Tolerance and cross-tolerance to morphine-like stimulus effects of μ opioids in rats

Psychopharmacology

Volumn 133, Issue 1, 1997, Pages 17-28

  Walker, Ellen A ^a,b   Richardson, Tonia M ^a   Young, Alice M ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Drug discrimination; Efficacy; Fentanyl; Morphine; Nalbuphine; Tolerance

Indexed keywords

FENTANYL; METHADONE; MORPHINE; NALBUPHINE; NALTREXONE; OPIATE AGONIST; PETHIDINE;

ANIMAL EXPERIMENT; ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; CROSS TOLERANCE; DISCRIMINATIVE STIMULUS; DRUG DISCRIMINATION; DRUG TOLERANCE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANALGESICS, OPIOID; ANIMALS; DISCRIMINATION LEARNING; DRUG TOLERANCE; FENTANYL; MALE; MORPHINE; NALBUPHINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU; SELF ADMINISTRATION;

EID: 0030833258     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050366     Document Type: Article

References (40)

1. Adams JU, Paronis CA, Holtzman SG (1990) Assessment of relative intrinsic activity of μ-opioid analgesic in vivo by using β-funaltrexainine. J Pharmacol Exp Ther 255: 1027-1032
2. Beaver WT, Feise GA (1978) A comparison of the analgesic effect of intramuscular nalbuphine and morphine in patients with postoperative pain. J Pharmacol Exp Ther 204: 487-496
3. Berkowitz BA, Cerreta KV, Spector S (1974) The influence of physiologic and pharmacologic factors on the disposition of morphine as determined by radioimmunoassay. J Pharmacol Exp Ther 191: 527-534
4. Bruning JL, Kintz BL (1987) Computational handbook of statistics, 3rd edn. Harper Collins Publishers, Glenview
5. Colpaert FC (1995) Drug discrimination: no evidence for tolerance to opiates. Pharmacol Rev 47[4]: 605-629
6. Emmett-Oglesby MW, Shippenberg TS, Herz A (1988) Tolerance and cross-tolerance to the discriminative stimulus properties of fentanyl and morphine. J Pharmacol Exp Ther 245: 17-23
7. Emmett-Oglesby MW, Shippenberg TS, Herz A (1989) Fentanyl and morphine discrimination in rats continuously infused with fentanyl. Behav Pharmacol 1: 3-11
8. Finney D (1964) Statistical methods in biological assay, 2nd edn. Hafner, New York
9. Fragen RJ, Caldwell N (1977) Acute intravenous premedication with nalbuphine. Anesthes Analg 56: 808-812
10. Gal T, DiFazio C, Moscicki M (1982) Analgesic and respiratory depressant activity of nalbuphine: a comparison with morphine. Anesthesiology 57: 367-374
11. Gerak LR, France CP (1996) Changes in sensitivity to the rate-decreasing effects of opioids in pigeons treated acutely or chronically with nalbuphine. Behav Pharmacol 7: 437-447
12. Gerak LR, Butelman ER, Woods JH, France CP (1994) Antinociceptive and respiratory effects of nalbuphine in rhesus monkeys. J Pharmacol Exp Ther 271[2]: 993-999
13. Goldstein A, Sheenan P (1969) Tolerance to opioid narcotics. I. Tolerance to the "running fit" caused by levorphanol in the mouse. J Pharmacol Exp Ther 169: 175-184
14. Hess R, Stiebler G, Herz A (1972) Pharmacokinetics of fentanyl in man and the rabbit. Eur J Clin Pharmacol 4: 137-141
15. Holtzman SG (1983) Discriminative stimulus properties of opioid agonists and antagonists. In: Cooper S (ed) Theory in psychopharmacology. Academic Press, London, pp 1-15
16. Holtzman SG, Locke KW (1988) Neural mechanisms of drug stimuli: experimental approaches. In: Colpaert FC, Balster R (eds) Transduction mechanisms of drug stimuli. In: Psychopharmacology series 4. Springer, Berlin Heidelberg, pp 139-153
17. Hug C, Murphy M (1981) Tissue redistribution of fentanyl and termination of its effects in rats. Anesthesiology 55: 369-375
18. Jaskinski DR, Mansky PA (1972) Evaluation of nalbuphine for abuse potential. Clin Pharinacol Ther 13: 78-90
19. Lo M, Lee F, Schary W (1987) The pharmacokinetics of intravenous, intramuscular, and subcutaneous nalbuphine in healthy subjects. Eur J Clin Pharmacol 33: 297-301
20. Miksic L, Lal H (1977) Tolerance to morphine-produced discriminative stimuli and analgesia. Psychopharmacology 54: 217-211
21. Miller R (1980) Evaluation of nalbuphine hydrochloride. Drug Ther Rev 37: 942-949
22. Paronis CA, Holtzman SG (1994) Sensitization and tolerance to the discriminative stimulus effects of mu-opioid agonists. Psychopharmacology 114: 601-310
23. Schmidt WK, Tam SW, Shotzberger GS, Smith DH Jr, Clark R, Vernier VG (1985) Nalbuphine. Drug Alcohol Depend 14: 339-362
24. Shannon HE, Holtzman SG (1976) Evaluation of the discriminative stimulus effects of morphine in the rat. J Pharmacol Exp Ther 198[1]: 54-65
25. Snedecor GW, Cochran WG (1967) Statistical methods, 6th edn. Iowa State University Press, Ames, Iowa
26. Stanski DR, Greenblatt DJ, Lowenstein E (1978) Kinetics of intravenous and intramuscular morphine. Clin Pharmacol Ther 24: 52-59
27. Steinfels GF, Young GA, Khazan N (1982) Self-administration of nalbuphine, butorphanol and pentazocine by morphine post-addict rats. Pharmacol Biochem Behav 16: 167-71
28. Vanecek SA, Young AM (1996) Repeated treatment with high doses of morphine produces comparable tolerance to low- and high-dose discriminative stimulus effects of morphine. Exp Clin Psychopharmacol 4:251-257
29. Walker EA, Young AM (1993) Discriminative stimulus effects of the low efficacy mu agonist nalbuphine. J Pharmacol Exp Ther 267[1]: 322-330
30. Walker EA, Butelman ER, Woods JH (1993) Opioid thermal antinociception in rhesus monkeys: receptor mechanisms and temperature dependency. J Pharmacol Exp Ther 267[1]: 280-286
31. 2 analysis for naltrexone antagonism of discriminative stimulus and analgesic effects of opiate agonists in rats. J Pharmacol Exp Ther 271[2]: 959-968
32. Walker EA, Zernig G, Woods JH (1995) Buprenorphine antagonism of μ opioids in the rhesus monkey tail-withdrawal procedure. J Pharmacol Exp Ther 273: 1345-1352
33. Woods JH, Gmerek DE (1985) Substitution and primary dependence studies in animals. Drug Alcohol Depend 14: 233-47
34. Woods JH, Bertalmio AJ, Young AM, Essman WD, Winger G (1988) Receptor mechanisms of opioid drug discrimination. In: Colpaert FC, Balster R (eds) Psychopharmacology series 4. In: Transduction mechanisms of drug stimuli. Springer, Berlin Heidelberg, pp 95-106
35. Young AM (1991) Discriminative stimulus profiles of psychoactive drugs. In: Mello NK (ed) Advances in substance abuse, behavioral and biological research 4. Jessica Kingsley Publishers, London, pp 139-203
36. Young AM, Sannerud CA (1984) Tolerance to drug discriminative stimuli. In: Goudie A, Emmett-Oglesby M (eds) Psychoactive drugs. Humana Press, New Jersey, pp 221-278
37. Young AM, Sannerud CA, Steigerwald ES, Doty MD, Lipinski WJ, Tetrick LE (1990) Tolerance to morphine stimulus control: role of morphine maintenance dose. Psychopharmacology 102: 59-67
38. Young AM, Kapitsopoulos G, Makhay MM (1991) Tolerance to morphine-like stimulus effects of mu opioid agonists. J Pharmacol Exp Ther 257: 795-805
39. Young AM, Masaki MA, Geula C (1992) Discriminative stimulus effects of morphine: effects of training dose on agonist and antagonist effects of mu opioids. J Pharmacol Exp Ther 261: 246-257
40. Zimmerman DM, Leander JD, Reel JK, Hynes MD (1987) Use of β-funaltrexamine to determine μ opioid receptor involvement in the analgesic activity of various opioid ligands. J Pharmacol Exp Ther 241:374-378