Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells

Molecular Cancer

Volumn 5, Issue , 2006, Pages

  Komatsu, Koga ^a,b   Buchanan, F Gregory ^c   Otaka, Michiro ^b   Jin, Mario ^b   Odashima, Masaru ^b   Horikawa, Yohei ^b   Watanabe, Sumio ^b   DuBois, Raymond N ^c  

^a Honjo Daiichi General Hospital   (Japan)

^b AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE MONOPHOSPHATE DEAMINASE; DOXYCYCLINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; SERINE PROTEINASE;

ANIMAL CELL; ARTICLE; CANCER CELL; CANCER PATIENT; CELL TRANSFORMATION; COLON CANCER; COLON CARCINOGENESIS; CONTROLLED STUDY; DOWN REGULATION; GENE ACTIVATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENETIC CODE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE EPITHELIUM CELL; MALIGNANT TRANSFORMATION; MICROARRAY ANALYSIS; NONHUMAN; ONCOGENE; PROTEIN TARGETING; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SEQUENCE HOMOLOGY; UPREGULATION;

ANIMALS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; COLONIC NEOPLASMS; ENZYME ACTIVATION; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; INTESTINES; MAP KINASE KINASE 1; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; RATS; SIGNAL TRANSDUCTION; TIME FACTORS;

RATTUS;

EID: 33845680351     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-5-63     Document Type: Article

References (42)

1. Seger R, Krebs EG: The MAPK signaling cascade. FASEB J 1995, 9:726-735.
2. Robinson MJ, Cobb MH: Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 1997, 9:180-186.
3. Davis H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA: Mutations of the BRAF gene in human cancer. Nature 2002, 417:949-954.
4. Hoshino R, Chatani Y, Yamori T, Tsuruo T, Oka H, Yoshida O, Shimada Y, Ari-i S, Wada H, Fujimoto J, Kohno M: Constitutive activation of the 41-/ 43-kDa mitogen-activated protein kinase signaling pathway in human tumors. Oncogene 1999, 18:813-822.
5. Licato LL, Brenner DA: Analysis of signaling protein kinases in human colon or colorectal carcinomas. Dig Dis Sci 1998, 43:1454-1464.
6. Kuno Y, Kondo K, Iwata H, Senga T, Akiyama S, Ito K, Takagi H, Hamaguchi M: Tumor-specific activation of mitogen-activated protein kinase in human colorectal and gastric carcinoma tissues. Jpn J Cancer Res 1998, 89:903-909.
7. Lee SH, Lee JW, Soung YH, Kim SY, Nam SW, Park WS, Kim SH, Yoo NJ, Lee JY: Colorectal tumors frequently express phosphorylated mitogen-activated protein kinase. APMIS 2004, 112:233-238.
8. Komatsu K, Buchannan GF, Katkuri S, Morrow JD, Inoue H, Otaka M, Watanabe S, DuBois RN: Oncogenic potential of MEK1 in rat intestinal epithelial cells is mediated via COX-2. Gastroenterology 2005, 129:577-590.
9. Bos JL: Ras oncogene in human cancer: a review. Cancer Res 1989, 49:4682-4689.
10. Cowley S, Paterson H, Kemp P, Marshall CJ: Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 1994, 77:841-852.
11. Mansour SJ, Matten WT, Hermann AS, Candia JM, Rong S, Fukasawa K, Vande Woude GF, Ahn NG: Transformation of mammalian cells by constitutively activate MAP kinase kinase. Science 1994, 265:966-970.
12. Alessandrini A, Greulich H, Huang W, Erickson RL: Mek1 phosphorylation site mutants activate Raf-1 in NIH3T3 cells. J Biol Chem 1996, 271:31612-31618.
13. Montesano R, Soriano JV, Hosseini G, Pepper MS, Schramek H: Constitutively active mitogen-activated protein kinase kinase MEK1 disrupts morphogenesis and induces an invasive phenotype in Madin-Darby canine kidney epithelial cells. Cell Growth Differ 1999, 10:317-332.
14. Pinkas J, Leder P: MEK1 signaling mediates transformation and metastasis of EpH4 mammary epithelial cells independent of an epithelial to mesenchymal transition. Cancer Res 2002, 62:4781-4790.
15. Boucher M-J, Jean D, Vezina A, Rivard N: Dual role of MEK/ERK signaling in senescence and transformation of intestinal epithelial cells. Am J Physiol 2004, 286:G736-G746.
16. Gupta RA, DuBois RN: Colorectal cancer preventation and treatment by inhibition of cyclooxygenase-2. Nat Rev Cancer 2001, 1:11-21.
17. Kawai N, Tsujii M, Tsuji S: Cyclooxygenases and colon cancer. Prostaglandins Other Lipid Mediat 2002, 68-69:187-196.
18. Taniura S, Nomura K, Ozaki K-I, Tsujimoto M, Kondo T, Kohno M: Prolonged nuclear retention of activated extracellular signal-regulated kinase 1/2 is required for hepatocyte growth factor-induced cell motility. J Biol Chem 2002, 277:28256-28264.
19. Taniura S, Asato K, Fujishiro S-H, Kohno M: Specific blockade of the ERK pathway inhibits the invasiveness of tumor cells: down-regulation of matrix metalloproteinase-3/-9/-14 and CD44. Biochem Biophys Res Commun 2003, 304:801-806.
20. Hoshino R, Taniura S, Watanabe K, Kataoka T, Kohno M: Blockade of the extracellular signal-regulated kinase pathway induces marked G1 cell cycle arreat and apoptosis in tumor cells in which the pathway is constitutively activated. Up-regulation of p27Kip1. J Biol Chem 2001, 276:2686-2692.
21. Milanini J, Vinals F, Pouyssegur J, Pages G: p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts. J Biol Chem 1998, 273:18165-18172.
22. Boucher M-J, Morisset J, Vachon PH, Reed JC, Laine J, Rivard N: MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-XL, and Mcl-1 and promotes survival of human pancreatic cancer cells. J Cell Biochem 2000, 79:355-369.
23. MacKeigan JP, Collins TS, Ting J-Y: MEK inhibition enhances paclitaxel-induced tumor apoptosis. J Biol Chem 2000, 275:38953-38956.
24. Dent P, Grant S: Pharmacologic interruption of the mitogenactivated extracellular regulated kinase/mitogen-activated protein kinase signal transduction pathway: Potential role in promoting cytotoxic drug action. Clin Cancer Res 2001, 7:775-783.
25. Schena M, Shalon D, Davis RW, Brown PO: Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 1995, 270:467-470.
26. Cockett MI, Bebbington CR, Yarranton GT: High level expression of tissue inhibitor of metalloproteinases in Chinese hamster ovary cells using glutamine synthetase gene amplification. Biotechnology 1990, 8:662-667.
27. Davis SJ, Ward HA, Puklavec MJ, Willis AC, Williams AF, Barclay AN: High level expression in Chinese hamster ovary cells of soluble forms of CD4 T lymphocyte glycoprotein including glycosylation variants. J Biol Chem 1990, 265:10410-10418.
28. Kim NS, Lee GM: Overexpression of bcl-2 inhibits sodium butyrate-induced apoptosis in Chinese hamster ovary cells resulting in enhanced humanized antibody production. Biotechnol Bioeng 2000, 71:184-193.
29. Lockhart DJ, Dong H, Byrne MC, Follettie MT, Gallo MV, Chee MS, Mittmann M, Wang C, Kobayashi M, Horton H, Brown EL: Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat Biotechnol 1996, 14:1675-1680.
30. Smith JG, Yokoyama WH, German JB: Butyric acid from the diet: actions at the level of gene expression. Crit Rev Food Sci Nutr 1998, 38:259-297.
31. Suzuki H, Gabrielson E, Chen W, Anbazhagan R, van Engeland M, Weijenberg MP, Herman JG, Baylin SB: A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat Genet 2002, 31:141-149.
32. Okamoto I, Tsuiki H, Kenyon LC, Godwin AK, Emlet DR, Holgado-Madruga M, Lanham IS, Joynes CJ, Vo KT, Guha A, Matsumoto M, Ushio Y, Saya H, Wong AJ: Proteolytic cleavage of the CD44 adhesion molecule in multiple human tumors. Am J Pathol 2002, 160:441-447.
33. Holla VR, Wang D, Brown JR, Mann JR, Katkuri S, DuBois RN: Prostaglandin E2 regulates the complement inhibitor CD55/decay accelerating factor in colorectal cancer. J Biol Chem 2005, 280:476-483.
34. Irby RB, McCarthy SM, Yeatman TJ: Osteopontin regulates multiple functions contributing to human colon cancer development and progression. Clin Exp Metastasis 2004, 21:515-523.
35. Agrawal D, Chen T, Irby R, Quackenbush J, Chambers AF, Szabo M, Cantor A, Coppola D, Yeatman TJ: Osteopontin identified as colon cancer tumor progression marker. C R Biol 2003, 326:1041-1043.
36. Wong GW, Yasuda S, Madhusudhan MS, Li L, Yang Y, Krilis SA, Sali A, Stevens RL: Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells. J Biol Chem 2001, 276:49169-49182.
37. Netzel-Arnett S, Hooper JD, Szabo R, Madison EL, Quigley JP, Bugge TH, Antalis TM: Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer. Cancer Metastasis Rev 2003, 22:237-258.
38. Sims B, Mahnke-Zizelman DK, Profit AA, Prestwich GD, Sabina RL, Theibert AB: Regulation of AMP deaminase by phosphoinositides. J Biol Chem 1999, 274:25701-25707.
39. Chapman AG, Miller AL, Atkinson DE: Role of the adenylate deaminase reaction in regulation of adenine nucleotide metabolism in Ehrlich ascites tumor cells. Cancer Res 1976, 36:1144-1150.
40. Weber G: Enzymes of purine metabolism in cancer. Clin Biochem 1983, 16:57-63.
41. Colas JF, Schoenwolf GC: Localization of cartilage linking protein 1 during primary neurulation in the chick embryo. Brain Res Dev Brain Res 2003, 141:141-148.
42. Naishiro Y, Yamada T, Idogawa M, Honda K, Takada M, Kondo T, Imai K, Hirohashi S: Morphological and transcriptional responses of untransformed intestinal epithelial cells to an oncogenic beta-catenin protein. Oncogene 24:3141-3153. 2005 Apr 28