Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitis

Critical Care

Volumn 10, Issue 1, 2006, Pages

  Lindstrom, Outi ^a   Kylanpaa, Leena ^a   Mentula, Panu ^a   Puolakkainen, Pauli ^a   Kemppainen, Esko ^a   Haapiainen, Reijo ^a   Fernandez, Jose A ^b   Griffin, John H ^b   Repo, Heikki ^c,d   Petaja, Jari ^e  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF HELSINKI   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

^e JORVI HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; D DIMER; HLA DR ANTIGEN; INOTROPIC AGENT; PROTEIN C;

ACUTE PANCREATITIS; ADULT; AGED; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; FEASIBILITY STUDY; FEMALE; FLOW CYTOMETRY; HOSPITALIZATION; HUMAN; IMMUNE DEFICIENCY; INFLAMMATION; INTENSIVE CARE UNIT; MONOCYTE; MULTIPLE ORGAN FAILURE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; THROMBOCYTE COUNT; UPREGULATION; ACUTE DISEASE; BIOSYNTHESIS; BLOOD; COMPARATIVE STUDY; MALE; METABOLISM; MIDDLE AGED; PANCREATITIS; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; PANCREATITIS; PROTEIN C; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 33846028402     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc3966     Document Type: Article

References (34)

1. Gronroos J Nylamo E Mortality in acute pancreatitis in Turku University Central Hospital 1971-1995 Hepatogastroenterology 1999 46 2572-2574 10522043
2. Tenner S Sica G Hughes M Noordhoek E Feng S Zinner M Banks B Relationship of necrosis to organ failure in severe acute pancreatitis Gastroenterology 1997 113 899-903 10.1016/S0016-5085(97)70185-9 9287982
3. Deitch E Multiple organ failure Ann Surg 1992 216 117-134 1503516
4. Mentula P Kylanpaa-Back M-L Kemppainen E Takala A Jansson S-E Kautiainen H Puolakkainen P Haapiainen R Repo H Decreased HLA (human leucocyte antigen)-DR expression on peripheral blood monocytes predicts the development of organ failure in patients with acute pancreatitis Clin Sci 2003 105 409-417 10.1042/CS20030058 12780344
5. Levi M ten Cate H Disseminated intravascular coagulation N Engl J Med 1999 341 586-592 10.1056/NEJM199908193410807 10451465
6. Shen L Dahlback B Factor V and protein S as synergistic cofactors to activated protein C in degradation of factor VIIIa J Biol Chem 1994 269 18735-18738 8034625
7. Taylor FB Jr Peer GT Lockhart MS Ferrell G Esmon CT Endothelial cell protein C receptor plays an important role in protein C activation in vivo Blood 2001 97 1685-1688 10.1182/blood.V97.6.1685 11238108
8. Mosnier L Griffin JH Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor Biochem J 2003 373 65-70 1223481 12683950 10.1042/BJ20030341
9. Grey S Tcuchida A Hau H Orthner C Salem H Hancock W Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester J Immunol 1994 153 3664-3672 7523500
10. White B Schmidt M Murphy C Livingstone W O'Toole D Lawler M O'Neill L Kelleher D Schwarz H Smith O Activated protein C inhibits lipoplysaccharide-induced nuclear translocation of nuclear factor κB (NF-κB) and tumour necrosis factor α (TNF-α) production in the THP-1 monocytic cell line Br J Haematol 2000 110 130-134 10.1046/j.1365-2141.2000.02128.x 10930989
11. Yuksel M Okajima K Uchiba M Horiuchi S Okabe H Activated protein C inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappa B and activator protein-1 in human monocytes Thromb Haemost 2002 88 267-273 12195699
12. Bernard G Vincent J Laterre P LaRosa S Dhainaut J-F Lopez-Rodriguez A Steingrub J Garber G Helterbrand J Ely W Efficacy and safety of recombinant human activated protein C for severe sepsis N Engl J Med 2001 344 699-709 10.1056/NEJM200103083441001 11236773
13. Lasson A Ohlsson K Consumptive coagulopathy, fibrinolysis and protease-antiprotease interactions during acute human pancreatitis Thromb Res 1986 41 167-183 10.1016/0049-3848(86)90227-6 3515616
14. Radenkovic D Bajec D Karamarkovic A Stefanovic B Milic N Ignjatovic S Gregoric P Milicevic M Disorders of hemostasis during the surgical management of severe necrotizing pancreatitis Pancreas 2004 29 152-156 10.1097/00006676-200408000-00010 15257107
15. Salomone T Tosi P Palareti G Tomassetti P Migliori M Guariento A Saieva C Raiti C Romboli M Gullo L Coagulative disorders in human acute pancreatitis: Role for the D-dimer Pancreas 2003 26 111-116 10.1097/ 00006676-200303000-00003 12604906
16. Mantke R Pross M Kunz D Ebert M Kahl S Peters B Malfertheiner P Lippert H Schulz H-U Soluble thrombomodulin plasma levels are an early indication of a lethal course in human acute pancreatitis Surgery 2002 131 424-432 10.1067/msy.2002.122379 11935133
17. de Kleijn E de Groot R Hack C Mulder P Engl W Moritz B Joosten K Hazelzet J Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: A randomized, double-blinded, placebo-controlled, dose-finding study Crit Care Med 2003 31 1839-1847 10.1097/ 01.CCM.0000072121.61120.D8 12794428
18. Bradley E III A clinically based classification system for acute pancreatitis. Summary of the international symposium on acute pancreatitis, Atlanta, Ga, September 11-13, 1992 Arch Surg 1993 128 586-90 8489394
19. Gruber A Griffin JH Direct detection of activated protein C in blood from human subjects Blood 1992 79 2340-2348 1571547
20. Petaja J Hakala L Rasi V Griffin JH Circulating activated protein C in subjects with heterozygous Gln506-factor V Haemostasis 1998 28 31-36 9885368
21. Kylanpaa-Back M Takala A Kemppainen E Puolakkainen P Kautiainen H Jansson S-E Haapiainen R Repo H Cellular markers of systemic inflammation and immune suppression in patients with organ failure due to severe acute pancreatitis Scand J Gastroenterol 2001 36 1100-1107 10.1080/003655201750422738 11589386
22. Esmon CT Protein C anticoagulant pathway and its role in controlling microvascular thrombosis and inflammation Crit Care Med 2001 48-51 11445734 10.1097/00003246-200107001-00018
23. Griffin JH The thrombin paradox Nature 1995 378 337-338 10.1038/378337a0 7477366
24. Petaja J Pesonen E Fernández JA Vento A Rämö OJ Griffin JH Cardiopulmonary bypass and activation of antithrombotic plasma protein C J Thorac Cardiov Surg 1999 118 422-431 10.1016/ S0022-5223(99)70178-9 10469954
25. Fernández JA Petaja J Gruber A Griffin JH Activated protein C correlates inversely with thrombin levels in resting healthy individuals Am J Hematol 1997 56 29-31 10.1002/ (SICI)1096-8652(199709)56:1<29::AID-AJH6>3.0.CO;2-4 9298864
26. Ilmakunnas M Petaja J Fernandez JA Griffin JH Repo H Höckerstedt K Mäkisalo H Pesonen E Activation of antithrombotic and anti-inflammatory protein C during reperfusion in clinical liver transplantation Transplantation 2003 75 467-472 10.1097/ 01.TP.0000046529.83650.8A 12605111
27. Turunen A Fernández JA Lindgren L Salmela K Kyllonen L Makisalo H Griffin JH Siitonen SM Petaja J Pesonen EJ Activated protein C reduces graft neutrophil activation in clinical renal transplantation Am J Transplant 2005 5 2204-2212 16095499 10.1111/j.1600-6143.2005.00994.x
28. Liaw P Esmon C Kahnamoui K Schmidt S Kahnamoui S Ferrell G Beaudin S Julian J Weitz J Crowther M Patients with severe sepsis vary markedly in their ability to generate activated protein C Blood 2004 104 3958-3964 10.1182/blood-2004-03-1203 15319291
29. Ottesen L Bladbjerg E Osman M Lausten S Jacobsen N Gram J Jensen S Protein C activation during the initial phase of experimental acute pancreatitis in the rabbit Dig Surg 1999 16 486-495 10.1159/000018774 10805548
30. Powars D Larsen R Johnson J Hulbert T Sun T Patch M Francis R Chan L Epidemic meningococcemia and purpura fulminans with induced protein C deficiency Clin Infect Dis 1993 17 254-261 8399877
31. Mesters R Helterbrand J Utterback B Yan B Chao B Fernandez JA Griffin JH Hartman D Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications Crit Care Med 2000 28 2209-2216 10.1097/00003246-200007000-00005 10921542
32. Iba T Kidokoro A Fukunaga M Sugiyama K Sawada T Kato H Association between the severity of sepsis and the changes in hemostatic molecular markers and vascular endothelial damage markers Shock 2005 23 25-29 10.1097/01.shk.0000144422.32647.b6 15614127
33. Griffin JH Fernandez JA Liu D Cheng T Guo H Zlokovic B Activated protein C and ischemic stroke Crit Care Med 2004 247-253 15118526 10.1097/ 01.CCM.0000126127.87484.2B
34. Petaja J Pesonen E Fernández JA Griffin JH Repo H Jansson S Vento AE Rämö J Activated protein C and inflammation in human myocardium after heart surgery Am J Hematol 2001 67 210-212 10.1002/ ajh.1110 11391722