Expression profiling of heat stress effects on mice fed ergot alkaloids

Toxicological Sciences

Volumn 95, Issue 1, 2007, Pages 89-97

  Bhusari, Sachin ^a   Liu, Zhilin ^a   Hearne, Leonard B ^a   Spiers, Donald E ^a   Lamberson, William R ^a   Antoniou, Eric ^a,b  

^a UNIVERSITY OF MISSOURI   (United States)

^b S140 Animal Sciences Center   (United States)

Author keywords

Environmental toxicology; Gene expression regulation; Microarray

Indexed keywords

ACYL COENZYME A; ADENOSINE TRIPHOSPHATE CITRATE LYASE; APOLIPOPROTEIN B; BETA ACTIN; BETA2 GLYCOPROTEIN 1; CYTOCHROME B5 REDUCTASE; CYTOCHROME C OXIDASE; CYTOCHROME P450; DIAZEPAM BINDING INHIBITOR; DIMETHYLANILINE MONOOXYGENASE; DNA; ERGOT ALKALOID; FATTY ACID SYNTHASE; LIPID; LIPOPROTEIN RECEPTOR; LONG CHAIN FATTY ACID COENZYME A LIGASE; METALLOTHIONEIN I; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DETOXIFICATION; DNA DAMAGE; DNA MICROARRAY; DOWN REGULATION; ENDOPHYTE; FEMALE; FESCUE; FORAGE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GROWTH RETARDATION; HEAT STRESS; INTOXICATION; LIPID TRANSPORT; LIPOGENESIS; LIVER PARENCHYMA; MALE; MOUSE; NONHUMAN; PROTEIN FOLDING; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REPRODUCTIVE TOXICITY; SUMMER; UPREGULATION;

ANIMAL FEED; ANIMALS; DIET; ERGOT ALKALOIDS; FESTUCA; GENE EXPRESSION PROFILING; HEAT STRESS DISORDERS; LIVER; METABOLIC NETWORKS AND PATHWAYS; MICE; MICE, INBRED ICR; MYCOTOXICOSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; PRINCIPAL COMPONENT ANALYSIS; REPRODUCIBILITY OF RESULTS; SEEDS; TIME FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA; FESTUCA ARUNDINACEA; FUNGI; NEOTYPHODIUM COENOPHIALUM;

EID: 33845648555     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl142     Document Type: Article

References (43)

1. Akhtar, M. K., Kelly, S. L., and Kaderbhai, M. A. (2005). Cytochrome b5 modulation of 17{alpha} hydroxylase and 17-20 lyase (CYP17) activities in steroidogenesis. J. Endocrinol. 187, 267-274.
2. Ball, S., Maurer, G., Zollinger, M., Ladona, M., and Vickers, A. (1992). Characterization of the cytochrome P-450 gene family responsible for the N-dealkylation of the ergot alkaloid CQA 206-291 in humans. Drug Metab. Dispos. 20, 56-63.
3. Beigneux, A. P., Kosinski, C., Gavino, B., Horton, J. D., Skanes, W. C., and Young, S. G. (2004). ATP-citrate lyase deficiency in the mouse. J. Biol. Chem. 279, 9557-9564.
4. Bhusari, S., Hearne, L. B., Spiers, D. A., Lamberson, W. R., and Antoniou, E. (2006). Effect of fescue toxicosis on hepatic gene expression in mice. J. Anim. Sci. 84, 1600-1612.
5. Chirala, S. S., Chang, H., Matzuk, M., Abu-Elheiga, L., Mao, J., Mahon, K., Finegold, M., and Wakil, S. J. (2003). Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero. Proc. Natl. Acad. Sci. U.S.A. 100, 6358-6363.
6. Chrestensen, C. A., Starke, D. W., and Mieyal, J. J. (2000). Acute cadmium exposure inactivates thioltransferase (Glutaredoxin), inhibits intracellular reduction of protein-glutathionyl-mixed disulfides, and initiates apoptosis. J. Biol. Chem. 275, 26556-26565.
7. Churchill, G. A. (2002). Fundamentals of experimental design for cDNA microarrays. Nat. Genet. 32, 490-495.
8. Cui, X., Hwang, J. T. G., Qiu, J., Blades, N. J., and Churchill, G. A. (2005). Improved statistical tests for differential gene expression by shrinking variance components estimates. Biostatistics 6, 59-75.
9. Dennis, G., Sherman, B., Hosack, D., Yang, J., Gao, W., Lane, H. C., and Lempicki, R. (2003). DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 4, P3.
10. Duringer, J. M., Lewis, R., Kuehn, L., Fleischmann, T., and Craig, A. M. (2005). Growth and hepatic in vitro metabolism of ergotamine in mice divergently selected for response to endophyte toxicity. Xenobiotica 35, 531-548.
11. DuTeaux, S. B., Newman, J. W., Morisseau, C., Fairbaim, E. A., Jelks, K., Hammock, B. D., and Miller, M. G. (2004). Epoxide hydrolases in the rat epididymis: Possible roles in xenobiotic and endogenous fatty acid metabolism. Toxicol. Sci. 78, 187-195.
12. Gaigg, B., Neergaard, T. B. F., Schneiter, R., Hansen, J. K., Fargeman, N. J., Jensen, N. A., Andersen, J. R., Friis, J., Sandhoff, R., Schroder, H. D., et al. (2001). Depletion of acyl-coenzyme A-binding protein affects sphingolipid synthesis and causes vesicle accumulation and membrane defects in Saccharomyces cerevisiae. Mol. Biol. Cell 12, 1147-1160.
13. Gonzalez, F. J. (2005). Role of cytochromes P450 in chemical toxicity and oxidative stress: Studies with CYP2E1. Mutat. Res. 569, 101-110.
14. Hemken, R. W., Boling, J. A., Bull, L. S., Hatton, R. H., Buckner, R. C., and Bush, L. P. (1981). Interaction of environmental temperature and antiquality factors on the severity of summer fescue toxicosis. J. Anim. Sci. 52, 710-714.
15. Hildebrandt, A., and Estabrook, R. W. (1971). Evidence for the participation of cytochrome b 5 in hepatic microsomal mixed-function oxidation reactions. Arch. Biochem. Biophys. 143, 66-79.
16. Kim, G., Lee, T.-H., Wetzel, P, Geers, C., Robinson, M. A., Myers, T. G., Owens, J. W., Wehr, N. B., Eckhaus, M. W., Gros, G., et al. (2004). Carbonic anhydrase III is not required in the mouse for normal growth, development, and life span. Mol. Cell. Biol. 24, 9942-9947.
17. Kinlaw, W. B., Church, J. L., Harmon, J., and Mariash, C. N. (1995). Direct evidence for a role of the "spot 14" protein in the regulation of lipid synthesis. J. Biol. Chem. 270, 16615-16619.
18. Kurian, J. R., Bajad, S. U., Miller, J. L., Chin, N. A., and Trepanier, L. A. (2004). NADH cytochrome b5 reductase and cytochrome b5 catalyze the microsomal reduction of xenobiotic hydroxylamines and amidoximes in humans. J. Pharmacol. Exp. Ther. 311, 1171-1178.
19. Mesli, S., Javorschi, S., Berard, A. M., Landry, M., Priddle, H., Kivlichan, D., Smith, A. J. H., Yen, E T., Bihain, B. E., and Darmon, M. (2004). Distribution of the lipolysis stimulated receptor in adult and embryonic murine tissues and lethality of LSR-/- embryos at 12.5 to 14.5 days of gestation. Eur. J. Biochem. 271, 3103-3114.
20. Miller, B. F., Armstrong, K. L., Wilson, L. A., Hohenboken, W. D., and Saacke, R. G. (1994). Variation among inbred and linecross mice in response to fescue toxicosis. J. Anim. Sci. 72, 2896-2904.
21. Moubarak, A. S., and Rosenkrans, C. F., Jr. (2000). Hepatic metabolism of ergot alkaloids in beef cattle by cytochrome p450. Biochem. Biophys. Res. Commun. 274, 746-749.
22. Parkes, H. A., Preston, E., Wilks, D., Ballesteros, M., Carpenter, L., Wood, L., Kraegen, E. W., Furler, S., and Cooney, G. J. (2006). Overexpression of Acyl-CoA Synthetase-1 increases lipid deposition in hepatic (HepG2) cells and rodent liver in vivo. Am. J. Physiol. Endocrinol. Metab. 291, 737-744.
23. Polz, E., and Kostner, G. M. (1979a). Binding of [beta]2-glycoprotein-I to Intralipid: Determination of the dissociation constant. Biochem. Biophys. Res. Commun. 90, 1305-1312.
24. Polz, E., and Kostner, G. M. (1979b). The binding of [beta]2-glycoprotein-I to human serum lipoproteins: Distribution among density fractions. FEBS Lett. 102, 183-186.
25. Porras, P., Pedrajas, J. R., Martinez-Galisteo, E., Alicia Padilla, C., Johansson, C., Holmgren, A., and Antonio Barcena, J. (2002). Glutaredoxins catalyze the reduction of glutathione by dihydrolipoamide with high efficiency. Biochem. Biophys. Res. Commun. 295, 1046-1051.
26. Raisanen, S., Lehenkari, P., Tasanen, M., Rahikila, P., Harkonen, P. L., and Vaananen, H. K. (1999). Carbonic anhydrase III protects cells from hydrogen peroxide-induced apoptosis. FASEB J. 13, 513-522.
27. Rottinghaus, G. E., Schultz, L. M., Ross, P. F., and Hill, N. S. (1993). An HPLC method for the detection of ergot in ground and pelleted feeds. J. Vet. Diagn. Invest. 5, 242-247.
28. Saal, L., Troein, C., Vallon-Christersson, J., Gruvberger, S., Borg, A., and Peterson, C. (2002). BioArray Software Environment (BASE): A platform for comprehensive management and analysis of microarray data. Genome Biol. 3, software0003.1-software0003.6.
29. Saeed, A. I., Sharov, V., White, J., Li, J., Liang, W., Bhagabati, N., Braisted, J., Klapa, M., Currier, T., Thiagarajan, M., et al. (2003). TM4: A free, open-source system for microarray data management and analysis. Biotechniques 34, 374-378.
30. Sandberg, M. B., Bloksgaard, M., Duran-Sandoval, D., Duval, C., Staels, B., and Mandrup, S. (2005). The gene encoding Acyl-CoA-binding protein is subject to metabolic regulation by both sterol regulatory element-binding protein and peroxisome proliferator-activated receptor {alpha} in hepatocytes. J. Biol. Chem. 280, 5258-5266.
31. Sato, M., and Kondoh, M. (2002). Recent studies on metallothionein: Protection against toxicity of heavy metals and oxygen free radicals. Tohoku J. Exp. Med. 196, 9-22.
32. Schmidt, S. P., and Osborn, T. G. (1993). Effects of endophyte-infected tall fescue on animal performance. Agric. Ecosyst. Environ. 44, 233-262.
33. Settivari, R. S., Bhusari, S., Evans, T., Eichen, P. A., Hearne, L. B., Antoniou, E., and Spiers, D. E. (2006). Genomic analysis of the impact of fescue toxicosis on hepatic function. J. Anim. Sci. 84, 1279-1294.
34. Spiers, D. E., Eichen, P. A., and Rottinghaus, G. E. (2005). A model of fescue toxicosis: Responses of rats to intake of endophyte-infected tall fescue. J. Anim. Sci. 83, 1423-1434.
35. Swinnen, J. V, Alen, P., Heyns, W., and Verhoeven, G. (1998). Identification of Diazepam-binding inhibitor/Acyl-CoA-binding protein as a sterol regulatory element-binding protein-responsive gene. J. Biol. Chem 273, 19938-19944.
36. Thompson, F. N., and Stuedemann, J. A. (1993). Pathophysiology of fescue toxicosis. Agric. Ecosyst. Environ. 44, 263-281.
37. Wolfinger, R. D., Gibson, G., Wolfinger, E. D., Bennett, L., Hainadeh, H., Bushel, P., Afshari, C., and Paules, R. S. (2001). Assessing gene significance from cDNA microarray expression data via mixed models. J. Comput. Biol. 8, 625-637.
38. Wong, P. C., Waggoner, D., Subramaniam, J. R., Tessarollo, L., Bartnikas, T. B., Culotta, V. C., Price, D. L., Rothstein, J., and Gitlin, J. D. (2000). Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase. Proc. Natl. Acad. Sci. U.S.A. 97, 2886-2891.
39. Wu, H., Kerr, K., and Churchill, G. (2003). MAANOVA: A Software Package for the Analysis of Spotted cDNA Microarray Experiments. In the Analysis of Gene Expression Data: An Overview of Methods and Software, pp. 313-431. Springer, New York.
40. Yen, E T., Masson, M., Clossais-Besnard, N., Andre, P., Grosser, J.-M., Bougueleret, L., Dumas, J.-B., Guerassimenko, O., and Bihain, B. E. (1999). Molecular cloning of a lipolysis-stimulated remnant receptor expressed in the liver. J. Biol. Chem. 274, 13390-13398.
41. Zavos, P. M., Varney, D. R., Jackson, J. A., Siegel, M. R., Bush, L. P., and Hemken, R. W. (1987). Effect of feeding fungal endophyte (Acremonium Coenophialum)- infected tall fescue seed on reproductive performance in CD-1 mice through continuous breeding. Theriogenology 27, 549-559.
42. Zhu, Q., Anderson, G. W., Mucha, G. T., Parks, E. J., Metkowski, J. K., and Mariash, C. N. (2005). The spot 14 protein is required for de novo lipid synthesis in the lactating mammary gland. Endocrinology 146, 3343-3350.
43. Ziegler, D. M. (2002). An overview of the mechanism, substrate specificities, and structure of FMOs. Drug Metab. Rev. 34, 503-511.