Roles of nuclear receptors in the up-regulation of hepatic cholesterol 7α-hydroxylase by cholestyramine in rats

Life Sciences

Volumn 80, Issue 6, 2007, Pages 546-553

  Shibata, Shinya ^a   Hayakawa, Kazuhito ^a   Egashira, Yukari ^b   Sanada, Hiroo ^b  

^a YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

Bile acids; Cholesterol; Cholesterol 7 hydroxylase; Cholestyramine; Nuclear receptor

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER A1; ANTILIPEMIC AGENT; ATP BINDING CASSETTE TRANSPORTER B11; ATP BINDING CASSETTE TRANSPORTER G5; BILE ACID; CELL NUCLEUS RECEPTOR; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLIC ACID; COLESTYRAMINE; FARNESOID X RECEPTOR; LARD; LIVER X RECEPTOR; MESSENGER RNA; UNCLASSIFIED DRUG;

ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CHOLESTEROL LIVER LEVEL; CHOLESTEROL METABOLISM; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME REGULATION; GENE EXPRESSION REGULATION; LIPID DIET; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION; RAT; RNA ANALYSIS; STATISTICAL SIGNIFICANCE; UPREGULATION; WISTAR RAT;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CHOLESTYRAMINE; DISEASE MODELS, ANIMAL; GENE EXPRESSION; HYPERCHOLESTEROLEMIA; LIPIDS; LIVER; MALE; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

RATTUS NORVEGICUS;

EID: 33845953202     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2006.10.003     Document Type: Article

References (29)

1. Abrahamsson A., Gustafsson U., Ellis E., Nilsson L.M., Sahlin S., Bjorkhem I., and Einarsson C. Feedback regulation of bile acid synthesis in human liver: importance of HNF-4alpha for regulation of CYP7A1. Biochemical and Biophysical Research Communications 330 2 (2005) 395-399
2. American Institute of Nutrition. Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. Journal of Nutrition 107 (1977) 1340-1348
3. Ando H., Tsuruoka S., Yamamoto H., Takamura T., Kaneko S., and Fujimura A. Regulation of cholesterol 7alpha-hydroxylase mRNA expression in C57BL/6 mice fed an atherogenic diet. Atherosclerosis 178 2 (2005) 265-269
4. Chiang J.Y.L. Reversed phase high performance liquid chromatography assay of cholesterol 7α-hydroxylase. Methods in Enzymology 206 (1991) 483-491
5. Chiang J.Y.L. Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms. Journal of Hepatology 40 3 (2004) 539-551
6. Crestani M., Sadeghpour A., Stroup D., Galli G., and Chiang J.Y.L. Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors. Journal of Lipid Research 39 11 (1998) 2192-2200
7. Folch J., Lees M., and Sloane-Stanley G.H. A simple method for the isolation and purification of total lipids from animal tissues. Journal of Biological Chemistry 226 (1957) 497-509
8. Gupta S., Stravitz R.T., Dent P., and Hylemon P.B. Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway. Journal of Biological Chemistry 276 19 (2001) 15816-15822
9. Gupta S., Pandak W.M., and Hylemon P.B. LXR alpha is the dominant regulator of CYP7A1 transcription. Biochemical and Biophysical Research Communications 293 1 (2002) 338-343
10. Hoekstra M., Kruijt J.K., Van Eck M., and Van Berkel T.J. Specific gene expression of ATP-binding cassette transporters and nuclear hormone receptors in rat liver parenchymal, endothelial, and Kupffer cells. Journal of Biological Chemistry 278 28 (2003) 25448-25453
11. Honda A., Salen G., Matsuzaki Y., Batta A.K., Xu G., Hirayama T., Tint G.S., Doy M., and Shefer S. Disrupted coordinate regulation of farnesoid X receptor target genes in a patient with cerebrotendinous xanthomatosis. Journal of Lipid Research 46 2 (2005) 287-296
12. Inoue Y., Yu A.M., Yim S.H., Ma X., Krausz K.W., Inoue J., Xiang C.C., Brownstein M.J., Eggertsen G., Bjorkhem I., and Gonzalez F.J. Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4α. Journal of Lipid Research 47 1 (2006) 215-227
13. Kerr T.A., Saeki S., Schneider M., Schaefer K., Berdy S., Redder T., Shan B., Russell D.W., and Schwarz M. Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis. Developmental Cell 2 6 (2002) 713-720
14. Kuroda M., and Endo A. Inhibition of in vitro cholesterol synthesis by fatty acids. Biochimica et Biophysica Acta 486 (1977) 70-81
15. Li T., and Chiang J.Y. Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription. American Journal of Physiology: Gastrointestinal and Liver Physiology 288 1 (2005) G74-G84
16. Lehmann J.M., Kliewer S.A., Moore L.B., Smith-Oliver T.A., Oliver B.B., Su J.L., Sundseth S.S., Winegar D.A., Blanchard D.E., Spencer T.A., and Willson T.M. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. Journal of Biological Chemistry 272 6 (1997) 3137-3140
17. Malerød L., Sporstol M., Juvet L.K., Mousavi S.A., Gjøen T., Berg T., Roos N., and Eskild W. Bile acids reduce SR-BI expression in hepatocytes by a pathway involving FXR/RXR, SHP, and LRH-1. Biochemical and Biophysical Research Communications 336 4 (2005) 1096-1105
18. Miserez A.R., Cao G., Probst L.C., and Hobbs H.H. Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2). Genomics 40 1 (1997) 31-40
19. Nguyen L.B., Xu G., Shefer S., Tint G.S., Batta A., and Salen G. Comparative regulation of hepatic sterol 27-hydroxylase and cholesterol 7alpha-hydroxylase activities in the rat, guinea pig, and rabbit: effects of cholesterol and bile acids. Metabolism 48 12 (1999) 1542-1548
20. Nishimura N., Umeda C., Oda H., and Yokogoshi H. The effect of taurine on the cholesterol metabolism in rats fed diets supplemented with cholestyramine or high amounts of bile acid. Journal of Nutritional Science and Vitaminology 49 1 (2003) 21-26
21. Ogishima T., and Okuda K. An improved method for assay of cholesterol 7 alpha-hydroxylase activity. Analytical Biochemistry 158 1 (1986) 228-232
22. Repa J.J., Berge K.E., Pomajzl C., Richardson J.A., Hobbs H., and Mangelsdorf D.J. Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors α and β. Journal of Biological Chemistry 277 21 (2002) 18793-18800
23. Roberts C.K., Liang K., Barnard R.J., Kim C.H., and Vaziri N.D. HMG-CoA reductase, cholesterol 7α-hydroxylase, LDL receptor, SR-B1, and ACAT in diet-induced syndrome X. Kidney International 66 4 (2004) 1503-1511
24. Roglans N., Verd J.C., Peris C., Alegret M., Vázquez M., Adzet T., Díaz C., Hernández G., Laguna J.C., and Sánchez R.M. High doses of atorvastatin and simvastatin induce key enzymes involved in VLDL production. Lipids 37 5 (2002) 445-454
25. Russell D.W. The enzymes, regulation, and genetics of bile acid synthesis. Annual Review of Biochemistry 72 (2003) 137-174
26. Tovar A.R., Torre-Villalvazo I., Ochoa M., Elias A.L., Ortiz V., Aguilar-Salinas C.A., and Torres N. Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats. Journal of Lipid Research 46 9 (2005) 1823-1832
27. Whitney K.D., Watson M.A., Goodwin B., Galardi C.M., Maglich J.M., Wilson J.G., Willson T.M., Collins J.L., and Kliewer S.A. Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages. Journal of Biological Chemistry 276 47 (2001) 43509-43515
28. Wolters H., Elzinga B.M., Baller J.F., Boverhof R., Schwarz M., Stieger B., Verkade H.J., and Kuipers F. Effects of bile salt flux variations on the expression of hepatic bile salt transporters in vivo in mice. Journal of Hepatology 37 5 (2002) 556-563
29. Xu G., Pan L.X., Li H., Shang Q., Honda A., Shefer S., Bollineni J., Matsuzaki Y., Tint G.S., and Salen G. Dietary cholesterol stimulates CYP7A1 in rats because farnesoid X receptor is not activated. American Journal of Physiology: Gastrointestinal and Liver Physiology 286 5 (2004) G730-G735