Genomic analysis of the impact of fescue toxicosis on hepatic function

Journal of Animal Science

Volumn 84, Issue 5, 2006, Pages 1279-1294

  Settivari, R S ^a   Bhusari, S ^a   Evans, T ^b   Eichen, P A ^a   Hearne, L B ^a   Antoniou, E ^a   Spiers, D E ^a  

^a UNIVERSITY OF MISSOURI   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

Endophytic toxins; Fescue toxicosis; Genomic; Liver; Rat; Thermoregulation

Indexed keywords

FESTUCA ARUNDINACEA; FUNGI; LOLIUM; NEOTYPHODIUM COENOPHIALUM;

EID: 33748787177     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/2006.8451279x     Document Type: Article

References (48)

1. Aravind, L., and E. V. Koonin. 2001. The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases. Genome Biol. 2:60-71.
2. Arner, E. S., M. Bjornstedt, and A. Holmgren. 1995. 1-Chloro-2,4- dinitrobenzene is an irreversible inhibitor of humor thioredoxin reductas. Loss of the thioredoxin disulfide reductase activity is accompanied by a large increase in NADPH oxidase activity. J. Biol. Chem. 270:3479-3482.
3. Ball, S. E., G. Maurer, M. Zollinger, M. Ladona, and A. E. M. Vickers. 1992. Characterization of the cytochrome P450 gene family responsible for the N-dealkylation of the ergot alkaloid CQA 206-291 in humans. Drug Metab. Dispos. 20:56-63.
4. Bauer, M., A. C. Hamm, M. Bonaus, A. Jacob, J. Jaekel, H. Schorle, M. J. Pankratz, and J. D. Katzenberger. 2004. Starvation response in mouse liver shows strong correlation with life-span-prolonging processes. Physiol. Genomics 17:230-244.
5. Brouard, S. 2000. Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis. J. Exp. Med. 192:1015-1026.
6. Bush, J. A., D. E. Freeman, K. H. Kline, N. R. Merchen, and G. C. Fahey, Jr. 2001. Dietary fat supplementation effects on in vitro nutrient disappearance and in vivo nutrient intake and total tract digestibility by horses. J. Anim. Sci. 79:232-239.
7. Chestnut, A. B., P. D. Anderson, M. A. Cochran, A. Fribourg, and K. D. Gwinn. 1992. Effects of hydrated sodium calcium aluminosilicate on fescue toxicosis and mineral absorption. J. Anim. Sci. 70:2838-2846.
8. Cross, D. L., L. M. Redmond, and J. R. Strickland. 1995. Equine fescue toxicosis: Signs and solutions. J. Anim. Sci. 73:899-908.
9. Dennis, G., B. Sherman, D. Hosack, J. Yang, W. Gao, H. C. Lane, and R. Lempicki. 2003. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 4:3.
10. Dew, R. K., G. A. Boissonneault, N. Gay, J. A. Boling, R. J. Cross, and D. A. Cohen. 1999. The effect of the endophyte (Acremonium coenophialum) and associated toxin(s) of tall fescue on serum titer response to immunization and spleen cell flow cytometry analysis and response to mitogens. Vet. Immunol. Immunopathol. 26:285-295.
11. Duhau, L., J. Grassi, D. Grouselle, A. Enjalbert, and J. M. Grognet. 1991. An enzyme immunoassay for rat prolactin: Application to the determination of plasma levels. J. Immunoassay 12:233-250.
12. Eichen, P. A., D. E. Spiers, G. E. Rottinghaus, and D. P. Colling. 2001. Utilization of a small animal model of fescue toxicosis to evaluate the potential benefit of Ascophyllum nodosum. J. Anim. Sci. 79, Suppl. 1:16. Available: http://www.adsa.org/jointabs/iaafsc9.pdf. Accessed date 11/2005.
13. Eisen, M. B., P. T. Spellman, P. O. Brown, and D. Botstein. 1998. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA 95:14863-14868.
14. Elsasser, T. H., and D. J. Bolt. 1987. Dopaminergic-like activity in toxic fescue alters prolactin but not growth hormone or thyroid stimulating hormone in ewes. Domest. Anim. Endocrinol. 4:259-269.
15. Endo, F. 1999. Inborn errors of tyrosine metabolism: Abnormalities in catabolic pathway of phenylalanine and tyrosine. Seikagaku 71:1327-1331.
16. Filipov, N. M., F. N. Thompson, R. P. Sharma, and R. R. Dugyala. 1999a. Increased proinflammatory cytokines production by ergotamine in male BALB/c mice. J. Toxicol. Environ. Health 58:145-155.
17. Filipov, N. M., F. N. Thompson, J. A. Stuedemann, T. H. Elsasser, S. Kahl, R. R. Sharma, C. R. Young, L. H. Stanker, and C. K. Smith. 1999b. Increased responsiveness to intravenous lipopolysaccharide challenge in steers grazing endophyte-infected tall fescue compared with steers grazing endophyte-free tall fescue. J. Endocrinol. 163:213-220.
18. Flanagan, N. 2005. Advances in microgenomics: Less is more. Genetic Eng. News 25:1-3.
19. Gonzalez, B., and R. Manso. 2004. Induction, modification and accumulation of HSP70s in the rat liver after acute exercise: Early and late responses. J. Physiol. 556:369-385.
20. Grant, C. M., F. H. MacIver, and I. W. Dawes. 1997. Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide gamma-glutamyl-cysteine. Mol. Biol. Cell 8:1699-1707.
21. Jones, K. L., S. S. King, and M. J. Iqbal. 2004. Endophyte-infected tall fescue diet alters gene expression in heifer luteal tissue as revealed by interspecies microarray analysis. Mol. Reprod. Dev. 67:154-161.
22. Kerr, K. M., and G. A. Churchill. 2002. Bootstrapping cluster analysis: Assessing the reliability of conclusions from microarray experiments. Proc. Natl. Acad. Sci. USA 98:8961-8965.
23. Lakritz, J., M. J. Leonard, P. A. Eichen, G. E. Rottinghaus, G. C. Johnson, and D. E. Spiers. 2002. Whole-blood concentrations of glutathione in cattle exposed to heat stress or a combination of heat stress and endophyte-infected tall fescue toxins in controlled environmental conditions. Am. J. Vet. Res. 63:799-803.
24. Lopez-Hellin, J., R. Gonzalo, M. Tejeda, M. Carrascal, M. R. Vila, J. Abian, and F. Garcia-Arumi. 2005. Transcriptomic and proteomic analysis of liver and muscle alterations caused by surgical stress in rats. Clin. Sci. (Lond.) 108:167-178.
25. Maines, M. D. 2000. The heme oxygenase system and its functions in the brain. Cell. Mol. Biol. 46:573-585.
26. Mason, J. L., Y. K. Suzuki, A. J. D'Ercole, and G. K. Matsushima. 2000. Insulin like growth factor-1 inhibits mature oligodendrocyte apoptosis during primary demyelination. Neuroscience 20:5703-5708.
27. Moubarak, A. S., and C. F. Rosenkrans, Jr. 2000. Hepatic metabolism of ergot alkaoids in beef cattle by cytochrome P450. Biochem. Biophys. Res. Commun. 274:746-769.
28. Murthy, M. R., T. J. Reid, A. Sicignano, N. Tanaka, and M. G. Rossmann. 1981. The transcription machinery in mammalian mitochondria. J. Mol. Biol. 152:465-499.
29. Nihsen, M. E., E. L. Piper, C. P. West, R. J. Crawford, Jr., T. M. Denard, Z. B. Johnson, C. A. Roberts, D. E. Spiers, and C. F. Rosenkrans, Jr. 2004. Growth rate and physiology of steers grazing tall fescue inoculated with novel endophytes. J. Anim. Sci. 82:878-883.
30. Oguri, K., and H. Yamada. 1994. Regiochemistry of cytochrome P450 isozymes. Annu. Rev. Pharmacol. Toxicol. 34:251-279.
31. Oliver, J. W. 1997. Physiological manifestations of endophyte toxicosis in ruminant and laboratory species. Pages 311-345 in Neotyphodium/Grass Interactions. C. W. Bacon, and N. S. Hill, ed. Plenum Press, New York, NY.
32. Oliver, J. W. 2005. Pathophysiologic response to endophyte toxins. Pages 291-304 in Neotyphodium in Cool-Season Grasses. C. A. Roberts, C. P. West, and D. E. Spiers, ed. Blackwell Publ., Ames, IA.
33. Perez, J. X., A. Manzano, A. Tauler, and R. Bartrons. 1998. Effect of starvation on gene expression of regulatory enzymes of glycolysis/ gluconeogenesis in genetically obese (fa/fa) Zucker rats. Int. J. Obes. Relat. Metab. Disord. 22:667-672.
34. Piper, E. L., D. A. Hays, D. S. Hubbell, and S. M. Mashburn. 1991. Effect of long term grazing of endophyte-infected fescue on liver enzymes. Page 26 in Proc. Tall Fescue Toxicosis Workshop, SRIEG-37, Atlanta, GA.
35. Reid, J. M., M. J. Kuffel, S. L. Ruben, J. J. Morales, K. L. Rinehart, D. P. Squillace, and M. M. Ames. 2002. Detoxification pathways involving glutathione and epoxide hydrolase in the invitro metabolism of chloroprene. Clin. Cancer Res. 8:2952-2962.
36. Rottinghaus, G. E., L. M. Schultz, P. F. Ross, and N. S. Hill. 1993. An HPLC method for the detection of ergot in ground and pelleted feeds. J. Vet. Diagn. Invest. 5:242-247.
37. Saal, L., C. Troein, J. Vallon-Christersson, S. Gruvberger, A. Borg, and C. Peterson. 2002. BioArray Software Environment (BASE): A platform for comprehensive management and analysis of microarray data. Genome Biology 3: software0003.
38. Scanlan, N. 2001. Compromised hepatic detoxification in companion animals and its correction via nutritional supplementation and modified fasting. Altern. Med. Rev. 6:24-37.
39. Schillo, K. K., L. S. Leshin, J. A. Boling, and N. Gay. 1988. Effects of endophyte-infected fescue on concentrations of prolactin in blood sera and the anterior pituitary and concentrations of dopamine and dopamine metabolites in brains of steers. J. Anim. Sci. 66:713-718.
40. Spiers, D. E., P. A. Eichen, and G. E. Rottinghaus. 2005. A model of fescue toxicosis: Responses of rats to intake of endophyte-infected tall fescue. J. Anim. Sci. 83:1423-1434.
41. Spiers, D. E., J. Q. Zhang, P. A. Eichen, G. E. Rottinghaus, G. B. Garner, and M. R. Ellersieck. 1995. Temperature dependent responses of rats to ergovaline derived from endophyte-infected tall fescue. J. Anim. Sci. 73:1954-1961.
42. Strickland, J. R., J. W. Oliver, and D. L. Cross. 1993. Fescue toxicosis and its impact on animal agriculture. Vet. Hum. Toxicol. 35:454-464.
43. Stuedemann, J. A., T. S. Rumsey, J. Bond, S. R. Wilkinson, L. P. Bush, D. J. Williams, and A. B. Caudle. 1985. Association of blood cholesterol with occurrence of fat necrosis in cows and tall fescue summer toxicosis in steers. Am. J. Vet. Res. 46:1990-1995.
44. Tusher, V. G., R. Tibshirani, and G. Chu. 2001. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. USA 98:5116-5121.
45. Verhagen, A. M., B. S. Coulson, L. E. Otterbein, J. Anrather, E. Tobiasch, F. H. Bach, A. M. Choi, and M. P. Soares. 2001. Inhibitor of apoptosis proteins and their relatives. Genome Biol. 2:3001-3010.
46. Wolfinger, R. D., G. Gibson, E. D. Wolfinger, L. Bennett, H. Hamadeh, P. Bushel, C. Afshari, and R. S. Paules. 2001. Assessing gene significance from cDNA microarray expression data via mixed models. J. Comput. Biol. 8:625-637.
47. Yoshida, M., E. Muneyuki, and T. Hisabori. 2001. ATP synthase - A marvelous rotary engine of the cell. Nat. Rev. Mol. Cell Biol. 2:669-677.
48. Zanzalari, K. P., R. N. Heitmann, J. B. McLaren, and H. A. Fribourg. 1989. Effects of endophyte-infected fescue and cimetidine on respiration rates, rectal temperature and hepatic mixed function oxidase activity as measured by hepatic antipyrine metabolism in sheep. J. Anim. Sci. 67:3370-3378.