RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma

Cancer

Volumn 107, Issue 12, 2006, Pages 2752-2759

  Lal, Geeta ^a,c   Padmanabha, Lakshmi ^a   Smith, Brian J ^b   Nicholson, Rachael M ^a   Howe, James R ^a,c   O'Dorisio, M Sue ^a,c   Domann Jr , Frederick E ^a,c  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

Aberrant methylation; Cancer; Histone methyltransferase; RIZ1; Thyroid

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BISULFITE; DNA METHYLTRANSFERASE INHIBITOR; MESSENGER RNA; PROTEIN METHYLTRANSFERASE;

ARTICLE; CHROMOSOME 1P; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; GENE ACTIVATION; GENE INACTIVATION; GENE LOCATION; GENE SEQUENCE; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RIZ1 GENE; THYROID CARCINOMA; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; CARCINOMA; CELL LINE, TUMOR; DNA METHYLATION; DNA-BINDING PROTEINS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; THYROID NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 33845564665     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.22325     Document Type: Article

References (36)

1. Boltze C, Zack S, Quednow C, et al. Hypermethylation of the CDKN2/p16INK4A promoter in thyroid carcinogenesis. Pathol Res Pract. 2003;199:399-404.
2. Xing M, Usadel H, Cohen Y, et al. Methylation of the thyroid-stimulating hormone receptor gene in epithelial thyroid tumors: a marker of malignancy and a cause of gene silencing. Cancer Res. 2003;63:2316-2321.
3. Xing M, Tokumaru Y, Wu G, Westra WB, Ladenson PW, Sidransky D. Hypermethylation of the Pendred syndrome gene SLC26A4 is an early event in thyroid tumorigenesis. Cancer Res. 2003;63:2312-2315.
4. Schagdarsurengin U, Gimm O, Hoang-Vu C, Dralle H, Pfeifer GP Dammann R. Frequent epigenetic silencing of the CpG island promoter of RASSF1A in thyroid carcinoma. Cancer Res. 2002;62:3698-3701.
5. Hoque MO, Rosenbaum E, Westra WH, et al. Quantitative assessment of promoter methylation profiles in thyroid neoplasms. J Clin Endocrinol Metab. 2005;90:4011-4018.
6. Buyse IM, Shao G, Huang S. The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein. Proc Natl Acad Sci USA. 1995;92:4467-4471.
7. Huang S, Shao G, Liu L. The PR domain of the Rb-binding zinc finger protein RIZ1 is a protein binding interface and is related to the SET domain functioning in chromatin-mediated gene expression. J Biol Chem. 1998;273:15933-15939.
8. Huang S. The retinoblastoma protein-interacting zinc finger gene RIZ in 1p36-lmked cancers. Front Biosci. 1999;4:D528-D532.
9. Steele-Perkins G, Fang W, Yang XH, et al. Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein- methyltransferase superfamily. Genes Dev. 2001;15:2250-2262.
10. He L, Yu JX, Liu L, et al. RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis. Cancer Res. 1998;58:4238-4244.
11. Jiang G, Liu L, Buyse IM, Simon D, Huang S. Decreased RIZ1 expression but not RIZ2 in hepatoma and suppression of hepatoma tumorigenicity by RIZ1. Int J Cancer. 1999;83:541-546.
12. Chadwick RB, Jiang GL, Bennington GA, et al. Candidate tumor suppressor RIZ is frequently involved in colorectal carcinogenesis. Proc Natl Acad Sci USA. 2000;97:2662-2667.
13. Oshimo Y, Oue N, Mitani Y, et al. Frequent epigenetic inactivation of RIZ1 by promoter hypermethylation in human gastric carcinoma. Int J Cancer. 2004;110:212-218.
14. Takahashi T, Shivapurkar N, Riquelme E, et al. Aberrant promoter hypermethylation of multiple genes in gallbladder carcinoma and chronic cholecystitis. Clin Cancer Res. 2004;10:6126-6133.
15. Sasaki O, Meguro K, Tohmiya Y, Funato T, Shibahara S, Sasaki T. Altered expression of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukaemia. Br J Haematol. 2002;119:940-948.
16. Du Y, Carling T, Fang W, Piao Z, Sheu JC, Huang S. Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily. Cancer Res. 2001;61:8094-8099.
17. Matsushita C, Yang Y, Takeuchi S, et al. Aberrant methylation in promoter-associated CpG islands of multiple genes in relapsed childhood acute lymphoblastic leukemia. Oncol Rep. 2004;12:97-99.
18. Yang Y, Takeuchi S, Hofmann WK, et al. Aberrant methylation in promoter-associated CpG islands of multiple genes in acute lymphoblastic leukemia. Leuk Res. 2006;30:98-102.
19. Schulmann K, Sterian A, Berki A, et al. Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk. Oncogene. 2005;24:4138-4148.
20. Sakurada K, Furukawa T, Kato Y, Kayama T, Huang S, Horii A. RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum. Genes Chromosomes Cancer. 2001;30:207-211.
21. Ogawa T, Hasegawa Y, Nakayama B, et al. [An immunohistochemical study of RB tumor suppressor gene protein and bcl-2 gene protein in carcinomas of the thyroid gland]. Nippon Jibiinkoka Gakkai Kaiho. 1998;101:595-601.
22. Zou M, Shi Y, Farid NR, al-Sedairy ST. Inverse association between cyclin D1 overexpression and retinoblastoma gene mutation in thyroid carcinomas. Endocrine. 1998;8:61-64.
23. Holm R, Nesland JM. Retinoblastoma and p53 tumour suppressor gene protein expression in carcinomas of the thyroid gland. J Pathol. 1994;172:267-272.
24. Kleer CG, Bryant BR, Giordano TJ, Sobel M, Merino MJ. Genetic changes in chromosomes 1p and 17p in thyroid cancer progression. Endocr Pathol. 2000;11:137-143.
25. Relative quantification of gene expression. In: User Bulletin No. 2 ABI Prism 7700 Sequence Detection System. Foster City, California: Applied Biosystems; 1997.
26. Carling T, Du Y, Fang W, Correa P, Huang S. Intragenic allelic loss and promoter hypermethylation of the RIZ1 tumor suppressor gene in parathyroid tumors and pheochromocytomas. Surgery. 2003;134:932-939.
27. Geli J, Nord B, Frisk T, et al. Deletions and altered expression of the RIZ1 tumour suppressor gene in 1p36 in pheochromocytomas and abdominal paragangliomas. Int J Oncol. 2005; 26:1385-1391.
28. Rocha AS, De Wever O, Moreira S, et al. Mutated E-cadherin: genomic and functional characterization in thyroid cells from the KAT family. Thyroid. 2004;14:902-909.
29. Venkataraman GM, Yatin M, Marcinek R, Ain KB. Restoration of iodide uptake in dedifferentiated thyroid carcinoma: relationship to human Na+/I-symporter gene methylation status. J Clin Endocrinol Metab. 1999;84:2449-2457.
30. Ain KB, Taylor KD, Tofiq S, Venkataraman G. Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines. J Clin Endocrinol Metab. 1997;82:1857-1862.
31. Xu X, Quiros RM, Maxhimer JB, et al. Inverse correlation between heparan sulfate composition and heparanase-1 gene expression in thyroid papillary carcinomas: a potential role in tumor metastasis. Clin Cancer Res. 2003;9:5968-5979.
32. Ahuja N, Issa JP. Aging, methylation and cancer. Histol Histopathol. 2000;15:835-842.
33. Waki T, Tamura G, Tsuchiya T, Sato K, Nishizuka S, Motoyama T. Promoter methylation status of E-cadherin, hMLH1, and p16 genes in nonneoplastic gastric epithelia. Am J Pathol. 2002;161:399-403.
34. Feinberg AP, Ohlsson R, Henikoff S. The epigenetic progenitor origin of human cancer. Nat Rev Genet. 2006;7:21-33.
35. Lyko F, Brown R. DNA methyltransferase inhibitors and the development of epigenetic cancer therapies. J Natl Cancer Inst. 2005;97:1498-1506.
36. Jiang GL, Huang S. Adenovirus expressing RIZ1 in tumor suppressor gene therapy of microsatellite-unstable colorectal cancers. Cancer Res. 2001;61:1796-1798.