Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway

Cancer Letters

Volumn 245, Issue 1-2, 2007, Pages 341-349

  Dinkova Kostova, Albena T ^a   Cory, Ann H ^b   Bozak, Richard E ^c   Hicks, Ronald J ^c   Cory, Joseph G ^b  

^a Division of Clinical Pharmacology   (United States)

^b EAST CAROLINA UNIVERSITY   (United States)

^c CALIFORNIA STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; Bis(benzylidene)acetone; Chemoprotection; Glutathione; NQO1; Phase 2 response

Indexed keywords

BENZYLIDENEACETONE; BIS(2 HYDROXYBENZYLIDENE)ACETONE; CASPASE; CASPASE 10; CASPASE 3; CASPASE 6; CASPASE 8; DEOXYADENOSINE; GLUTATHIONE; GLUTATHIONE REDUCTASE; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN; PROTEIN KEAP1; PROTEIN P53; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL FREE SYSTEM; CELL MUTANT; CHEMOPROPHYLAXIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; LEUKEMIA CELL; LEUKEMIA L 1210; MICHAEL ADDITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

ACETONE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZYL COMPOUNDS; CASPASE 3; CASPASE 8; CASPASES; CELL CYCLE; CELL LINE, TUMOR; COUMARINS; CYSTEINE PROTEINASE INHIBITORS; DEOXYADENOSINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; FLOW CYTOMETRY; LEUKEMIA L1210; MICE; MUTATION; NAD(P)H DEHYDROGENASE (QUINONE); NADPH DEHYDROGENASE; OLIGOPEPTIDES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

MURINAE;

EID: 33845776058     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2006.01.024     Document Type: Article

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