Accelerating unimolecular decarboxylation by preassociated acid catalysis in thiamin-derived intermediates: Implicating Brønsted acids as carbanion traps in enzymes

Journal of the American Chemical Society

Volumn 128, Issue 49, 2006, Pages 15856-15864

  Kluger, Ronald ^a   Ikeda, Glenn ^a   Hu, Qingyan ^a   Cao, Pengpeng ^a   Drewry, Joel ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; CATALYSIS; CATALYSTS; CHEMICAL BONDS; ENZYMES; MOLECULAR DYNAMICS; REACTION KINETICS;

MANDELYLTHIAMIN (MT); PREASSOCIATED ACID CATALYSIS; THIAMIN DERIVED INTERMEDIATES; UNIMOLECULAR DECARBOXYLATION;

CARBOXYLATION;

ALDEHYDE; BENZOYLFORMATE DECARBOXYLASE; BRONSTED ACID; CARBON DIOXIDE; CARBOXYLYASE; MANDELYLTHIAMIN; OXOACID; PHENYLGLYOXYLIC ACID; PYRIDINE; THIAMINE;

ARTICLE; CARBOXYLATION; CATALYSIS; CHEMICAL BOND; CHEMICAL REACTION KINETICS; CHEMICAL STRUCTURE; DECARBOXYLATION; DIFFUSION; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; SYNTHESIS;

ACIDS; BINDING SITES; CARBON DIOXIDE; CARBOXY-LYASES; CATALYSIS; DECARBOXYLATION; GLYOXYLATES; HYDROGEN-ION CONCENTRATION; KINETICS; MANDELIC ACIDS; MODELS, CHEMICAL; ORGANOPHOSPHORUS COMPOUNDS; PYRIDINES; THIAMINE;

EID: 33845454604     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja066249j     Document Type: Article

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