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Volumn 36, Issue 1-2, 2006, Pages 57-68

The effects of dexamethasone and dehydroepiandrosterone (DHEA) on cytokines and receptor expression in a human osteoblastic cell line: Potential steroid-sparing role for DHEA

Author keywords

Cytokines; Dehydroepiandrosterone; Osteoblasts; Osteoprotegerin; RANKL

Indexed keywords

ANDROSTENEDIONE; COMPLEMENTARY DNA; CYTOKINE; DEXAMETHASONE; FIBROBLAST GROWTH FACTOR 5; GAMMA INTERFERON; INSULIN RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 6; MACROPHAGE MIGRATION INHIBITION FACTOR; MESSENGER RNA; NOTCH2 RECEPTOR; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PRASTERONE; PROTEINASE ACTIVATED RECEPTOR 1; SOMATOMEDIN BINDING PROTEIN 3; VASCULOTROPIN;

EID: 33846005178     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2006.10.012     Document Type: Article
Times cited : (20)

References (42)
  • 2
    • 0036220050 scopus 로고    scopus 로고
    • Autoimmunity, dehydroepiandrosterone (DHEA) and stress
    • Schwarz K.E. Autoimmunity, dehydroepiandrosterone (DHEA) and stress. J Adolescent Health 30S (2002) 37-40
    • (2002) J Adolescent Health , vol.30 S , pp. 37-40
    • Schwarz, K.E.1
  • 4
    • 0036307222 scopus 로고    scopus 로고
    • Mechanisms of glucocorticoid action in bone
    • Canalis E., and Delany A.M. Mechanisms of glucocorticoid action in bone. Ann NY Acad Sci 966 (2002) 73-81
    • (2002) Ann NY Acad Sci , vol.966 , pp. 73-81
    • Canalis, E.1    Delany, A.M.2
  • 5
    • 0024554774 scopus 로고    scopus 로고
    • Bone histomorphometry in glucocorticoid-induced osteoporosis
    • Dempster D. Bone histomorphometry in glucocorticoid-induced osteoporosis. J Bone Miner Res 13 (1998) 137-141
    • (1998) J Bone Miner Res , vol.13 , pp. 137-141
    • Dempster, D.1
  • 6
    • 0030939655 scopus 로고    scopus 로고
    • Gonadal and adrenal androgens are potent regulators of human bone cell metabolism in vitro
    • Kasperk C.H., Wakey G.K., Hierl T., and Ziegler R. Gonadal and adrenal androgens are potent regulators of human bone cell metabolism in vitro. J Bone Miner Res 12 3 (1997) 464-471
    • (1997) J Bone Miner Res , vol.12 , Issue.3 , pp. 464-471
    • Kasperk, C.H.1    Wakey, G.K.2    Hierl, T.3    Ziegler, R.4
  • 7
    • 0030883203 scopus 로고    scopus 로고
    • Effect of 12-month dehydroepiandrosterone replacement therapy on bone, vagina and endometrium in post-menopausal women
    • Labrie F., Diamond P., Cusan L., Gomez J.L., Belanger A., and Candas B. Effect of 12-month dehydroepiandrosterone replacement therapy on bone, vagina and endometrium in post-menopausal women. J Clin Endo Metab 82 10 (1997) 3498-3505
    • (1997) J Clin Endo Metab , vol.82 , Issue.10 , pp. 3498-3505
    • Labrie, F.1    Diamond, P.2    Cusan, L.3    Gomez, J.L.4    Belanger, A.5    Candas, B.6
  • 8
    • 0031803286 scopus 로고    scopus 로고
    • Predominant androgenic component in the stimulatory effect of dehydroepiandrosterone on bone mineral density in the rat
    • Martel C., Sourla A., Pelletier G., Labrie C., Formier M., Picard, et al. Predominant androgenic component in the stimulatory effect of dehydroepiandrosterone on bone mineral density in the rat. J Endocrinol 157 (1998) 433-442
    • (1998) J Endocrinol , vol.157 , pp. 433-442
    • Martel, C.1    Sourla, A.2    Pelletier, G.3    Labrie, C.4    Formier, M.5    Picard6
  • 9
    • 0032963061 scopus 로고    scopus 로고
    • Androgen effects on bone metabolism: recent progress and controversies
    • Hofbauer L.C., and Khosla S. Androgen effects on bone metabolism: recent progress and controversies. Eur J Endocrinol 140 (1999) 271-286
    • (1999) Eur J Endocrinol , vol.140 , pp. 271-286
    • Hofbauer, L.C.1    Khosla, S.2
  • 10
    • 0031732983 scopus 로고    scopus 로고
    • Serum dehydroepiandrosterone (DHEA) and DHEA sulphate are negatively correlated with serum interleukin-6 (IL-6) and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenenescence and immunosenescence
    • Straub R.H., Konecna L., Hrach S., Rothe R., Krentz M., Scholmerich J., et al. Serum dehydroepiandrosterone (DHEA) and DHEA sulphate are negatively correlated with serum interleukin-6 (IL-6) and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenenescence and immunosenescence. J Clin Endocrinol Metab 83 (1998) 2012-2017
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2012-2017
    • Straub, R.H.1    Konecna, L.2    Hrach, S.3    Rothe, R.4    Krentz, M.5    Scholmerich, J.6
  • 11
    • 0031835941 scopus 로고    scopus 로고
    • Dehydroepiandrosterone (DHEA) and systemic lupus erythematosus
    • Derksen R.H.M.W. Dehydroepiandrosterone (DHEA) and systemic lupus erythematosus. Semin Arthritis Rheum 27 (1998) 335-347
    • (1998) Semin Arthritis Rheum , vol.27 , pp. 335-347
    • Derksen, R.H.M.W.1
  • 12
    • 0034735792 scopus 로고    scopus 로고
    • Bone versus immune system
    • Arron J.R., and Choi Y. Bone versus immune system. Nature 408 (2000) 535-536
    • (2000) Nature , vol.408 , pp. 535-536
    • Arron, J.R.1    Choi, Y.2
  • 13
    • 0034735773 scopus 로고    scopus 로고
    • T-cell mediated regulation of osteoclastogenesis by signaling cross-talk between RANKL and IFN-γ
    • Takayanagi H., Ogasawara K., Hida S., Chiba T., Murata S., Sato K., Takaoka A., Yokochi T., et al. T-cell mediated regulation of osteoclastogenesis by signaling cross-talk between RANKL and IFN-γ. Nature 408 (2000) 600-605
    • (2000) Nature , vol.408 , pp. 600-605
    • Takayanagi, H.1    Ogasawara, K.2    Hida, S.3    Chiba, T.4    Murata, S.5    Sato, K.6    Takaoka, A.7    Yokochi, T.8
  • 14
    • 0033984313 scopus 로고    scopus 로고
    • The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption
    • Hofbauer L.C., Khosla S., Dunstan C.R., Lacey D.L., Boylew W.J., and Riggs B.L. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res 15 (2000) 2-12
    • (2000) J Bone Miner Res , vol.15 , pp. 2-12
    • Hofbauer, L.C.1    Khosla, S.2    Dunstan, C.R.3    Lacey, D.L.4    Boylew, W.J.5    Riggs, B.L.6
  • 15
    • 0033304809 scopus 로고    scopus 로고
    • Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis
    • Hofbauer L.C., Gori F., Riggs L., Lacey D.L., Dunstan C.R., Spelsberg T.C., and Khosla S. Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis. Endocrinology 140 (1999) 4382-4389
    • (1999) Endocrinology , vol.140 , pp. 4382-4389
    • Hofbauer, L.C.1    Gori, F.2    Riggs, L.3    Lacey, D.L.4    Dunstan, C.R.5    Spelsberg, T.C.6    Khosla, S.7
  • 16
    • 0036803168 scopus 로고    scopus 로고
    • Dexamethasone and retinoic acid differentially regulate growth and differentiation in an immortalized human clonal bone marrow cell line with osteoblastic characteristics
    • Ogston N., Harrison A.J., Cheung H.F.J., Ashton B.A., and Hampson G. Dexamethasone and retinoic acid differentially regulate growth and differentiation in an immortalized human clonal bone marrow cell line with osteoblastic characteristics. Steroids 67 (2002) 895-906
    • (2002) Steroids , vol.67 , pp. 895-906
    • Ogston, N.1    Harrison, A.J.2    Cheung, H.F.J.3    Ashton, B.A.4    Hampson, G.5
  • 17
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.1
  • 19
    • 0037398261 scopus 로고    scopus 로고
    • Role of RANK ligand in mediating increased bone resorption in early post-menopausal women
    • Egbali-Fatoureli G., Khosla S., Sanyal A., Boyle W.J., Lacey D.L., and Riggs B.L. Role of RANK ligand in mediating increased bone resorption in early post-menopausal women. J Clin Invest 111 (2003) 1221-1230
    • (2003) J Clin Invest , vol.111 , pp. 1221-1230
    • Egbali-Fatoureli, G.1    Khosla, S.2    Sanyal, A.3    Boyle, W.J.4    Lacey, D.L.5    Riggs, B.L.6
  • 21
    • 0038377650 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6), IL-1, receptor activator of nuclear factor κB ligand (RANKL) and osteoprotegerin production by human osteoblastic cells: comparison of the effects of 17-β oestradiol and raloxifene
    • Cheung J., Mak Y.T., Papaioannou S., Evans B.A.J., Fogelman I., and Hampson G. Interleukin-6 (IL-6), IL-1, receptor activator of nuclear factor κB ligand (RANKL) and osteoprotegerin production by human osteoblastic cells: comparison of the effects of 17-β oestradiol and raloxifene. J Endocrinol 177 (2003) 423-433
    • (2003) J Endocrinol , vol.177 , pp. 423-433
    • Cheung, J.1    Mak, Y.T.2    Papaioannou, S.3    Evans, B.A.J.4    Fogelman, I.5    Hampson, G.6
  • 23
    • 0033304632 scopus 로고    scopus 로고
    • Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells
    • Hofbauer L.C., Khosla S., Dunstan C.R., Lacet D.L., Spelsberg T.C., and Riggs B.L. Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells. Endocrinology 140 (1999) 4367-4370
    • (1999) Endocrinology , vol.140 , pp. 4367-4370
    • Hofbauer, L.C.1    Khosla, S.2    Dunstan, C.R.3    Lacet, D.L.4    Spelsberg, T.C.5    Riggs, B.L.6
  • 24
    • 0036280935 scopus 로고    scopus 로고
    • Effect of estrogen versus testosterone on circulating osteoprotegerin and other cytokine levels in normal elderly men
    • Khosla S., Atkinson E.J., Dunstan C.R., and O'Fallon W.M. Effect of estrogen versus testosterone on circulating osteoprotegerin and other cytokine levels in normal elderly men. J Clin Endocrinol Metab 87 (2002) 1550-1554
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1550-1554
    • Khosla, S.1    Atkinson, E.J.2    Dunstan, C.R.3    O'Fallon, W.M.4
  • 25
    • 1042287416 scopus 로고    scopus 로고
    • Effects of oral contraceptives on circulating osteoprotegerin and soluble RANK ligand serum levels in healthy young women
    • Hofbauer L.C., Schoppet M., Schuller P., Viereck V., and Christ M. Effects of oral contraceptives on circulating osteoprotegerin and soluble RANK ligand serum levels in healthy young women. Clin Endocrinol 60 (2004) 214-219
    • (2004) Clin Endocrinol , vol.60 , pp. 214-219
    • Hofbauer, L.C.1    Schoppet, M.2    Schuller, P.3    Viereck, V.4    Christ, M.5
  • 26
    • 0036679261 scopus 로고    scopus 로고
    • Regulation of osteoprotegerin production by androgens and anti-androgens in human osteoblastic lineage cells
    • Hofbauer L.C., Hicok K.C., Chen D., and Khosla S. Regulation of osteoprotegerin production by androgens and anti-androgens in human osteoblastic lineage cells. Eur J Endocrinol 147 2 (2002) 269-273
    • (2002) Eur J Endocrinol , vol.147 , Issue.2 , pp. 269-273
    • Hofbauer, L.C.1    Hicok, K.C.2    Chen, D.3    Khosla, S.4
  • 27
    • 0029783770 scopus 로고    scopus 로고
    • Estrogens, cytokines and pathogenesis of post-menopausal osteoporosis
    • Pacifici R. Estrogens, cytokines and pathogenesis of post-menopausal osteoporosis. J Bone Miner Res 11 (1996) 1043-1051
    • (1996) J Bone Miner Res , vol.11 , pp. 1043-1051
    • Pacifici, R.1
  • 29
    • 0041836267 scopus 로고    scopus 로고
    • Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II trans-activator
    • Cenci S., Toraldo G., Weitzmann M.W., Roggia C., Gao Y., Qian W.P., et al. Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II trans-activator. Proc Natl Acad Sci 100 (2003) 10405-10410
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 10405-10410
    • Cenci, S.1    Toraldo, G.2    Weitzmann, M.W.3    Roggia, C.4    Gao, Y.5    Qian, W.P.6
  • 30
    • 1542268356 scopus 로고    scopus 로고
    • Steroid-immunosuppression in kidney transplantation: a passing era
    • Schulak J.A. Steroid-immunosuppression in kidney transplantation: a passing era. J Surg Res 117 (2004) 154-162
    • (2004) J Surg Res , vol.117 , pp. 154-162
    • Schulak, J.A.1
  • 31
    • 0029821686 scopus 로고    scopus 로고
    • Machanisms of glucocorticoid-action in bone: implications to glucocorticoid-induced osteoporosis
    • Canalis E. Machanisms of glucocorticoid-action in bone: implications to glucocorticoid-induced osteoporosis. J Clin Endocrinol Metab 81 (1996) 3441-3447
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3441-3447
    • Canalis, E.1
  • 33
    • 0024851161 scopus 로고
    • The characterization, regulation and function of insulin receptors on osteoblast-like clonal osteosarcoma cell line
    • Pun K.K., Lau P., and Ho P.W. The characterization, regulation and function of insulin receptors on osteoblast-like clonal osteosarcoma cell line. J Bone Miner Res 4 6 (1989) 853-862
    • (1989) J Bone Miner Res , vol.4 , Issue.6 , pp. 853-862
    • Pun, K.K.1    Lau, P.2    Ho, P.W.3
  • 34
    • 4644222869 scopus 로고    scopus 로고
    • Studies on the receptors mediating responses of osteoblasts to thrombin
    • Song S.J., Pagel C.N., Pike R.N., and Mackie E.J. Studies on the receptors mediating responses of osteoblasts to thrombin. Int J Biochem Cell Biol 37 1 (2005) 206-213
    • (2005) Int J Biochem Cell Biol , vol.37 , Issue.1 , pp. 206-213
    • Song, S.J.1    Pagel, C.N.2    Pike, R.N.3    Mackie, E.J.4
  • 35
    • 2342559234 scopus 로고    scopus 로고
    • Endothelial monocyte-activating polypeptide-II (EMAP-II): a novel inducer of lymphocyte apoptosis
    • Murray J.C., Heng Y.M., Symonds P., Rice K., Ward W., Huggins M., Todd I., and Robins R.A. Endothelial monocyte-activating polypeptide-II (EMAP-II): a novel inducer of lymphocyte apoptosis. J Leukoc Biol 75 95 (2004) 772-776
    • (2004) J Leukoc Biol , vol.75 , Issue.95 , pp. 772-776
    • Murray, J.C.1    Heng, Y.M.2    Symonds, P.3    Rice, K.4    Ward, W.5    Huggins, M.6    Todd, I.7    Robins, R.A.8
  • 36
    • 0034102528 scopus 로고    scopus 로고
    • Cortisol inhibits hepatocyte growth factor/scatter factor expression and induces c-met transcripts in osteoblasts
    • Blanquaert F., Pereira R.C., and Canalis E. Cortisol inhibits hepatocyte growth factor/scatter factor expression and induces c-met transcripts in osteoblasts. Am J Physiol Endocrinol 278 (2000) 509-515
    • (2000) Am J Physiol Endocrinol , vol.278 , pp. 509-515
    • Blanquaert, F.1    Pereira, R.C.2    Canalis, E.3
  • 37
    • 18844364782 scopus 로고    scopus 로고
    • CD 27 and CD70 in T cell and B cell activation
    • Borst J., Hendricks J., and Xiao Y. CD 27 and CD70 in T cell and B cell activation. Curr Opin Immunol 17 (2005) 275-281
    • (2005) Curr Opin Immunol , vol.17 , pp. 275-281
    • Borst, J.1    Hendricks, J.2    Xiao, Y.3
  • 39
    • 0141890063 scopus 로고    scopus 로고
    • Is macrophage inhibitory factor a therapeutic target in systemic lupus erythematosus?
    • Hoi A.Y., Morand E.F., and Leech M. Is macrophage inhibitory factor a therapeutic target in systemic lupus erythematosus?. Immunol Cell Biol 81 (2003) 367-373
    • (2003) Immunol Cell Biol , vol.81 , pp. 367-373
    • Hoi, A.Y.1    Morand, E.F.2    Leech, M.3
  • 40
    • 0028263883 scopus 로고
    • Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts
    • Harada S., Nagy J.A., Sullivan K.A., et al. Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts. J Clin Invest 93 (1994) 2490-2496
    • (1994) J Clin Invest , vol.93 , pp. 2490-2496
    • Harada, S.1    Nagy, J.A.2    Sullivan, K.A.3
  • 41
    • 0037162547 scopus 로고    scopus 로고
    • Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover
    • Street J., Bao M., De Guzman L., Bunting S., Peale F.V., Ferrara N., et al. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci 99 (2002) 9656-9661
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 9656-9661
    • Street, J.1    Bao, M.2    De Guzman, L.3    Bunting, S.4    Peale, F.V.5    Ferrara, N.6
  • 42
    • 20844441406 scopus 로고    scopus 로고
    • Decreased release of the angiogenic peptide vascular endothelial growth factor in Alzheimer's disease: recovering effect with insulin and DHEA sulfate
    • Solerte S.B., Ferrari E., Cuzzoni G., Locatelli E., Giustina A., Zamboni M., Schifoni N., et al. Decreased release of the angiogenic peptide vascular endothelial growth factor in Alzheimer's disease: recovering effect with insulin and DHEA sulfate. Dement Geriatr Cogn Disord 19 1 (2005) 1-10
    • (2005) Dement Geriatr Cogn Disord , vol.19 , Issue.1 , pp. 1-10
    • Solerte, S.B.1    Ferrari, E.2    Cuzzoni, G.3    Locatelli, E.4    Giustina, A.5    Zamboni, M.6    Schifoni, N.7


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