Effects of chronic nitric oxide inhibition on the renal excretory response to leptin

Obesity Research

Volumn 12, Issue 6, 2004, Pages 1006-1010

  Villarreal, Daniel ^a   Reams, Garry ^b   Samar, Huma ^a   Spear, Robert ^a   Freeman, Ronald H ^b  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

Natriuresis; Sodium nitroprusside; Systemic hemodynamics

Indexed keywords

MURINAE;

ENZYME INHIBITOR; LEPTIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM; SODIUM;

ANIMAL; ARTICLE; BLOOD PRESSURE; DRUG ANTAGONISM; DRUG EFFECT; MALE; NATRIURESIS; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; URINE;

ANIMALS; BLOOD PRESSURE; ENZYME INHIBITORS; LEPTIN; MALE; NATRIURESIS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONORS; NITROPRUSSIDE; RATS; RATS, SPRAGUE-DAWLEY; SODIUM;

EID: 4644363328     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2004.123     Document Type: Article

References (26)

1. Misra A, Garg A. Leptin, its receptor and obesity. J Invest Med. 1996;44:540-8.
2. Caro JF, Sinha MK, Kolaezynski JW, Zhang PL, Considine RV. Leptin: the tale of an obesity gene. Diabetes. 1996;45:1455-62.
3. Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor OB-R. Cell. 1995;83:1263-71.
4. Chen H, Charlat O, Tartaglia A, et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 1996;84:491-5.
5. Lee GH, Proenca R, Monteg JM, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature. 1996;379:632-5.
6. Hoggard N, Mercer JG, Ragner DV, Moar K, Trayhurn P, Williams LM. Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridization. Biochem Biophys Res Commun. 1997;232:383-7.
7. Villarreal D, Reams GP, Freeman RH, Taraben A. Renal effects of leptin in normotensive, hypertensive, and obese rats. Am J Physiol. 1998;275:R2056-60.
8. Jackson EK, Li P. Human leptin has natriuretic activity in the rat. Am J Physiol. 1997;272:F333-8.
9. Villarreal D, Reams GP, Freeman RH. Effects of renal denervation on the renal actions of leptin in hypertensive rats. Kidney Int. 2000;58:989-94.
10. Haynes WG, Morgan DA, Walsh SA, Mark AL, Sivitz WI. Receptors-mediated regional sympathetic nerve activation by leptin. J Clin Invest. 1997;100:270-8.
11. Shek EW, Brands MW, Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension. 1998;31:409-14.
12. Lembo L, Vecchione C, Fratta L, et al. Leptin induces direct vasodilation through distinct endothelial mechanisms. Diabetes. 2000;49:293-7.
13. Sierra-Honigmann MR, Nath AK, Murakami C, et al. Biological action of leptin as an angiogenic factor. Science. 1998;281:1683-6.
14. Frübeck G. Pivotal role of nitric oxide in the control of blood pressure after leptin administration. Diabetes. 1999;48:903-8.
15. Beltkowski J, Wojcicka G, Borkowska E. Human leptin stimulates systemic nitric oxide production in the rat. Obes Res. 2002;10:939-46.
16. Knoblich PR, Freeman RH, Villarreal D. Pressure-dependent renin release during chronic blockade of nitric oxide synthase. Hypertension. 1996;28:738-42.
17. Bruning JL, Kintz BL. Computational Handbook of Statistics. 2nd ed. Glenview, IL: Scott Foresman ED; 1997; pp 44-61.
18. Lonquist F. The obese (ob) gene and its product leptin: a new route toward obesity treatment in man? QJM. 1996;89:327-32.
19. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 1995;269:546-9.
20. Nickola MW, Wold LE, Colligan PB, Wang GJ, Samson WK, Ren J. Leptin attenuates cardiac contraction in rat ventricular myocytes: role of NO. Hypertension. 2000;36:501-5.
21. Serradeil-Le Gal S, Raufaste D, Brossard G, et al. Characterization and localization of leptin receptors in the rat kidney. FEBS Lett. 1997;404:185-91.
22. Shimizu K, Izumiya Y, Keaton T, et al. Renal effets of leptin: interrelationship between natriuresis and sympathoactivation. J Hypertens. 2000;18:S15 (abstr).
23. Villarreal D, Guha PK, Samar HY, et al. Role of leptin in the regulation of body-fluid balance. FASEB J. 2003;17:5:A928 (abstr).
24. Kone BC. Nitric oxide in renal health and disease. Am J Kid Dis. 1997;30:311-31.
25. Salazar FJ, Llinas MT. Role of nitric oxide in the control of sodium excretion. News Physiol Sci. 1996;11:62-7.
26. G-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo. Cir Res. 1992;70:607-11.