Evaluation of the influence of protein precipitation prior to on-line SPE-LC-API/MS procedures using multivariate data analysis

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 845, Issue 2, 2007, Pages 244-252

  Marchi, Ivano ^a   Rudaz, Serge ^a   Selman, Maurice ^a   Veuthey, Jean Luc ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

APPI; Human plasma; Matrix effects; On line SPE; Post column infusion

Indexed keywords

APPI; HUMAN PLASMA; MATRIX EFFECTS; ON-LINE SPE; POST-COLUMN INFUSION;

ACETONITRILE; ATMOSPHERIC PRESSURE; DATA REDUCTION; IONIZATION; MASS SPECTROMETRY; PRECIPITATION (CHEMICAL); PRINCIPAL COMPONENT ANALYSIS;

PROTEINS;

2 ETHYLIDENE 1,5 DIMETHYL 1,3 DIPHENYLPYRROLIDINE PERCHLORATE; ACETONITRILE; COLECALCIFEROL; FLUNITRAZEPAM; FLUOXETINE; METALAXYL; METHADONE; NORFLUNITRAZEPAM; NORFLUOXETINE; PESTICIDE; PROTEIN; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD ANALYSIS; COMPARATIVE STUDY; ELECTROSPRAY MASS SPECTROMETRY; EVALUATION; HUMAN; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MULTIVARIATE ANALYSIS; ONLINE ANALYSIS; PLASMA; PRECIPITATION; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; SIGNAL DETECTION; SOLID PHASE EXTRACTION; SPECTRAL SENSITIVITY;

ALANINE; BLOOD PROTEINS; CHOLECALCIFEROL; CHROMATOGRAPHY, LIQUID; FLUNITRAZEPAM; FLUOXETINE; MASS SPECTROMETRY; METHADONE; MULTIVARIATE ANALYSIS; ONLINE SYSTEMS; PRECIPITATION; PYRROLIDINES; SOLID PHASE EXTRACTION;

EID: 33846119260     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.08.045     Document Type: Article

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