E., et al. (1995). Abnormal excitatory neurotransmitter metabolism in schizophrenic brains. Archives of General Psychiatry, 52, 829-836.
71. van Beijsterveldt, C. E., Molenaar, P. C., de Geus, E. J., & Boomsma, D. I. (1998). Individual differences in P300 amplitude: A genetic study in adolescent twins. Biological Psychology, 47, 97-120.
72. Vollenweider, F. X., Leenders, K. L., Oye, I., Hell, D., & Angst, J. (1997). Differential psychopathology and patterns of cerebral glucose utilisation produced by (S)- and (R)-ketamine in healthy volunteers using positron emission tomography (PET). European Neuropsychopharmacology, 7, 25-38.
73. Vollenweider, F. X., Leenders, K. L., Scharfetter, C., Antonini, A., Maguire, P., Missimer, J., et al. (1997). Metabolic hyperfrontality and psychopathology in the ketamine model of psychosis using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG). European Neuropsychopharmacology, 7, 9-24.
74. Winterer, G., Adams, C. M., Jones, D. W., & Knutson, B. (2002). Volition to action - an event-related fMRI study. Neuroimage, 17, 851-858.
75. Winterer, G., Egan, M. F., Raedler, T., Sanchez, C., Jones, D. W., Coppola, R., et al. (2003). P300 and genetic risk for schizophrenia. Archives of General Psychiatry, 60, 1158-1167.
76. Winterer, G., Mulert, C., Mientus, S., Gallinat, J., Schlattmann, P., Dorn, H., et al. (2001). P300 and LORETA: Comparison of normal subjects and schizophrenic patients. Brain Topography, 13, 299-313.
77. Winterer, G., Ziller, M., Dorn, H., Frick, K., Mulert, C., Dahhan, N., et al. (1999). Cortical activation, signal-to-noise ratio and stochastic resonance during information processing in man. Clinical Neurophysiology, 110, 1193-1203.
78. Wood, C. C., & Allison, T. (1981). Interpretation of evoked potentials: A neurophysiological perspective. Canadian Journal of Psychology, 35, 113-135.
79. Wood, C. C., & McCarthy, G. (1985). A possible frontal lobe contribution to scalp P300. Neuroscience Abstracts, 11, 879-884.
80. Wynn, J. K., Dawson, M. E., Schell, A. M., McGee, M., Salveson, D., & Green, M. F. (2004). Prepulse facilitation and prepulse inhibition in schizophrenia patients and their unaffected siblings. Biological Psychiatry, 55, 518-523.