The importomer-A peroxisomal membrane complex involved in protein translocation into the peroxisome matrix

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1763, Issue 12, 2006, Pages 1613-1619

  Rayapuram, Naganand ^a   Subramani, Suresh ^a  

^a SECTION OF MOLECULAR BIOLOGY   (United States)

Author keywords

Docking and RING subcomplexes; Importomer; Peroxisomal matrix protein import

Indexed keywords

IMPORTOMER; MEMBRANE PROTEIN;

MAMMAL CELL; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TRANSPORT; REVIEW; STOICHIOMETRY; STRUCTURE ANALYSIS;

INTRACELLULAR MEMBRANES; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; PEROXISOMES; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE PROTEINS;

EUKARYOTA;

EID: 33845370951     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2006.08.035     Document Type: Review

References (48)

1. Agne B., Meindl N.M., Niederhoff K., Einwachter H., Rehling P., Sickmann A., Meyer H.E., Girzalsky W., and Kunau W.H. Pex8p: an intraperoxisomal organizer of the peroxisomal import machinery. Mol. Cell 11 (2003) 635-646
2. Hazra P.P., Suriapranata I., Snyder W.B., and Subramani S. Peroxisome remnants in pex3Δ cells and the requirement of Pex3p for interactions between the peroxisomal docking and translocation subcomplexes. Traffic 3 (2002) 560-574
3. Terlecky S.R., Nuttley W.M., McCollum D., Sock E., and Subramani S. The Pichia pastoris peroxisomal protein PAS8p is the receptor for the C-terminal tripeptide peroxisomal targeting signal. EMBO J. 14 (1995) 3627-3634
4. Dodt G., Braverman N., Wong C., Moser A., Moser H.W., Watkins P., Valle D., and Gould S.J. Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders. Nat. Genet. 9 (1995) 115-125
5. Wiemer E.A., Nuttley W.M., Bertolaet B.L., Li X., Francke U., Wheelock M.J., Anne U.K., Johnson K.R., and Subramani S. Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders. J. Cell Biol. 130 (1995) 51-65
6. Marzioch M., Erdmann R., Veenhuis M., and Kunau W.H. PAS7 encodes a novel yeast member of the WD-40 protein family essential for import of 3-oxoacyl-CoA thiolase, a PTS2-containing protein, into peroxisomes. EMBO J. 13 (1994) 4908-4918
7. Zhang J.W., and Lazarow P.B. PEB1 (PAS7) in Saccharomyces cerevisiae encodes a hydrophilic, intra-peroxisomal protein that is a member of the WD repeat family and is essential for the import of thiolase into peroxisomes. J. Cell Biol. 129 (1995) 65-80
8. Elgersma Y., Elgersma-Hooisma M., Wenzel T., McCaffery J.M., Farquhar M.G., and Subramani S. A mobile PTS2 receptor for peroxisomal protein import in Pichia pastoris. J. Cell Biol. 140 (1998) 807-820
9. Mukai S., Ghaedi K., and Fujiki Y. Intracellular localization, function, and dysfunction of the peroxisome-targeting signal type 2 receptor, Pex7p, in mammalian cells. J. Biol. Chem. 277 (2002) 9548-9561
10. Purdue P.E., Yang X., and Lazarow P.B. Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway. J. Cell Biol. 143 (1998) 1859-1869
11. Leon S., Zhang L., McDonald W.H., Yates III J., Cregg J.M., and Subramani S. Dynamics of the peroxisomal import cycle of PpPex20p: ubiquitin-dependent localization and regulation. J. Cell Biol. 172 (2006) 67-78
12. Rehling P., Marzioch M., Niesen F., Wittke E., Veenhuis M., and Kunau W.H. The import receptor for the peroxisomal targeting signal 2 (PTS2) in Saccharomyces cerevisiae is encoded by the PAS7 gene. EMBO J. 15 (1996) 2901-2913
13. Otzen M., Wang D., Lunenborg M.G., and van der Klei I.J. Hansenula polymorpha Pex20p is an oligomer that binds the peroxisomal targeting signal 2 (PTS2). J. Cell Sci. 118 (2005) 3409-3418
14. Stein K., Schell-Steven A., Erdmann R., and Rottensteiner H. Interactions of Pex7p and Pex18p/Pex21p with the peroxisomal docking machinery: implications for the first steps in PTS2 protein import. Mol. Cell Biol. 22 (2002) 6056-6069
15. Sichting M., Schell-Steven A., Prokisch H., Erdmann R., and Rottensteiner H. Pex7p and Pex20p of Neurospora crassa function together in PTS2-dependent protein import into peroxisomes. Mol. Biol. Cell 14 (2003) 810-821
16. Erdmann R., and Blobel G. Identification of Pex13p a peroxisomal membrane receptor for the PTS1 recognition factor. J. Cell Biol. 135 (1996) 111-121
17. Elgersma Y., Kwast L., Klein A., Voorn-Brouwer T., van den Berg M., Metzig B., America T., Tabak H.F., and Distel B. The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins. J. Cell Biol. 135 (1996) 97-109
18. Gould S.J., Kalish J.E., Morrell J.C., Bjorkman J., Urquhart A.J., and Crane D.I. Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor. J. Cell Biol. 135 (1996) 85-95
19. Albertini M., Rehling P., Erdmann R., Girzalsky W., Kiel J.A., Veenhuis M., and Kunau W.H. Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways. Cell 89 (1997) 83-92
20. Huhse B., Rehling P., Albertini M., Blank L., Meller K., and Kunau W.H. Pex17p of Saccharomyces cerevisiae is a novel peroxin and component of the peroxisomal protein translocation machinery. J. Cell Biol. 140 (1998) 49-60
21. Snyder W.B., Koller A., Choy A.J., Johnson M.A., Cregg J.M., Rangell L., Keller G.A., and Subramani S. Pex17p is required for import of both peroxisome membrane and lumenal proteins and interacts with Pex19p and the peroxisome targeting signal-receptor docking complex in Pichia pastoris. Mol. Biol. Cell 10 (1999) 4005-4019
22. Johnson M.A., Snyder W.B., Cereghino J.L., Veenhuis M., Subramani S., and Cregg J.M. Pichia pastoris Pex14p, a phosphorylated peroxisomal membrane protein, is part of a PTS-receptor docking complex and interacts with many peroxins. Yeast 18 (2001) 621-641
23. Einwächter H., Sowinski S., Kunau W.H., and Schliebs W. Yarrowia lipolytica Pex20p, Saccharomyces cerevisiae Pex18p/Pex21p and mammalian Pex5pL fulfil a common function in the early steps of the peroxisomal PTS2 import pathway. EMBO Rep. 2 (2001) 1035-1039
24. Otera H., Harano T., Honsho M., Ghaedi K., Mukai S., Tanaka A., Kawai A., Shimizu N., and Fujiki Y. The mammalian peroxin Pex5pL, the longer isoform of the mobile peroxisome targeting signal (PTS) type 1 transporter, translocates the Pex7p.PTS2 protein complex into peroxisomes via its initial docking site, Pex14p. J. Biol. Chem. 275 (2000) 21703-21714
25. Braverman N., Dodt G., Gould S.J., and Valle D. An isoform of Pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes. Hum. Mol. Genet. 7 (1998) 1195-1205
26. Matsumura T., Otera H., and Fujiki Y. Disruption of the interaction of the longer isoform of Pex5p, Pex5pL, with Pex7p abolishes peroxisome targeting signal type 2 protein import in mammals. Study with a novel Pex5-impaired Chinese hamster ovary cell mutant. J. Biol. Chem. 275 (2000) 21715-21721
27. Woodward A.W., and Bartel B. The Arabidopsis peroxisomal targeting signal type 2 receptor PEX7 Is necessary for peroxisome function and dependent on PEX5. Mol. Biol. Cell 16 (2005) 573-583
28. Urquhart A.J., Kennedy D., Gould S.J., and Crane D.I. Interaction of Pex5p, the type 1 peroxisome targeting signal receptor, with the peroxisomal membrane proteins Pex14p and Pex13p. J. Biol. Chem. 275 (2000) 4127-4136
29. Otera H., Setoguchi K., Hamasaki M., Kumashiro T., Shimizu N., and Fujiki Y. Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import. Mol. Cell Biol. 22 (2002) 1639-1655
30. Itoh R., and Fujiki Y. Functional domains and dynamic assembly of the peroxin Pex14p, the entry site of matrix proteins. J. Biol. Chem. (2006)
31. Platta H.W., Grunau S., Rosenkranz K., Girzalsky W., and Erdmann R. Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol. Nat. Cell Biol. 7 (2005) 817-822
32. Miyata N., and Fujiki Y. Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export. Mol. Cell Biol. 25 (2005) 10822-10832
33. Collins C.S., Kalish J.E., Morrell J.C., McCaffery J.M., and Gould S.J. The peroxisome biogenesis factors Pex4p, Pex22p, Pex1p, and Pex6p act in the terminal steps of peroxisomal matrix protein import. Mol. Cell Biol. 20 (2000) 7516-7526
34. Nair D.M., Purdue P.E., and Lazarow P.B. Pex7p translocates in and out of peroxisomes in Saccharomyces cerevisiae. J. Cell Biol. 167 (2004) 599-604
35. Dammai V., and Subramani S. The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol. Cell 105 (2001) 187-196
36. Birschmann I., Stroobants A.K., van den Berg M., Schafer A., Rosenkranz K., Kunau W.H., and Tabak H.F. Pex15p of Saccharomyces cerevisiae provides a molecular basis for recruitment of the AAA peroxin Pex6p to peroxisomal membranes. Mol. Biol. Cell 14 (2003) 2226-2236
37. Matsumoto N., Tamura S., and Fujiki Y. The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes. Nat. Cell Biol. 5 (2003) 454-460
38. Chang C.C., Warren D.S., Sacksteder K.A., and Gould S.J. PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import. J. Cell Biol. 147 (1999) 761-774
39. Zhang L., Leon S., and Subramani S. Two independent pathways traffic the intraperoxisomal peroxin PpPex8p into peroxisomes: mechanism and evolutionary implications. Mol. Biol. Cell 17 (2006) 690-699
40. Erdmann R., and Schliebs W. Peroxisomal matrix protein import: the transient pore model. Nat. Rev. Mol. Cell Biol. 6 (2005) 738-742
41. Platta H.W., Girzalsky W., and Erdmann R. Ubiquitination of the peroxisomal import receptor Pex5p. Biochem. J. 384 (2004) 37-45
42. Kiel J.A., Emmrich K., Meyer H.E., and Kunau W.H. Ubiquitination of the peroxisomal targeting signal type 1 receptor, Pex5p, suggests the presence of a quality control mechanism during peroxisomal matrix protein import. J. Biol. Chem. 280 (2005) 1921-1930
43. Kragt A., Voorn-Brouwer T., van den Berg M., and Distel B. The Saccharomyces cerevisiae peroxisomal import receptor Pex5p is monoubiquitinated in wild type cells. J. Biol. Chem. 280 (2005) 7867-7874
44. Albertini M., Girzalsky W., Veenhuis M., and Kunau W.H. Pex12p of Saccharomyces cerevisiae is a component of a multi-protein complex essential for peroxisomal matrix protein import. Eur. J. Cell Biol. 80 (2001) 257-270
45. Okumoto K., Abe I., and Fujiki Y. Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p. J. Biol. Chem. 275 (2000) 25700-25710
46. Reguenga C., Oliveira M.E., Gouveia A.M., Sa-Miranda C., and Azevedo J.E. Characterization of the mammalian peroxisomal import machinery: Pex2p, Pex5p, Pex12p, and Pex14p are subunits of the same protein assembly. J. Biol. Chem. 276 (2001) 29935-29942
47. Smith J.J., and Rachubinski R.A. A role for the peroxin Pex8p in Pex20p-dependent thiolase import into peroxisomes of the yeast Yarrowia lipolytica. J. Biol. Chem. 276 (2001) 1618-1625
48. Dodt G., and Gould S.J. Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p, the PTS1 receptor: evidence that PTS1 protein import is mediated by a cycling receptor. J. Cell Biol. 135 (1996) 1763-1774