Enhanced anticryptococcal activity of chloroquine in phosphatidylserine-containing liposomes in a murine model

Journal of Antimicrobial Chemotherapy

Volumn 55, Issue 2, 2005, Pages 223-228

  Khan, Masood Alam ^a   Jabeen, Rukhsana ^a   Nasti, T H ^a   Mohammad, Owais ^a  

^a ALIGARH MUSLIM UNIVERSITY   (India)

Author keywords

Cryptococcus neoformans; Fluconazole; Macrophages; Therapy

Indexed keywords

CHLOROQUINE; FLUCONAZOLE; LIPOSOME; PHOSPHATIDYLSERINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; BRAIN; COLONY FORMING UNIT; CONTROLLED STUDY; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; DRUG DELIVERY SYSTEM; DRUG DOSE REGIMEN; DRUG EFFICACY; FEMALE; FUNGUS GROWTH; IN VITRO STUDY; IN VIVO STUDY; LIVER; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; SURVIVAL;

ANIMALS; CELL LINE; CHLOROQUINE; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; FEMALE; HUMANS; LIPOSOMES; MICE; PHOSPHATIDYLSERINES;

EID: 14744289103     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkh522     Document Type: Article

References (28)

1. Singh, N. (2001). Trends in the epidemiology of opportunistic fungal infections: predisposing factors and the impact of antimicrobial use practices. Clinical Infectious Diseases 33, 1692-6.
2. Kontoyiannis, D. P., Mantadakis, E. & Samonis, G. (2003). Systemic mycoses in the immunocompromised host: an update in antifungal therapy. Journal of Hospital Infection 53, 243-58.
3. Ruhnke, M. (2004). Mucosal and systemic fungal infections in patients with AIDS: prophylaxis and treatment. Drugs 64, 1163-80.
4. Chen, W. C., Chou, D. L. & Feingold, D. S. (1978). Dissociation between ion permeability and the lethal action of polyene antibiotics on C. albicans. Antimicrobial Agents and Chemotherapy 13, 914-7.
5. Masia Canuto, M. & Gutierrez Rodero, F. (2002). Antifungal drug resistance to azoles and polyenes. Lancet Infectious Diseases 2, 550-63.
6. O'Neill, P. M., Bray, P. G., Hawley, S. R. et al. (1998). 4-Aminoquinolines - past, present and future: a chemical perspective. Pharmacology and Therapeutics 77, 29-58.
7. Zhu, X., Ertel, W., Ayala, A. et al. (1993). Chloroquine inhibits macrophage tumour necrosis factor-alpha mRNA transcription. Immunology 80, 122-6.
8. Weber, S. M., Levitz, S. M. & Harrison, T. S. (2000). Chloroquine and the fungal phagosome. Current Opinion in Microbiology 3, 349-53.
9. Mazzolla, R., Barluzzi, R., Brozzetti, A. et al. (1997). Enhanced resistance to Cryptococcus neoformans infection induced by chloroquine in a murine model of meningoencephalitis. Antimicrobial Agents and Chemotherapy 41, 802-7.
10. Harrison, T., Griffin, G. & Levitz, S. (2000). Conditional lethality of diprotic weak bases chloroquine and quinacrine against Cryptococcus neoformans. Journal of Infectious Diseases 182, 283-9.
11. Schaible, U. E., Sturgill-Koszycki, S., Schlesinger, P. H. et al. (1998). Cytokine activation leads to acidification and increases maturation of Mycobacterium avium-containing phagosomes in murine macrophages. Journal of Immunology 160, 1290-6.
12. Sibley, L. D., Weidner, E. & Krahenbuhl, J. L. (1985). Phagosome acidification blocked by intracellular Toxoplasma gondii. Nature 315, 416-9.
13. Horwitz, M. A. & Maxfield, F. R. (1984). Legionella pneumophila inhibits acidification of its phagosome in human monocytes. Journal of Cell Biology 99, 1936-43.
14. Byrd, T. F. & Horwitz, M. A. (1991). Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of the iron. A potential new mechanism for the therapeutic effect of chloroquine against intracellular pathogens. Journal of Clinical Investigation 88, 351-7.
15. Newman, S. L., Gootee, L., Brunner, G. et al. (1994). Chloroquine induces human macrophage killing of Histoplasma capsulatum by limiting the availability of the intracellular iron and is therapeutic in murine model of histoplasmosis. Journal of Clinical Investigation 93, 1422-9.
16. Fortier, A. H., Leiby, D. A., Narayan, R. B. et al. (1995). Growth of Francisella tulerensis LVS in macrophages: the acidic intracellular environment provides essential intracellular iron required for growth. Infection and Immunity 63, 1478-83.
17. Levitz, S. M., Harrison, S. T., Abdulmoneim, T. et al. (1997). Chloroquine induces human mononuclear phagocytes to inhibit and kill Cryptococcus neoformans by a mechanism independent of iron deprivation. Journal of Clinical Investigation 100, 1640-6.
18. Bergers, J. J., ten Hagen, T. L., Van Etten, E. W. et al. (1995). Liposomes as delivery systems in the prevention and treatment of infectious diseases. Pharmacy World & Science 17, 1-11.
19. Gilbreath, M. J., Nacy, C. A., Hoover, D. L. et al. (1985). Macrophage activation for microbicidal activity against Leishmania major. inhibition of lymphokine activation by phosphatidylcholine-phosphatidylserine liposomes. Journal of Immunology 134, 3420-5.
20. Tempone, A. G., Perez, D., Rath, S. et al. (2004). Targeting Leishmania (L.) chagasi amastigotes through macrophage scavenger receptors: the use of drugs entrapped in liposomes containing phosphatidylserine. Journal of Antimicrobial Chemotherapy 54, 60-8.
21. Singleton, W. S., Gray, M. S. & Brown, M. L. (1965). A method for adsorbent fractionation of cottonseed oil for experimental intravenous fat emulsions. Journal of the American Oil Chemists' Society 42, 53-6.
22. Owais, M., Varshney, G. C., Choudhury, A. et al. (1995). Chloroquine encapsulated in malaria-infected erythrocyte-specific antibody-bearing liposomes effectively controls chloroquine-resistant Plasmodium berghei infections in mice. Antimicrobial Agents and Chemotherapy 39, 180-4.
23. Owais, M. & Gupta, C. M. (2002). Liposome mediated cytosolic delivery of macromolecules and its possible role in vaccine development. European Journal of Biochemistry 267, 3946-56.
24. National Committee for Clinical Laboratory Standards. (1997). Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts: Approved Standard M27-A. NCCLS, Villanova, PA, USA.
25. Khan, M. A., Faisal, S. M., Haque, W. et al. (2002). Immunomodulator tuftsin augments anti-fungal activity of amphotericin B against experimental murine candidiasis. Journal of Drug Targeting 10, 185-92.
26. Orenstein, J. M., Fox, C. & Wahl, S. M. (1997). Macrophages as a source of HIV during opportunistic infections. Science 276 1857-61.
27. Weber, S. M. & Levitz, S. M. (2001). Chloroquine antagonizes the proinflammatory cytokine response to opportunistic fungi by alkalizing the fungal phagolysosome. Journal of Infectious Diseases 183, 935-42.,
28. Pardridge, W. M., Yang, J. & Diagne, A. (1998). Chloroquine inhibits HIV-1 replication in human peripheral blood lymphocytes. Immunology Letters 64, 45-7.