Endothelial monocyte-activating polypeptide-II (EMAP-II): A novel inducer of lymphocyte apoptosis

Journal of Leukocyte Biology

Volumn 75, Issue 5, 2004, Pages 772-776

  Murray, J C ^a   Heng, Y M ^a   Symonds, P ^a   Rice, K ^a   Ward, W ^a   Huggins, M ^b   Todd, I ^b   Robins, R A ^b  

^a NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Cytokine; Immune evasion; P43; Tumor

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTHELIAL MONOCYTE ACTIVATING POLYPEPTIDE II; PADGEM PROTEIN; PROTEIN P43; TUMOR NECROSIS FACTOR RECEPTOR 1;

APOPTOSIS; CELL PROLIFERATION; CHEMOTAXIS; COLORECTAL CANCER; CONFERENCE PAPER; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHOCYTE; MONOCYTE; NEUTROPHIL; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS;

ADJUVANTS, IMMUNOLOGIC; APOPTOSIS; CELL DIVISION; CELL LINE, TUMOR; COCULTURE TECHNIQUES; COLORECTAL NEOPLASMS; CYTOKINES; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; NEOPLASM PROTEINS; RNA-BINDING PROTEINS; T-LYMPHOCYTES;

EID: 2342559234     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1003487     Document Type: Conference Paper

References (17)

1. Berger, A. C., Tang, G., Alexander, H. R., Libutti, S. K. (2000) Endothelial monocyte-activating polypeptide II, a tumor-derived cytokine that plays an important role in inflammation, apoptosis, and angiogenesis. J. Immunother. 23, 519-527.
2. Murray, J. C., Tas, M. P. R. (2001) Endothelial monocyte-activating polypeptide 2: a novel injury signal? In The New Angiotherapy (T. P. Fan, E. C. Kohn, eds.), Clifton, NJ, Humana, 491-498.
3. Kao, J., Ryan, J., Brett, J., Chen, J., Shen, H., Fan, Y-G., Godman, G., Familletti, P., Pan, Y-C., Stern, D., Clauss, M. (1992) Endothelial monocyte-activating polypeptide II. A novel tumor-derived polypeptide that activates host-response mechanisms. J. Biol. Chem. 267, 20239-20247.
4. Kao, J., Houck, K., Fan, Y., Haehnel, I., Libutti, S. K., Kayton, M. L., Grikscheit, T., Chabot, J., Nowygrod, R., Greenberg, S., Kuang, W-J., Leung, D. W.; Hayward, Kisiel, W., Heath, M., Brett, J., Stern, D. (1994) Characterization of a novel tumor-derived cytokine. Endothelial monocyte-activating polypeptide II. J. Biol. Chem. 269, 25106-25119.
5. Tas, M. P. R., Houghton, J., Jakobsen, A. M., Tolmachova, T., Carmichael, J., Murray, J. C. (1997) Cloning and expression of human endothelial monocyte-activating polypeptide 2 (EMAP-II) and identification of its putative precursor. Cytokine 9, 535-539.
6. Kao, J., Fan, Y., Haehnel, I., Brett, J., Greenberg, S., Clauss, M., Kayton, M. L., Houck, K., Kisiel, W., Seljelid, R., Burnier, J., Stern, D. (1994) A peptide derived from the amino terminus of endothelial monocyte-activating polypeptide II modulates mononuclear and polymorphonuclear leukocyte functions, defines an apparently novel cellular interaction site, and induces an acute inflammatory response. J. Biol. Chem. 269, 9774-9782.
7. Kim, Y., Shin, J., Li, R., Cheong, C., Kim, K., Kim, S. (2000) A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetase. J. Biol. Chem. 275, 27062-27068.
8. Behrensdorf, H. A., van de Craen, M., Knies, U. E., Vandenabeele, P., Clauss, M. (2000) The endothelial monocyte-activating polypeptide II (EMAP-II) is a substrate for caspase 7. FEBS Lett. 466, 143-147.
9. Murray, J. C., Barnett, G., Tas, M. P. R., Jakobsen, A. M., Brown, J., Powe, D., Clelland, C. (2000) Immunohistochemical analysis of endothelial monocyte-activating polypeptide-II (EMAP-II) expression in vivo. Am. J. Pathol. 157, 2045-2053.
10. Zhang, F. R., Schwarz, M. A. (2002) Pro-EMAP-II is not primarily cleaved by caspase-3 and -7. Am. J. Physiol. Lung Cell. Mol. Physiol. 282, L1239-L1244.
11. MacKenzie, A., Wilson, H. L., Kiss-Toth, E., Dower, S. K., North, R. A., Suprenant, A. (2001) Rapid secretion of interleukin-1β by microvesicle shedding. Immunity 15, 825-835.
12. Quevillon, S., Agou, F., Robinson, J-C., Mirande, M. (1997) The p43 component of the mammalian multi-synthetase complex is likely to be the precursor of the endothelial monocyte-activating polypeptide II cytokine. J. Biol. Chem. 272, 32573-32579.
13. Schwarz, M., Brett, J., Li, J., Hayward, J., Schwarz, R., Kao, J., Chappey, O., Wautier, J. L., Chabot, J., Lo Gerfo, P., Stern, D. (1999) Endothelial-monocyte activating polypeptide II, a novel anti-tumor cytokine that suppresses primary and metastatic tumor growth and induces apoptosis in growing endothelial cells. J. Exp. Med. 190, 341-354.
14. Berger, A. C., Alexander, H. R., Tang, G., Wu, P. C., Hewitt, S. M., Turner, E. S., Kruger, E., Figg, W. D., Grove, A., Kohn, E., Stern, D., Libutti, S. K. (2000) Endothelial monocyte-activating polypeptide-II induces endothelial cell apoptosis and may inhibit tumor angiogenesis. Microvasc. Res. 60, 70-80.
15. Schwarz, M., Lee, M., Zhang, F., Zhao, J., Jim, Y., Smith, S., Bhuva, J., Stern, D., Warburton, D., Starnes, V. (1999). EMAP II: a modulator of neovascularization in the developing lung. Am. J. Physiol, 276, L365-L375.
16. Barnett, G., Jakobsen, A. M., Tas, M., Rice, K., Carmichael, J., Murray, J. C. (2000) Prostate adenocarcinoma cells release the novel pro-inflammatory polypeptide EMAP-II in response to stress. Cancer Res. 60, 2850-2857.
17. Murray, J. C., Symonds, P., Ward, W., Huggins, M., Tiga, A., Rice, K., Heng, Y. M., Todd, I., Robins, R. A. (2004) Colorectal cancer cells induce apoptosis in lymphocytes by an EMAP-II-dependent mechanism. J. Immunol. 172, 274-281.