Endogenous MMTV proviruses induce susceptibility to both viral and bacterial pathogens

PLoS Pathogens

Volumn 2, Issue 12, 2006, Pages 1134-1143

  Bhadra, Sanchita ^a   Lozano, Mary M ^a   Payne, Shelley M ^a   Dudley, Jaquelin P ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SUPERANTIGEN; BACTERIUM ANTIBODY; VIRUS ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL VIRULENCE; CARCINOGENESIS; CONTROLLED STUDY; IMMUNE RESPONSE; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; PROVIRUS; RAT; SALMONELLA TYPHIMURIUM; T CELL LYMPHOMA; T LYMPHOCYTE; VIBRIO CHOLERAE; VIRUS LOAD; VIRUS VIRULENCE; ANIMAL; BAGG ALBINO MOUSE; CHOLERA; COMPARATIVE STUDY; CONGENIC STRAIN; DISEASE PREDISPOSITION; EXPERIMENTAL NEOPLASM; GENETIC TRANSFECTION; GENETICS; IMMUNOLOGY; MICROBIOLOGY; PATHOGENICITY; PHYSIOLOGY; RETROVIRUS; RETROVIRUS INFECTION; SALMONELLOSIS; VIROLOGY; VIRUS INFECTION;

ANIMALIA; BACTERIA (MICROORGANISMS); BETARETROVIRUS; HUMAN ENDOGENOUS RETROVIRUSES; MOUSE MAMMARY TUMOR VIRUS; NEGIBACTERIA; SALMONELLA TYPHIMURIUM; VIBRIO CHOLERAE;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODIES, VIRAL; CHOLERA; DISEASE SUSCEPTIBILITY; MAMMARY NEOPLASMS, EXPERIMENTAL; MAMMARY TUMOR VIRUS, MOUSE; MICE; MICE, CONGENIC; MICE, INBRED BALB C; PROVIRUSES; RATS; RETROVIRIDAE; RETROVIRIDAE INFECTIONS; SALMONELLA INFECTIONS; SALMONELLA TYPHIMURIUM; SUPERANTIGENS; TRANSFECTION; TUMOR VIRUS INFECTIONS; VIBRIO CHOLERAE;

EID: 33846001696     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.0020128     Document Type: Article

References (56)

1. Froy O (2005) Regulation of mammalian defensin expression by Toll-like receptor-dependent and independent signaling pathways. Cell Microbiol 7: 1387-1397.
2. O'Neill LA (2002) Signal transduction pathways activated by the IL-1 receptor/toll-like receptor superfamily. Curr Top Microbiol Immunol 270: 47-61.
3. Takeda K, Akira S (2005) Toll-like receptors in innate immunity. Int Immunol 17: 1-14.
4. Akira S, Takeda K, Kaisho T (2001) Toll-like receptors: Critical proteins linking innate and acquired immunity. Nat Immunol 2: 675-680.
5. Mangeat B, Trono D (2005) Lentiviral vectors and antiretroviral intrinsic immunity. Hum Gene Ther 16: 913-920.
6. Golovkina TV, Chervonsky A, Dudley JP, Ross SR (1992) Transgenic mouse mammary tumor virus superantigen expression prevents viral infection. Cell 69: 637-645.
7. Held W, Waanders GA, Shakhov AN, Scarpellino L, Acha-Orbea H, et al. (1993) Superantigen-induced immune stimulation amplifies mouse mammary tumor virus infection and allows virus transmission. Cell 74: 529-540.
8. Cohen JC, Varmus HE (1979) Endogenous mammary tumor virus DNA varies among wild mice and segregates during inbreeding. Nature 278: 418-423.
9. Mertz JA, Simper MS, Lozano MM, Payne SM, Dudley JP (2005) Mouse mammary tumor virus encodes a self-regulatory RNA export protein and is a complex retrovirus. J Virol 79: 14737-14747.
10. Golovkina TV, Shlomchik M, Hannum L, Chervonsky A (1999) Organogenic role of B lymphocytes in mucosal immunity. Science 286: 1965-1968.
11. Baribaud F, Maillard I, Vacheron S, Brocker T, Diggelmann H, et al. (1999) Role of dendritic cells in the immune response induced by mouse mammary tumor virus superantigen. J Virol 73: 8403-8410.
12. Korman AJ, Bourgarel P, Meo T, Rieckhof GE (1992) The mouse mammary tumor virus long terminal repeat encodes a type II transmembrane glycoprotein. EMBO J 11: 1901-1905.
13. Maillard I, Launois P, Xenarios I, Louis JA, Acha-Orbea H, et al. (1998) Immune response to mouse mammary tumor virus in mice lacking the α/β interferon or the c interferon receptor. J Virol 72: 2638-2646.
14. Golovkina TV, Dudley JP, Ross SR (1998) B and T cells are required for mouse mammary tumor virus spread within the mammary gland. J Immunol 161: 2375-2382.
15. Acha-Orbea H, Palmer E (1991) Mls: A retrovirus exploits the immune system. Immunol Today 12: 356-361.
16. Champagne E, Scarpellino L, Lane P, Acha-Orbea H (1996) CD28/CTLA4-B7 interaction is dispensable for T-cell stimulation by mouse mammary tumor virus superantigen, but not for B-cell differentiation and virus dissemination. Eur J Immunol 26: 1595-1602.
17. Tsubura A, Inaba M, Imai S, Murakami A, Oyaizu N, et al. (1988) Intervention of T cells in transportation of mouse mammary tumor virus (milk factor) to mammary gland cells in vivo. Cancer Res 48: 6555-6559.
18. Beutner U, Kraus E, Kitamura D, Rajewsky K, Huber BT (1994) B cells are essential for murine mammary tumor virus transmission, but not for presentation of endogenous superantigens. J Exp Med 179: 1457-1466.
19. Chervonsky AV, Xu J, Barlow AK, Khery M, Flavell RA, et al. (1995) Direct physical interaction involving CD40 ligand on T cells and CD40 on B cells is required to propagate MMTV. Immunity 3: 139-146.
20. Palmer LD, Saha B, Hodes RJ, Abe R (1996) The role of CD28 co-stimulation in immune-mediated responses against mouse mammary tumor viruses. J Immunol 156: 2112-2118.
21. Kozak C, Peters G, Pauley R, Morris V, Michalides R, et al. (1987) A standardized nomenclature for endogenous mouse mammary tumor viruses. J Virol 61: 1651-1654.
22. Scherer MT, Ignatowicz L, Pullen A, Kappler J, Marrack P (1995) The use of mammary tumor virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T-cell repertoire. J Exp Med 182: 1493-1504.
23. Yazdanbakhsh K, Park CG, Winslow GM, Choi Y (1993) Direct evidence for the role of COOH terminus of mouse mammary tumor virus superantigen in determining T cell receptor Vb specificity. J Exp Med 178: 737-741.
24. Ross SR (1997) Mouse mammary tumor virus and the immune system. Adv Pharmacol 39: 21-46.
25. Ross SR, Schofield JJ, Farr CJ, Bucan M (2002) Mouse transferin receptor 1 is the cell entry receptor for mouse mammary tumor virus. Proc Natl Acad Sci U S A 99: 12386-12390.
26. Rassa JC, Meyers JL, Zhang Y, Kudaravalli R, Ross SR (2002) Murine retroviruses activate B cells via interaction with toll-like receptor 4. Proc Natl Acad Sci U S A 99: 2281-2286.
27. Velupillai P, Yoshizawa I, Dey DC, Nahill SR, Carroll JP, et al. (1999) Wild-derived inbred mice have a novel basis of susceptibility to polyomavirus-induced tumors. J Virol 73: 10079-10085.
28. Held W, Shakhov AN, Waanders G, Scarpellino L, Luethy R, et al. (1992) An exogenous mouse mammary tumor virus with properties of Mls-1a (Mtv-7). J Exp Med 175: 1623-1633.
29. Shackleford GM, Varmus HE (1988) Construction of a clonable, infectious, and tumorigenic mouse mammary tumor virus provirus and a derivative genetic vector. Proc Natl Acad Sci U S A 85: 9655-9659.
30. Mustafa F, Lozano M, Dudley JP (2000) C3H mouse mammary tumor virus superantigen function requires a splice donor site in the envelope gene. J Virol 74: 9431-9440.
31. Nusse R, van Ooyen A, Cox D, Fung YK, Varmus H (1984) Mode of proviral activation of a putative mammary oncogene (int-1) on mouse Chromosome 15. Nature 307: 131-136.
32. Dickson C, Smith R, Brookes S, Peters G (1984) Tumorigenesis by mouse mammary tumor virus: Proviral activation of a cellular gene in the common integration region int-2. Cell 37: 529-536.
33. Gallahan D, Kozak C, Callahan R (1987) A new common integration region (int-3) for mouse mammary tumor virus on mouse Chromosome 17. J Virol 61: 218-220.
34. Mustafa F, Bhadra S, Johnston D, Lozano M, Dudley JP (2003) The type B leukemogenic virus truncated superantigen is dispensable for T-cell lymphomagenesis. J Virol 77: 3866-3870.
35. Ball JK, Arthur LO, Dekaban GA (1985) The involvement of a type-B retrovirus in the induction of thymic lymphomas. Virology 140: 159-172.
36. Hsu CL, Fabritius C, Dudley J (1988) Mouse mammary tumor virus proviruses in T-cell lymphomas lack a negative regulatory element in the long terminal repeat. J Virol 62: 4644-4652.
37. Liu J, Bramblett D, Zhu Q, Lozano M, Kobayashi R, et al. (1997) The matrix attachment region-binding protein SATB1 participates in negative regulation of tissue-specific gene expression. Mol Cell Biol 17: 5275-5287.
38. Finke D, Luther SA, Acha-Orbea H (2003) The role of neutralizing antibodies for mouse mammary tumor virus transmission and mammary cancer development. Proc Natl Acad Sci U S A 100: 199-204.
39. Purdy A, Case L, Duvall M, Overstrom-Coleman M, Monnier N, et al. (2003) Unique resistance of I/LnJ mice to a retrovirus is due to sustained interferon gamma-dependent production of virus-neutralizing antibodies. J Exp Med 197: 233-243.
40. Kim KJ, Kanellopoulos-Langevin C, Merwin RM, Sachs DH, Asofsky R (1979) Establishment and characterization of BALB/c lymphoma lines with B-cell properties. J Immunol 122: 549-554.
41. Stoebner JA, Butterton JR, Calderwood SB, Payne SM (1992) Identification of the vibriobactin receptor of Vibrio cholerae. J Bacteriol 174: 3270-3274.
42. Wrona T, Dudley JP (1996) Major histocompatibility complex class II I-E-independent transmission of C3H mouse mammary tumor virus. J Virol 70: 1246-1249.
43. Ball JK, Diggelmann H, Dekaban GA, Grossi GF, Semmler R, et al. (1988) Alterations in the U3 region of the long terminal repeat of an infectious thymotropic type B retrovirus. J Virol 62: 2985-2993.
44. Lukacher AE, Ma Y, Carroll JP, Abromson-Leeman SR, Laning JC, et al. (1995) Susceptibility to tumors induced by polyoma virus is conferred by an endogenous mouse mammary tumor virus superantigen. J Exp Med 181: 1683-1692.
45. Cho K, Ferrick DA, Morris DW (1995) Structure and biological activity of the subgenomic Mtv-6 endogenous provirus. Virology 206: 395-402.
46. Gill RF, Abastado JP, Wei WZ (1994) Systematic identification of H-2 Kd binding peptides and induction of peptide specific CTL. J Immunol Methods 176: 245-253.
47. Barnett A, Mustafa F, Wrona TJ, Lozano M, Dudley JP (1999) Expression of mouse mammary tumor virus superantigen mRNA in the thymus correlates with kinetics of self-reactive T-cell loss. J Virol 73: 6634-6645.
48. Haines GK III, Sayed BA, Rohrer MS, Olivier V, Satchell KJ (2005) Role of toll-like receptor 4 in the proinflammatory response to Vibrio cholerae O1 El tor strains deficient in production of cholera toxin and accessory toxins. Infect Immun 73: 6157-6164.
49. Jude BA, Pobezinskaya Y, Bishop J, Parke S, Medzhitov RM, et al. (2003) Subversion of the innate immune system by a retrovirus. Nat Immunol 4: 573-578.
50. Hopkins PA, Fraser JD, Pridmore AC, Russell HH, Read RC, et al. (2005) Superantigen recognition by HLA class II on monocytes upregulates toll-like receptor 4 and enhances proinflammatory responses to endotoxin. Blood 105: 3655-3662.
51. Yang JN, Dudley J (1992) Endogenous Mtv-8 or a closely linked sequence stimulates rearrangement of the downstream Vκ9 gene. J Immunol 149: 1242-1251.
52. Henderson DP, Payne SM (1994) Vibrio cholerae iron transport systems: Roles of heme and siderophore iron transport in virulence and identification of a gene associated with multiple iron transport systems. Infect Immun 62: 5120-5125.
53. Mey AR, Wyckoff EE, Oglesby AG, Rab E, Taylor RK, et al. (2002) Identification of the Vibrio cholerae enterobactin receptors VctA and IrgA: IrgA is not required for virulence. Infect Immun 70: 3419-3426.
54. Reed LJ, Muench H (1938) A simple method of estimating fifty percent endpoint. Amer J Hyg 27: 493-497.
55. Mertz JA, Mustafa F, Meyers S, Dudley JP (2001) Type B leukemogenic virus has a T-cell-specific enhancer that binds AML-1. J Virol 75: 2174-2184.
56. Wrona TJ, Lozano M, Binhazim AA, Dudley JP (1998) Mutational and functional analysis of the C-terminal region of the C3H mouse mammary tumor virus superantigen. J Virol 72: 4746-4755.