Probing cofactor specificity in phenylalanine hydroxylase by molecular dynamics simulations

Journal of Biomolecular Structure and Dynamics

Volumn 20, Issue 6, 2003, Pages 733-740

  Teigen, Knut ^a   Martínez, Aurora ^a  

^a UNIVERSITY OF BERGEN   (Norway)

Author keywords

Cofactor analogs; Enzyme regulation; Molecular dynamic simulations; Molecular modeling; Phenylalanine hydroxylase; Tetrahydrobiopterin

Indexed keywords

6 METHYLTETRAHYDROPTERIN; GLUTAMIC ACID; HYDROXYL GROUP; IRON; OXYGEN; PHENYLALANINE; PHENYLALANINE 4 MONOOXYGENASE; SERINE; TETRAHYDROBIOPTERIN; TYROSINE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; AUTOREGULATION; BINDING SITE; CATALYSIS; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; SIMULATION;

EID: 0037780842     PISSN: 07391102     EISSN: 15380254     Source Type: Journal    
DOI: 10.1080/07391102.2003.10506889     Document Type: Article

References (28)

1. Flatmark, T., and Stevens, R. C., 1999. Chem. Rev., 99:2137–2160.
2. Kappock, T. J., and Caradonna, J. P., 1996. Chem. Rev., 96:2659–2756.
3. Mitnaul, L. J., and Shiman, R., 1995. Proc. Natl. Acad. Sci. USA, 92:885–889.
4. Teigen, K., Å. Frøystein, N., and Martínez, A., 1999. J. Mol. Biol., 294:807–823.
5. Erlandsen, H., and Stevens, R. C., 1999. Mol. Genet. Metab., 68:103–125.
6. Andersen, O. A., Flatmark, T., and Hough, E., 2001. J. Mol. Biol., 314:279–291.
7. Andersen, O. A., Flatmark, T., and Hough, E., 2002. J. Mol. Biol., 320:1095–1108.
8. McKinney, J. A., Teigen, K., Frøystein, N. A., Salaun, C., Knappskog, P. M., Haavik, J., and Martínez, A., 2001. Biochemistry, 40:15591–15601.
9. Wang, L., Erlandsen, H., Haavik, J., Knappskog, P. M., and Stevens, R. C., 2002. Biochemistry, 41:12569–12574.
10. Erlandsen, H., Bjørgo, E., Flatmark, T., and Stevens, R. C., 2000. Biochemistry, 39:2208–2217.
11. Bailey, S. W., Dillard, S. B., and Ayling, J. E., 1991. Biochemistry, 30:10226–10235.
12. Bailey, S. W., and Ayling, J. E., 1978. Biochem. Biophys. Res. Commun., 85:1614–16121.
13. Haavik, J., Døskeland, A. P., and Flatmark, T., 1986. Eur J. Biochem., 160:1–8.
14. Shiman, R., 1985. Folates and Pterins Edited by:Blakely, R. L., and Benkovic, S. J., 179–249. New York:Wiley and Sons.
15. Døskeland, A. P., Haavik, J., Flatmark, T., and Døskeland, S. O., 1987. Biochem. J., 242:867–874.
16. Kaufman, S., 1985. Biochem. Soc. Trans., 13:433–435.
17. Kobe, B., Jennings, I. G., House, C. M., Michell, B. J., Goodwill, K. E., Santarsiero, B. D., Stevens, R. C., Cotton, R. G., and Kemp, B. E., 1999. Nat. Struct. Biol., 6:442–448.
18. Thórólfsson, M., Teigen, K., and Martínez, A., 2003. Biochemistry, In Press
19. Erlandsen, H., Fusetti, F., Martínez, A., Hough, E., Flatmark, T., and Stevens, R. C., 1997. Nat. Struct. Biol., 4:995–1000.
20. Weiner, S. J., Kollman, P. A., Nguyen, D. T., and Case, D. A., 1986. J. Comp. Chem., 7:230–252.
21. Weiner, S. J., Kollman, P. A., Case, D. A., Singh, U. C., Ghio, C., Alagona, G., Profeta, S. J., and Weiner, P., 1984. J. Am. Chem. Soc., 106:765–784.
22. Christensen, I. T., and Jorgensen, F. S., 1997. J. Biomol. Struct. Dyn., 15:473–488.
23. Martínez, A., Dao, K. K., McKinney, J., Teigen, K., and Frøystein, N. A., 2000. Pteridines, 11:32–33.
24. Jennings, I. G., Teh, T., and Kobe, B., 2001. FEBS Lett., 488:196–200.
25. Almås, B., Toska, K., Teigen, K., Groehn, V., Pfleiderer, W., Martínez, A., Flatmark, T., and Haavik, J., 2000. Biochemistry, 39:13676–13686.
26. Wang, G. A., Gu, P., and Kaufman, S., 2001. Proc. Natl. Acad. Sci. USA, 98:1537–1542.
27. Iwaki, M., Phillips, R. S., and Kaufman, S., 1986. J. Biol. Chem., 261:2051–2056.
28. Bailey, S. W., and Ayling, J. E., 1977. J. Biol. Chem., 253:1598–1605.