Activation of protein C and hemodynamic recovery after coronary artery bypass surgery

Journal of Thoracic and Cardiovascular Surgery

Volumn 133, Issue 1, 2007, Pages 44-51

  Raivio, Peter ^a   Fernández, Jose A ^b   Kuitunen, Anne ^a   Griffin, John H ^b   Lassila, Riitta ^a   Petäjä, Jari ^c  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c JORVI HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE; D DIMER; HEPARIN; PROTEIN C; PROTHROMBIN; THROMBIN; TROPONIN T;

ARTICLE; CORONARY ARTERY BYPASS SURGERY; CORRELATION ANALYSIS; FIBRINOLYSIS; HEART INDEX; HEART MUSCLE INJURY; HEMODYNAMIC PARAMETERS; HEMODYNAMICS; HUMAN; MAJOR CLINICAL STUDY; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN FUNCTION; REPERFUSION; THROMBIN TIME; VASCULAR RESISTANCE;

ANTICOAGULANTS; CARDIOVASCULAR PHYSIOLOGY; CORONARY ARTERY BYPASS; CREATINE KINASE, MB FORM; FIBRIN; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HUMANS; MYOCARDIAL REPERFUSION; PEPTIDE FRAGMENTS; PROTEIN C; PROTEIN PRECURSORS; PROTHROMBIN; THROMBIN; TROPONIN T; UP-REGULATION;

EID: 33845726164     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2006.10.003     Document Type: Article

References (24)

1. Esmon C.T. Inflammation and thrombosis. J Thromb Haemost 1 (2003) 1343-1348
2. Van de Wouwer M., Collen D., and Conway E.M. Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation. Arterioscler Thromb Vasc Biol 24 (2004) 1374-1383
3. Griffin J.H. Blood coagulation. The thrombin paradox. Nature 378 (1995) 337-338
4. Taylor Jr. F.B., Chang A., Esmon C.T., D'Angelo A., Vigano-D'Angelo S., and Blick K.E. Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon. J Clin Invest 79 (1987) 918-925
5. Bernard G.R., Vincent J.L., Laterre P.F., LaRosa S.P., Dhainaut J.F., Lopez-Rodriguez A., et al., Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344 (2001) 699-709
6. Vincent J.L., Angus D.C., Artigas A., Kalil A., Basson B.R., Jamal H.H., et al., Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) Study Group. Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med 31 (2003) 834-840
7. Levi M., Choi G., Schoots I., Schultz M., and van der Poll T. Beyond sepsis: activated protein C and ischemia-reperfusion injury. Crit Care Med 32 suppl (2004) S309-S312
8. Liaw P.C., Esmon C.T., Kahnamoui K., Schmidt S., Kahnamoui S., Ferrell G., et al. Patients with severe sepsis vary markedly in their ability to generate activated protein C. Blood 104 (2004) 3958-3964
9. Lindström O, Kylänpää L, Mentula P, Puolakkainen P, Kemppainen E, Haapiainen R, et al. Up-regulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitis. Crit Care. 2006;10:R16.
10. Raivio P., Kuitunen A., Suojaranta-Ylinen R., Lassila R., and Petäjä J. Thrombin generation during reperfusion after coronary artery bypass surgery associates with postoperative myocardial damage. J Thromb Haemost 4 (2006) 1523-1529
11. Petäjä J., Pesonen E., Fernandez J.A., Vento A.E., Rämö O.J., and Griffin J.H. Cardiopulmonary bypass and activation of antithrombotic plasma protein C. J Thorac Cardiovasc Surg 118 (1999) 422-429
12. Petäjä J., Pesonen E., Fernandez J.A., Griffin J.H., Repo H., Jansson S.E., et al. Activated protein C and inflammation in human myocardium after heart surgery. Am J Hematol 67 (2001) 210-212
13. Nilsson J., Algotsson L., Hoglund P., Luhrs C., and Brandt J. Early mortality in coronary bypass surgery: the EuroSCORE versus the Society of Thoracic Surgeons risk algorithm. Ann Thorac Surg 77 (2004) 1235-1239
14. Gruber A., and Griffin J.H. Direct detection of activated protein C in blood from human subjects. Blood 79 (1992) 2340-2348
15. Ilmakunnas M., Pesonen E.J., Höckerstedt K., Mäkisalo H., Fernandez J.A., Griffin J.H., et al. Graft protein C entrapment is associated with reduced phagocyte activation during reperfusion in human liver transplantation. Crit Care Med 34 (2006) 426-432
16. Turunen A.J., Fernandez J.A., Lindgren L., Salmela K.T., Kyllönen L.E., Mäkisalo H., et al. Activated protein C reduces graft neutrophil activation in clinical renal transplantation. Am J Transplant 5 (2005) 2204-2212
17. Shibata M., Kumar S.R., Amar A., Fernandez J.A., Hofman F., Griffin J.H., et al. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation 103 (2001) 1799-1805
18. Cheng T., Liu D., Griffin J.H., Fernandez J.A., Castellino F., Rosen E.D., et al. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med 9 (2003) 338-342
19. Hirose K., Okajima K., Taoka Y., Uchiba M., Tagami H., Nakano K., et al. Activated protein C reduces the ischemia/reperfusion-induced spinal cord injury in rats by inhibiting neutrophil activation. Ann Surg 232 (2000) 272-280
20. Mizutani A., Okajima K., Uchiba M., and Noguchi T. Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation. Blood 95 (2000) 3781-3787
21. Schoots I.G., Levi M., van Vliet A.K., Maas A.M., Roossink E.H., and van Gulik T.M. Inhibition of coagulation and inflammation by activated protein C or antithrombin reduces intestinal ischemia/reperfusion injury in rats. Crit Care Med 32 (2004) 1375-1383
22. Snow T.R., Deal M.T., Dickey D.T., and Esmon C.T. Protein C activation following coronary artery occlusion in the in situ porcine heart. Circulation 84 (1991) 293-299
23. Takazoe K., Ogawa H., Yasue H., Sakamoto T., Oshima S., Arai H., et al. Association of plasma levels of activated protein C with recanalization of the infarct-related coronary artery after thrombolytic therapy in acute myocardial infarction. Thromb Res 95 (1999) 37-47
24. French J.K., and White H.D. Clinical implications of the new definition of myocardial infarction. Heart 90 (2004) 99-106