Drotrecogin alfa (activated) prevents smoke-induced increases in pulmonary microvascular permeability and proinflammatory cytokine IL-1β in rats

Lung

Volumn 182, Issue 6, 2004, Pages 319-330

  Wong, S S ^a   Sun, N N ^a   Hyde, J D ^a   Ruiz, L ^a   Meigs, E ^a   Herrin, B R ^a   Fastje, C D ^a   Macdonald, S J ^a   Witten, M L ^a,b  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Activated protein C; Acute lung injury; Cytokine; Fire smoke; Substance P

Indexed keywords

DIESEL FUEL; DROTRECOGIN; INTERLEUKIN 1BETA; CYTOKINE; INTERLEUKIN 1; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN C; RECOMBINANT PROTEIN; SUBSTANCE P;

AIR; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; LUNG BURN; LUNG COMPLIANCE; LUNG LAVAGE; LUNG RESISTANCE; MALE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; ANIMAL; CAPILLARY PERMEABILITY; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; FISCHER 344 RAT; LUNG; METABOLISM; PATHOPHYSIOLOGY; SMOKE; TIME; VASCULARIZATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRONCHOALVEOLAR LAVAGE FLUID; CAPILLARY PERMEABILITY; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INTERLEUKIN-1; LUNG; MALE; PROTEIN C; RATS; RATS, INBRED F344; RECOMBINANT PROTEINS; SMOKE; SMOKE INHALATION INJURY; SUBSTANCE P; TIME FACTORS;

EID: 17144390190     PISSN: 03412040     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00408-004-2512-5     Document Type: Article

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