Radiation-induced molecular changes in rat mammary tissue: Possible implications for radiation-induced carcinogenesis

International Journal of Radiation Biology

Volumn 82, Issue 11, 2006, Pages 805-815

  Loree, Jonathan ^a   Koturbash, Igor ^a   Kutanzi, Kristy ^a   Baker, Mike ^a   Pogribny, Igor ^b   Kovalchuk, Olga ^a  

^a UNIVERSITY OF LETHBRIDGE   (Canada)

^b National Center for Toxicological Research   (United States)

Author keywords

Apoptosis; Cellular proliferation; DNA methylation; DNA repair; Mammary tissue; Radiation; Signaling

Indexed keywords

CELL ANTIGEN; CYCLIN D1; CYCLINE; CYTOSINE; DNA METHYLTRANSFERASE; METHYL CPG BINDING PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST CANCER; CARCINOGENESIS; CELL CYCLE REGULATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA METHYLATION; DNA REPAIR; EPIGENETICS; FEMALE; IONIZING RADIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION EXPOSURE; RAT; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DNA REPAIR; FEMALE; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; NEOPLASMS, RADIATION-INDUCED; RAD51 RECOMBINASE; RATS; RATS, LONG-EVANS;

EID: 33845490045     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.1080/09553000600960027     Document Type: Article

References (63)

1. Arnold A, Papanikolaou A. 2005. Cyclin D1 in breast cancer pathogenesis. Journal of Clinical Oncology 23:4215-4224.
2. Aubrecht J, Rugo R, Schiestl RH. 1995. Carcinogens induce intrachromosomal recombination in human cells. Carcinogenesis 16:2841-2846.
3. Bernardino J, Roux C, Almeida A, Vogt N, Gibaud A, Gerbault-Seureau M, Magdelenat H, Bourgeois CA, Malfoy B, Dutrillaux B. 1997. DNA hypomethylation in breast cancer: An independent parameter of tumor progression? Cancer Genetics and Cytogenetics 97:83-89.
4. Bishop AJ, Barlow C, Wynshaw-Boris AJ, Schiestl RH. 2000. Atm deficiency causes an increased frequency of intrachromosomal homologous recombination in mice. Cancer Research 60:395-399.
5. Bishop AJ, Schiestl RH. 2003. Role of homologous recombination in carcinogenesis. Experimental and Molecular Pathology 74:94-105.
6. Boice JD Jr, Preston D, Davis FG, Monson RR. 1991. Frequent chest X-ray fluoroscopy and breast cancer incidence among tuberculosis patients in Massachusetts. Radiation Research 125:214-222.
7. Doody MM, Lonstein JE, Stoval M, Hacker DG, Luckyanov N, Land CE. 2000. Breast cancer mortality after diagnostic radiology. Spine 25:2052-2063.
8. Ellsworth DL, Ellsworth RE, Liebman MN, Hooke JA, Shriver CD. 2004. Genomic instability in histologically normal breast tissues: Implications for carcinogenesis. Lancet Oncology 5:753-758.
9. Fackler MJ, McVeigh M, Merotra J, Blum MA, Lange J, Lapides A, Garrett E, Argani P, Sukumar S. 2004. Quantitative multiplex methylation-specific PCR assay for the detection of promoter hypermethylation in multiple genes in breast cancer. Cancer Research 64:4442-4452.
10. Feinberg AP, Tycko B. 2004. The history of cancer epigenetics. Nature Reviews Cancer 4:143-153.
11. Feinberg AP, Vogelstein B. 1983. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 301:89-92.
12. Feinberg AP. 2004. The epigenetic of cancer etiology. Seminars Cancer Biology 14:427-432.
13. Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, Bonaldi T, Haydon C, Ropero S, Petrie K, Iyer NG, Perez-Rosado A, Calvo E, Lopez JA, Cano A, Calasanz MJ, Colomer D, Piris MA, Ahn N, Imhof A, Caldas C, Jenuwein T, Esteller M. 2005. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nature Genetics 37:391-400.
14. Greene MH. 1997. Genetics of breast cancer. Mayo Clinic Proceedings 72:54-65.
15. Hellgren D. 1992. Mutagen-induced recombination in mammalian cells in vitro. Mutation Research 284:37-51.
16. Hoeijmakers JH. 2001. Genome maintenance mechanisms for preventing cancer. Nature 411:366-374.
17. Howe GR, McLaughlin J. 1996. Breast cancer mortality between 1950 and 1987 after exposure to fractionated moderate-doserate ionizing radiation in the Canadian fluoroscopy cohort study and a comparison with breast cancer mortality in the atomic bomb survivors study. Radiation Research 145:694-707.
18. Jaenisch R, Bird A. 2003. Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals. Nature Genetics 33:245-254.
19. Jeltsch A. 2006. Molecular enzymology of mammalian DNA methyltransferases. Current Topics in Microbiology and Immunology 301:203-225.
20. Jenner TJ, Fulford J, O'Neill P. 2001. Contribution of base lesions to radiation-induced clustered DNA damage: Implication for models of radiation response. Radiation Research 156:590-593.
21. Jones PA, Laird PW. 1999. Cancer epigenetic comes of age. Nature Genetics 21:163-167.
22. Jones PA, Baylin SB. 2002. The fundamental role of epigenetic events in cancer. Nature Reviews 3:415-428.
23. Jones PA. 2005. Overview of cancer epigenetics. Seminars Hematology 42:S3-S8.
24. Jones PL, Veenstra GJ, Wade PA, Vermaak D, Kass SU, Landsberger N, Strouboulis J, Wolffe AP. 1998. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nature Genetics 19:187-191.
25. Josephy PD. 2005. Environmental factors associated with human cancer: breast cancer. Mutation Research 577S:e216.
26. Koturbash I, Pogribny I, Kovalchuk O. 2005. Stable loss of global DNA methylation in the radiation-target tissue-a possible mechanism contributing to radiation carcinogenesis? Biochemical and Biophysical Research Communications 337:526-533.
27. Lambert S, Saintigny Y, Delacote F, Amiot F, Chaput B, Lecomte M, Huck S, Bertrand P, Lopez BS. 1999. Analysis of intrachromosomal homologous recombination in mammalian cell, using tandem repeat sequences Mutation Research 433:159-168.
28. Land CE, Tokunaga M, Koyama K, Soda M, Preston DL, Nishimori I, Tokuoka S. 2003. Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950-1990. Radiation Research 160:707-717.
29. Liang K, Jin W, Knuefermann C, Schmidt M, Mills GB, Ang KK, Milas L, Fan Z. 2003. Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy. Molecular Cancer Therapeutics 2:353-360.
30. Mattsson A, Ruden BI, Hall P, Wilking N, Rutqvist LE. 1993. Radiation-induced breast cancer: Long-term follow-up of radiation therapy for benign breast disease. Journal of National Cancer Institute 85:1679-1685.
31. Mattsson A, Hall P, Ruden BI, Rutqvist LE. 1997. Incidence of primary malignancies other than breast cancer among women treated with radiation therapy for benign breast disease. Radiation Research 148:152-160.
32. Osborne C, Wilson P, Tripathy D. 2004. Oncogenes and tumor suppressor genes in breast cancer: Potential diagnostic and therapeutic applications. Oncologist 9:361-377.
33. Panayiotidis MI, Rancourt RC, Allen CB, Riddle SR, Schneider BK, Ahmad S, White CW. 2004. Hyperoxia-induced DNA damage causes decreased DNA methylation in human lung epithelial-like A549 cells. Antioxidants and Redox Signaling 6:129-136.
34. Parkin DM, Bray F, Ferlay J, Pisani P. 2005. Global cancer statistic, 2002. CA Cancer Journal for Clinicians 55:74-108.
35. Parkin DM. 2001. Global cancer statistic in the year 2000. Lancet Oncology 9:533-543.
36. Pogribny I, Koturbash I, Tryndyak V, Hudson D, Stevenson SML, Sedelnikova O, Bonner W, Kovalchuk O. 2005. Fractionated low dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in murine thymus. Molecular Cancer Research 3:553-361.
37. Pogribny I, Yi P, James SJ. 1999. A sensitive new method for rapid detection of abnormal methylation patterns in global DNA and within CpG islands. Biochemical and Biophysical Research Communications 262:624-628.
38. Pogribny IP, James SJ, Jernigan S, Pogribna M. 2004. Genomic hypomethylation is specific for preneoplastic liver in folate/ methyl deficient rats and does not occur in non-target tissues. Mutation Research 548:53-59.
39. Prise KM, Pinto M, Newman HC, Michael BD. 2001. A review of studies of ionizing radiation-induced double-strand break clustering. Radiation Research 156:572-576.
40. Raiche J, Rodriguez-Juarez R, Pogribny I, Kovalchuk O. 2004. Sex and tissue specific expression of maintenance and de novo DNA methyltransferases upon low dose X-irradiation in mice. Biochemical and Biophysical Research Communications 325:39-47.
41. Richardson C, Stark JM, Ommundsen M, Jasin M. 2004. Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability. Oncogene 23:546-553.
42. Ronckers CM, Erdmann CA, Land CE. 2005. Radiation and breast cancer: A review of current evidence. Breast Cancer Research 7:21-32.
43. Russo IH, Russo J. 1996a. Experimentally induced mammary tumors in rats. Breast Cancer Research and Treatment 39:7-20.
44. Russo IH, Russo J. 1996b. Mammary gland neoplasia in long-term rodent studies. Environmental Health Perspectives 104:938-967.
45. Santen RJ, Song RX, McPherson R, Kumar R, Adam L, Jeng MH, Yue W. 2002. The role of mitogen-activated protein (MAP) kinase in breast cancer. The Journal of Steroid Biochemistry and Molecular Biology 80:239-256.
46. Schairer C, Mink PJ, Carroll L, Devesa SS. 2004. Probabilities of death from breast cancer and other causes among female breast cancer patients. Journal of National Cancer Institute 96:1311-1321.
47. Sedelnikova OA, Pilch DR, Redon C, Bonner WM. 2003. Histone H2AX in DNA damage and repair. Cancer Biology and Therapy 2:233-235.
48. Shackney SE, Silverman JF. 2003. Molecular evolutionary patterns in breast cancer. Advances in Anatomic Pathology 10:278-290.
49. Simpson PT, Reis-Filho JS, Cale T, Lakhani SR. 2005. Molecular evolution of breast cancer. Journal of Pathology 205:248-225.
50. Smith SS. 1998. Stalling of DNA methyltransferase in chromosome stability and chromosome remodeling. International Journal of Molecular Medicine 1:147-156.
51. Sobol RW, Kartalou M, Almeida KH, Joyce DF, Engelward BP, Horton JK, Prasad R, Samson LD, Wilson SH. 2003. Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses. Journal of Biological Chemistry 278:39951-39959.
52. Soderlund K, Perez-Tenorio G, Stal O. 2005. Activation of the phosphatidylinositol 3-kinase/Akt pathway prevents radiation-induced apoptosis in breast cancer cells. International Journal of Oncology 26:25-32.
53. Sokal R, Rohlf FJ. 1995. Biometry. New York: Freeman.
54. Storm HH, Andersson M, Boice JD Jr, Blettner M, Stovall M, Mouridsen HT, Dombernowsky P, Rose C, Jacobsen A, Pedersen M. 1992. Adjuvant radiotherapy and risk of contralateral breast cancer. Journal of National Cancer Institute 84:1245-1250.
55. Szyf M, Pakneshan P, Rabbani SA. 2004. DNA methylation and breast cancer. Biochemical Pharmacology 68:1187-1197.
56. Turk PW, Laayoun A, Smith SS, Weitzman SA. 1995. DNA adduct 8-hydroxyl-20-deoxyguanosine (8-hydroxyguanine) affects function of human DNA methyltransferase. Carcinogenesis 16:1253-1255.
57. Wang T, Hu YC, Dong S, Fan M, Tamae D, Ozeki M, Gao Q, Gius D, Li JJ. 2005. Co-activation of ERK, NF-kappa B, and GADD45beta in response to ionizing radiation. Journal of Biological Chemistry 280:12593-12601.
58. West SC. 2003. Molecular views of recombination proteins and their control. Nature Reviews Molecular Cell Biology 4:435-445.
59. Widschwendter M, Jones PA. 2002. DNA methylation and breast carcinogenesis. Oncogene 21:5462-5482.
60. Widschwendter M, Siegmund KD, Muller HM, Fiegl H, Marth C, Muller-Holzner E, Jones PA, Laird PW. 2004. Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen. Cancer Research 64:3807-3813.
61. Wilson SH, Sobol RW, Beard WA, Horton JK, Prasad R, Vande Berg BJ. 2000. DNA polymerase beta and mammalian base excision repair. Cold Spring Harbor Symposium on Quantitative Biology 65:143-155.
62. Yang X, Yan L, Davidson NE. 2001. DNA methylation in breast cancer. Endocrine-Related Cancer 8:115-127.
63. Ye Y, Qiu TH, Kavanaugh C, Green JE. 2004. Molecular mechanisms of breast cancer progression: Lessons from mouse mammary cancer models and gene expression profiling. Breast Disease 19:69-82.