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Volumn 74, Issue 6, 2006, Pages

Effect of supercoiling on formation of protein-mediated DNA loops

Author keywords

[No Author keywords available]

Indexed keywords

FREE ENERGY; GENES; MATHEMATICAL MODELS; MICROORGANISMS; PROTEINS; STRESS ANALYSIS;

EID: 33845793417     PISSN: 15393755     EISSN: 15502376     Source Type: Journal    
DOI: 10.1103/PhysRevE.74.061907     Document Type: Article
Times cited : (30)

References (59)
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    • The twist stiffness given here is smaller than the value found in single-molecule studies. Widom and Cloutier found that this small value was needed to fit their data on cyclization of short DNA, and proposed that it was an effective value reflecting a nonlinear breakdown of elasticity under high strain. Previous authors also found that a significant, though less dramatic, reduction of the value of twist stiffess was needed to fit cyclization of longer DNA. In the present work we found that a reduced effective twist stiffness was needed to get the required magnitude of the peak-to-valley energy change in Fig. 1; however, Saiz and Vilar have argued that the existence of multiple looping geometries can also reduce this modulation.


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