Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: Conserved Pex5p WXXXF/Y motifs are critical for matrix protein import

Molecular and Cellular Biology

Volumn 22, Issue 6, 2002, Pages 1639-1655

  Otera, Hidenori ^a   Setoguchi, Kiyoko ^a   Hamasaki, Maho ^a   Kumashiro, Toshitaka ^a   Shimizu, Nobuhiro ^a   Fujiki, Yukio ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; ISOPROTEIN; MEMBRANE RECEPTOR; MUTANT PROTEIN; PENTAPEPTIDE; PEPTIDE DERIVATIVE; PEROXIN; PEROXISOMAL TARGETING SIGNAL RECEPTOR; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL MUTANT; COMPLEX FORMATION; DISSOCIATION; MEMBRANE TRANSPORT; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN TRANSPORT;

AMINO ACID MOTIFS; ANIMALS; CARRIER PROTEINS; CATALASE; CHO CELLS; CONSERVED SEQUENCE; CRICETINAE; GLUTATHIONE TRANSFERASE; HUMANS; MEMBRANE PROTEINS; MUTAGENESIS, SITE-DIRECTED; PEROXISOMES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; TRANSFECTION;

ANIMALIA; MAMMALIA;

EID: 0036179374     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.6.1639-1655.2002     Document Type: Article

References (46)

1. cDNA cloning and characterization of a constitutively expressed isoform of the human peroxin Pex11p
2. Clofibrate-inducible, 28-kDa peroxisomal integral membrane protein is encoded by PEX11
3. Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways
4. The peroxisomal membrane protein Pex13p shows a novel mode of SH3 interaction
5. Saccharomyces cerevisiae PTS1 receptor Pex5p interacts with the SH3 domain of the peroxisomal membrane protein Pex13p in an unconventional, non-PXXP-related manner
6. An isoform of Pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes
7. Pex14p is a member of the protein linkage map of Pex5p
8. PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import
9. Modular binding domains in signal transduction proteins
10. The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol
11. A unified nomenclature for peroxisome biogenesis factors
12. Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders
13. The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import of PTS1-containing proteins
14. Identification of Pex13p, a peroxisomal membrane receptor for the PTS1 recognition factor
15. Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import
16. Molecular defects in genetic diseases of peroxisomes
17. Peroxisome biogenesis and peroxisome biogenesis disorders
18. Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5
19. Isolation and characterization of novel peroxisome biogenesis-defective Chinese hamster ovary cell mutants using green fluorescent protein
20. The peroxin Pex3p initiates membrane assembly in peroxisome biogenesis
21. Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes
22. Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTS1 receptor
23. Peroxisome biogenesis disorders: Genetics and cell biology
24. Hsp70 regulates the interaction of the peroxisome targeting signal type 1 (PTS1)-receptor Pex5p and PTS1
25. Biogenesis of peroxisomes
26. Disruption of interaction of the longer isoform of Pex5p, Pex5pL, with Pex7p abolishes the PTS2 protein import in mammals: Study with a novel PEX5-impaired Chinese hamster ovary cell mutant
27. Peroxisome targeting signal of rat liver acyl-coenzyme A oxidase resides at the carboxy terminus
28. Molecular anatomy of the peroxin Pex12p: RING finger domain is essential for the Pex12p function and interacts with the peroxisome targeting signal type 1-receptor Pex5p and a RING peroxin, Pex10p
29. The mammalian peroxin Pex5pL, the longer isoform of mobile PTS1-transporter, translocates Pex7p-PTS2 protein complex into peroxisomes via its initial docking site Pex14p
30. Biogenesis of nonspecific lipid transfer protein and sterol carrier protein x: Studies using peroxisome assembly-defective pex cell mutants
31. Peroxisome targeting signal type 1 (PTS1) receptor is involved in import of both PTS1 and PTS2: Studies with PEX5-defective CHO cell mutants
32. Targeting of human catalase to peroxisomes is dependent upon a novel COOH-terminal peroxisomal targeting sequence
33. Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway
34. Characterization of the mammalian peroxisomal import machinery: Pex2p, Pex5p, Pex12p, and Pex14p are subunits of the same protein assembly
35. The di-aromatic pentapeptide repeats of the human peroxisome import receptor PEX5 are separate high affinity binding sites for the peroxisomal membrane protein PEX14
36. Recombinant human peroxisomal targeting signal receptor PEX5. Structural basis for interaction of PEX5 with PEX14
37. Expression of PEX11β mediates peroxisome proliferation in the absence of extracellular stimuli
38. The peroxin Pex14p: cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis
39. Functional heterogeneity of C-terminal peroxisome targeting signal 1 (PTS1) in PEX5-defective patients
40. PEX genes on the rise
41. Import of peroxisomal matrix and membrane proteins
42. The life cycle of the peroxisome
43. Isolation, characterization, and mutation analysis of PEX13-defective Chinese hamster ovary cell mutants
44. Isolation and characterization of Chinese hamster ovary cell mutants defective in assembly of peroxisomes
45. Interaction of Pex5p, the type 1 peroxisome targeting signal receptor, with the peroxisomal membrane proteins Pex14p and Pex13p
46. Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders