Zirconia-based column high-performance liquid chromatography/atmospheric pressure photoionization tandem mass spectrometric analyses of drug molecules in rat plasma

Rapid Communications in Mass Spectrometry

Volumn 17, Issue 15, 2003, Pages 1775-1780

  Hsieh, Yunsheng ^a   Merkle, Kara ^b   Wang, Ganfeng ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b APPLIED BIOSYSTEMS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATMOSPHERIC PRESSURE; BODY FLUIDS; COLUMN CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; PHARMACOKINETICS; RATS; SILICA; ZIRCONIA;

ATMOSPHERIC PRESSURE PHOTO IONIZATION; BIOLOGICAL MATRIXES; DRUG MOLECULES; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; NEW CHEMICAL ENTITIES; PHARMACOKINETIC STUDIES; QUANTITATIVE DETERMINATIONS; RAT PLASMA; TANDEM MASS; TANDEM MASS SPECTROMETRIC ANALYSIS;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

4 [2 [4 (3,10 DIBROMO 8 CHLORO 6,11 DIHYDRO 5H BENZO[5,6]CYCLOHEPTA[1,2 B]PYRIDIN 11 YL) 1 PIPERIDINYL] 2 OXOETHYL] 1 PIPERIDINECARBOXAMIDE; CLOZAPINE; LONAFARNIB; NEW DRUG; SILICON DIOXIDE; UNCLASSIFIED DRUG; ZIRCONIUM OXIDE;

ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; ATMOSPHERIC PRESSURE PHOTOIONIZATION; BODY FLUID; CONTROLLED STUDY; DRUG SCREENING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH TEMPERATURE; IONIZATION; MOLECULE; NONHUMAN; PLASMA; QUANTITATIVE ANALYSIS; RAT; REPRODUCIBILITY; STATISTICAL ANALYSIS; TANDEM MASS SPECTROMETRY; TIME;

EID: 0042268065     PISSN: 09514198     EISSN: None     Source Type: Journal    
DOI: 10.1002/rcm.1089     Document Type: Article

References (25)

1. Weber T, Jackson P, Carr P. Anal. Chem. 1995; 67: 3042.
2. Weber T, Carr P. J. Chromatogr. 1990; 519: 31.
3. Yan B, Zhao J, Brown JS, Blackwell J, Carr P. Anal. Chem. 2000; 72: 1253.
4. Weber T, Carr P. Anal. Chem. 1990; 62: 2620.
5. Jackson P, Kim T, Carr P. Anal. Chem. 1997; 69: 5011.
6. Hsieh Y, Chintala M, Mei H, Agans J, Brisson J, Ng K, Korfmacher WA. Rapid Commun. Mass Spectrom. 2001; 15: 2481.
7. Hsieh Y, Brisson J, Wang G, Ng K, Korfmacher WA. J. Pharm. Biomed. Anal. 2003; in press.
8. Mei H, Hsieh Y, Nardo C, Xu X, Wang S, Ng K, Korfmacher WA. Rapid Commun. Mass Spectrom. 2003; 17: 97.
9. Matuszewski BK, Constanzer ML, Chavez-Eng CM. Anal. Chem. 1998; 70: 882.
10. Zheng JJ, Lynch ED, Unger SE. J. Pharm. Biomed. Anal. 2002; 28: 279.
11. Hsieh Y, Chintala M, Mei H, Agans J, Brisson J, Ng K, Korfmacher WA. Rapid Commun. Mass Spectrom. 2001; 15: 2481.
12. Hsieh Y, Wang G, Wang Y, Chackalamannil S, Ng K, Korfmacher WA. Rapid Commun. Mass Spectrom. 2002; 16: 944.
13. Hsieh Y, Wang G, Wang Y, Chackalamannil S, Korfmacher WA. Anal. Chem. 2003; 75: 1812.
14. King R, Bonfiglio R, Fernandez-Metzler C, Miller-Stein C, Olah T. J. Am. Soc. Mass Spectrom. 2000; 11: 942.
15. Bonfiglio R, King RC, Olah TV, Merkle K. Rapid Commun. Mass Spectrom. 1999; 13: 175.
16. Liu M, Bryant MS, Chen J, Lee S, Yaremko B, Lipari P, Malkowski M, Ferrari E, Nielsen L, Prioli N, Dell J, Sinha D, Syed J, Korfmacher WA, Nomeir A, Lin C, Wang L, Taveras A, Doll R, Njoroge G, Mallams A, Remiszewski S, Catino J, Girijavallabhan V, Kirschmeier P, Bishop R. Cancer Res. 1998; 58: 4947.
17. Robb DB, Covey TR, Bruins AP. Anal. Chem. 2000; 72: 3653.
18. Hsieh Y, Merkle K, Wang G, Brisson J, Korfmacher WA. Anal. Chem. 2003; 75: in press.
19. Korfmacher WA, Cox KA, Ng K, Veals J, Hsieh Y, Wainhaus S, Broske L, Nomeir A, White RE. Rapid Commun. Mass Spectrom. 2001; 15: 335.
20. Cox KA, White RE, Korfmacher WA. Combinatorial Chem. High Throughput Screening 2002; 5: 29.
21. Hsieh Y, Bryant M, Brisson J, Ng K, Korfmacher WA. J. Chromatogr. B 2002; 767: 353.
22. Hsieh Y, Brisson J, Ng K, Korfmacher WA. J. Pharm. Biomed. Anal. 2002; 27: 285.
23. Wang G, Hsieh Y, Cheng K, Ng K, Korfmacher WA. Spectroscopy An International Journal 2003; 17: 511.
24. Jemal M, Ouyang Z. Rapid Commun. Mass Spectrom. 2000; 14: 1757.
25. Jemal M, Ouyang Z, Powell ML. Rapid Commun. Mass Spectrom. 2002; 16: 1538.